{"id":"https://openalex.org/W2120249404","doi":"https://doi.org/10.1007/3-7643-7417-9_16","title":"NPY and extreme stress: lessons learned from posttraumatic stress disorder","display_name":"NPY and extreme stress: lessons learned from posttraumatic stress disorder","publication_year":2006,"publication_date":"2006-03-23","ids":{"openalex":"https://openalex.org/W2120249404","doi":"https://doi.org/10.1007/3-7643-7417-9_16","mag":"2120249404","pmid":"https://pubmed.ncbi.nlm.nih.gov/16383009"},"language":"en","primary_location":{"id":"doi:10.1007/3-7643-7417-9_16","doi":"https://doi.org/10.1007/3-7643-7417-9_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-7643-7417-9_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306462922","display_name":"Birkh\u00e4user-Verlag eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experientia Supplementum","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W573529810","display_name":"NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017769397","display_name":"Mary Ann Dutton","orcid":"https://orcid.org/0000-0002-0195-0791","observed_orcids":["https://orcid.org/0000-0002-0195-0791"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann Dutton","raw_affiliation_strings":["Department of Psychiatry, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670406","display_name":"Edward Wolfgang Lee","orcid":"https://orcid.org/0000-0003-0418-1454","observed_orcids":["https://orcid.org/0000-0003-0418-1454"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward W. Lee","raw_affiliation_strings":["Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington DC, 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington DC, 20057, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088211126","display_name":"Zofia \u017bukowska","orcid":"https://orcid.org/0000-0003-3893-0206","observed_orcids":["https://orcid.org/0000-0003-3893-0206"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zofia Zukowska","raw_affiliation_strings":["Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington DC, 20057, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington DC, 20057, USA","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799903593"],"apc_list":null,"apc_paid":null,"fwci":2.2048,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86909373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":"95","first_page":"213","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9950000047683716},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.8840000033378601},{"id":"https://openalex.org/keywords/extreme-trauma","display_name":"extreme trauma","score":0.6489999890327454},{"id":"https://openalex.org/keywords/stress-resilience","display_name":"stress resilience","score":0.7580000162124634},{"id":"https://openalex.org/keywords/y1-receptor","display_name":"Y1 receptor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/npy-receptors","display_name":"NPY receptors","score":0.5},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.6000000238418579},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8330000042915344},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9860000014305115},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.847000002861023},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.7429999709129333},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2991847609","wikidata":"https://www.wikidata.org/wiki/Q202387","display_name":"Posttraumatic stress","level":2,"score":0.7758679389953613},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5361165404319763},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.483309268951416},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3838440477848053},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.07711037993431091},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040921","descriptor_name":"Stress Disorders, Traumatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040921","descriptor_name":"Stress Disorders, Traumatic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/3-7643-7417-9_16","doi":"https://doi.org/10.1007/3-7643-7417-9_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-7643-7417-9_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306462922","display_name":"Birkh\u00e4user-Verlag eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experientia