{"id":"https://openalex.org/W2120468520","doi":"https://doi.org/10.1158/1078-0432.ccr-10-2836","title":"Differential Response of Human and Mouse Dendritic Cells to VEGF Determines Interspecies Discrepancies in Tumor-Mediated Th1/Th2 Polarity Shift","display_name":"Differential Response of Human and Mouse Dendritic Cells to VEGF Determines Interspecies Discrepancies in Tumor-Mediated Th1/Th2 Polarity Shift","publication_year":2011,"publication_date":"2011-02-25","ids":{"openalex":"https://openalex.org/W2120468520","doi":"https://doi.org/10.1158/1078-0432.ccr-10-2836","mag":"2120468520","pmid":"https://pubmed.ncbi.nlm.nih.gov/21349994"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-10-2836","doi":"https://doi.org/10.1158/1078-0432.ccr-10-2836","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-10-2836","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000164383","display_name":"Matthew Stephen Block","orcid":"https://orcid.org/0000-0001-5692-4219","observed_orcids":["https://orcid.org/0000-0001-5692-4219"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Block","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054678780","display_name":"Wendy Kay Nevala","orcid":"https://orcid.org/0009-0004-2256-6715","observed_orcids":["https://orcid.org/0009-0004-2256-6715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy K. Nevala","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085479273","display_name":"Alexey A. Leontovich","orcid":"https://orcid.org/0009-0002-2014-8996","observed_orcids":["https://orcid.org/0009-0002-2014-8996"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey A. Leontovich","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082719040","display_name":"Svetomir N. Markovic","orcid":"https://orcid.org/0000-0002-9238-4325","observed_orcids":["https://orcid.org/0000-0002-9238-4325"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Svetomir N. Markovic","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota","Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Oncology and 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Hematology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082719040"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":1.1308,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76688661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"7","first_page":"1776","last_page":"1783"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.18410000205039978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.6660000085830688},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.6209999918937683},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.4560000002384186},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7897375822067261},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5435500144958496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5131760239601135},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5101569294929504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4592592120170593},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4402201473712921},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43352025747299194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053762","descriptor_name":"Interleukin-12 Subunit p40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053762","descriptor_name":"Interleukin-12 Subunit p40","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-10-2836","doi":"https://doi.org/10.1158/1078-0432.ccr-10-2836","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-10-2836","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:21349994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21349994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W121613652","https://openalex.org/W148060563","https://openalex.org/W150729901","https://openalex.org/W1498187417","https://openalex.org/W1558372199","https://openalex.org/W1783580437","https://openalex.org/W1931518331","https://openalex.org/W1935230887","https://openalex.org/W1972012033","https://openalex.org/W1983521199","https://openalex.org/W1985359220","https://openalex.org/W1987611102","https://openalex.org/W1989312265","https://openalex.org/W1989773065","https://openalex.org/W1998811052","https://openalex.org/W1999406693","https://openalex.org/W2014638731","https://openalex.org/W2023440295","https://openalex.org/W2037050834","https://openalex.org/W2042674715","https://openalex.org/W2052626082","https://openalex.org/W2057427371","https://openalex.org/W2060100686","https://openalex.org/W2079953288","https://openalex.org/W2088571368","https://openalex.org/W2124618015","https://openalex.org/W2565117873","https://openalex.org/W2593611879","https://openalex.org/W3021254998","https://openalex.org/W4253754155","https://openalex.org/W6604974521","https://openalex.org/W6731341337"],"related_works":["https://openalex.org/W2596974663","https://openalex.org/W2954959338","https://openalex.org/W2118118281","https://openalex.org/W2161739759","https://openalex.org/W2057427371","https://openalex.org/W2088571368","https://openalex.org/W4295956400","https://openalex.org/W7208308513","https://openalex.org/W1993391966","https://openalex.org/W1985398175"],"abstract_inverted_index":{"PURPOSE:":[0],"Metastatic":[1],"cancer":[2,44,166,212],"patients":[3,119],"exhibit":[4],"systemic":[5],"dysregulation":[6],"of":[7,26,43,57,197,208,210],"immune":[8,15,37,78,93,126,135,142,169,195],"polarity":[9,38,127,170],"and":[10,61,66,73,83,87,103,113,124,153],"are":[11],"biased":[12],"toward":[13],"Th-2":[14],"responses.":[16],"This":[17,181],"is":[18],"due,":[19],"at":[20],"least":[21],"in":[22,40,48,69,81,107,111,128,144,157,171,188,205],"part,":[23],"to":[24,109,130,159,173,183,186,191],"effects":[25,196],"VEGF":[27,110,138,192,198],"on":[28],"antigen":[29],"presenting":[30],"cell":[31,79],"(APC)":[32],"function.":[33],"We":[34,53,76,90],"therefore":[35],"compared":[36,77],"changes":[39],"mouse":[41,112,149],"models":[42],"with":[45,71,86,164],"those":[46],"seen":[47],"human":[49,114,118],"patients.":[50],"EXPERIMENTAL":[51],"DESIGN:":[52],"measured":[54],"plasma":[55,122,175],"levels":[56],"vascular":[58],"growth":[59],"factors":[60],"multiple":[62],"cytokines":[63,123],"via":[64],"ELISA":[65],"multiplex":[67,96],"analysis":[68],"mice":[70,85,132,178],"transplantable":[72],"spontaneous":[74],"tumors.":[75,89],"subsets":[80],"naive":[82],"vaccinated":[84],"without":[88],"assessed":[91,100],"cytokine":[92],"responses":[94,190],"by":[95],"analysis.":[97],"Finally,":[98],"we":[99],"gene":[101],"expression":[102,106],"receptor":[104],"surface":[105],"response":[108,129,158,172],"APCs.":[115],"RESULTS:":[116],"Although":[117],"have":[120,133],"elevated":[121],"altered":[125],"antigen,":[131],"minimal":[134],"abnormalities.":[136],"Mouse":[137],"does":[139],"not":[140,148],"mediate":[141],"repolarization":[143],"vitro.":[145],"Human":[146],"but":[147],"APCs":[150],"upregulate":[151],"VEGFR2":[152],"downregulate":[154],"interleukin":[155],"(IL)-12\u03b2":[156],"VEGF.":[160],"CONCLUSIONS:":[161],"Whereas":[162],"humans":[163],"metastatic":[165],"demonstrate":[167],"dysregulated":[168],"excess":[174],"VEGF,":[176],"tumor":[177],"do":[179],"not.":[180],"appears":[182],"be":[184],"due":[185],"differences":[187],"APC":[189],"stimulation.":[193],"Differential":[194],"may":[199],"represent":[200],"a":[201],"key":[202],"species":[203],"difference":[204],"the":[206],"context":[207],"translation":[209],"preclinical":[211],"immunotherapeutics":[213],"into":[214],"early":[215],"clinical":[216],"testing.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
