{"id":"https://openalex.org/W2120801774","doi":"https://doi.org/10.1161/hypertensionaha.111.199588","title":"Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor\u2013Dependent Mechanism","display_name":"Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor\u2013Dependent Mechanism","publication_year":2013,"publication_date":"2013-02-05","ids":{"openalex":"https://openalex.org/W2120801774","doi":"https://doi.org/10.1161/hypertensionaha.111.199588","mag":"2120801774","pmid":"https://pubmed.ncbi.nlm.nih.gov/23381789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667616"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.111.199588","doi":"https://doi.org/10.1161/hypertensionaha.111.199588","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.111.199588","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.111.199588","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.111.199588","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082919356","display_name":"Vijaya Karoor","orcid":"https://orcid.org/0000-0002-1488-1801","observed_orcids":["https://orcid.org/0000-0002-1488-1801"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vijaya Karoor","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050459313","display_name":"Masahiko Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiko Oka","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028910994","display_name":"Sandra J. Walchak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra J. Walchak","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109249437","display_name":"Louis B. Hersh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis B. Hersh","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112903856","display_name":"York E. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"York E Miller","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059343570","display_name":"Edward C. Dempsey","orcid":"https://orcid.org/0000-0002-9407-0549","observed_orcids":["https://orcid.org/0000-0002-9407-0549"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210101549","display_name":"Denver VA Medical Center","ror":"https://ror.org/018hk2b97","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101549","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210148403","display_name":"VA Eastern Colorado Health Care System","ror":"https://ror.org/04d7ez939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210113540","https://openalex.org/I4210148403"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward C. Dempsey","raw_affiliation_strings":["From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiovascular Pulmonary Research Laboratory (V.K., S.J.W., E.C.D.), Division of Pulmonary Sciences and Critical Care Medicine (V.K., Y.E.M., E.C.D.), and University of Colorado Cancer Center (Y.E.M., E.C.D.), University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY; Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.); and Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210134151","https://openalex.org/I51713134","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry, University of Kentucky (L.B.H.), Lexington, KY","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile, AL (M.O.)","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Pulmonary and Critical Care Section (E.C.D.), VA Eastern Colorado Health Care System, Denver, CO","institution_ids":["https://openalex.org/I4210101549","https://openalex.org/I4210148403"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082919356"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210101549","https://openalex.org/I4210134151","https://openalex.org/I4210148403","https://openalex.org/I51713134","https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":1.8965,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.86700737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"61","issue":"4","first_page":"921","last_page":"930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neprilysin","display_name":"neprilysin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"platelet-derived growth factor receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9070000052452087},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.75},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.6930000185966492},{"id":"https://openalex.org/keywords/endothelin-a-receptor-antagonist","display_name":"endothelin A receptor antagonist","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6349063515663147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.607747495174408},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5402241945266724},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.5327691435813904},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.513043999671936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4903395175933838},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.48761263489723206},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4554445743560791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3382534384727478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3325178325176239},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3312980532646179},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.291193425655365},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28207796812057495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1852796971797943},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.14235979318618774},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.11155819892883301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020797","descriptor_name":"Receptor, Platelet-Derived Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/hypertensionaha.111.199588","doi":"https://doi.org/10.1161/hypertensionaha.111.199588","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.111.199588","