Supplementum","raw_type":"book-chapter"},{"id":"pmid:16383009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16383009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXS","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1508829286","display_name":null,"funder_award_id":"HL55310","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W104224639","https://openalex.org/W1628939789","https://openalex.org/W1777339175","https://openalex.org/W1967231325","https://openalex.org/W1967287454","https://openalex.org/W1968219857","https://openalex.org/W1968266203","https://openalex.org/W1985046175","https://openalex.org/W1991514010","https://openalex.org/W2002703591","https://openalex.org/W2003230142","https://openalex.org/W2003685995","https://openalex.org/W2007280687","https://openalex.org/W2014199091","https://openalex.org/W2014520755","https://openalex.org/W2016255142","https://openalex.org/W2020032681","https://openalex.org/W2024434676","https://openalex.org/W2026279809","https://openalex.org/W2027053039","https://openalex.org/W2029651085","https://openalex.org/W2035872217","https://openalex.org/W2043454995","https://openalex.org/W2046752054","https://openalex.org/W2048625352","https://openalex.org/W2055896532","https://openalex.org/W2057743484","https://openalex.org/W2066773095","https://openalex.org/W2078059086","https://openalex.org/W2097383944","https://openalex.org/W2100835249","https://openalex.org/W2112174584","https://openalex.org/W2112341090","https://openalex.org/W2114214919","https://openalex.org/W2118109922","https://openalex.org/W2120950665","https://openalex.org/W2130314112","https://openalex.org/W2130507237","https://openalex.org/W2133466515","https://openalex.org/W2145161166","https://openalex.org/W2146949395","https://openalex.org/W2150998541","https://openalex.org/W2164122544","https://openalex.org/W2165374000","https://openalex.org/W2171757197","https://openalex.org/W2334787351","https://openalex.org/W2491207572","https://openalex.org/W2905885202","https://openalex.org/W3145925695","https://openalex.org/W4251606575"],"related_works":["https://openalex.org/W328041270","https://openalex.org/W1988954465","https://openalex.org/W1991924547","https://openalex.org/W2079007392","https://openalex.org/W2558677516","https://openalex.org/W2060594075","https://openalex.org/W2005123330","https://openalex.org/W2996418834","https://openalex.org/W2078059086","https://openalex.org/W2461182992"],"abstract_inverted_index":{"NPY":[0,63,85,107,123],"is":[1],"a":[2,5,26],"mediator":[3],"and":[4,15,37,54,71,118,149,172,181],"marker":[6],"of":[7,61,104,114,122,132,140,146,169,174,184],"chronic":[8,185],"stress":[9,98,111],"in":[10,43,68,78,177],"humans,":[11],"including":[12],"extreme":[13],"trauma":[14],"PTSD,":[16,58,188],"but":[17],"its":[18],"actions":[19,77,121,171],"are":[20,50,64,91,160],"complex.":[21],"In":[22,41,57],"the":[23,34,44,79,105,115,129,134,138,158],"periphery,":[24],"as":[25],"sympathetic":[27],"neurotransmitter,":[28],"it":[29],"exerts":[30],"excitatory":[31],"effects":[32],"on":[33],"cardiovascular":[35,80,148,180],"system":[36,108],"modulates":[38],"immune":[39,150,182],"responses.":[40],"contrast,":[42],"central":[45,106,119],"nervous":[46],"system,":[47],"NPY-ergic":[48],"neurons":[49],"powerful":[51],"inhibitory,":[52],"anti-stress":[53,120],"anxiolytic":[55],"system.":[56,81],"stress-induced":[59],"elevations":[60],"plasma":[62,84],"associated":[65,92],"with":[66,75,93],"increases":[67],"cortisol,":[69],"catecholamines":[70],"blood":[72],"pressure,":[73],"consistent":[74],"peptide\u2019s":[76,190],"However,":[82],"lower":[83],"levels,":[86],"baseline,":[87],"stress-induced,":[88],"and/or":[89],"post-stress":[90],"poorer":[94],"behavioral":[95],"performance":[96],"under":[97],"\u2014":[99],"suggesting":[100],"that":[101],"reduced":[102],"activity":[103],"diminishes":[109],"individual\u2019s":[110],"resilience.":[112],"Many":[113],"peripheral":[116],"pro-stress":[117],"appears":[124,192],"to":[125,193],"be":[126,194],"mediated":[127],"by":[128],"same":[130],"subtype":[131],"receptors,":[133],"Y1,":[135],"which":[136,154],"complicates":[137],"case":[139],"using":[141],"Y1":[142],"antagonists":[143],"for":[144],"treatment":[145],"stress-related":[147],"symptoms,":[151],"unless":[152],"drugs":[153],"do":[155],"not":[156],"penetrate":[157],"blood-brain-barrier":[159],"used.":[161],"Future":[162],"studies":[163],"should":[164],"determine":[165],"more":[166],"precise":[167],"mechanisms":[168],"NPY\u2019s":[170],"type":[173],"receptors":[175],"involved":[176],"psychological,":[178],"behavioral,":[179],"consequences":[183],"stress,":[186],"particularly":[187],"where":[189],"role":[191],"quite":[195],"compelling.":[196]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}