{"id":"https://openalex.org/W2120257529","doi":"https://doi.org/10.1101/gr.188920.114","title":"Genome-wide activities of Polycomb complexes control pervasive transcription","display_name":"Genome-wide activities of Polycomb complexes control pervasive transcription","publication_year":2015,"publication_date":"2015-05-18","ids":{"openalex":"https://openalex.org/W2120257529","doi":"https://doi.org/10.1101/gr.188920.114","mag":"2120257529","pmid":"https://pubmed.ncbi.nlm.nih.gov/25986499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510001"},"language":"en","primary_location":{"id":"doi:10.1101/gr.188920.114","doi":"https://doi.org/10.1101/gr.188920.114","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.188920.114","pdf_url":"http://genome.cshlp.org/content/25/8/1170.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genome.cshlp.org/content/25/8/1170.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046660153","display_name":"Hun-Goo Lee","orcid":"https://orcid.org/0000-0002-2840-7684","observed_orcids":["https://orcid.org/0000-0002-2840-7684"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hun-Goo Lee","raw_affiliation_strings":["Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031002917","display_name":"Tatyana G. Kahn","orcid":"https://orcid.org/0000-0001-6109-6243","observed_orcids":["https://orcid.org/0000-0001-6109-6243"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Tatyana G. Kahn","raw_affiliation_strings":["Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA; Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","2Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA; Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I90267481"]},{"raw_affiliation_string":"1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"2Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058119070","display_name":"Amanda A. Simcox","orcid":"https://orcid.org/0000-0002-5572-7042","observed_orcids":["https://orcid.org/0000-0002-5572-7042"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Simcox","raw_affiliation_strings":["Molecular Genetics, Ohio State University, Columbus, Ohio, USA","3Molecular Genetics, Ohio State University, Columbus, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics, Ohio State University, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"3Molecular Genetics, Ohio State University, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091533821","display_name":"Yuri B. Schwartz","orcid":"https://orcid.org/0000-0003-4790-3920","observed_orcids":["https://orcid.org/0000-0003-4790-3920"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Yuri B. Schwartz","raw_affiliation_strings":["Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA; Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","2Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA; Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I90267481"]},{"raw_affiliation_string":"1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"2Molecular Biology, Ume\u00e5 University, NUS, 901 87 Ume\u00e5, Sweden;","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054682312","display_name":"Vincenzo Pirrotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincenzo Pirrotta","raw_affiliation_strings":["Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"1Molecular Biology & Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA;","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"8","first_page":"1170","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-group-complexes","display_name":"Polycomb group complexes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.8450000286102295},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":1.0},{"id":"https://openalex.org/keywords/h3k27-methylation","display_name":"H3K27 methylation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/h3k27me2","display_name":"H3K27me2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/h3k27-demethylation","display_name":"H3K27 demethylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/kdm6a","display_name":"KDM6A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.8539999723434448},{"id":"https://openalex.org/keywords/h3k4me1","display_name":"H3K4me1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/transcriptional-derepression","display_name":"transcriptional derepression","score":0.800000011920929},{"id":"https://openalex.org/keywords/intergenic-regions","display_name":"intergenic regions","score":0.8579999804496765},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.9143520593643188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7883365154266357},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.6984363198280334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6646038293838501},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.6038268804550171},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5704257488250732},{"id":"https://openalex.org/C73766848","wikidata":"https://www.wikidata.org/wiki/Q5262529","display_name":"Derepression","level":5,"score":0.5041528940200806},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.46525436639785767},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4436590373516083},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.44003966450691223},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.41609883308410645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3963027000427246},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.37376290559768677},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1434258222579956},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1101/gr.188920.114","doi":"https://doi.org/10.1101/gr.188920.114","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.188920.114","pdf_url":"http://genome.cshlp.org/content/25/8/1170.