{"id":"https://openalex.org/W2120671990","doi":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","title":"Caracter\u00edsticas metab\u00f3licas diferenciais de distintos territ\u00f3rios adiposos em ratos submetidos a tratamento prolongado, cont\u00ednuo e excessivo com glicocorticoides: um modelo de s\u00edndrome de Cushing iatrog\u00eanica.","display_name":"Caracter\u00edsticas metab\u00f3licas diferenciais de distintos territ\u00f3rios adiposos em ratos submetidos a tratamento prolongado, cont\u00ednuo e excessivo com glicocorticoides: um modelo de s\u00edndrome de Cushing iatrog\u00eanica.","publication_year":2013,"publication_date":"2013-04-11","ids":{"openalex":"https://openalex.org/W2120671990","doi":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","mag":"2120671990"},"language":"pt","primary_location":{"id":"doi:10.11606/t.42.2013.tde-20092013-082538","doi":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42137/tde-20092013-082538/publico/PatriciaChimin_Doutorado_Corr.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/42/42137/tde-20092013-082538/publico/PatriciaChimin_Doutorado_Corr.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074429642","display_name":"Patr\u00edcia Chimin","orcid":"https://orcid.org/0000-0002-4686-4280","observed_orcids":["https://orcid.org/0000-0002-4686-4280"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Patricia Chimin","raw_affiliation_strings":["Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo; 2013","metab\u00f3licas diferenciais de distintos territ\u00f3rios adiposos em ratos submetidos a tratamento prolongado, cont\u00ednuo","que houve maior incorpora\u00e7\u00e3o de glicose na por\u00e7\u00e3o \u00e1cido graxo dos triacilglicer\u00f3is. Corroborando essa maior s\u00edntese de novo de \u00e1cidos graxos,","resposta tamb\u00e9m foi refletida na express\u00e3o g\u00eanica dessas enzimas. Esses resultados mostram que diversos aspectos da indu\u00e7\u00e3o iatrog\u00eanica de s\u00edndrome de Cushing em ratos foram obtidos,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo; 2013","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"metab\u00f3licas diferenciais de distintos territ\u00f3rios adiposos em ratos submetidos a tratamento prolongado, cont\u00ednuo","institution_ids":[]},{"raw_affiliation_string":"que houve maior incorpora\u00e7\u00e3o de glicose na por\u00e7\u00e3o \u00e1cido graxo dos triacilglicer\u00f3is. Corroborando essa maior s\u00edntese de novo de \u00e1cidos graxos,","institution_ids":[]},{"raw_affiliation_string":"resposta tamb\u00e9m foi refletida na express\u00e3o g\u00eanica dessas enzimas. Esses resultados mostram que diversos aspectos da indu\u00e7\u00e3o iatrog\u00eanica de s\u00edndrome de Cushing em ratos foram obtidos,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074429642"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iatrogenic-cushing-syndrome","display_name":"iatrogenic Cushing's syndrome","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glucocorticoid-excess","display_name":"glucocorticoid excess","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8650000095367432},{"id":"https://openalex.org/keywords/adipose-tissue-metabolism","display_name":"adipose tissue metabolism","score":0.6420000195503235},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glucose-oxidation","display_name":"glucose oxidation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/fatty-acid-incorporation","display_name":"fatty acid incorporation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.925000011920929},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.7960000038146973},{"id":"https://openalex.org/keywords/retroperitoneal-fat","display_name":"retroperitoneal fat","score":0.972000002861023},{"id":"https://openalex.org/keywords/mesenteric-fat","display_name":"mesenteric fat","score":0.968999981880188},{"id":"https://openalex.org/keywords/plasma-corticosterone","display_name":"plasma corticosterone","score":0.574999988079071},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6413677334785461},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.48459112644195557},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34170928597450256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18845200538635254}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.11606/t.42.2013.tde-20092013-082538","doi":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42137/tde-20092013-082538/publico/PatriciaChimin_Doutorado_Corr.