{"id":"https://openalex.org/W2120024176","doi":"https://doi.org/10.1002/cncr.21216","title":"Curcumin\u2010induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of I\u03baB kinase and nuclear factor \u03baB activity and are independent of the B\u2010Raf/mitogen\u2010activated/extracellular signal\u2010regulated protein kinase pathway and the Akt pathway","display_name":"Curcumin\u2010induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of I\u03baB kinase and nuclear factor \u03baB activity and are independent of the B\u2010Raf/mitogen\u2010activated/extracellular signal\u2010regulated protein kinase pathway and the Akt pathway","publication_year":2005,"publication_date":"2005-07-11","ids":{"openalex":"https://openalex.org/W2120024176","doi":"https://doi.org/10.1002/cncr.21216","mag":"2120024176","pmid":"https://pubmed.ncbi.nlm.nih.gov/16007726"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.21216","doi":"https://doi.org/10.1002/cncr.21216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.21216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.21216","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.21216","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054385659","display_name":"Doris R. Siwak","orcid":"https://orcid.org/0000-0002-5064-0570","observed_orcids":["https://orcid.org/0000-0002-5064-0570"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris R. Siwak","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085218671","display_name":"Shishir Shishodia","orcid":"https://orcid.org/0000-0001-8135-8757","observed_orcids":["https://orcid.org/0000-0001-8135-8757"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shishir Shishodia","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048675624","display_name":"Bharat Bhushan Aggarwal","orcid":"https://orcid.org/0000-0003-3534-2898","observed_orcids":["https://orcid.org/0000-0003-3534-2898"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat B. Aggarwal","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["","Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053481267"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":8.334,"has_fulltext":false,"cited_by_count":236,"citation_normalized_percentile":{"value":0.98870889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"104","issue":"4","first_page":"879","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.953000009059906},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mek","display_name":"MEK","score":0.8090000152587891},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9819999933242798},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/akt-inhibitors","display_name":"AKT inhibitors","score":0.4020000100135803},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.49399998784065247},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.49300000071525574},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.48899999260902405},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5410000085830688},{"id":"https://openalex.org/keywords/nf-kappab-inhibitors","display_name":"NF-\u03baB inhibitors","score":0.5329999923706055},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/erk-inhibitor","display_name":"ERK inhibitor","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8727915287017822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7190531492233276},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6292038559913635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5739876627922058},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5583716630935669},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5565047860145569},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5228664875030518},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4972100555896759},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.47907859086990356},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2898049056529999},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27760934829711914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14456325769424438}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.21216","doi":"https://doi.org/10.1002/cncr.21216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.21216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.21216","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:16007726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16007726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cncr.21216","doi":"https://doi.org/10.1002/cncr.21216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.21216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.21216","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W74993898","https://openalex.org/W296450459","https://openalex.org/W1486150850","https://openalex.org/W1492381941","https://openalex.org/W1502665310","https://openalex.org/W1532741974","https://openalex.org/W1536486871","https://openalex.org/W1542257568","https://openalex.org/W1555340919","https://openalex.org/W1565998937","https://openalex.org/W1575628845","https://openalex.org/W1577838670