{"id":"https://openalex.org/W2120014985","doi":"https://doi.org/10.1161/circresaha.107.169664","title":"H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors","display_name":"H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors","publication_year":2008,"publication_date":"2008-05-09","ids":{"openalex":"https://openalex.org/W2120014985","doi":"https://doi.org/10.1161/circresaha.107.169664","mag":"2120014985","pmid":"https://pubmed.ncbi.nlm.nih.gov/18467631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2743877"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.107.169664","doi":"https://doi.org/10.1161/circresaha.107.169664","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.107.169664","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2743877","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024304169","display_name":"Doinita Serban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doinita Serban","raw_affiliation_strings":["From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","Cell Biolabs Inc (J.L.), San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084369496","display_name":"Jie Leng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Leng","raw_affiliation_strings":["From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","Cell Biolabs Inc (J.L.), San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Cheresh","raw_affiliation_strings":["From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","Cell Biolabs Inc (J.L.), San Diego, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Moores Cancer Center (D.S., D.C.), University of California, San Diego, La Jolla; and Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Cell Biolabs Inc (J.L.), San Diego, Calif","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7037,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.91064259,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"102","issue":"11","first_page":"1350","last_page":"1358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h-ras","display_name":"H-Ras","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7739999890327454},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7840425968170166},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6779124736785889},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.6318039894104004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5195927619934082},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5139538645744324},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.5104552507400513},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5081939697265625},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5024659633636475},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43382126092910767},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41183674335479736},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34997543692588806},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1504257321357727},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circresaha.107.169664","doi":"https://doi.org/10.1161/circresaha.107.169664","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.107.169664","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:18467631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18467631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2743877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2743877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"},{"id":"mag:2886211003","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/suppl/10.1161/circresaha.107.169664","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2743877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2743877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1648785187","display_name":null,"funder_award_id":"CA-50286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G243309107","display_name":"Integrin alpha v beta 3 promotes resistance to EGF receptor inhibitors","funder_award_id":"R01CA045726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4572209492","display_name":"CRAF-mediated vascular resistance to cancer therapies","funder_award_id":"R01CA050286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5954555810","display_name":"Endothelial Barrier Function Regulation by VEGF","funder_award_id":"R01HL078912","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6100102529","display_name":"VEGF and PDGF in angiogenesis and tumor progression","funder_award_id":"R37CA050286","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6189164895","display_name":"Combinatorial Chemistry and Cancer Target","funder_award_id":"P01CA078045","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7842632493","display_name":"Regulation of cell invasion by apoptotic mechanisms","funder_award_id":"R01CA095262","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8931877706","display_name":"Integrin Signaling in Hemostasis and Blood Diseases","funder_award_id":"P01HL057900","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1500624186","https://openalex.org/W1512627452","https://openalex.org/W1514513302","https://openalex.org/W1525205194","https://openalex.org/W1573363574","https://openalex.org/W1965343041","https://openalex.org/W1967125902","https://openalex.org/W1971248879","https://openalex.org/W1975216289","https://openalex.org/W1980952363","https://openalex.org/W1991992481","https://openalex.org/W1992159395","https://openalex.org/W1992643899","https://openalex.org/W1996537616","https://openalex.org/W2008607458","https://openalex.org/W2013024179","https://openalex.org/W2017352211","https://openalex.org/W2025084353","https://openalex.org/W2033096588","https://openalex.org/W2033194415","https://openalex.org/W2034691869","https://openalex.org/W2057711788","https://openalex.org/W2061754224","https://openalex.org/W2062594120","https://openalex.org/W2068793465","https://openalex.org/W2072931885","https://openalex.org/W2077689653","https://openalex.org/W2088037057","https://openalex.org/W2090410012","https://openalex.org/W2093498435","https://openalex.org/W2099078722","https://openalex.org/W2100363932","https://openalex.org/W2110764937","https://openalex.org/W2115689424","https://openalex.org/W2124593509","https://openalex.org/W2144026946","https://openalex.org/W2168770561","https://openalex.org/W4243003607"],"related_works":["https://openalex.org/W2335242161","https://openalex.org/W1983064145","https://openalex.org/W2146651717","https://openalex.org/W177380973","https://openalex.org/W2046941864","https://openalex.org/W2013024179","https://openalex.org/W2013139259","https://openalex.org/W2016675290","https://openalex.org/W2106597930","https://openalex.org/W7099126562"],"abstract_inverted_index":{"Angiogenesis":[0],"and":[1,53,73,106,123,140,215],"vascular":[2,9,19,49,108,124,136,158,184,216],"permeability":[3,159,185,217],"occur":[4],"following":[5],"endothelium":[6],"activation":[7,24,90,111,219],"by":[8,51,77,99,116,174,218],"endothelial":[10,75,145,169],"growth":[11],"factor":[12],"(VEGF).":[13],"Downstream":[14],"mechanisms":[15],"that":[16,202,212],"define":[17],"these":[18],"responses":[20,42],"remain":[21],"unknown.":[22],"H-Ras":[23,34,52,206],"has":[25],"been":[26],"associated":[27],"with":[28,162],"the":[29,54,59,81,92,113],"angiogenic":[30,196],"response.":[31],"However,":[32,149],"active":[33],"initiates":[35],"a":[36,194,209],"wide":[37],"spectrum":[38],"of":[39,80,91,112,128,142,151,167,204,220],"other":[40],"biological":[41],"through":[43],"multiple":[44],"downstream":[45,203],"effectors.":[46,222],"To":[47],"identify":[48],"signaling":[50],"immediate":[55],"effectors":[56],"we":[57],"activated":[58],"extracellular":[60,93],"signal":[61],"regulated":[62],"kinase/mitogen-activated":[63,95],"protein":[64,96],"kinase":[65,97],"or":[66,86,134,156,189],"phosphatidylinositol":[67],"3-kinase":[68],"(PI3K)":[69],"pathways":[70],"in":[71,138,147,160],"chicken":[72],"mouse":[74],"tissues":[76],"ectopic":[78],"expression":[79],"Ras":[82],"effector":[83],"mutants":[84],"H-RasV12S35":[85,100],"H-RasV12C40,":[87],"respectively.":[88],"Constitutive":[89],"signal-regulate":[94],"pathway":[98,115],"was":[101,118,172],"sufficient":[102],"to":[103,187,198],"induce":[104],"angiogenesis":[105,122],"not":[107],"permeability,":[109],"whereas":[110],"PI3K":[114,129,152,178],"H-RasV12C40":[117,190],"required":[119],"for":[120],"both":[121,132],"permeability.":[125],"Pharmacological":[126],"inhibition":[127,150],"(alpha/beta)":[130],"suppressed":[131,154],"Ras-":[133,155],"VEGF-mediated":[135,157],"response":[137,186,197],"vivo":[139],"survival":[141,166],"primary":[143,168],"human":[144],"cells":[146],"vitro.":[148],"(gamma/delta)":[153],"vivo,":[161],"no":[163],"effect":[164],"on":[165],"cells.":[170],"This":[171],"supported":[173],"genetic":[175],"studies":[176],"because":[177],"p110gamma":[179],"knockout":[180],"mice":[181],"showed":[182],"impaired":[183],"VEGF":[188],"treatment":[191],"yet":[192],"produced":[193],"wild-type":[195],"H-RasV12S35.":[199],"We":[200],"conclude":[201],"VEGF,":[205],"serves":[207],"as":[208],"cellular":[210],"switch":[211],"controls":[213],"neovascularization":[214],"distinct":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}