{"id":"https://openalex.org/W2120138947","doi":"https://doi.org/10.1158/0008-5472.can-06-2979","title":"Tumor Angiogenesis Promoted by Ex vivo Differentiated Endothelial Progenitor Cells Is Effectively Inhibited by an Angiogenesis Inhibitor, TK1-2","display_name":"Tumor Angiogenesis Promoted by Ex vivo Differentiated Endothelial Progenitor Cells Is Effectively Inhibited by an Angiogenesis Inhibitor, TK1-2","publication_year":2007,"publication_date":"2007-05-15","ids":{"openalex":"https://openalex.org/W2120138947","doi":"https://doi.org/10.1158/0008-5472.can-06-2979","mag":"2120138947","pmid":"https://pubmed.ncbi.nlm.nih.gov/17510415"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-2979","doi":"https://doi.org/10.1158/0008-5472.can-06-2979","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-2979","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102139505","display_name":"Ho-Kyun Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ho-Kyun Oh","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jung-Min Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Min Ha","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090292901","display_name":"O Eunju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunju O","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024294301","display_name":"Byung Hun Lee","orcid":"https://orcid.org/0000-0002-0001-4846","observed_orcids":["https://orcid.org/0000-0002-0001-4846"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung Hun Lee","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024195643","display_name":"Suk Keun Lee","orcid":"https://orcid.org/0000-0001-6255-4197","observed_orcids":["https://orcid.org/0000-0001-6255-4197","https://orcid.org/0000-0002-2314-5654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suk Keun Lee","raw_affiliation_strings":["2Department of Oral Pathology, College of Dentistry, Kangnung National University, Kangnung, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Oral Pathology, College of Dentistry, Kangnung National University, Kangnung, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027506604","display_name":"Byoung\u2010Shik Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung-Shik Shim","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112398924","display_name":"Yong-Kil Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Kil Hong","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103082462","display_name":"Young Ae Joe","orcid":"https://orcid.org/0000-0002-1073-2606","observed_orcids":["https://orcid.org/0000-0002-1073-2606"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Ae Joe","raw_affiliation_strings":["1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cancer Research Institute and Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea and","institution_ids":["https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8531,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84791421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"67","issue":"10","first_page":"4851","last_page":"4859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ex-vivo-differentiation","display_name":"ex vivo differentiation","score":0.625},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.6179999709129333},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.7879999876022339},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-microvessel-density","display_name":"tumor microvessel density","score":0.5860000252723694},{"id":"https://openalex.org/keywords/a549-lung-cancer","display_name":"A549 lung cancer","score":0.6940000057220459},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.652999997138977},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7913997173309326},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.683144748210907},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6284160614013672},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.5960047245025635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5666987299919128},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4863875210285187},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4797207713127136},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4607454538345337},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.44026410579681396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39274391531944275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3752927780151367},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35639920830726624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.344196081161499},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.32565122842788696},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.28889894485473633},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16471266746520996},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.13947272300720215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