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:americanae.aecid.es:2241429","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2241429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:teses.usp.br:tde-20092013-082538","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.42.2013.tde-20092013-082538","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.11606/t.42.2013.tde-20092013-082538","doi":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2013.tde-20092013-082538","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42137/tde-20092013-082538/publico/PatriciaChimin_Doutorado_Corr.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120671990.pdf","grobid_xml":"https://content.openalex.org/works/W2120671990.grobid-xml"},"referenced_works_count":115,"referenced_works":["https://openalex.org/W1507233279","https://openalex.org/W1566830427","https://openalex.org/W1602023824","https://openalex.org/W1823058265","https://openalex.org/W1836660506","https://openalex.org/W1890547526","https://openalex.org/W1898851905","https://openalex.org/W1937194455","https://openalex.org/W1968390752","https://openalex.org/W1969060340","https://openalex.org/W1975898092","https://openalex.org/W1977774038","https://openalex.org/W1979545505","https://openalex.org/W1979783747","https://openalex.org/W1985097119","https://openalex.org/W1985504383","https://openalex.org/W1987083058","https://openalex.org/W1988365339","https://openalex.org/W1990495554","https://openalex.org/W1991788834","https://openalex.org/W1994514157","https://openalex.org/W1995324236","https://openalex.org/W1998919487","https://openalex.org/W1999971397","https://openalex.org/W2001146181","https://openalex.org/W2001543312","https://openalex.org/W2006433855","https://openalex.org/W2011571924","https://openalex.org/W2023613490","https://openalex.org/W2026444406","https://openalex.org/W2028944015","https://openalex.org/W2029031435","https://openalex.org/W2031508205","https://openalex.org/W2033740553","https://openalex.org/W2034231070","https://openalex.org/W2035227503","https://openalex.org/W2037438579","https://openalex.org/W2042917553","https://openalex.org/W2043320564","https://openalex.org/W2044310473","https://openalex.org/W2045432341","https://openalex.org/W2045684805","https://openalex.org/W2048375374","https://openalex.org/W2056613530","https://openalex.org/W2057410422","https://openalex.org/W2060862416","https://openalex.org/W2064912664","https://openalex.org/W2067333236","https://openalex.org/W2067557210","https://openalex.org/W2071160487","https://openalex.org/W2071588443","https://openalex.org/W2071773521","https://openalex.org/W2071926369","https://openalex.org/W2072747772","https://openalex.org/W2081136502","https://openalex.org/W2088216132","https://openalex.org/W2089065438","https://openalex.org/W2090993804","https://openalex.org/W2091512107","https://openalex.org/W2093924402","https://openalex.org/W2097775881","https://openalex.org/W2098544099","https://openalex.org/W2099828973","https://openalex.org/W2104053160","https://openalex.org/W2106338242","https://openalex.org/W2106798564","https://openalex.org/W2107863336","https://openalex.org/W2110967191","https://openalex.org/W2110992214","https://openalex.org/W2111218950","https://openalex.org/W2113232110","https://openalex.org/W2116180626","https://openalex.org/W2116404316","https://openalex.org/W2117268230","https://openalex.org/W2117358660","https://openalex.org/W2119513121","https://openalex.org/W2119603834","https://openalex.org/W2124941107