{"id":"https://openalex.org/W2120392829","doi":"https://doi.org/10.3109/09513590.2014.945767","title":"The frequency of clinical pregnancy and implantation rate after cultivation of embryos in a medium with granulocyte macrophage colony-stimulating factor (GM-CSF) in patients with preceding failed attempts of ART","display_name":"The frequency of clinical pregnancy and implantation rate after cultivation of embryos in a medium with granulocyte macrophage colony-stimulating factor (GM-CSF) in patients with preceding failed attempts of ART","publication_year":2014,"publication_date":"2014-09-09","ids":{"openalex":"https://openalex.org/W2120392829","doi":"https://doi.org/10.3109/09513590.2014.945767","mag":"2120392829","pmid":"https://pubmed.ncbi.nlm.nih.gov/25200819"},"language":"en","primary_location":{"id":"doi:10.3109/09513590.2014.945767","doi":"https://doi.org/10.3109/09513590.2014.945767","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09513590.2014.945767","pdf_url":null,"source":{"id":"https://openalex.org/S144560499","display_name":"Gynecological Endocrinology","issn_l":"0951-3590","issn":["0951-3590","1473-0766"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecological Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084091145","display_name":"\u0421.\u0418. \u0422\u0435\u0432\u043a\u0438\u043d","orcid":"https://orcid.org/0000-0003-4876-0327","observed_orcids":["https://orcid.org/0000-0003-4876-0327"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Tevkin","raw_affiliation_strings":["Institute of Reproductive Medicine, \"EKO\" Centre , Almaty , Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, \"EKO\" Centre , Almaty , Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061034398","display_name":"Vyacheslav Notanovich Lokshin","orcid":"https://orcid.org/0000-0002-4792-5380","observed_orcids":["https://orcid.org/0000-0002-4792-5380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Lokshin","raw_affiliation_strings":["Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081878811","display_name":"\u041c.\u0421. \u0428\u0438\u0448\u0438\u043c\u043e\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-8957-2851","observed_orcids":["https://orcid.org/0000-0002-8957-2851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Shishimorova","raw_affiliation_strings":["Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"V. Polumiskov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Polumiskov","raw_affiliation_strings":["Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive Medicine, \u201cEKO\u201d Centre AlmatyKazakhstan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084091145"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8101,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68495309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"sup1","first_page":"9","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9919999837875366},{"id":"https://openalex.org/keywords/embryo-culture-medium","display_name":"embryo culture media","score":0.890999972820282},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.7289999723434448},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.7770000100135803},{"id":"https://openalex.org/keywords/implantation-rate","display_name":"implantation rate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5},{"id":"https://openalex.org/keywords/fertilization-rate","display_name":"fertilization rate","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6600009799003601},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.633378803730011},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6186013221740723},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.583358645439148},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5820547342300415},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.5768303871154785},{"id":"https://openalex.org/C2779335785","wikidata":"https://www.wikidata.org/wiki/Q5370217","display_name":"Embryo culture","level":4,"score":0.5354692339897156},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4970400631427765},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.48467472195625305},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.48106956481933594},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.47994282841682434},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.4416612386703491},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.4348643720149994},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41122516989707947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38485187292099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837658166885376},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.34518977999687195},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.23442703485488892},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13232392072677612},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11133474111557007},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.08429005742073059},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0778200626373291},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D027724","descriptor_name":"Reproductive