{"id":"https://openalex.org/W2120151544","doi":"https://doi.org/10.1084/jem.134.5.1131","title":"BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO","display_name":"BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO","publication_year":1971,"publication_date":"1971-11-01","ids":{"openalex":"https://openalex.org/W2120151544","doi":"https://doi.org/10.1084/jem.134.5.1131","mag":"2120151544","pmid":"https://pubmed.ncbi.nlm.nih.gov/5112201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139022"},"language":"en","primary_location":{"id":"doi:10.1084/jem.134.5.1131","doi":"https://doi.org/10.1084/jem.134.5.1131","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.134.5.1131","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139022","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020405246","display_name":"Ralph Snyderman M. D","orcid":"https://orcid.org/0009-0003-5252-5036","observed_orcids":["https://orcid.org/0009-0003-5252-5036"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Snyderman","raw_affiliation_strings":["From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013120969","display_name":"J. K. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean K. Phillips","raw_affiliation_strings":["From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085157026","display_name":"Stephan E. Mergenhagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan E. Mergenhagen","raw_affiliation_strings":["From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":2.5374,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.89128747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"134","issue":"5","first_page":"1131","last_page":"1143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c5","display_name":"complement C5","score":0.8550000190734863},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.921999990940094},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/leukocyte-accumulation","display_name":"leukocyte accumulation","score":0.597000002861023},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.7519999742507935},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/c5-deficient-mice","display_name":"C5-deficient mice","score":0.8320000171661377},{"id":"https://openalex.org/keywords/peritoneal-cavity","display_name":"peritoneal cavity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8035248517990112},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.7924728393554688},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7323163747787476},{"id":"https://openalex.org/C71318922","wikidata":"https://www.wikidata.org/wiki/Q426181","display_name":"Complement component 5","level":4,"score":0.631436288356781},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6266709566116333},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.49255356192588806},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.4729806184768677},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4539863169193268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41744425892829895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40174490213394165},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2714002728462219},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15781861543655396},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10179367661476135},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0815822184085846},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005122","descriptor_name":"Exudates and Transudates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.134.5.1131","doi":"https://doi.org/10.1084/jem.134.5.1131","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.134.5.1131","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2139022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:5112201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5112201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.998","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.998","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/77/12/J_Exp_Med_1971_Oct_31_134(5)_1131-1143.tar.gz","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:ssbb1971-2575","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1971/1576","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1971","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2139022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2139022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2377543","https://openalex.org/W20867046","https://openalex.org/W1671029066","https://openalex.org/W1859805933","https://openalex.org/W1964522162","https://openalex.org/W1981428829","https://openalex.org/W2010747196","https://openalex.org/W2023396127","https://openalex.org/W2090109532","https://openalex.org/W2117228071","https://openalex.org/W2126903130","https://openalex.org/W2128537154","https://openalex.org/W2133829670","https://openalex.org/W2135045908","https://openalex.org/W2138170739","https://openalex.org/W2163510837","https://openalex.org/W2212227232","https://openalex.org/W2335302374","https://openalex.org/W4313307422"],"related_works":["https://openalex.org/W7074074327","https://openalex.org/W2335302374","https://openalex.org/W2316950616","https://openalex.org/W2123719970","https://openalex.org/W4313310008","https://openalex.org/W2077477489","https://openalex.org/W1500020315","https://openalex.org/W2399118872","https://openalex.org/W1903696630","https://openalex.org/W2470958413"],"abstract_inverted_index":{"The":[0,76,161,182],"importance":[1],"of":[2,7,27,41,49,59,64,78,88,93,99,106,119,128,134,141,152,174,185,212],"C5":[3,21,89,165],"in":[4,12,24,34,55,74,103,121,138,170,177,187,205],"the":[5,18,25,46,56,62,66,96,104,117,122,131,139,155,171],"generation":[6,105,140],"complement":[8],"(C)-dependent":[9],"chemotactic":[10,70,108,145],"activity":[11,80,146],"vitro":[13],"is":[14],"well":[15],"recognized.":[16],"However,":[17],"actual":[19],"role":[20,169],"may":[22],"play":[23],"accumulation":[26,58,118,151,176,184],"polymorphonuclear":[28],"leukocytes":[29],"(PMN)":[30],"at":[31],"inflammatory":[32,180,191],"sites":[33],"vivo":[35],"has":[36],"not":[37],"been":[38],"established.":[39],"Injection":[40],"glycogen":[42],"or":[43],"endotoxin":[44,94,129,196],"into":[45,95,130],"peritoneal":[47,67,97,123,132],"cavities":[48],"guinea":[50],"pigs":[51],"resulted,":[52],"shortly":[53],"thereafter,":[54],"local":[57],"PMN.":[60],"Preceding":[61],"influx":[63],"leukocytes,":[65],"fluid":[68],"became":[69],"for":[71,110],"rabbit":[72],"PMN":[73,112,120,153,175,186],"vitro.":[75],"majority":[77],"this":[79],"could":[81],"be":[82,198,201],"attributed":[83],"to":[84,179,189,200],"a":[85,107,148,202],"cleavage":[86],"product":[87],"(C5a).":[90],"Similarly,":[91],"injection":[92,127],"cavity":[98,133],"C5-normal":[100],"mice":[101,136],"resulted":[102,137],"factor":[109,204],"mouse":[111],"which":[113],"was":[114],"followed":[115],"by":[116],"fluid.":[124],"In":[125],"contrast,":[126],"C5-deficient":[135],"virtually":[142],"no":[143],"detectable":[144],"and":[147,210],"markedly":[149],"depressed":[150],"during":[154],"first":[156],"24":[157],"hr":[158],"after":[159],"injection.":[160],"data":[162],"suggest":[163],"that":[164],"plays":[166],"an":[167,190],"important":[168],"early":[172],"phases":[173],"response":[178,188],"stimuli.":[181],"rapid":[183],"stimulus":[192],"such":[193],"as":[194],"bacterial":[195],"would":[197],"expected":[199],"major":[203],"host":[206],"defense":[207],"against":[208],"proliferation":[209],"dissemination":[211],"infectious":[213],"agents.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
