{"id":"https://openalex.org/W2120436655","doi":"https://doi.org/10.1128/cvi.00341-09","title":"Humoral Immune Responses in Patients with Lyme Neuroborreliosis","display_name":"Humoral Immune Responses in Patients with Lyme Neuroborreliosis","publication_year":2010,"publication_date":"2010-02-18","ids":{"openalex":"https://openalex.org/W2120436655","doi":"https://doi.org/10.1128/cvi.00341-09","mag":"2120436655","pmid":"https://pubmed.ncbi.nlm.nih.gov/20164248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2849339"},"language":"en","primary_location":{"id":"doi:10.1128/cvi.00341-09","doi":"https://doi.org/10.1128/cvi.00341-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00341-09","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/cvi.00341-09","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087227794","display_name":"Tja\u0161a Cerar","orcid":"https://orcid.org/0000-0002-4053-5590","observed_orcids":["https://orcid.org/0000-0002-4053-5590"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]},{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Tjas\u030ca Cerar","raw_affiliation_strings":["Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","Institute of Microbiology and Immunology, Medical Faculty Ljubljana","University of Ljubljana, Institute of Microbiology and Immunology, Zaloska 4, 1105 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]},{"raw_affiliation_string":"Institute of Microbiology and Immunology, Medical Faculty Ljubljana","institution_ids":[]},{"raw_affiliation_string":"University of Ljubljana, Institute of Microbiology and Immunology, Zaloska 4, 1105 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031356163","display_name":"Katarina Ogrinc","orcid":"https://orcid.org/0000-0002-8134-749X","observed_orcids":["https://orcid.org/0000-0002-8134-749X"]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Katarina Ogrinc","raw_affiliation_strings":["Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","Institute of Microbiology and Immunology, Medical Faculty Ljubljana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]},{"raw_affiliation_string":"Institute of Microbiology and Immunology, Medical Faculty Ljubljana","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019692561","display_name":"Franc Strle","orcid":"https://orcid.org/0000-0003-4163-0503","observed_orcids":["https://orcid.org/0000-0003-4163-0503"]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Franc Strle","raw_affiliation_strings":["Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","Institute of Microbiology and Immunology, Medical Faculty Ljubljana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]},{"raw_affiliation_string":"Institute of Microbiology and Immunology, Medical Faculty Ljubljana","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070531020","display_name":"Eva Ru\u017ei\u0107\u2010Sablji\u0107","orcid":"https://orcid.org/0000-0001-7906-555X","observed_orcids":["https://orcid.org/0000-0001-7906-555X"]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Eva Ruz\u030cic\u0301-Sabljic\u0301","raw_affiliation_strings":["Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","Institute of Microbiology and Immunology, Medical Faculty Ljubljana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]},{"raw_affiliation_string":"Institute of Microbiology and Immunology, Medical Faculty Ljubljana","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087227794"],"corresponding_institution_ids":["https://openalex.org/I153976015","https://openalex.org/I2801323708"],"apc_list":null,"apc_paid":null,"fwci":2.0557,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.83168317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"4","first_page":"645","last_page":"650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyme-neuroborreliosis","display_name":"Lyme neuroborreliosis","score":1.0},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-antibodies","display_name":"cerebrospinal fluid antibodies","score":0.8730000257492065},{"id":"https://openalex.org/keywords/intrathecal-antibody-production","display_name":"intrathecal antibody synthesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tick-borne-encephalitis","display_name":"tick-borne encephalitis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/h-antigen","display_name":"H antigen","score":0.8140000104904175},{"id":"https://openalex.org/keywords/igg-and-igm-antibodies","display_name":"IgM and IgG antibodies","score":0.8019999861717224},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2777147708","wikidata":"https://www.wikidata.org/wiki/Q819124","display_name":"Neuroborreliosis","level":4,"score":0.9681236743927002},{"id":"https://openalex.org/C2909216522","wikidata":"https://www.wikidata.org/wiki/Q819124","display_name":"Lyme Neuroborreliosis","level":4,"score":0.9361891746520996},{"id":"https://openalex.org/C2777553296","wikidata":"https://www.wikidata.org/wiki/Q201989","display_name":"Lyme