{"id":"https://openalex.org/W2120071129","doi":"https://doi.org/10.1128/jvi.01578-10","title":"Increased Susceptibility of Human-PrP Transgenic Mice to Bovine Spongiform Encephalopathy Infection following Passage in Sheep","display_name":"Increased Susceptibility of Human-PrP Transgenic Mice to Bovine Spongiform Encephalopathy Infection following Passage in Sheep","publication_year":2010,"publication_date":"2010-11-18","ids":{"openalex":"https://openalex.org/W2120071129","doi":"https://doi.org/10.1128/jvi.01578-10","mag":"2120071129","pmid":"https://pubmed.ncbi.nlm.nih.gov/21084466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020518"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01578-10","doi":"https://doi.org/10.1128/jvi.01578-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01578-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059501356","display_name":"Chris Plinston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Plinston","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088323348","display_name":"Patricia Hart","orcid":"https://orcid.org/0000-0002-9634-3483","observed_orcids":["https://orcid.org/0000-0002-9634-3483"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patricia Hart","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113512236","display_name":"Angela Chong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela Chong","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102747981","display_name":"Nora Hunter","orcid":"https://orcid.org/0000-0002-2663-148X","observed_orcids":["https://orcid.org/0000-0002-2663-148X"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nora Hunter","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081734448","display_name":"James D. Foster","orcid":"https://orcid.org/0000-0002-5595-0623","observed_orcids":["https://orcid.org/0000-0002-5595-0623"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Foster","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028700274","display_name":"Pedro Piccardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Pedro Piccardo","raw_affiliation_strings":["Laboratory of Bacterial and TSE Agents, Food and Drug Administration, Rockville, Maryland","Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bacterial and TSE Agents, Food and Drug Administration, Rockville, Maryland","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008085821","display_name":"Jean C. Manson","orcid":"https://orcid.org/0000-0002-0175-9890","observed_orcids":["https://orcid.org/0000-0002-0175-9890"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jean C. Manson","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016615089","display_name":"Rona M. Barron","orcid":"https://orcid.org/0000-0003-4512-9177","observed_orcids":["https://orcid.org/0000-0003-4512-9177"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rona M. Barron","raw_affiliation_strings":["Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathogenesis Division, The Roslin Institute, and R(D)SVS, University of Edinburgh, Roslin, Midlothian, United Kingdom","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016615089"],"corresponding_institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":2.8639,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91357986,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"85","issue":"3","first_page":"1174","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.8790000081062317},{"id":"https://openalex.org/keywords/human-prion-disease","display_name":"human prion disease","score":0.5299999713897705},{"id":"https://openalex.org/keywords/variant-creutzfeldt-jakob-disease","display_name":"variant Creutzfeldt-Jakob disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/prnp-gene","display_name":"PRNP gene","score":0.6209999918937683},{"id":"https://openalex.org/keywords/public-health-risk","display_name":"public health risk","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.9652233123779297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8449288606643677},{"id":"https://openalex.org/C2778147599","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"PRNP","level":4,"score":0.7866542339324951},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7789348363876343},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.6921197175979614},{"id":"https://openalex.org/C2776797465","wikidata":"https://www.wikidata.org/wiki/Q703961","display_name":"Transmissible spongiform encephalopathy","level":5,"score":0.6678023338317871},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.564532458782196},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.5196179747581482},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4722898602485657},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3128474950790405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3075103163719177},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.2763463854789734},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2709707021713257},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24513831734657288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14916524291038513},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10746371746063232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08650881052017212},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007562","descriptor_name":"Creutzfeldt-Jakob Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.01578-10","doi":"https://doi.org/10.1128/jvi.01578-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01578-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3020518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:21084466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21084466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/36827850-fea1-4cb3-afbc-9e754f312f08","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/36827850-fea1-4cb3-afbc-9e754f312f08","pdf_url":"https://www.research.ed.ac.uk/files/7516490/JVITMP_03962_10_1_complete.