{"id":"https://openalex.org/W2120545009","doi":"https://doi.org/10.1146/annurev.physiol.63.1.757","title":"Genetic and Molecular Analysis of Circadian Rhythms in Neurospora","display_name":"Genetic and Molecular Analysis of Circadian Rhythms in Neurospora","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2120545009","doi":"https://doi.org/10.1146/annurev.physiol.63.1.757","mag":"2120545009","pmid":"https://pubmed.ncbi.nlm.nih.gov/11181975"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.physiol.63.1.757","doi":"https://doi.org/10.1146/annurev.physiol.63.1.757","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.63.1.757","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028655150","display_name":"Jennifer Loros","orcid":"https://orcid.org/0000-0003-0451-2858","observed_orcids":["https://orcid.org/0000-0003-0451-2858"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J Loros","raw_affiliation_strings":["Departments of 12Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755;","Departments of 1Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755;","Department of Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755, USA. jennifer.loros@dartmouth.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 12Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755;","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Departments of 1Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755;","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755, USA. jennifer.loros@dartmouth.edu","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012555968","display_name":"Jay Dunlap","orcid":"https://orcid.org/0000-0003-1577-0457","observed_orcids":["https://orcid.org/0000-0003-1577-0457"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay C Dunlap","raw_affiliation_strings":["Departments of 12Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755;","Departments of 1Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 12Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755;","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]},{"raw_affiliation_string":"Departments of 1Biochemistry Dartmouth Medical School, Hanover, New Hampshire 03755;","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9974,"has_fulltext":false,"cited_by_count":224,"citation_normalized_percentile":{"value":0.92553191,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"63","issue":"1","first_page":"757","last_page":"794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9240000247955322},{"id":"https://openalex.org/keywords/neurospora","display_name":"Neurospora","score":0.9860000014305115},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.8059999942779541},{"id":"https://openalex.org/keywords/period-length","display_name":"period length","score":0.7360000014305115},{"id":"https://openalex.org/keywords/photic-entrainment","display_name":"light entrainment","score":0.8970000147819519},{"id":"https://openalex.org/keywords/temperature-entrainment","display_name":"temperature entrainment","score":0.8700000047683716},{"id":"https://openalex.org/keywords/frq","display_name":"FRQ","score":0.8949999809265137},{"id":"https://openalex.org/keywords/wc-1","display_name":"WC1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bmal1","display_name":"Bmal1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2776769606","wikidata":"https://www.wikidata.org/wiki/Q309943","display_name":"Neurospora","level":5,"score":0.7956222295761108},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7756192088127136},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.7074368596076965},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.686214804649353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6770973205566406},{"id":"https://openalex.org/C139992725","wikidata":"https://www.wikidata.org/wiki/Q5380656","display_name":"Entrainment (biomusicology)","level":3,"score":0.5925991535186768},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.5187899470329285},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.451777845621109},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43799322843551636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42730289697647095},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.41274234652519226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38034552335739136},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36739665269851685},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3075476884841919},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.2784372568130493},{"id":"https://openalex.org/C2776739539","wikidata":"https://www.wikidata.org/wiki/Q133459","display_name":"Neurospora