{"id":"https://openalex.org/W2120738808","doi":null,"title":"Safety and effectiveness of the new inactivated hepatitis A virus vaccine.","display_name":"Safety and effectiveness of the new inactivated hepatitis A virus vaccine.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2120738808","mag":"2120738808","pmid":"https://pubmed.ncbi.nlm.nih.gov/7828098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1337532"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:251523","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1337532","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1337532","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001199593","display_name":"John Furesz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288894424","display_name":"Health Canada","ror":"https://ror.org/05p8nb362","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Furesz","raw_affiliation_strings":["Bureau of Biologics, Health Canada, Ottawa, Ont"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau of Biologics, Health Canada, Ottawa, Ont","institution_ids":["https://openalex.org/I1288894424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043472782","display_name":"David W. Scheifele","orcid":"https://orcid.org/0000-0001-6078-7843","observed_orcids":["https://orcid.org/0000-0001-6078-7843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D W Scheifele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047868101","display_name":"Laszlo Palkonyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Palkonyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5023,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84987705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"152","issue":"3","first_page":"343","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inactivated-hepatitis-a-vaccine","display_name":"inactivated hepatitis A vaccine","score":0.878000020980835},{"id":"https://openalex.org/keywords/hepatitis-a-virus","display_name":"hepatitis A virus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/formaldehyde-inactivation","display_name":"formalin inactivation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/aluminum-hydroxide-adjuvant","display_name":"aluminum hydroxide adjuvant","score":0.9269999861717224},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antibody-persistence","display_name":"antibody persistence","score":0.8669999837875366},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7680000066757202},{"id":"https://openalex.org/keywords/pre-exposure-prophylaxis","display_name":"pre-exposure prophylaxis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/travel-vaccination","display_name":"travel vaccination","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2780799908","wikidata":"https://www.wikidata.org/wiki/Q3553093","display_name":"Hepatitis A vaccine","level":4,"score":0.7758206725120544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7713311910629272},{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.6935092210769653},{"id":"https://openalex.org/C2775876817","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis A","level":3,"score":0.6341400146484375},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4831632971763611},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47239941358566284},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4575689136981964},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4573393166065216},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41134801506996155},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38313180208206177},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3704226613044739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3374062776565552},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3313603699207306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19885092973709106}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006506","descriptor_name":"Hepatitis A","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006506","descriptor_name":"Hepatitis A","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014761","descriptor_name":"Viral Hepatitis Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015164","descriptor_name":"Vaccines, Inactivated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D022362","descriptor_name":"Hepatitis A Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:251523","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1337532","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1337532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1337532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CMAJ","raw_type":"Text"},{"id":"pmid:7828098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7828098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne","raw_type":"Journal