061248064041137695},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018082","descriptor_name":"Kringles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-06-2979","doi":"https://doi.org/10.1158/0008-5472.can-06-2979","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-2979","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:17510415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17510415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1499075785","https://openalex.org/W1586474677","https://openalex.org/W1890785972","https://openalex.org/W1978685806","https://openalex.org/W1978859651","https://openalex.org/W1978900520","https://openalex.org/W1982479831","https://openalex.org/W1985804036","https://openalex.org/W1990900025","https://openalex.org/W1999579644","https://openalex.org/W2008018400","https://openalex.org/W2022234182","https://openalex.org/W2027306653","https://openalex.org/W2034916016","https://openalex.org/W2038860341","https://openalex.org/W2049466721","https://openalex.org/W2049586591","https://openalex.org/W2053704719","https://openalex.org/W2059448966","https://openalex.org/W2072510499","https://openalex.org/W2073132341","https://openalex.org/W2073268996","https://openalex.org/W2073994827","https://openalex.org/W2082601349","https://openalex.org/W2086073957","https://openalex.org/W2091525591","https://openalex.org/W2098282622","https://openalex.org/W2098444281","https://openalex.org/W2098743872","https://openalex.org/W2101024432","https://openalex.org/W2104208382","https://openalex.org/W2107922629","https://openalex.org/W2109134893","https://openalex.org/W2110667326","https://openalex.org/W2113551024","https://openalex.org/W2127209890","https://openalex.org/W2141954642","https://openalex.org/W2145639716","https://openalex.org/W2163087495","https://openalex.org/W2163678193","https://openalex.org/W2164506013","https://openalex.org/W2165054307","https://openalex.org/W2169024888"],"related_works":["https://openalex.org/W2040884783","https://openalex.org/W1970656918","https://openalex.org/W188744379","https://openalex.org/W172402269","https://openalex.org/W2423021542","https://openalex.org/W2775158615","https://openalex.org/W2165054307","https://openalex.org/W2165040347","https://openalex.org/W1982294132","https://openalex.org/W2803071297"],"abstract_inverted_index":{"Neovascularization":[0],"plays":[1],"a":[2],"critical":[3],"role":[4],"in":[5,68,126,163,189,211],"the":[6,55,69,94,129,135,139,158,170,230],"growth":[7,131,137,182],"and":[8,13,44,101,138,166,185,226],"metastatic":[9],"spread":[10],"of":[11,16,29,59,73,84,96,142,161,179,218,233,251],"tumors":[12],"involves":[14],"recruitment":[15],"circulating":[17],"endothelial":[18,31,110,181,223,244],"progenitor":[19],"cells":[20,116],"(EPC)":[21],"from":[22,76],"bone":[23],"marrow":[24],"as":[25,27,240,242],"well":[26,241],"sprouting":[28],"preexisting":[30],"cells.":[32,89],"In":[33,90,174],"this":[34],"study,":[35],"we":[36,209,236],"examined":[37],"if":[38],"EPCs":[39,74,86,100,124,148,162,203],"could":[40,246],"promote":[41],"tumor":[42,130,136,143,164,190],"angiogenesis":[43,53],"would":[45],"be":[46,247],"an":[47,52,248],"effective":[48],"cellular":[49],"target":[50,250],"for":[51],"inhibitor,":[54],"recombinant":[56],"kringle":[57],"domain":[58],"tissue-type":[60],"plasminogen":[61],"activator":[62],"(TK1-2).":[63],"When":[64,113],"TK1-2":[65,80,152,155,195,214,220],"was":[66,132,204],"applied":[67],"ex":[70,97,121],"vivo":[71,98,122],"culture":[72],"isolated":[75],"human":[77],"cord":[78],"blood,":[79],"inhibited":[81,93,103,215,222],"adhesive":[82],"differentiation":[83],"mononuclear":[85],"into":[87,169],"endothelial-like":[88],"addition,":[91,175],"it":[92],"migration":[95,227],"cultivated":[99,123],"also":[102,221],"their":[104,167],"adhesion":[105],"to":[106],"fibronectin":[107],"matrix":[108],"or":[109],"cell":[111,224],"monolayer.":[112],"A549":[114],"cancer":[115],"were":[117,149,192],"coimplanted":[118,147],"along":[119],"with":[120],"s.c.":[125],"nude":[127],"mice,":[128],"increased.":[133],"However,":[134],"vascular":[140,172,180],"density":[141],"tissues":[144,165,191],"increased":[145],"by":[146,201,206,229],"decreased":[150,193,205],"upon":[151,194],"treatment.":[153,196],"Accordingly,":[154],"treatment":[156],"reduced":[157],"remaining":[159],"number":[160],"incorporation":[168],"host":[171],"channels.":[173],"overall":[176],"expression":[177,200],"levels":[178],"factor":[183,188],"(VEGF)":[184],"von":[186],"Willebrand":[187],"Interestingly,":[197],"strong":[198],"VEGF":[199,216],"implanted":[202],"TK1-2.":[207,252],"Finally,":[208],"confirmed":[210],"vitro":[212],"that":[213,238],"secretion":[217],"EPCs.":[219,234],"proliferation":[225],"induced":[228],"conditioned":[231],"medium":[232],"Therefore,":[235],"concluded":[237],"EPCs,":[239],"mature":[243],"cells,":[245],"important":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