crassa","level":4,"score":0.27687209844589233},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2580200433731079},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.16539320349693298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07356533408164978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06948727369308472}],"mesh":[{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009491","descriptor_name":"Neurospora","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.physiol.63.1.757","doi":"https://doi.org/10.1146/annurev.physiol.63.1.757","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.physiol.63.1.757","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:11181975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11181975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3797673679","display_name":"Genetic and Molecular Dissection of the Neurospora Clock","funder_award_id":"R37GM034985","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4398246120","display_name":null,"funder_award_id":"MH 44651","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5467103833","display_name":"Identification and Analysis of Clock Controlled Genes","funder_award_id":"R01MH044651","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":146,"referenced_works":["https://openalex.org/W12596212","https://openalex.org/W73040960","https://openalex.org/W210896024","https://openalex.org/W584463037","https://openalex.org/W1492572309","https://openalex.org/W1504695067","https://openalex.org/W1519373750","https://openalex.org/W1535755208","https://openalex.org/W1537881109","https://openalex.org/W1562804965","https://openalex.org/W1571815557","https://openalex.org/W1661083499","https://openalex.org/W1774577362","https://openalex.org/W1814360945","https://openalex.org/W1837513873","https://openalex.org/W1874015250","https://openalex.org/W1875084745","https://openalex.org/W1891211155","https://openalex.org/W1891791960","https://openalex.org/W1896509130","https://openalex.org/W1904305605","https://openalex.org/W1916193949","https://openalex.org/W1945661233","https://openalex.org/W1962384043","https://openalex.org/W1965208933","https://openalex.org/W1967327116","https://openalex.org/W1968482461","https://openalex.org/W1969487309","https://openalex.org/W1972107530","https://openalex.org/W1973980785","https://openalex.org/W1978618066","https://openalex.org/W1979385177","https://openalex.org/W1981166024","https://openalex.org/W1983373264","https://openalex.org/W1984593704","https://openalex.org/W1985078116","https://openalex.org/W1986062317","https://openalex.org/W1986382418","https://openalex.org/W1987216903","https://openalex.org/W1994334231","https://openalex.org/W1994880500","https://openalex.org/W1997522177","https://openalex.org/W1998999712","https://openalex.org/W1999469941","https://openalex.org/W2000183670","https://openalex.org/W2001848604","https://openalex.org/W2002592476","https://openalex.org/W2002806543","https://openalex.org/W2003442364","https://openalex.org/W2004306212","https://openalex.org/W2004690990","https://openalex.org/W2005811101","https://openalex.org/W2006030584","https://openalex.org/W2007158191","https://openalex.org/W2007885546","https://openalex.org/W2008319728","https://openalex.org/W2008946687","https://openalex.org/W2010791305","https://openalex.org/W2011909181","https://openalex.org/W2013168964","https://openalex.org/W2013230321","https://openalex.org/W2014167171","https://openalex.org/W2018967072","https://openalex.org/W2019031754","https://openalex.org/W2020496009","https://openalex.org/W2022442940","https://openalex.org/W2022623691","https://openalex.org/W2023408861","https://openalex.org/W2023458981","https://openalex.org/W2025247797","https://openalex.org/W2027456443","https://openalex.org/W2027580915","https://openalex.org/W2027976373","https://openalex.org/W2028402943","https://openalex.org/W2030470198","https://openalex.org/W2033758706","https://openalex.org/W2035097877","https://openalex.org/W2040617029","https://openalex.org/W2042068133","https://openalex.org/W2045636894","https://openalex.org/W2045647450","https://openalex.org/W2046290772","https://openalex.org/W2048466060","https://openalex.org/W2053326555","https://