{"id":"https://openalex.org/W2120155459","doi":"https://doi.org/10.1016/s1470-2045(11)70337-0","title":"Chordoma: current concepts, management, and future directions","display_name":"Chordoma: current concepts, management, and future directions","publication_year":2012,"publication_date":"2012-01-31","ids":{"openalex":"https://openalex.org/W2120155459","doi":"https://doi.org/10.1016/s1470-2045(11)70337-0","mag":"2120155459","pmid":"https://pubmed.ncbi.nlm.nih.gov/22300861"},"language":"en","primary_location":{"id":"doi:10.1016/s1470-2045(11)70337-0","doi":"https://doi.org/10.1016/s1470-2045(11)70337-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1470-2045(11)70337-0","pdf_url":null,"source":{"id":"https://openalex.org/S116900674","display_name":"The Lancet Oncology","issn_l":"1470-2045","issn":["1470-2045","1474-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062083385","display_name":"Brian Patrick Walcott","orcid":"https://orcid.org/0000-0003-1318-1253","observed_orcids":["https://orcid.org/0000-0003-1318-1253"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P Walcott","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. walcott.brian@mgh.harvard.edu","Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. walcott.brian@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080480694","display_name":"Brian Vala Nahed","orcid":"https://orcid.org/0000-0001-8537-106X","observed_orcids":["https://orcid.org/0000-0001-8537-106X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian V Nahed","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019691833","display_name":"Ahmed Mohyeldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Mohyeldin","raw_affiliation_strings":["Department of Neurosurgery, Ohio State University College of Medicine, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Ohio State University College of Medicine, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111175814","display_name":"Jean-Val\u00e9ry C. E. Coumans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Valery Coumans","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058936141","display_name":"Kristopher Thomas Kahle","orcid":"https://orcid.org/0000-0002-5922-7547","observed_orcids":["https://orcid.org/0000-0002-5922-7547"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher T Kahle","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101519976","display_name":"Manuel Lima Ferreira","orcid":"https://orcid.org/0000-0002-1720-7441","observed_orcids":["https://orcid.org/0000-0002-1720-7441"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manuel J Ferreira","raw_affiliation_strings":["Dept. of Neurosurgery, University of Washington Medical School, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Neurosurgery, University of Washington Medical School, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":6.6121,"has_fulltext":false,"cited_by_count":776,"citation_normalized_percentile":{"value":0.9910045,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"2","first_page":"e69","last_page":"e76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chordoma","display_name":"chordoma","score":1.0},{"id":"https://openalex.org/keywords/notochord-remnants","display_name":"notochord remnants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sacral-chordoma","display_name":"sacral chordoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/skull-base-chordoma","display_name":"skull base chordoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/spinal-chordoma","display_name":"spinal chordoma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/en-bloc-resection","display_name":"en bloc resection","score":0.8109999895095825},{"id":"https://openalex.org/keywords/wide-surgical-margins","display_name":"wide surgical margins","score":0.6809999942779541},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/clival-chordoma","display_name":"clival chordoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neurological-function-preservation","display_name":"neurological function preservation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/molecular-characterization","display_name":"molecular characterization","score":0.7789999842643738},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2781190729","wikidata":"https://www.wikidata.org/wiki/Q1076389","display_name":"Chordoma","level":2,"score":0.8995798230171204},{"id":"https://openalex.org/C2779455797","wikidata":"https://www.wikidata.org/wiki/Q233316","display_name":"Sacrum","level":2,"score":0.881758451461792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7028257250785828},{"id":"https://openalex.org/C2777971045","wikidata":"https://www.wikidata.org/wiki/Q1377526","display_name":"Axial