Techniques, Assisted","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/09513590.2014.945767","doi":"https://doi.org/10.3109/09513590.2014.945767","is_oa":false,"landing_page_url":"https://doi.org/10.3109/09513590.2014.945767","pdf_url":null,"source":{"id":"https://openalex.org/S144560499","display_name":"Gynecological Endocrinology","issn_l":"0951-3590","issn":["0951-3590","1473-0766"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecological Endocrinology","raw_type":"journal-article"},{"id":"pmid:25200819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25200819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1934389460","https://openalex.org/W1972385567","https://openalex.org/W1974522827","https://openalex.org/W1986046955","https://openalex.org/W1990897043","https://openalex.org/W1998424689","https://openalex.org/W2000598875","https://openalex.org/W2011647496","https://openalex.org/W2012722097","https://openalex.org/W2013150268","https://openalex.org/W2034089747","https://openalex.org/W2043329764","https://openalex.org/W2044461908","https://openalex.org/W2053021474","https://openalex.org/W2053556358","https://openalex.org/W2077207180","https://openalex.org/W2081771397","https://openalex.org/W2087537457","https://openalex.org/W2101194416","https://openalex.org/W2113610605","https://openalex.org/W2119513202","https://openalex.org/W2126520365","https://openalex.org/W2141567615","https://openalex.org/W2147501302","https://openalex.org/W2148734614","https://openalex.org/W2155648144","https://openalex.org/W2156851952","https://openalex.org/W2157330515","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3132841452","https://openalex.org/W2000598875","https://openalex.org/W7167688629","https://openalex.org/W4313275131","https://openalex.org/W2004039634","https://openalex.org/W2805729465","https://openalex.org/W2087537457","https://openalex.org/W7096819345","https://openalex.org/W3015678588","https://openalex.org/W2810265265"],"abstract_inverted_index":{"The":[0,114],"application":[1],"in":[2,15,33,38,53,87,105,119,173,177],"IVF":[3],"practice":[4],"of":[5,12,25,56,67,80,91,116,184],"modern":[6],"techniques":[7],"can":[8,98],"improve":[9,60,109],"positive":[10],"outcome":[11],"each":[13],"cycle":[14],"the":[16,23,34,54,65,68,71,81,95,110,143,154],"assisted":[17],"reproductive":[18,36,88],"technology":[19],"(ART)":[20],"programs":[21],"and":[22,45,62,70,108,129,161,187,190,194],"effectiveness":[24],"treatment":[26],"as":[27],"a":[28],"whole.":[29],"There":[30],"are":[31],"embryos":[32,102,118,175],"female":[35],"tract":[37],"physiological":[39],"medium":[40,97,121,179,185],"which":[41],"contain":[42],"various":[43],"cytokines":[44,82],"growth":[46],"factors.":[47],"It":[48,150],"plays":[49],"an":[50,84],"important":[51,85],"role":[52,86],"regulation":[55],"normal":[57],"embryonic":[58],"development,":[59],"implantation":[61,155],"subsequently":[63],"optimizing":[64],"development":[66],"fetus":[69],"placenta.":[72],"Granulocyte":[73],"macrophage":[74],"colony-stimulating":[75],"factor":[76],"(GM-CSF":[77],"is":[78,151],"one":[79],"playing":[83],"function.":[89],"Addition":[90],"recombinant":[92],"GM-CSF":[93],"to":[94,104,131,142,181],"culture":[96,103,117,128,176],"makes":[99],"closer":[100],"human":[101],"vivo":[106],"conditions":[107],"efficacy":[111],"ART":[112],"cycles.":[113],"analysis":[115],"EmbryoGen":[120,178],"has":[122],"shown":[123],"that":[124,153],"fertilization":[125],"rate":[126,140,156,165],"embryo":[127],"transfer":[130],"patients":[132],"with":[133],"previous":[134],"unsuccessful":[135],"attempts":[136],"increases":[137],"clinical":[138,163],"pregnancy":[139,164],"compared":[141,180],"control":[144],"group":[145,174],"39.1":[146],"versus":[147,192],"27.8%,":[148],"respectively.":[149,196],"noted":[152],"(on":[157,166],"7":[158],"weeks'":[159,168],"gestation)":[160,169],"progressive":[162],"12":[167],"were":[170,188],"significantly":[171],"higher":[172],"standard":[182],"combination":[183],"(ISM1+VA),":[186],"20.4":[189],"17.4%":[191],"11.6":[193],"9.1%,":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}