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3695656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4510001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25986499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25986499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4510001","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4510001/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:umu-107857","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107857","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/gr.188920.114","doi":"https://doi.org/10.1101/gr.188920.114","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.188920.114","pdf_url":"http://genome.cshlp.org/content/25/8/1170.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320307","display_name":"European Network and Information Security Agency","ror":"https://ror.org/00wqx6897"},{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"},{"id":"https://openalex.org/F4320321501","display_name":"Carl Tryggers Stiftelse f\u00f6r Vetenskaplig Forskning","ror":"https://ror.org/048p4fn82"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120257529.pdf","grobid_xml":"https://content.openalex.org/works/W2120257529.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W180065705","https://openalex.org/W1882476417","https://openalex.org/W1892124455","https://openalex.org/W1970888745","https://openalex.org/W1971801159","https://openalex.org/W1978139037","https://openalex.org/W2001858515","https://openalex.org/W2009166526","https://openalex.org/W2009782581","https://openalex.org/W2018865924","https://openalex.org/W2025553576","https://openalex.org/W2026914820","https://openalex.org/W2029733458","https://openalex.org/W2033890654","https://openalex.org/W2034261044","https://openalex.org/W2037480758","https://openalex.org/W2037589637","https://openalex.org/W2037967594","https://openalex.org/W2064261519","https://openalex.org/W2069223267","https://openalex.org/W2072466432","https://openalex.org/W2077738293","https://openalex.org/W2084699632","https://openalex.org/W2093800333","https://openalex.org/W2095111355","https://openalex.org/W2096149923","https://openalex.org/W2099927467","https://openalex.org/W2103315616","https://openalex.org/W2106785524","https://openalex.org/W2108196925","https://openalex.org/W2110241629","https://openalex.org/W2111709760","https://openalex.org/W2120021898","https://openalex.org/W2120060263","https://openalex.org/W2124985265","https://openalex.org/W2127455821","https://openalex.org/W2127921893","https://openalex.org/W2140462087","https://openalex.org/W2144328273","https://openalex.org/W2150090219","https://openalex.org/W2154138399","https://openalex.org/W2156821248","https://openalex.org/W2158610627","https://openalex.org/W2162958692","https://openalex.org/W2165090821","https://openalex.org/W2171439874","https://openalex.org/W2242029997","https://openalex.org/W2404848833","https://openalex.org/W2739174192","https://openalex.org/W6992757371","https://openalex.org/W7074230359"],"related_works":["https://openalex.org/W2569384213","https://openalex.org/W2294010564","https://openalex.org/W2106785524","https://openalex.org/W2064261519","https://openalex.org/W4391360810","https://openalex.org/W2997396822","https://openalex.org/W2123419812","https://openalex.org/W2061925865","https://openalex.org/W3170310643","https://openalex.org/W2972895673"],"abstract_inverted_index":{"Polycomb":[0],"group":[1],"(PcG)":[2],"complexes":[3,78,137],"PRC1":[4],"and":[5,22,65,68,77,101,104,111,127,186],"PRC2":[6,15,42,76,180],"are":[7],"well":[8,30],"known":[9,31],"for":[10,26],"silencing":[11],"specific":[12],"developmental":[13],"genes.":[14,135],"is":[16,37,69,187],"a":[17,116,145,191,196],"methyltransferase":[18],"targeting":[19],"histone":[20,149],"H3K27":[21,81],"producing":[23],"H3K27me3,":[24],"essential":[25],"stable":[27],"silencing.":[28],"Less":[29],"but":[32],"quantitatively":[33],"much":[34],"more":[35],"important":[36],"the":[38,80,125,130,164,178,183],"genome-wide":[39],"role":[40],"of":[41,46,75,86,109,132,148,157,167,198],"that":[43,51,118,173],"dimethylates":[44],"\u223c70%":[45],"total":[47],"H3K27.":[48],"We":[49,170],"show":[50],"H3K27me2":[52,87,113],"occurs":[53],"in":[54,60,89,95],"inverse":[55],"proportion":[56],"to":[57],"transcriptional":[58,91],"activity":[59,131,181],"most":[61],"non-PcG":[62],"target":[63,160],"genes":[64],"intergenic":[66,100],"regions":[67,103],"governed":[70],"by":[71,106,190],"opposing":[72],"roaming":[73],"activities":[74],"containing":[79],"demethylase":[82],"UTX.":[83],"Surprisingly,":[84],"loss":[85],"results":[88],"global":[90,140,179,184],"derepression":[92],"proportionally":[93],"greatest":[94],"silent":[96],"or":[97,182],"weakly":[98],"transcribed":[99,134],"genic":[102],"accompanied":[105],"an":[107],"increase":[108],"H3K27ac":[110],"H3K4me1.":[112],"therefore":[114],"sets":[115],"threshold":[117],"prevents":[119],"random,":[120],"unscheduled":[121],"transcription":[122],"all":[123],"over":[124],"genome":[126],"even":[128],"limits":[129],"highly":[133],"PRC1-type":[136,168],"also":[138],"have":[139],"roles.":[141],"Unexpectedly,":[142],"we":[143],"find":[144],"pervasive":[146],"distribution":[147],"H2A":[150],"ubiquitylated":[151],"at":[152],"lysine":[153],"118":[154],"(H2AK118ub)":[155],"outside":[156],"canonical":[158],"PcG":[159],"regions,":[161],"dependent":[162],"on":[163],"RING/Sce":[165],"subunit":[166],"complexes.":[169],"show,":[171],"however,":[172],"H2AK118ub":[174],"does":[175],"not":[176],"mediate":[177],"repression":[185],"predominantly":[188],"produced":[189],"new":[192],"complex":[193],"involving":[194],"L(3)73Ah,":[195],"homolog":[197],"mammalian":[199],"PCGF3.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
