{"id":"https://openalex.org/W2120761583","doi":"https://doi.org/10.1186/1748-717x-6-8","title":"Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo","display_name":"Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo","publication_year":2011,"publication_date":"2011-01-20","ids":{"openalex":"https://openalex.org/W2120761583","doi":"https://doi.org/10.1186/1748-717x-6-8","mag":"2120761583","pmid":"https://pubmed.ncbi.nlm.nih.gov/21247507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3035588"},"language":"en","primary_location":{"id":"doi:10.1186/1748-717x-6-8","doi":"https://doi.org/10.1186/1748-717x-6-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-8","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-8","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hitoshi Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Fujii","raw_affiliation_strings":["Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033747502","display_name":"Akifumi Matsuyama","orcid":"https://orcid.org/0000-0001-7011-0326","observed_orcids":["https://orcid.org/0000-0001-7011-0326"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akifumi Matsuyama","raw_affiliation_strings":["Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210155576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000595844","display_name":"Hiroshi Komoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Komoda","raw_affiliation_strings":["Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102927120","display_name":"Masao Sasai","orcid":"https://orcid.org/0000-0001-9696-9796","observed_orcids":["https://orcid.org/0000-0001-9696-9796"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Sasai","raw_affiliation_strings":["Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210155576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077846797","display_name":"Minoru Suzuki","orcid":"https://orcid.org/0000-0002-5421-9417","observed_orcids":["https://orcid.org/0000-0002-5421-9417"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210165181","display_name":"Institute for Integrated Radiation and Nuclear Science, Kyoto University","ror":"https://ror.org/05qs31q25","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242","https://openalex.org/I4210165181"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Suzuki","raw_affiliation_strings":["Particle Radiation Oncology Research Center Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Particle Radiation Oncology Research Center Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210165181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112314397","display_name":"Tomoyuki Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Asano","raw_affiliation_strings":["Department of Agriculture, Osaka Prefectural University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agriculture, Osaka Prefectural University, Osaka, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028284770","display_name":"Yuichiro\ufffd Doki","orcid":"https://orcid.org/0000-0001-7346-0209","observed_orcids":["https://orcid.org/0000-0001-7346-0209"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Doki","raw_affiliation_strings":["Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045190842","display_name":"Mitsunori Kirihata","orcid":"https://orcid.org/0000-0002-4183-9107","observed_orcids":["https://orcid.org/0000-0002-4183-9107"]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunori Kirihata","raw_affiliation_strings":["Department of Agriculture, Osaka Prefectural University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agriculture, Osaka Prefectural University, Osaka, Japan","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101749646","display_name":"Koji Ono","orcid":"https://orcid.org/0000-0003-2268-0804","observed_orcids":["https://orcid.org/0000-0003-2268-0804"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210165181","display_name":"Institute for Integrated Radiation and Nuclear Science, Kyoto University","ror":"https://ror.org/05qs31q25","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242","https://openalex.org/I4210165181"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Ono","raw_affiliation_strings":["Particle Radiation Oncology Research Center Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Particle Radiation Oncology Research Center Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210165181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055033211","display_name":"Yasuhiko Tabata","orcid":"https://orcid.org/0000-0001-8974-277X","observed_orcids":["https://orcid.org/0000-0001-8974-277X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Tabata","raw_affiliation_strings":["Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026777","display_name":"Yasufumi Kaneda","orcid":"https://orcid.org/0009-0009-6106-5434","observed_orcids":["https://orcid.org/0009-0009-6106-5434"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasufumi Kaneda","raw_affiliation_strings":["Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045683397","display_name":"Yoshiki Sawa","orcid":"https://orcid.org/0000-0001-6132-9684","observed_orcids":["https://orcid.org/0000-0001-6132-9684"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiki Sawa","raw_affiliation_strings":["Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114040694","display_name":"Chun Man Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Chun Man Lee","raw_affiliation_strings":["Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","Health Care Economics and Industrial Policy, Osaka University Graduate School of Medicine, Osaka, Japan","Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Health Care Economics and Industrial Policy, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210155576"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5114040694"],"corresponding_institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":1.0722,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75952928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12055","display_name":"Boron Compounds in Chemistry","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12055","display_name":"Boron Compounds in Chemistry","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boron-neutron-capture-therapy","display_name":"boron neutron capture therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sodium-borocaptate","display_name":"sodium borocaptate","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hemagglutinating-activity","display_name":"hemagglutination activity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tumor-to-normal-tissue-ratio","display_name":"tumor-to-normal tissue ratio","score":0.5070000290870667},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.45500001311302185},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7459999918937683},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.3490000069141388},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9318559169769287},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7859036922454834},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.48417431116104126},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.44762298464775085},{"id":"https://openalex.org/C65155139","wikidata":"https://www.wikidata.org/wiki/Q5380912","display_name":"Envelope (radar)","level":3,"score":0.4466014802455902},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.41272664070129395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3945852518081665},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3386484682559967},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32497262954711914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2770920991897583},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.1368187963962555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0792585015296936},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001894","descriptor_name":"Borohydrides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016754","descriptor_name":"Boron Neutron Capture Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029082","descriptor_name":"Sendai virus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D029082","descriptor_name":"Sendai virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1748-717x-6-8","doi":"https://doi.org/10.1186/1748-717x-6-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-8","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-8","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3035588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3035588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiat Oncol","raw_type":"Text"},{"id":"pmid:21247507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21247507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation oncology (London, England)","raw_type":"Evaluation Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.294.473","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.294.473","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a9/1f/Radiat_Oncol_2011_Jan_20_6_8.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ce4e8de69e51496295ca9099ffac79db","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ce4e8de69e51496295ca9099ffac79db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Radiation Oncology, Vol 6, Iss 1, p 8 (2011)","raw_type":"article"},{"id":"mag:2340212292","doi":null,"is_oa":false,"landing_page_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/58941/24868_%E8%A6%81%E6%97%A8.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1748-717x-6-8","doi":"https://doi.org/10.1186/1748-717x-6-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1748-717x-6-8","pdf_url":"https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-6-8","source":{"id":"https://openalex.org/S42123126","display_name":"Radiation Oncology","issn_l":"1748-717X","issn":["1748-717X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120761583.pdf","grobid_xml":"https://content.openalex.org/works/W2120761583.