openalex.org/W2054512979","https://openalex.org/W2054513544","https://openalex.org/W2056296605","https://openalex.org/W2057136280","https://openalex.org/W2057389902","https://openalex.org/W2057522076","https://openalex.org/W2064741711","https://openalex.org/W2069849645","https://openalex.org/W2071236119","https://openalex.org/W2071927268","https://openalex.org/W2072877419","https://openalex.org/W2073233233","https://openalex.org/W2074057019","https://openalex.org/W2079086513","https://openalex.org/W2080916634","https://openalex.org/W2082732597","https://openalex.org/W2088348233","https://openalex.org/W2089891149","https://openalex.org/W2093597556","https://openalex.org/W2094994250","https://openalex.org/W2100591642","https://openalex.org/W2102492814","https://openalex.org/W2103557186","https://openalex.org/W2107478358","https://openalex.org/W2107964261","https://openalex.org/W2109312212","https://openalex.org/W2115127749","https://openalex.org/W2118239746","https://openalex.org/W2118967648","https://openalex.org/W2121743466","https://openalex.org/W2130618526","https://openalex.org/W2132689128","https://openalex.org/W2134476899","https://openalex.org/W2136562943","https://openalex.org/W2137252071","https://openalex.org/W2140228199","https://openalex.org/W2143692847","https://openalex.org/W2144024091","https://openalex.org/W2146280395","https://openalex.org/W2147908001","https://openalex.org/W2150926065","https://openalex.org/W2151024037","https://openalex.org/W2151468131","https://openalex.org/W2152849929","https://openalex.org/W2155265122","https://openalex.org/W2157490739","https://openalex.org/W2158714788","https://openalex.org/W2160091872","https://openalex.org/W2164615969","https://openalex.org/W2170078281","https://openalex.org/W2170644906","https://openalex.org/W2170788432","https://openalex.org/W2177802280","https://openalex.org/W2282928750","https://openalex.org/W2318546206","https://openalex.org/W2414151884","https://openalex.org/W2417423677","https://openalex.org/W2470769715","https://openalex.org/W2490709321","https://openalex.org/W2527733246","https://openalex.org/W4246852895","https://openalex.org/W4254001687"],"related_works":["https://openalex.org/W2102142621","https://openalex.org/W1485192022","https://openalex.org/W3082286378","https://openalex.org/W2103505699","https://openalex.org/W7221105583","https://openalex.org/W2133274717","https://openalex.org/W2052111348","https://openalex.org/W2912134962","https://openalex.org/W1992089890","https://openalex.org/W1985078116"],"abstract_inverted_index":{"Over":[0],"the":[1,4,19,22,33,39,46,71,78,94,99,118,129,161],"course":[2],"of":[3,21,25,38,45,52,73,81,96,101,115,139,163,170],"past":[5],"40":[6],"years":[7],"Neurospora":[8,62,148],"has":[9,149,158],"become":[10],"a":[11,66,124,153],"well-known":[12],"and":[13,36,42,49,55,61,112,123,141,157],"uniquely":[14],"tractable":[15],"model":[16],"system":[17,48,68],"for":[18,32,50,69],"analysis":[20],"molecular":[23],"basis":[24],"eukaryotic":[26],"circadian":[27,47,145],"oscillatory":[28],"systems.":[29],"Molecular":[30],"bases":[31],"period":[34],"length":[35],"sustainability":[37],"rhythm,":[40],"light,":[41],"temperature":[43],"resetting":[44],"gating":[51],"light":[53,56,97],"input":[54],"effects":[57],"are":[58],"becoming":[59],"understood,":[60],"promises":[63],"to":[64,128],"be":[65],"suitable":[67],"examining":[70],"role":[72,114],"coupled":[74],"feedback":[75,110],"loops":[76],"in":[77,90,107,117,133,147],"clock.":[79],"Many":[80],"these":[82],"insights":[83],"have":[84],"shown":[85],"or":[86],"foreshadow":[87],"direct":[88],"parallels":[89],"mammalian":[91],"systems,":[92],"including":[93],"mechanism":[95],"entrainment,":[98],"involvement":[100],"PAS:PAS":[102],"heterodimers":[103],"as":[104,120],"transcriptional":[105],"activators":[106],"essential":[108],"clock-associated":[109],"loops,":[111],"dual":[113],"FRQ":[116],"loop":[119],"an":[121],"activator":[122],"repressor;":[125],"similarities":[126],"extend":[127],"primary":[130],"sequence":[131],"level":[132],"at":[134,160,166],"least":[135],"one":[136],"case,":[137],"that":[138],"WC-1":[140],"BMAL1.":[142],"Work":[143],"on":[144],"output":[146],"identified":[150],"more":[151],"than":[152],"dozen":[154],"regulated":[155],"genes":[156],"been":[159],"forefront":[162],"studies":[164],"aimed":[165],"understanding":[167],"clock":[168],"control":[169],"gene":[171],"expression.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