","https://openalex.org/W2127187614","https://openalex.org/W2128352893","https://openalex.org/W2128979836","https://openalex.org/W2129138669","https://openalex.org/W2131878174","https://openalex.org/W2132611682","https://openalex.org/W2134096679","https://openalex.org/W2135050619","https://openalex.org/W2140979952","https://openalex.org/W2141532801","https://openalex.org/W2143657346","https://openalex.org/W2143873575","https://openalex.org/W2144285392","https://openalex.org/W2146618671","https://openalex.org/W2153965794","https://openalex.org/W2154731042","https://openalex.org/W2156518031","https://openalex.org/W2156877200","https://openalex.org/W2158075769","https://openalex.org/W2158079900","https://openalex.org/W2158273437","https://openalex.org/W2159967827","https://openalex.org/W2160065587","https://openalex.org/W2160635355","https://openalex.org/W2160737824","https://openalex.org/W2165139442","https://openalex.org/W2166129373","https://openalex.org/W2185515430","https://openalex.org/W2199385567","https://openalex.org/W2266981038","https://openalex.org/W2315237468","https://openalex.org/W2324387122","https://openalex.org/W2344508516","https://openalex.org/W2415745300","https://openalex.org/W2428422796","https://openalex.org/W3023773984","https://openalex.org/W4250289807"],"related_works":["https://openalex.org/W7120587739","https://openalex.org/W7120714028","https://openalex.org/W2080314360","https://openalex.org/W4413105285","https://openalex.org/W2325191363","https://openalex.org/W4412407702","https://openalex.org/W2038016555","https://openalex.org/W4296525219","https://openalex.org/W7120779275","https://openalex.org/W7120723723"],"abstract_inverted_index":{"O":[0],"objetivo":[1],"desse":[2,18],"trabalho":[3],"foi":[4,64,74,152],"caracterizar":[5],"um":[6],"quadro":[7],"experimental":[8],"que":[9,149],"apresenta":[10],"excesso":[11,19],"de":[12,20,57,78,123,132,140,145,154,164],"glicocorticoides":[13,21],"e":[14,35,52,71,89,106,111,117,142],"verificar":[15],"o":[16,23,72,150,156],"efeito":[17],"sobre":[22],"metabolismo":[24],"dos":[25,69],"carboidratos":[26],"no":[27],"tecido":[28],"adiposo":[29],"branco.Vinte":[30],"ratos":[31],"Wistar":[32],"foram":[33,41,87,109,115],"usados,":[34],"ap\u00f3s":[36],"a":[37,119],"aclimata\u00e7\u00e3o":[38],"ao":[39,76],"biot\u00e9rio,":[40],"divididos":[42],"aleatoriamente":[43],"em":[44,135,137,143],"dois":[45],"grupos:":[46],"controle":[47],"(CON":[48],"-receberam":[49],"salina":[50],"0,9%)":[51],"dexametasona":[53],"(DEXreceberam":[54],"0,25":[55],"mg/kg/d":[56],"dexametasona).Ao":[58],"completarem":[59],"10":[60],"semanas,":[61],"microbomba":[62],"osm\u00f3tica":[63],"inserida":[65],"entre":[66],"as":[67],"esc\u00e1pulas":[68],"animais,":[70],"tratamento":[73,151],"liberado":[75],"longo":[77],"4":[79],"semanas.Ao":[80],"final":[81],"do":[82,91],"per\u00edodo":[83],"experimental,":[84],"os":[85],"animais":[86],"sacrificados,":[88],"sangue":[90],"tronco,":[92],"gl\u00e2ndulas":[93],"adrenais,":[94],"m\u00fasculo":[95],"s\u00f3leo,":[96],"al\u00e9m":[97],"das":[98],"gorduras":[99],"subcut\u00e2nea":[100],"(SC),":[101],"periepididimal":[102],"(PE),":[103],"retroperitoneal":[104],"(RP)":[105],"mesent\u00e9rica":[107],"(MS)":[108],"retirados":[110],"armazenados":[112],"para":[113],"an\u00e1lise.Adip\u00f3citos":[114],"isolados":[116],"submetidos":[118],"ensaios":[120],"biol\u00f3gicos":[121],"(oxida\u00e7\u00e3o":[122],"D-[U-14":[124,133],"C]-glicose":[125,134],"at\u00e9":[126],"14":[127],"CO":[128],"2":[129],",":[130],"incorpora\u00e7\u00e3o":[131],"triacilglicer\u00f3is,":[136],"\u00e1cidos":[138],"graxos":[139],"triacilglicer\u00f3is":[141],"glicerol":[144],"triacilglicer\u00f3is).Os":[146],"resultados":[147],"mostraram":[148],"capaz":[153],"bloquear":[155],"eixo":[157],"hipot\u00e1lamo-hip\u00f3fise-adrenal,":[158],"como":[159],"verificado":[160],"pela":[161],"menor":[162],"concentra\u00e7\u00e3o":[163],"corticosterona":[165],"plasm\u00e1tica":[166]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}