skeleton","level":2,"score":0.6971970796585083},{"id":"https://openalex.org/C2779300802","wikidata":"https://www.wikidata.org/wiki/Q13147","display_name":"Skull","level":2,"score":0.6614201068878174},{"id":"https://openalex.org/C2776133846","wikidata":"https://www.wikidata.org/wiki/Q243469","display_name":"Notochord","level":4,"score":0.6540135145187378},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5296440124511719},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.41095849871635437},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.39358100295066833},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39353296160697937},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1877562701702118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0919080376625061},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1470-2045(11)70337-0","doi":"https://doi.org/10.1016/s1470-2045(11)70337-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1470-2045(11)70337-0","pdf_url":null,"source":{"id":"https://openalex.org/S116900674","display_name":"The Lancet Oncology","issn_l":"1470-2045","issn":["1470-2045","1474-5488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Oncology","raw_type":"journal-article"},{"id":"pmid:22300861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22300861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W110242811","https://openalex.org/W143962617","https://openalex.org/W260918882","https://openalex.org/W1485331114","https://openalex.org/W1503533733","https://openalex.org/W1519503949","https://openalex.org/W1563804318","https://openalex.org/W1943633044","https://openalex.org/W1970089039","https://openalex.org/W1970135198","https://openalex.org/W1973214024","https://openalex.org/W1974490995","https://openalex.org/W1975372065","https://openalex.org/W1976856828","https://openalex.org/W1981260970","https://openalex.org/W1984301456","https://openalex.org/W1984531175","https://openalex.org/W1985829063","https://openalex.org/W1986376168","https://openalex.org/W1989584038","https://openalex.org/W1990575180","https://openalex.org/W1992564750","https://openalex.org/W1993386443","https://openalex.org/W1999319600","https://openalex.org/W2003264925","https://openalex.org/W2003574955","https://openalex.org/W2004331530","https://openalex.org/W2008845707","https://openalex.org/W2014347393","https://openalex.org/W2015782123","https://openalex.org/W2020748852","https://openalex.org/W2021657948","https://openalex.org/W2024049936","https://openalex.org/W2031325912","https://openalex.org/W2036951052","https://openalex.org/W2037686417","https://openalex.org/W2037812023","https://openalex.org/W2041138881","https://openalex.org/W2043201487","https://openalex.org/W2043979562","https://openalex.org/W2044480165","https://openalex.org/W2045903651","https://openalex.org/W2047778810","https://openalex.org/W2048513804","https://openalex.org/W2052289283","https://openalex.org/W2054238713","https://openalex.org/W2055083549","https://openalex.org/W2056035945","https://openalex.org/W2061223908","https://openalex.org/W2064338263","https://openalex.org/W2064775100","https://openalex.org/W2065105749","https://openalex.org/W2065106881","https://openalex.org/W2066139713","https://openalex.org/W2069332292","https://openalex.org/W2069519337","https://openalex.org/W2072244561","https://openalex.org/W2075596171","https://openalex.org/W2076283983","https://openalex.org/W2077480850","https://openalex.org/W2078137040","https://openalex.org/W2078869486","https://openalex.org/W2087705775","https://openalex.org/W2087962738","https://openalex.org/W2088413560","https://openalex.org/W2090283530","https://openalex.org/W2091123140","https://openalex.org/W2092080187","https://openalex.org/W2092201288","https://openalex.org/W2093368043","https://openalex.org/W2093541301","https://openalex.org/W2096410467","https://openalex.org/W2099252068","https://openalex.org/W2102171639","https://openalex.org/W2103111526","https://openalex.org/W2123142428","https://openalex.org/W2133087142","https://openalex.org/W2134070848","https://openalex.org/W2138582752","https://openalex.org/W2145498271","https://openalex.org/W2150090970","https://openalex.org/W2152248266","https://openalex.org/W2161324454","https://openalex.org/W2165813281","https://openalex.org/W2167747731","https://openalex.org/W2170583701","https://openalex.org/W2171353922","https://openalex.org/W2280711182","https://openalex.org/W2316329388","https://openalex.org/W2331332416","https://openalex.org/W2331772138","https://openalex.org/W2334191077","https://openalex.org/W2340049491","https://openalex.org/W2342391614","https://openalex.org/W2401881170","https://openalex.org/W2410963319","https://openalex.org/W2412857206","https://openalex.org/W2938404125","https://openalex.org/W3022652828","https://openalex.org/W4235164524","https://openalex.org/W4241212885","https://openalex.org/W4297811202","https://openalex.org/W6714865604"],"related_works":["https://openalex.org/W3092077817","https://openalex.org/W2135302583","https://openalex.org/W2008758954","https://openalex.org/W2918693926","https://openalex.org/W4239525184","https://openalex.org/W1978703819","https://openalex.org/W2883253497","https://openalex.org/W7098451682","https://openalex.org/W4377220274","https://openalex.org/W2039605009"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":49},{"year":2025,"cited_by_count":54},{"year":2024,"cited_by_count":63},{"year":2023,"cited_by_count":60},{"year":2022,"cited_by_count":64},{"year":2021,"cited_by_count":101},{"year":2020,"cited_by_count":62},{"year":2019,"cited_by_count":62},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":67},{"year":2016,"cited_by_count":45},{"year":2015,"cited_by_count":38},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}