{"id":"https://openalex.org/W2120123261","doi":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","title":"Urea transporters in kidney: molecular analysis and contribution to the urinary concentrating process","display_name":"Urea transporters in kidney: molecular analysis and contribution to the urinary concentrating process","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2120123261","doi":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","mag":"2120123261","pmid":"https://pubmed.ncbi.nlm.nih.gov/9729501"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1998.275.3.f319","doi":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056653447","display_name":"Hiroyasu Tsukaguchi","orcid":"https://orcid.org/0000-0001-9563-5356","observed_orcids":["https://orcid.org/0000-0001-9563-5356"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyasu Tsukaguchi","raw_affiliation_strings":["Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025147349","display_name":"Chairat Shayakul","orcid":"https://orcid.org/0000-0002-1729-7555","observed_orcids":["https://orcid.org/0000-0002-1729-7555"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chairat Shayakul","raw_affiliation_strings":["Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006874104","display_name":"Urs V. Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urs V. Berger","raw_affiliation_strings":["Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3204,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.39076035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"275","issue":"3","first_page":"F319","last_page":"F324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urea-transporter","display_name":"urea transporter","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ut1","display_name":"UT1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/urine-concentrating-mechanism","display_name":"urine concentrating mechanism","score":0.8100000023841858},{"id":"https://openalex.org/keywords/renal-inner-medulla","display_name":"renal inner medulla","score":0.8130000233650208},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.628000020980835},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.902999997138977},{"id":"https://openalex.org/keywords/vasa-recta","display_name":"vasa recta","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/urea-reabsorption","display_name":"urea reabsorption","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hydration-status","display_name":"hydration status","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6832454800605774},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6575051546096802},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.5993750095367432},{"id":"https://openalex.org/C2779066075","wikidata":"https://www.wikidata.org/wiki/Q7916297","display_name":"Vasa recta","level":3,"score":0.5527905821800232},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.549562931060791},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5219968557357788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.497226744890213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4260562062263489},{"id":"https://openalex.org/C168785527","wikidata":"https://www.wikidata.org/wiki/Q1401099","display_name":"Solute carrier family","level":4,"score":0.4192489981651306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4083152413368225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3858986496925354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3763918876647949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3726084232330322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21719807386398315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08856290578842163}],"mesh":[{"descriptor_ui":"D000096982","descriptor_name":"Urea Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007671","descriptor_name":"Kidney Concentrating Ability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.1998.275.3.f319","doi":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1998.275.3.f319","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:9729501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9729501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5299005049","display_name":"MOLECULAR PHYSIOLOGY OF UREA TRANSPORTERS","funder_award_id":"R01DK046289","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W304164921","https://openalex.org/W1541548986","https://openalex.org/W1618643845","https://openalex.org/W1937829052","https://openalex.org/W1972181065","https://openalex.org/W1974633406","https://openalex.org/W1975794640","https://openalex.org/W1976839272","https://openalex.org/W1978915398","https://openalex.org/W2013187640","https://openalex.org/W2016214282","https://openalex.org/W2018779154","https://openalex.org/W2025460399","https://openalex.org/W2031280687","https://openalex.org/W2035136859","https://openalex.org/W2041613806","https://openalex.org/W2050400976","https://openalex.org/W2074936851","https://openalex.org/W2076216028","https://openalex.org/W2087534198","https://openalex.org/W2090959453","https://openalex.org/W2154701338","https://openalex.org/W2188895203","https://openalex.org/W2244891665","https://openalex.org/W2279354174","https://openalex.org/W2302385627","https://openalex.org/W2304609717","https://openalex.org/W2328054176","https://openalex.org/W2338026443","https://openalex.org/W2402411013","https://openalex.org/W2402716553","https://openalex.org/W2441082476"],"related_works":["https://openalex.org/W1998098091","https://openalex.org/W112423454","https://openalex.org/W4408328673","https://openalex.org/W2129795635","https://openalex.org/W2080823491","https://openalex.org/W2040267567","https://openalex.org/W2038459924","https://openalex.org/W1953206860","https://openalex.org/W1986543162","https://openalex.org/W2131256448"],"abstract_inverted_index":{"Facilitated":[0],"urea":[1,7,75,102,131],"transporters":[2,47,132],"(UTs)":[3],"are":[4,48,80,111],"responsible":[5],"for":[6],"accumulation":[8],"in":[9,24,50,61,82,96,119],"the":[10,15,25,30,36,54,62,105,137,143],"renal":[11],"inner":[12,67,106],"medulla":[13],"of":[14,35,53,65,86,129,136,142],"mammalian":[16,55],"kidney":[17],"and":[18,41,78,89,94,109,114,123,127,140],"therefore":[19],"play":[20],"a":[21],"central":[22],"role":[23],"urinary":[26,97,144],"concentrating":[27,145],"process.":[28],"Recently,":[29],"cDNAs":[31],"encoding":[32],"three":[33],"members":[34],"UT":[37],"family,":[38],"UT1,":[39],"UT2,":[40],"UT3":[42,79],"have":[43],"been":[44],"cloned.":[45],"These":[46],"expressed":[49],"different":[51],"structures":[52],"kidney.":[56],"In":[57],"rat,":[58],"UT1":[59,108],"resides":[60],"apical":[63],"membrane":[64],"terminal":[66],"medullary":[68],"collecting":[69],"ducts,":[70],"where":[71],"it":[72],"mediates":[73],"vasopressin-regulated":[74],"reabsorption.":[76],"UT2":[77,110],"located":[81],"descending":[83,90],"thin":[84],"limbs":[85],"Henle's":[87],"loop":[88],"vasa":[91],"recta,":[92],"respectively,":[93],"participate":[95],"recycling":[98],"processes,":[99],"which":[100],"minimize":[101],"escape":[103],"from":[104],"medulla.":[107],"regulated":[112],"independently":[113],"respond":[115],"differently":[116],"to":[117],"changes":[118],"dietary":[120],"protein":[121],"content":[122],"hydration":[124],"state.":[125],"Identification":[126],"characterization":[128],"these":[130],"advances":[133],"our":[134],"understanding":[135],"molecular":[138],"basis":[139],"regulation":[141],"mechanism.":[146]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}