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.111.199588","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:23381789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23381789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2949905","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3667616","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3667616","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667616","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hypertension","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.111.199588","doi":"https://doi.org/10.1161/hypertensionaha.111.199588","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.111.199588","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.111.199588","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2939015535","display_name":null,"funder_award_id":"HL078927","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3021903388","display_name":"Selected Peptidases and Pulmonary Vascular Remodeling in Chronic Obstructive Pulm","funder_award_id":"R03HL095439","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3448714656","display_name":null,"funder_award_id":"HL095439","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4175496475","display_name":null,"funder_award_id":"HL-014985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7063068489","display_name":"Adaptation to Hypoxia","funder_award_id":"P01HL014985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7937762165","display_name":"Neprilysin Apoptosis and Hypoxic Pulmonary Hypertension","funder_award_id":"R01HL078927","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120801774.pdf","grobid_xml":"https://content.openalex.org/works/W2120801774.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1971634248","https://openalex.org/W1987444143","https://openalex.org/W1990641932","https://openalex.org/W1997505965","https://openalex.org/W2012200154","https://openalex.org/W2014729261","https://openalex.org/W2029509569","https://openalex.org/W2031414702","https://openalex.org/W2033587732","https://openalex.org/W2041642022","https://openalex.org/W2054008469","https://openalex.org/W2062002285","https://openalex.org/W2071077259","https://openalex.org/W2075858474","https://openalex.org/W2075919386","https://openalex.org/W2085898726","https://openalex.org/W2106412710","https://openalex.org/W2118995428","https://openalex.org/W2129815268","https://openalex.org/W2146888695","https://openalex.org/W2153638986","https://openalex.org/W2162345239","https://openalex.org/W2167355903","https://openalex.org/W2172100996","https://openalex.org/W2172244737","https://openalex.org/W2187100721","https://openalex.org/W2399042156","https://openalex.org/W4256623230"],"related_works":["https://openalex.org/W2330574767","https://openalex.org/W2041839354","https://openalex.org/W3170788327","https://openalex.org/W2775303211","https://openalex.org/W2075919386","https://openalex.org/W2466492819","https://openalex.org/W4220691719","https://openalex.org/W2500819067","https://openalex.org/W4288885903","https://openalex.org/W2150029109"],"abstract_inverted_index":{"Reduced":[0],"neprilysin":[1],"(NEP),":[2],"a":[3,78,132,231],"cell":[4],"surface":[5],"metallopeptidase,":[6],"which":[7,66,167],"cleaves":[8],"and":[9,12,42,56,62,93,106,139,142,162,183,201,224,245],"inactivates":[10],"proinflammatory":[11],"vasoactive":[13],"peptides,":[14],"predisposes":[15],"the":[16,114,188,214,235],"lung":[17,250],"vasculature":[18],"to":[19,24,60,99,178,187],"exaggerated":[20],"remodeling":[21],"in":[22,32,39,58,88,102,111,144,164,190,205,217,268],"response":[23,59],"hypoxia.":[25],"We":[26],"hypothesize":[27],"that":[28,248],"loss":[29],"of":[30,73,77,96,108,113,121,160,197,237,265],"NEP":[31,70,74,97,149,241,251],"pulmonary":[33,191,219,269],"artery":[34,45,192,220],"smooth":[35,46,146,193,221],"muscle":[36,47,147,194,222],"cells":[37,48,90,223],"results":[38,229],"increased":[40,91,158],"migration":[41,55,92,141],"proliferation.":[43,94],"Pulmonary":[44],"isolated":[49],"from":[50],"NEP(-/-)":[51,145,206,218],"mice":[52],"exhibited":[53],"enhanced":[54,215],"proliferation":[57,143],"serum":[61],"platelet-derived":[63,115],"growth":[64,116,155,180],"factor,":[65],"was":[67,168],"attenuated":[68,140,213],"by":[69,75,84,170,240],"replacement.":[71],"Inhibition":[72],"overexpression":[76],"peptidase":[79],"dead":[80],"mutant":[81],"or":[82,128,153,253,261],"knockdown":[83],"small":[85,125],"interfering":[86,126],"RNA":[87,127],"NEP(+/+)":[89,165],"Loss":[95],"led":[98],"an":[100,171],"increase":[101,249],"Src":[103,122,161,184,244],"kinase":[104,123,134],"activity":[105],"phosphorylation":[107,138],"PTEN,":[109,260],"resulting":[110],"activation":[112,159],"factor":[117,156,181],"receptor":[118,174,210],"(PDGFR).":[119],"Knockdown":[120],"with":[124,130],"inhibition":[129],"PP2,":[131],"src":[133],"inhibitor,":[135],"decreased":[136,169],"PDGFR(Y751)":[137],"cells.":[148],"substrates,":[150],"endothelin":[151,172],"1":[152],"fibroblast":[154,179],"2,":[157],"PDGFR":[163,238],"cells,":[166,195],"A":[173,209],"antagonist,":[175],"neutralizing":[176],"antibody":[177],"2":[182],"inhibitor.":[185],"Similar":[186],"observations":[189],"levels":[196],"phosphorylated":[198],"PDGFR,":[199,262],"Src,":[200,259],"PTEN":[202],"were":[203],"elevated":[204],"lungs.":[207,225],"Endothelin":[208],"antagonist":[211],"also":[212],"responses":[216],"Taken":[226],"together":[227],"our":[228],"suggest":[230],"novel":[232],"mechanism":[233],"for":[234],"regulation":[236],"signaling":[239],"substrates":[242],"involving":[243],"PTEN.":[246],"Strategies":[247],"activity/expression":[252],"target":[254],"key":[255],"downstream":[256],"effectors,":[257],"like":[258],"may":[263],"be":[264],"therapeutic":[266],"benefit":[267],"vascular":[270],"disease.":[271]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
