{"id":"https://openalex.org/W2120183282","doi":"https://doi.org/10.1128/mcb.12.5.2339","title":"The -6.1-kilobase chicken lysozyme enhancer is a multifactorial complex containing several cell-type-specific elements.","display_name":"The -6.1-kilobase chicken lysozyme enhancer is a multifactorial complex containing several cell-type-specific elements.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W2120183282","doi":"https://doi.org/10.1128/mcb.12.5.2339","mag":"2120183282","pmid":"https://pubmed.ncbi.nlm.nih.gov/1569954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/364406"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.12.5.2339","doi":"https://doi.org/10.1128/mcb.12.5.2339","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.12.5.2339","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/364406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071105199","display_name":"Thomas Grewal","orcid":"https://orcid.org/0000-0002-7937-8887","observed_orcids":["https://orcid.org/0000-0002-7937-8887"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Grewal","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024806489","display_name":"Manfred Theisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Theisen","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031967351","display_name":"Uwe Borgmeyer","orcid":"https://orcid.org/0000-0003-3727-4083","observed_orcids":["https://orcid.org/0000-0003-3727-4083"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U Borgmeyer","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112324191","display_name":"T. Grussenmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Grussenmeyer","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008046523","display_name":"Ralph A.W. Rupp","orcid":"https://orcid.org/0000-0002-8068-9957","observed_orcids":["https://orcid.org/0000-0002-8068-9957"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R A Rupp","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071534868","display_name":"Aribert Stief","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Stief","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Qian","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015331994","display_name":"Andreas Hecht","orcid":"https://orcid.org/0000-0003-2262-2575","observed_orcids":["https://orcid.org/0000-0003-2262-2575"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Hecht","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108420065","display_name":"A. E. Sippel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A E Sippel","raw_affiliation_strings":["Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biologie III, Albert-Ludwigs Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":null,"apc_paid":null,"fwci":1.5231,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83163787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"5","first_page":"2339","last_page":"2350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-type-specific-gene-regulation","display_name":"cell type-specific gene regulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oviduct-cells","display_name":"oviduct cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/trans-acting-factors","display_name":"trans-acting factors","score":0.746999979019165},{"id":"https://openalex.org/keywords/chromatin-domains","display_name":"chromatin domains","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9416358470916748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8596606254577637},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.7864050269126892},{"id":"https://openalex.org/C143211211","wikidata":"https://www.wikidata.org/wiki/Q1343064","display_name":"Enhancer trap","level":5,"score":0.6385560035705566},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6112618446350098},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5211965441703796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48160168528556824},{"id":"https://openalex.org/C39981086","wikidata":"https://www.wikidata.org/wiki/Q3455568","display_name":"Locus control region","level":5,"score":0.473435640335083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.434656023979187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3407973051071167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2842683792114258}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010057","descriptor_name":"Oviducts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.12.5.2339","doi":"https://doi.org/10.1128/mcb.12.5.2339","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.12.5.2339","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.12.5.2339-2350.1992","doi":"https://doi.org/10.1128/mcb.12.5.2339-2350.1992","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.12.5.2339-2350.1992","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:364406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/364406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:1569954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1569954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:364406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/364406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