disease","level":2,"score":0.785614550113678},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6586894392967224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.642698347568512},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6422405242919922},{"id":"https://openalex.org/C2776307562","wikidata":"https://www.wikidata.org/wiki/Q15968355","display_name":"LYME","level":4,"score":0.5663124918937683},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5636927485466003},{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.5071268081665039},{"id":"https://openalex.org/C2780508971","wikidata":"https://www.wikidata.org/wiki/Q115528","display_name":"Borrelia","level":4,"score":0.49832725524902344},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49650174379348755},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.4563591480255127},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4333200454711914},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4187451899051666},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.41774046421051025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.330178827047348}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015748","descriptor_name":"Borrelia burgdorferi Group","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020852","descriptor_name":"Lyme Neuroborreliosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/cvi.00341-09","doi":"https://doi.org/10.1128/cvi.00341-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00341-09","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},{"id":"pmid:20164248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20164248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and vaccine immunology : CVI","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2849339","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2849339/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Vaccine Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1128/cvi.00341-09","doi":"https://doi.org/10.1128/cvi.00341-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00341-09","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W275114559","https://openalex.org/W1745693202","https://openalex.org/W1932761272","https://openalex.org/W1967138600","https://openalex.org/W1979936866","https://openalex.org/W2015820775","https://openalex.org/W2024767574","https://openalex.org/W2028365217","https://openalex.org/W2039414761","https://openalex.org/W2053139562","https://openalex.org/W2053685790","https://openalex.org/W2090242200","https://openalex.org/W2103128190","https://openalex.org/W2114617203","https://openalex.org/W2125641599","https://openalex.org/W2138231945","https://openalex.org/W2139171590","https://openalex.org/W2147279763","https://openalex.org/W2162873756","https://openalex.org/W2171858853","https://openalex.org/W2432317730","https://openalex.org/W2434739352","https://openalex.org/W4210982538"],"related_works":["https://openalex.org/W2037423689","https://openalex.org/W1984826995","https://openalex.org/W2403617845","https://openalex.org/W2148722122","https://openalex.org/W4295990982","https://openalex.org/W2048552246","https://openalex.org/W2097166633","https://openalex.org/W2047460851","https://openalex.org/W4394848128","https://openalex.org/W2028326832"],"abstract_inverted_index":{"The":[0,153],"aim":[1],"of":[2,49,55,95,101,119,125,131,157,160,167,177,189,199,214,219],"this":[3],"study":[4],"was":[5,136],"to":[6,45],"analyze":[7],"and":[8,16,36,68,81,86,104,114,122,147,163,197,216],"compare":[9,46],"the":[10,47,53,60,73,79,99,116,164,174,190,195,209,212,217],"humoral":[11,191],"immune":[12,192],"responses":[13],"in":[14,98,115,138,143,149,194],"serum":[15],"cerebrospinal":[17,117],"fluid":[18,118],"(CSF)":[19],"for":[20,52],"34":[21],"adult":[22],"patients":[23,30,38,107,146,200,220],"with":[24,31,39,108,201,221],"clinically":[25,32,109],"evident":[26,110],"Lyme":[27,34,62,111,203],"neuroborreliosis,":[28,35,112],"27":[29],"suspected":[33],"32":[37],"tick-borne":[40],"encephalitis.":[41],"Additionally,":[42],"we":[43],"wanted":[44],"findings":[48,207],"two":[50],"methods":[51,97],"detection":[54],"intrathecally":[56],"synthesized":[57],"borrelial":[58,132,161],"antibodies:":[59],"IDEIA":[61],"neuroborreliosis":[63,204],"test":[64],"using":[65,78],"flagellar":[66],"antigen":[67],"an":[69],"approach":[70],"based":[71],"on":[72,208],"Liaison":[74],"indirect":[75],"chemiluminescence":[76],"immunoassay":[77],"OspC":[80],"VlsE":[82],"antigens.":[83],"Borrelial":[84],"IgM":[85,133,142,168],"IgG":[87,135,148],"antibodies":[88,162],"were":[89],"detected":[90],"by":[91,173,182],"at":[92],"least":[93],"one":[94],"these":[96,126],"sera":[100,196],"22/34":[102,120],"(64.7%)":[103,121],"28/34":[105],"(82.4%)":[106],"respectively,":[113],"20/34":[123],"(58.8%)":[124],"patients,":[127],"respectively.":[128],"Intrathecal":[129],"synthesis":[130,159],"and/or":[134],"found":[137],"19/34":[139],"(55.9%)":[140],"patients:":[141],"17/34":[144],"(50%)":[145],"15/34":[150],"(44.1%)":[151],"patients.":[152],"relatively":[154],"low":[155],"proportion":[156,218],"intrathecal":[158],"high":[165],"ratio":[166],"positivity":[169],"could":[170],"be":[171],"explained":[172],"short":[175],"duration":[176,213],"neurological":[178],"disease":[179],"as":[180],"evidenced":[181],"reported":[183],"symptoms":[184],"(median,":[185],"10":[186],"days).":[187],"Assessment":[188],"response":[193],"CSF":[198],"early":[202],"confirmed":[205],"previous":[206],"relationship":[210],"between":[211],"illness":[215],"detectable":[222],"responses.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}