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W123243861","https://openalex.org/W1557974720","https://openalex.org/W1726775692","https://openalex.org/W1971195407","https://openalex.org/W1973997306","https://openalex.org/W1980525257","https://openalex.org/W1981501643","https://openalex.org/W1986688713","https://openalex.org/W1987666899","https://openalex.org/W1988742771","https://openalex.org/W1992847347","https://openalex.org/W2002516695","https://openalex.org/W2013759034","https://openalex.org/W2014231835","https://openalex.org/W2015454126","https://openalex.org/W2024209265","https://openalex.org/W2024587687","https://openalex.org/W2028750783","https://openalex.org/W2028784773","https://openalex.org/W2033992132","https://openalex.org/W2045218004","https://openalex.org/W2046164380","https://openalex.org/W2050475689","https://openalex.org/W2051068137","https://openalex.org/W2067864160","https://openalex.org/W2068781134","https://openalex.org/W2074864153","https://openalex.org/W2083939721","https://openalex.org/W2085731391","https://openalex.org/W2091753221","https://openalex.org/W2118067111","https://openalex.org/W2121948017","https://openalex.org/W2123247779","https://openalex.org/W2132834456","https://openalex.org/W2133835288","https://openalex.org/W2143978130","https://openalex.org/W2145030327","https://openalex.org/W2149684470","https://openalex.org/W2163147443","https://openalex.org/W2164396168","https://openalex.org/W2169180705","https://openalex.org/W2262736290","https://openalex.org/W4243396275"],"related_works":["https://openalex.org/W7098034367","https://openalex.org/W2243101214","https://openalex.org/W2028750783","https://openalex.org/W1926284819","https://openalex.org/W4413969638","https://openalex.org/W3209382101","https://openalex.org/W1973997306","https://openalex.org/W2606494627","https://openalex.org/W2045074227","https://openalex.org/W2069175627"],"abstract_inverted_index":{"BACKGROUND:":[0],"Boron":[1],"neutron":[2,23],"capture":[3,24],"therapy":[4,10,210],"(BNCT)":[5],"is":[6,27,113,326],"a":[7,28,116,145,212,300,319,327],"cell-selective":[8],"radiation":[9],"that":[11,88],"uses":[12],"the":[13,21,53,61,64,68,73,259,273,282,309,331],"alpha":[14],"particles":[15],"and":[16,60,100,156,181,191,204,206,226],"lithium":[17],"nuclei":[18],"produced":[19],"by":[20,224],"boron":[22],"reaction.":[25],"BNCT":[26,50,77,165,209,289,332],"relatively":[29],"safe":[30],"tool":[31],"for":[32,105,118,138,148,159,187,272,330],"treating":[33,160],"multiple":[34,161,199,216,255],"or":[35,47],"diffuse":[36],"malignant":[37],"tumors":[38,80,83,163,201,336],"with":[39,128,164,178,245,248,294,297],"little":[40],"injury":[41],"to":[42,67,81,126,198,316,341],"normal":[43,98,343],"tissue.":[44],"The":[45],"success":[46],"failure":[48],"of":[49,63,76,109,122,215,263,270,284,312,322,334],"depends":[51],"upon":[52],"10B":[54,86,149,236,303],"compound":[55],"accumulation":[56,96,190],"within":[57],"tumor":[58,65,92,188,194,285],"cells":[59,66,93,241,286],"proximity":[62],"body":[69],"surface.":[70],"To":[71],"extend":[72],"therapeutic":[74],"use":[75],"from":[78],"surface":[79],"visceral":[82,335],"will":[84],"require":[85],"compounds":[87],"accumulate":[89],"strongly":[90],"in":[91,97,193,202,208,211,231,238,287],"without":[94,166,337],"significant":[95],"cells,":[99,189,195],"an":[101],"appropriate":[102],"delivery":[103,120,153],"method":[104],"deeper":[106],"tissues.Hemagglutinating":[107],"Virus":[108],"Japan":[110],"Envelope":[111],"(HVJ-E)":[112],"used":[114],"as":[115,292,296],"vehicle":[117],"gene":[119],"because":[121],"its":[123,131,183],"high":[124],"ability":[125],"fuse":[127],"cells.":[129],"However,":[130],"strong":[132],"hemagglutination":[133,222],"activity":[134,223],"makes":[135],"HVJ-E":[136,155,176],"unsuitable":[137],"systemic":[139],"administration.In":[140],"this":[141],"study,":[142],"we":[143],"developed":[144,172],"novel":[146],"vector":[147],"(sodium":[150],"borocaptate:":[151],"BSH)":[152],"using":[154],"cationized":[157,173],"gelatin":[158,174],"liver":[162,200,217,257,261],"severe":[167,338],"adverse":[168,339],"events.":[169],"METHODS:":[170],"We":[171],"conjugate":[175],"combined":[177],"BSH":[179,271,298,317],"(CG-HVJ-E-BSH),":[180],"evaluated":[182],"characteristics":[184],"(toxicity,":[185],"affinity":[186],"retention":[192],"boron-carrying":[196],"capacity":[197],"vivo,":[203],"bio-distribution)":[205],"effectiveness":[207],"murine":[213,239],"model":[214],"tumors.":[218],"RESULTS:":[219],"CG-HVJ-E":[220],"reduced":[221],"half":[225],"was":[227,291],"significantly":[228,266,307],"less":[229],"toxic":[230],"mice":[232,253,314],"than":[233,247,268],"HVJ-E.":[234],"Higher":[235],"concentrations":[237],"osteosarcoma":[240],"(LM8G5)":[242],"were":[243,265],"achieved":[244],"CG-HVJ-E-BSH":[246,264,295,306,325],"BSH.":[249],"When":[250],"administered":[251],"into":[252],"bearing":[254],"LM8G5":[256],"tumors,":[258],"tumor/normal":[260],"ratios":[262],"higher":[267,302],"those":[269],"first":[274],"48":[275],"hours":[276],"(p":[277],"<":[278],"0.05).":[279],"In":[280],"suppressing":[281],"spread":[283],"mice,":[288],"treatment":[290,333],"effective":[293],"containing":[299],"35-fold":[301],"dose.":[304],"Furthermore,":[305],"increased":[308],"survival":[310],"time":[311],"tumor-bearing":[313],"compared":[315],"at":[318],"comparable":[320],"dosage":[321],"10B.":[323],"CONCLUSION:":[324],"promising":[328],"strategy":[329],"events":[340],"surrounding":[342],"tissues.":[344]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}