{"id":"https://openalex.org/W2120407239","doi":"https://doi.org/10.1186/1471-2350-12-97","title":"An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study","display_name":"An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study","publication_year":2011,"publication_date":"2011-07-20","ids":{"openalex":"https://openalex.org/W2120407239","doi":"https://doi.org/10.1186/1471-2350-12-97","mag":"2120407239","pmid":"https://pubmed.ncbi.nlm.nih.gov/21774808","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3160350"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2350-12-97","doi":"https://doi.org/10.1186/1471-2350-12-97","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-12-97","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-12-97","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-12-97","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065562694","display_name":"Hironori Masuko","orcid":"https://orcid.org/0000-0002-5917-7973","observed_orcids":["https://orcid.org/0000-0002-5917-7973"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironori Masuko","raw_affiliation_strings":["Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080209460","display_name":"Tohru Sakamoto","orcid":"https://orcid.org/0000-0002-8876-1466","observed_orcids":["https://orcid.org/0000-0002-8876-1466"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tohru Sakamoto","raw_affiliation_strings":["Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103063012","display_name":"Yoshiko Kaneko","orcid":"https://orcid.org/0000-0003-3334-198X","observed_orcids":["https://orcid.org/0000-0003-3334-198X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiko Kaneko","raw_affiliation_strings":["Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroaki Iijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139719","display_name":"Tsukuba Medical Center Hospital","ror":"https://ror.org/03tjj1227","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210139719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Iijima","raw_affiliation_strings":["Tsukuba Medical Center, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Medical Center, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210139719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103695151","display_name":"Takashi Naito","orcid":"https://orcid.org/0009-0003-4486-4580","observed_orcids":["https://orcid.org/0009-0003-4486-4580"]},"institutions":[{"id":"https://openalex.org/I4210139719","display_name":"Tsukuba Medical Center Hospital","ror":"https://ror.org/03tjj1227","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210139719"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Naito","raw_affiliation_strings":["Tsukuba Medical Center, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Medical Center, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210139719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048903492","display_name":"Emiko Noguchi","orcid":"https://orcid.org/0000-0001-9319-1763","observed_orcids":["https://orcid.org/0000-0001-9319-1763"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emiko Noguchi","raw_affiliation_strings":["Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091637","display_name":"Tomomitsu Hirota","orcid":"https://orcid.org/0009-0002-9791-2980","observed_orcids":["https://orcid.org/0009-0002-9791-2980"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomitsu Hirota","raw_affiliation_strings":["Laboratory for Respiratory Diseases, Center for Genomic Medicine, the Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Respiratory Diseases, Center for Genomic Medicine, the Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026942255","display_name":"Mayumi Tamari","orcid":"https://orcid.org/0000-0002-5755-9177","observed_orcids":["https://orcid.org/0000-0002-5755-9177"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Tamari","raw_affiliation_strings":["Laboratory for Respiratory Diseases, Center for Genomic Medicine, the Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Respiratory Diseases, Center for Genomic Medicine, the Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112013626","display_name":"Nobuyuki Hizawa","orcid":"https://orcid.org/0000-0003-1822-2448","observed_orcids":["https://orcid.org/0000-0003-1822-2448"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Hizawa","raw_affiliation_strings":["Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080209460"],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":{"value":2380,"currency":"USD","value_usd":2380},"fwci":2.9774,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.91193221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"97","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fev1-decline","display_name":"FEV1 decline","score":0.8920000195503235},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.7519999742507935},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.871999979019165},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6779999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8240000009536743},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.674793004989624},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.624709963798523},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5265662670135498},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5164895057678223},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5145677924156189},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49060311913490295},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4884835481643677},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.48350074887275696},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4771413505077362},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.44622865319252014},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.4459574222564697},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.40224167704582214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22954705357551575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2248142659664154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12730500102043152},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12278920412063599},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08936807513237},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2350-12-97","doi":"https://doi.org/10.1186/1471-2350-12-97","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-12-97","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-12-97","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},{"id":"pmid:21774808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21774808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genetics","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00843:0001616365","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/records/25081","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3160350","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3160350/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genet","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.4020","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.4020","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1b/c4/BMC_Med_Genet_2011_Jul_20_12_97.