Article"},{"id":"mag:2120738808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7828098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:251523","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1337532","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W231400662","https://openalex.org/W1841148314","https://openalex.org/W1956388418","https://openalex.org/W1967060350","https://openalex.org/W1975752051","https://openalex.org/W1978696684","https://openalex.org/W1992077812","https://openalex.org/W2001947764","https://openalex.org/W2013652602","https://openalex.org/W2017352315","https://openalex.org/W2021422720","https://openalex.org/W2029475777","https://openalex.org/W2032528638","https://openalex.org/W2043985689","https://openalex.org/W2046590146","https://openalex.org/W2046762214","https://openalex.org/W2063313528","https://openalex.org/W2065540135","https://openalex.org/W2069113633","https://openalex.org/W2086001135","https://openalex.org/W2092085548","https://openalex.org/W2092710220","https://openalex.org/W2093035293","https://openalex.org/W2099525015","https://openalex.org/W2122784612","https://openalex.org/W2143842982","https://openalex.org/W2158459008","https://openalex.org/W2320159189","https://openalex.org/W2337114621","https://openalex.org/W2412900939","https://openalex.org/W4254277391"],"related_works":["https://openalex.org/W1956388418","https://openalex.org/W2359121222","https://openalex.org/W3139570953","https://openalex.org/W2083500248","https://openalex.org/W2383092741","https://openalex.org/W2418630881","https://openalex.org/W2417151122","https://openalex.org/W2183044946","https://openalex.org/W1964079321","https://openalex.org/W2077738168"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"the":[3,6,11,34,63,67,93,100,140,159,203,209,216,234,251,261,298,313,317,334,342],"evidence":[4],"concerning":[5],"safety":[7],"and":[8,66,97,115,130,163,184,208,224,274,315,324,341],"effectiveness":[9],"of":[10,28,52,70,84,99,118,143,161,253,286,328,336,344],"inactivated":[12,157],"hepatitis":[13,73],"A":[14,74],"virus":[15,75,154],"vaccine":[16,65,122,138,270,314,318],"recently":[17],"licensed":[18],"for":[19,57,171,185,288],"use":[20,160],"in":[21,44,121,150,180,190,280],"Canada.":[22],"DATA":[23,102,134],"SOURCES:":[24],"The":[25,50,104,136,153,168,196,267],"main":[26],"source":[27],"information":[29],"were":[30,55,77,128],"papers":[31,54],"presented":[32],"at":[33],"International":[35],"Symposium":[36],"on":[37,92,109],"Active":[38],"Immunization":[39],"against":[40],"Hepatitis":[41],"A,":[42],"held":[43],"Vienna,":[45],"Austria,":[46],"Jan.":[47],"27-29,":[48],"1992.":[49],"bibliographies":[51],"these":[53,126],"searched":[56],"additional":[58],"references.":[59],"Recent":[60],"articles":[61],"describing":[62],"new":[64,137,268],"epidemiologic":[68],"aspects":[69],"infection":[71,287,323],"with":[72,158,282],"(HAV)":[76],"also":[78,350],"reviewed.":[79],"STUDY":[80],"SELECTION:":[81],"Peer-reviewed":[82],"reports":[83,108,127],"trials":[85,331],"approved":[86],"by":[87],"a":[88,181,191],"government":[89],"regulatory":[90],"agency":[91],"safety,":[94],"immunogenic":[95],"properties":[96],"efficacy":[98,241],"vaccine.":[101],"EXTRACTION:":[103],"authors":[105],"assembled":[106],"key":[107],"adverse":[110],"reactions,":[111],"protection":[112,337],"from":[113,125,321],"disease":[114,299],"serologic":[116],"assessment":[117],"immune":[119],"response":[120],"recipients;":[123],"data":[124],"tabulated":[129],"analysed.":[131],"RESULTS":[132],"OF":[133],"SYNTHESIS:":[135],"contains":[139],"HM175":[141],"strain":[142],"HAV,":[144],"which":[145],"is":[146,155,173,199,237,245,271,300],"adapted":[147],"to":[148,212,247,277,295,306,312,332],"grow":[149],"tissue":[151],"culture.":[152],"purified,":[156],"formaldehyde":[162],"adsorbed":[164],"onto":[165],"aluminum":[166],"hydroxide.":[167],"recommended":[169],"dose":[170,183],"adults":[172],"720":[174],"enzyme-linked":[175],"immunosorbent":[176],"assay":[177],"(ELISA)":[178],"units":[179,189],"1.0-mL":[182],"children":[186],"360":[187],"ELISA":[188],"0.5-mL":[192],"dose,":[193],"injected":[194],"intramuscularly.":[195],"usual":[197],"schedule":[198],"three":[200],"serial":[201],"doses,":[202,233],"second":[204],"given":[205],"1":[206],"month":[207],"third":[210],"6":[211],"12":[213],"months":[214],"after":[215,242],"initial":[217],"dose.":[218],"Reported":[219],"side":[220],"effects":[221,343],"are":[222,304,349],"infrequent":[223],"minor.":[225],"In":[226],"healthy":[227],"persons":[228],"who":[229],"have":[230],"received":[231],"two":[232,243],"seroconversion":[235],"rate":[236],"almost":[238],"100%.":[239],"Protective":[240],"doses":[244],"estimated":[246],"be":[248],"94%.":[249],"However,":[250],"persistence":[252],"protective":[254],"antibodies":[255],"has":[256],"been":[257],"studied":[258],"only":[259],"over":[260],"short":[262],"term":[263],"(3":[264],"years).":[265],"CONCLUSIONS:":[266],"HAV":[269],"safe,":[272],"effective":[273],"best":[275],"suited":[276],"pre-exposure":[278],"prophylaxis":[279],"people":[281],"an":[283,289],"increased":[284],"risk":[285],"extended":[290],"period,":[291],"such":[292],"as":[293],"travellers":[294],"areas":[296],"where":[297],"endemic.":[301],"Further":[302],"studies":[303],"needed":[305],"determine":[307,333],"whether":[308,316],"infants":[309],"respond":[310],"well":[311],"protects":[319],"recipients":[320],"subclinical":[322],"associated":[325],"fecal":[326],"shedding":[327],"HAV.":[329],"Controlled":[330],"duration":[335],"beyond":[338],"3":[339],"years":[340],"more":[345],"rapid":[346],"dosage":[347],"schedules":[348],"needed.":[351]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
