{"id":"https://openalex.org/W2120155377","doi":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","title":"Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats","display_name":"Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats","publication_year":2011,"publication_date":"2011-07-04","ids":{"openalex":"https://openalex.org/W2120155377","doi":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","mag":"2120155377","pmid":"https://pubmed.ncbi.nlm.nih.gov/21723093"},"language":"en","primary_location":{"id":"doi:10.1016/j.eplepsyres.2011.06.005","doi":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","pdf_url":null,"source":{"id":"https://openalex.org/S144140688","display_name":"Epilepsy Research","issn_l":"0920-1211","issn":["0920-1211","1872-6844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090019737","display_name":"Melanie Langer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Langer","raw_affiliation_strings":["Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108685956","display_name":"Claudia Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Brandt","raw_affiliation_strings":["Center for Systems Neuroscience, Hannover, Germany","Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010235451","display_name":"Wolfgang L\u00f6scher","orcid":"https://orcid.org/0000-0002-9648-8973","observed_orcids":["https://orcid.org/0000-0002-9648-8973"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang L\u00f6scher","raw_affiliation_strings":["Center for Systems Neuroscience, Hannover, Germany","Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Neuroscience, Hannover, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010235451"],"corresponding_institution_ids":["https://openalex.org/I189991"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":null,"fwci":3.3336,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92122846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"3","first_page":"207","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.699999988079071},{"id":"https://openalex.org/keywords/interstrain-differences","display_name":"interstrain differences","score":0.49799999594688416},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.9660000205039978},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":1.0},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/spontaneous-recurrent-seizures","display_name":"spontaneous recurrent seizures","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7160000205039978},{"id":"https://openalex.org/keywords/behavioral-alterations","display_name":"behavioral alterations","score":0.8309999704360962},{"id":"https://openalex.org/keywords/seizure-susceptibility","display_name":"seizure susceptibility","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8600870370864868},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.7883850336074829},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.760627031326294},{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.653222382068634},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6445515751838684},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6320067048072815},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5218407511711121},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.45881423354148865},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4179292917251587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38368549942970276},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38348594307899475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37715283036231995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3557834029197693},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34366798400878906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10453343391418457}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013226","descriptor_name":"Status Epilepticus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021461","descriptor_name":"Animals, Outbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.eplepsyres.2011.06.005","doi":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eplepsyres.2011.06.005","pdf_url":null,"source":{"id":"https://openalex.org/S144140688","display_name":"Epilepsy Research","issn_l":"0920-1211","issn":["0920-1211","1872-6844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy Research","raw_type":"journal-article"},{"id":"pmid:21723093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21723093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsy research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328599","display_name":"Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W10836137","https://openalex.org/W568406528","https://openalex.org/W1498734521","https://openalex.org/W1945375049","https://openalex.org/W1965016243","https://openalex.org/W1966037459","https://openalex.org/W1966798504","https://openalex.org/W1968066079","https://openalex.org/W1972293363","https://openalex.org/W1972894928","https://openalex.org/W1981007992","https://openalex.org/W1983021935","https://openalex.org/W1983550840","https://openalex.org/W1984727063","https://openalex.org/W1986901635","https://openalex.org/W1990539313","https://openalex.org/W1993427764","https://openalex.org/W1995755186","https://openalex.org/W1996241894","https://openalex.org/W1998252483","https://openalex.org/W2003439788","https://openalex.org/W2008728377","https://openalex.org/W2009792683","https://openalex.org/W2013529252","https://openalex.org/W2016724629","https://openalex.org/W2016943135","https://openalex.org/W2017083014","https://openalex.org/W2022637923","https://openalex.org/W2028127492","https://openalex.org/W2029830651","https://openalex.org/W2031616221","https://openalex.org/W2034715941","https://openalex.org/W2037784091","https://openalex.org/W2040500050","https://openalex.org/W2045932599","https://openalex.org/W2048006221","https://openalex.org/W2054836530","https://openalex.org/W2063416740","https://openalex.org/W2065111363","https://openalex.org/W2079624598","https://openalex.org/W2079714688","https://openalex.org/W2079783599","https://openalex.org/W2083399904","https://openalex.org/W2086659984","https://openalex.org/W2090631537","https://openalex.org/W2094512975","https://openalex.org/W2101000119","https://openalex.org/W2101703484","https://openalex.org/W2103049279","https://openalex.org/W2103946141","https://openalex.org/W2108722273","https://openalex.org/W2110599089","https://openalex.org/W2113113253","https://openalex.org/W2126274301","https://openalex.org/W2133252476","https://openalex.org/W2157912935","https://openalex.org/W2161276777","https://openalex.org/W2163815564","https://openalex.org/W2169006271","https://openalex.org/W2172284528","https://openalex.org/W2401340076","https://openalex.org/W2413091729","https://openalex.org/W2427229941","https://openalex.org/W6600440092"],"related_works":["https://openalex.org/W2463101958","https://openalex.org/W2113113253","https://openalex.org/W2079624598","https://openalex.org/W4246437490","https://openalex.org/W2086659984","https://openalex.org/W1973268826","https://openalex.org/W2648952709","https://openalex.org/W4233020382","https://openalex.org/W2037784091","https://openalex.org/W6941384402"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}