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f44fcc2c2f264aaab5b612c47e2c7809","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f44fcc2c2f264aaab5b612c47e2c7809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genetics, Vol 12, Iss 1, p 97 (2011)","raw_type":"article"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00025081","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2241/113929","pdf_url":null,"source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1471-2350-12-97","doi":"https://doi.org/10.1186/1471-2350-12-97","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-12-97","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-12-97","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1186815047","display_name":"Risk factors for inflammatory obstructive pulmonary diseases: a prospective cohort study.","funder_award_id":"22590834","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3816964492","display_name":"Exploring genetic susceptibility to food allergy in innate and mucosal immunity genes","funder_award_id":"23791204","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6150983532","display_name":"Study on the pathogenesis of asthma and COPD-genetic heterogeneity and pharmacogenetics-","funder_award_id":"21390254","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120407239.pdf","grobid_xml":"https://content.openalex.org/works/W2120407239.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1631169176","https://openalex.org/W1892660313","https://openalex.org/W1906550937","https://openalex.org/W1963768187","https://openalex.org/W1974501995","https://openalex.org/W1991631628","https://openalex.org/W1994808395","https://openalex.org/W2001288684","https://openalex.org/W2005334314","https://openalex.org/W2021085462","https://openalex.org/W2022045742","https://openalex.org/W2031679199","https://openalex.org/W2031768476","https://openalex.org/W2060004156","https://openalex.org/W2066874799","https://openalex.org/W2069298307","https://openalex.org/W2089097264","https://openalex.org/W2090430326","https://openalex.org/W2091979380","https://openalex.org/W2094965528","https://openalex.org/W2095835362","https://openalex.org/W2107766358","https://openalex.org/W2112197447","https://openalex.org/W2118020384","https://openalex.org/W2119621267","https://openalex.org/W2127175782","https://openalex.org/W2137894554","https://openalex.org/W2138420210","https://openalex.org/W2145129819","https://openalex.org/W2155635136","https://openalex.org/W2162530578","https://openalex.org/W2164603088","https://openalex.org/W2168909456","https://openalex.org/W2172071634","https://openalex.org/W2172281302","https://openalex.org/W2333081132","https://openalex.org/W2555519846","https://openalex.org/W4232591682","https://openalex.org/W4236132672","https://openalex.org/W4300514609"],"related_works":["https://openalex.org/W2082426740","https://openalex.org/W2112197447","https://openalex.org/W2322666618","https://openalex.org/W1983393049","https://openalex.org/W2956699548","https://openalex.org/W4401930434","https://openalex.org/W2322264012","https://openalex.org/W2970019361","https://openalex.org/W2001949906","https://openalex.org/W2991133758"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"Nrf2-dependent":[2,210],"response":[3,211],"is":[4,232],"a":[5,26,43,51,66,172,241],"central":[6],"protective":[7],"mechanism":[8],"against":[9],"oxidative":[10],"stress.":[11],"We":[12,41,169],"propose":[13],"that":[14,208,226],"particular":[15],"genetic":[16,228],"variants":[17],"of":[18,47,55,230,240],"the":[19,87,100,110,182,221,227,238],"Nrf2":[20,88,101,111,231],"gene":[21,89],"may":[22,215],"be":[23],"associated":[24,125,194],"with":[25,78,126,132,145,195],"rapid":[27],"forced":[28],"expiratory":[29],"volume":[30],"in":[31,58,86,99,143,160,199,220,244,247],"one":[32,95],"second":[33],"(FEV1)":[34],"decline":[35,57,123,184,198,219,246],"induced":[36],"by":[37,234],"cigarette":[38],"smoking.":[39],"METHODS:":[40],"conducted":[42],"retrospective":[44],"cohort":[45],"study":[46,206],"915":[48],"Japanese":[49],"from":[50],"general":[52,222],"population.":[53,223],"Values":[54],"annual":[56,79,117,140,197,217],"FEV1":[59,80,118,122,135,141,183,200,218],"were":[60,73,104,151,163],"computed":[61],"for":[62,186],"each":[63],"individual":[64],"using":[65],"linear":[67],"mixed-effect":[68],"model.":[69],"Multiple":[70],"clinical":[71],"characteristics":[72],"assessed":[74],"to":[75,106,212],"identify":[76],"associations":[77],"decline.":[81,119],"Tag":[82],"single-nucleotide":[83],"polymorphisms":[84,112],"(SNPs)":[85],"(rs2001350,":[90],"rs6726395,":[91],"rs1962142,":[92],"rs2364722)":[93],"and":[94,113,129,134,154,158,178],"functional":[96],"SNP":[97],"(rs6721961)":[98],"promoter":[102],"region":[103],"genotyped":[105],"assess":[107],"interactions":[108],"between":[109,175],"smoking":[114,127,179,235],"status":[115,180],"on":[116,181],"RESULTS:":[120],"Annual":[121],"was":[124,193],"behavior":[128],"inversely":[130],"correlated":[131],"FEV1/FVC":[133],"%":[136],"predicted.":[137],"The":[138,190],"mean":[139],"declines":[142],"individuals":[144],"rs6726395":[146,176],"G/G,":[147],"G/A,":[148],"or":[149],"A/A":[150],"26.2,":[152],"22.3,":[153],"20.8":[155],"mL/year,":[156],"respectively,":[157],"differences":[159],"these":[161],"means":[162],"statistically":[164],"significant":[165,173],"(pcorr":[166],"=":[167,188,202],"0.016).":[168],"also":[170],"found":[171],"interaction":[174,187,243],"genotype":[177],"(p":[185,201],"0.011).":[189],"haplotype":[191],"rs2001350T/rs6726395A/rs1962142A/rs2364722A/rs6721961T":[192],"lower":[196],"0.004).":[203],"CONCLUSIONS:":[204],"This":[205],"indicated":[207],"an":[209],"exogenous":[213],"stimuli":[214],"affect":[216],"It":[224],"appears":[225],"influence":[229],"modified":[233],"status,":[236],"suggesting":[237],"presence":[239],"gene-environment":[242],"accelerated":[245],"FEV1.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}