W8332211","https://openalex.org/W112486650","https://openalex.org/W126863029","https://openalex.org/W179606503","https://openalex.org/W205061201","https://openalex.org/W224890781","https://openalex.org/W238696801","https://openalex.org/W1550856848","https://openalex.org/W1791967303","https://openalex.org/W1963872767","https://openalex.org/W1964351745","https://openalex.org/W1967004332","https://openalex.org/W1968102722","https://openalex.org/W1968244375","https://openalex.org/W1968902673","https://openalex.org/W1970132032","https://openalex.org/W1973075378","https://openalex.org/W1978713358","https://openalex.org/W1982598173","https://openalex.org/W1988632657","https://openalex.org/W2001187632","https://openalex.org/W2002873026","https://openalex.org/W2005030887","https://openalex.org/W2010401784","https://openalex.org/W2012681636","https://openalex.org/W2016103382","https://openalex.org/W2018458653","https://openalex.org/W2019673480","https://openalex.org/W2022416772","https://openalex.org/W2027216583","https://openalex.org/W2027469396","https://openalex.org/W2029053627","https://openalex.org/W2034279963","https://openalex.org/W2035416523","https://openalex.org/W2036553614","https://openalex.org/W2037223378","https://openalex.org/W2038457691","https://openalex.org/W2052977964","https://openalex.org/W2054618390","https://openalex.org/W2055654988","https://openalex.org/W2056799965","https://openalex.org/W2057893650","https://openalex.org/W2059576474","https://openalex.org/W2062438194","https://openalex.org/W2062617470","https://openalex.org/W2065207255","https://openalex.org/W2067956561","https://openalex.org/W2070907662","https://openalex.org/W2083490046","https://openalex.org/W2085124463","https://openalex.org/W2088094960","https://openalex.org/W2093458878","https://openalex.org/W2118299921","https://openalex.org/W2129130616","https://openalex.org/W2144634347","https://openalex.org/W2151396228","https://openalex.org/W2158837478","https://openalex.org/W2177704086","https://openalex.org/W2235991681","https://openalex.org/W2291668409","https://openalex.org/W2314225431","https://openalex.org/W2314347539","https://openalex.org/W2400112015","https://openalex.org/W2413706263"],"related_works":["https://openalex.org/W2235991681","https://openalex.org/W2068463431","https://openalex.org/W1495969925","https://openalex.org/W7064030113","https://openalex.org/W2097715400","https://openalex.org/W1988632657","https://openalex.org/W2160012647","https://openalex.org/W2036470133","https://openalex.org/W7097630211","https://openalex.org/W2132958046"],"abstract_inverted_index":{"In":[0],"the":[1,5,17,21,36,63,67,80,86,106,148,154,181,196,217,222],"chromatin":[2],"domain":[3],"of":[4,9,35,66,110,147,156,175,180,221],"chicken":[6],"lysozyme":[7,68],"gene":[8,69,102,167],"myeloid":[10,57],"and":[11,138,161],"oviduct":[12],"cells,":[13,58],"which":[14,44],"both":[15],"have":[16],"potential":[18],"to":[19,49,119,136],"activate":[20],"gene,":[22],"a":[23,52,74,128,199,212],"developmentally":[24],"stable":[25],"DNase":[26],"I-hypersensitive":[27],"site":[28,151],"is":[29,59],"formed":[30],"around":[31],"6.1":[32],"kb":[33],"upstream":[34],"gene.":[37],"This":[38],"implies":[39],"that":[40,78,105,203,209],"this":[41],"DNA":[42],"region,":[43],"has":[45],"previously":[46],"been":[47],"demonstrated":[48],"function":[50],"as":[51,85],"transcriptional":[53],"enhancer":[54,83,91,120,125,141,162,186],"element":[55],"in":[56,62,100,153,159,164],"intimately":[60],"involved":[61],"cell-type-specific":[64],"activation":[65],"locus.":[70],"Deletion":[71],"analysis":[72],"identifies":[73],"157-bp":[75],"minimal":[76,107],"fragment":[77,108],"confers":[79],"same":[81],"promacrophage-specific":[82],"activity":[84,163],"originally":[87],"described":[88,204],"562-bp":[89],"-6.1-kb":[90,182,197,223],"fragment.":[92],"By":[93],"introducing":[94],"specific":[95],"point":[96],"mutations,":[97],"we":[98,207],"demonstrate":[99],"transient":[101],"transfer":[103],"experiments":[104],"consists":[109],"at":[111,176],"least":[112,177],"six":[113],"adjacent":[114],"elements,":[115],"each":[116,173],"substantially":[117],"contributing":[118],"function.":[121],"The":[122],"compact":[123],"multifactorial":[124],"complex":[126],"includes":[127],"nuclear":[129],"factor":[130,215],"I":[131],"(NF-I)/TGGCA":[132],"binding":[133,150,158],"site,":[134],"homologies":[135],"AP1,":[137],"octanucleotide":[139],"or":[140],"core":[142],"consensus":[143],"motifs.":[144],"Point":[145],"mutation":[146],"NF-I":[149,157],"results":[152],"loss":[155],"vitro":[160],"vivo":[165],"after":[166],"transfer.":[168],"Surprisingly,":[169],"four":[170],"overlapping":[171],"oligonucleotides,":[172],"consisting":[174],"two":[178],"elements":[179],"enhancer,":[183,198],"confer":[184],"myeloid-cell-specific":[185,191],"activity.":[187],"We":[188],"found":[189],"several":[190],"DNA-binding":[192],"proteins":[193],"interacting":[194],"with":[195,202],"result":[200],"consistent":[201],"above.":[205],"Therefore,":[206],"suggest":[208],"more":[210],"than":[211],"single":[213],"trans-acting":[214],"mediates":[216],"cell":[218],"type":[219],"specificity":[220],"enhancer.":[224]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}