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plinston, C, Hart, P, Chong, A, Hunter, N, Foster, J, Piccardo, P, Manson, J C & Barron, R M 2011, 'Increased Susceptibility of Human-PrP Transgenic Mice to Bovine Spongiform Encephalopathy Infection following Passage in Sheep', Journal of Virology, vol. 85, no. 3, pp. 1174-1181. https://doi.org/10.1128/JVI.01578-10","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eresearch.qmu.ac.uk:20.500.12289/12715","doi":null,"is_oa":false,"landing_page_url":"https://eresearch.qmu.ac.uk/handle/20.500.12289/12715","pdf_url":null,"source":{"id":"https://openalex.org/S4306402028","display_name":"Queen Margaret University Publications Repository (Queen Margaret University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181656237","host_organization_name":"Queen Margaret University","host_organization_lineage":["https://openalex.org/I181656237"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3020518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1718518320","display_name":"Nature of TSE infection and Routes of Transmission","funder_award_id":"BBS/E/D/05241340","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3040448107","display_name":null,"funder_award_id":"224-05-1307","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5672408714","display_name":null,"funder_award_id":"224-05-1307","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7848331787","display_name":null,"funder_award_id":"Y1-A1-4893-02","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8236242795","display_name":null,"funder_award_id":"BBS/E/D/05241340","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G9000425650","display_name":"The relative transmissibility of atypical forms of scrapie to humans.","funder_award_id":"SE1441","funder_id":"https://openalex.org/F4320319995","funder_display_name":"Department for Environment, Food and Rural Affairs, UK Government"},{"id":"https://openalex.org/G9000430356","display_name":"The Relative Transmissibility of Sheep and Cattle BSE to Humans","funder_award_id":"SE1439","funder_id":"https://openalex.org/F4320319995","funder_display_name":"Department for Environment, Food and Rural Affairs, UK Government"}],"funders":[{"id":"https://openalex.org/F4320319995","display_name":"Department for Environment, Food and Rural Affairs, UK Government","ror":"https://ror.org/00tnppw48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1528983532","https://openalex.org/W1557724928","https://openalex.org/W1624018543","https://openalex.org/W1638078791","https://openalex.org/W1793935752","https://openalex.org/W1829344915","https://openalex.org/W1976611065","https://openalex.org/W2016165466","https://openalex.org/W2016565903","https://openalex.org/W2034655619","https://openalex.org/W2036078080","https://openalex.org/W2041939047","https://openalex.org/W2045406892","https://openalex.org/W2051373589","https://openalex.org/W2052317760","https://openalex.org/W2053699160","https://openalex.org/W2078290196","https://openalex.org/W2082438097","https://openalex.org/W2082573664","https://openalex.org/W2111407373","https://openalex.org/W2115911288","https://openalex.org/W2129644856","https://openalex.org/W2131082569","https://openalex.org/W2133145715","https://openalex.org/W2134138339","https://openalex.org/W2134393699","https://openalex.org/W2144337714","https://openalex.org/W2149246722","https://openalex.org/W2152769370","https://openalex.org/W2156023394","https://openalex.org/W2158386265","https://openalex.org/W2264024633","https://openalex.org/W2462187323","https://openalex.org/W4256493423"],"related_works":["https://openalex.org/W2170686177","https://openalex.org/W1966728694","https://openalex.org/W2000966908","https://openalex.org/W2077118428","https://openalex.org/W2111407373","https://openalex.org/W1966972884","https://openalex.org/W7099290839","https://openalex.org/W2134393699","https://openalex.org/W2045406892","https://openalex.org/W1971672438"],"abstract_inverted_index":{"The":[0],"risk":[1],"of":[2,5,22,30,64,79,95,111,133,142,177,187],"the":[3,20,28,62,77,104,109,164,178],"transmission":[4,63,82,106],"ruminant":[6,55],"transmissible":[7,58,214],"spongiform":[8,46],"encephalopathy":[9,47],"(TSE)":[10],"to":[11,15,19,42,59,67,92,101,174,189,203,215],"humans":[12,68,188,216],"was":[13],"thought":[14],"be":[16,172],"low":[17],"due":[18,173],"lack":[21],"association":[23],"between":[24,84],"sheep":[25,182,211],"scrapie":[26],"and":[27,49,86,153,217],"incidence":[29],"human":[31,50,105,125],"TSE.":[32],"However,":[33,136,197],"a":[34,80,93,114,149,195,210,224],"single":[35],"TSE":[36,134],"agent":[37,180],"strain":[38],"has":[39,73,89],"been":[40,74,90,146],"shown":[41],"cause":[43],"both":[44],"bovine":[45],"(BSE)":[48],"vCJD,":[51],"indicating":[52,76],"that":[53,144,209,218],"some":[54],"TSEs":[56],"are":[57],"humans.":[60],"While":[61],"cattle":[65,85,119],"BSE":[66,88,112,143,179,190,219],"in":[69,113,160,181],"transgenic":[70,122],"mouse":[71],"models":[72],"inefficient,":[75],"presence":[78],"significant":[81],"barrier":[83,107],"humans,":[87],"transmitted":[91],"number":[94],"other":[96,221],"species.":[97],"Here,":[98],"we":[99],"aimed":[100],"further":[102],"investigate":[103],"following":[108,137,192],"passage":[110,193],"sheep.":[115,196],"Following":[116],"inoculation":[117,138],"with":[118,139],"BSE,":[120],"gene-targeted":[121],"mice":[123,161],"expressing":[124],"PrP":[126,156],"showed":[127],"no":[128],"clinical":[129],"or":[130,183],"pathological":[131],"signs":[132],"disease.":[135],"an":[140,184],"isolate":[141],"had":[145],"passaged":[147],"through":[148,194],"sheep,":[150],"TSE-associated":[151],"vacuolation":[152],"proteinase":[154],"K-resistant":[155],"deposition":[157],"were":[158],"observed":[159],"homozygous":[162],"for":[163],"codon":[165],"129-methionine":[166],"PRNP":[167],"gene.":[168],"This":[169],"observation":[170],"may":[171],"higher":[175],"titers":[176],"increased":[185],"susceptibility":[186],"prions":[191],"these":[198],"data":[199],"confirm":[200],"that,":[201],"contrary":[202],"previous":[204],"predictions,":[205],"it":[206],"is":[207,213,223],"possible":[208],"prion":[212],"from":[220],"species":[222],"public":[225],"health":[226],"risk.":[227]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