","https://openalex.org/W1606885912","https://openalex.org/W1825540737","https://openalex.org/W1874095272","https://openalex.org/W1916387106","https://openalex.org/W1951046932","https://openalex.org/W1969959673","https://openalex.org/W1970534746","https://openalex.org/W1972519024","https://openalex.org/W1980692157","https://openalex.org/W2000818889","https://openalex.org/W2005484362","https://openalex.org/W2006705806","https://openalex.org/W2022683869","https://openalex.org/W2024957091","https://openalex.org/W2031272027","https://openalex.org/W2036285327","https://openalex.org/W2037175822","https://openalex.org/W2041186477","https://openalex.org/W2041968890","https://openalex.org/W2070023258","https://openalex.org/W2072614562","https://openalex.org/W2086484409","https://openalex.org/W2087433131","https://openalex.org/W2089002950","https://openalex.org/W2093944970","https://openalex.org/W2111025555","https://openalex.org/W2113724986","https://openalex.org/W2114003326","https://openalex.org/W2131365547","https://openalex.org/W2139749780","https://openalex.org/W2142277736","https://openalex.org/W2143894503","https://openalex.org/W2149122802","https://openalex.org/W2151015976","https://openalex.org/W2152315800","https://openalex.org/W2155299791","https://openalex.org/W2156889170","https://openalex.org/W2160307820","https://openalex.org/W2163411441","https://openalex.org/W2166655452","https://openalex.org/W2424607300","https://openalex.org/W4241216156","https://openalex.org/W4241294365"],"related_works":["https://openalex.org/W7099334808","https://openalex.org/W2015311620","https://openalex.org/W2065983150","https://openalex.org/W2358824231","https://openalex.org/W2056533846","https://openalex.org/W2045324074","https://openalex.org/W2016652483","https://openalex.org/W2171257998","https://openalex.org/W2096685256","https://openalex.org/W2104526249"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nuclear":[1],"factor-kappaB":[2],"(NF-kappaB)":[3],"plays":[4],"a":[5,163],"central":[6],"role":[7],"in":[8,13,41,162,181,215,238],"cell":[9,46,155,160,184],"survival":[10],"and":[11,38,50,63,74,96,124,144,172,176,187,194,209,235,250,259],"proliferation":[12],"human":[14],"melanoma;":[15],"therefore,":[16],"the":[17,20,64,98,202,216,220,246,257],"authors":[18,65],"explored":[19],"possibility":[21],"of":[22,54,78,100,127,157,204,218,248,256],"exploiting":[23],"NF-kappaB":[24,89,175,193,249],"for":[25,88,97],"melanoma":[26,45,183,239],"treatment":[27,153],"by":[28,117,133],"using":[29],"curcumin,":[30,62,188,219],"an":[31],"agent":[32],"with":[33,61,245],"known,":[34],"potent,":[35],"NF-kappaB-inhibitory":[36],"activity":[37,91,99,120],"little":[39],"toxicity":[40],"humans.":[42],"METHODS:":[43],"Three":[44],"lines":[47,161,185],"(C32,":[48],"G-361,":[49],"WM":[51],"266-4),":[52],"all":[53,158,182],"which":[55],"had":[56],"B-raf":[57],"mutations,":[58],"were":[59,86,149,178,243,254],"treated":[60],"assessed":[66],"its":[67,101],"effects":[68,237,242],"on":[69],"viability":[70,156],"((3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium":[71],"bromide":[72],"assay)":[73,95],"apoptosis":[75],"(flow-cytometric":[76],"analysis":[77],"annexin":[79],"V/propidium":[80],"iodide-stained":[81],"cells).":[82],"Curcumin-treated":[83],"cells":[84],"also":[85],"examined":[87],"binding":[90],"(electrophoretic":[92],"mobility":[93],"shift":[94],"upstream":[102],"regulator,":[103],"IkappaB":[104],"kinase":[105,109,119,137,142],"(IKK)":[106],"(immune":[107],"complex":[108],"assay).":[110],"In":[111],"addition,":[112],"relevant":[113],"signaling,":[114],"as":[115,131],"reflected":[116,132],"B-Raf":[118],"(kinase":[121],"cascade":[122],"assay),":[123],"steady-state":[125],"levels":[126,147],"activated,":[128],"downstream":[129],"effectors,":[130],"mitogen-activated":[134],"signal-regulated":[135,140],"protein":[136,141],"(MEK),":[138],"extracellular":[139],"(ERK),":[143],"Akt":[145,210,221,228,260],"phosphorylation":[146,211],"(immunoblots),":[148],"assessed.":[150],"RESULTS:":[151],"Curcumin":[152,231],"decreased":[154],"3":[159],"dose-dependent":[164],"manner":[165],"(50%":[166],"inhibitory":[167],"concentration":[168],"=":[169],"6.1-7.7":[170],"microM)":[171],"induced":[173],"apoptosis.":[174],"IKK":[177,195,251],"active":[179],"constitutively":[180],"examined,":[186],"under":[189],"apoptosis-inducing":[190],"conditions,":[191],"down-regulated":[192],"activities.":[196],"However,":[197],"curcumin":[198],"did":[199],"not":[200],"inhibit":[201],"activities":[203,252],"B-Raf,":[205],"MEK,":[206],"or":[207],"ERK,":[208],"was":[212],"enhanced.":[213],"Furthermore,":[214],"presence":[217],"inhibitor":[222],"1L-6-hydroxymethyl-chiro-inositol":[223],"2-[(R)-2-O-methyl-3-O-octadecylcarbonate]":[224],"no":[225],"longer":[226],"suppressed":[227],"phosphorylation.":[229],"CONCLUSIONS:":[230],"has":[232],"potent":[233],"antiproliferative":[234],"proapoptotic":[236],"cells.":[240],"These":[241],"associated":[244],"suppression":[247],"but":[253],"independent":[255],"B-Raf/MEK/ERK":[258],"pathways.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}