{"id":"https://openalex.org/W2120002906","doi":"https://doi.org/10.1099/mic.0.2007/007575-0","title":"Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadE","display_name":"Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadE","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2120002906","doi":"https://doi.org/10.1099/mic.0.2007/007575-0","mag":"2120002906","pmid":"https://pubmed.ncbi.nlm.nih.gov/17768258"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.2007/007575-0","doi":"https://doi.org/10.1099/mic.0.2007/007575-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.2007/007575-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077860393","display_name":"Hope Richard","orcid":"https://orcid.org/0000-0002-5956-0585","observed_orcids":["https://orcid.org/0000-0002-5956-0585"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope Richard","raw_affiliation_strings":["Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034053792","display_name":"John W. Foster","orcid":"https://orcid.org/0000-0001-5987-2434","observed_orcids":["https://orcid.org/0000-0001-5987-2434"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Foster","raw_affiliation_strings":["Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":1.2707,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.80260984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"153","issue":"9","first_page":"3154","last_page":"3161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9279999732971191},{"id":"https://openalex.org/keywords/acid-tolerance","display_name":"acid resistance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sodium-regulation","display_name":"sodium regulation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gades","display_name":"Gades","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gada","display_name":"GADA","score":0.625},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sodium-detection","display_name":"sodium ion detection","score":0.41999998688697815},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.5230000019073486},{"id":"https://openalex.org/keywords/ph-homeostasis","display_name":"pH homeostasis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8627079725265503},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5010809898376465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49782562255859375},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4792940020561218},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.443036288022995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.362728476524353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23905134201049805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1860787272453308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08596473932266235},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051777","descriptor_name":"AraC Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/mic.0.2007/007575-0","doi":"https://doi.org/10.1099/mic.0.2007/007575-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.2007/007575-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:17768258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17768258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1486946238","https://openalex.org/W1519479476","https://openalex.org/W1533135048","https://openalex.org/W1574886161","https://openalex.org/W1579105736","https://openalex.org/W1602344975","https://openalex.org/W1602768166","https://openalex.org/W1606454224","https://openalex.org/W1611980546","https://openalex.org/W1691891364","https://openalex.org/W1854916942","https://openalex.org/W1940825484","https://openalex.org/W1943112463","https://openalex.org/W1974392384","https://openalex.org/W1974657155","https://openalex.org/W1985143147","https://openalex.org/W1986915415","https://openalex.org/W1991828007","https://openalex.org/W1999305069","https://openalex.org/W2004254961","https://openalex.org/W2024318573","https://openalex.org/W2026044975","https://openalex.org/W2028879987","https://openalex.org/W2041695050","https://openalex.org/W2050974949","https://openalex.org/W2057098387","https://openalex.org/W2065121109","https://openalex.org/W2079931398","https://openalex.org/W2092808125","https://openalex.org/W2101637688","https://openalex.org/W2106696768","https://openalex.org/W2107441982","https://openalex.org/W2108795036","https://openalex.org/W2114411529","https://openalex.org/W2114448039","https://openalex.org/W2120075755","https://openalex.org/W2120211414","https://openalex.org/W2120233418","https://openalex.org/W2126184496","https://openalex.org/W2127675550","https://openalex.org/W2128404962","https://openalex.org/W2136121450","https://openalex.org/W2136806453","https://openalex.org/W2138156768","https://openalex.org/W2138371117","https://openalex.org/W2139489886","https://openalex.org/W2144624514","https://openalex.org/W2148885731","https://openalex.org/W2157285911","https://openalex.org/W2160403140","https://openalex.org/W2226771775","https://openalex.org/W6634597841","https://openalex.org/W6636212175"],"related_works":["https://openalex.org/W2120075755","https://openalex.org/W7097584777","https://openalex.org/W2139489886","https://openalex.org/W2114411529","https://openalex.org/W7047400160","https://openalex.org/W7096160258","https://openalex.org/W6950344186","https://openalex.org/W2101637688","https://openalex.org/W2131410730","https://openalex.org/W2106696768"],"abstract_inverted_index":{"Enteric":[0],"bacteria":[1],"must":[2],"survive":[3],"the":[4,8,16,46,80,84,126,132,161,175],"extreme":[5],"acid":[6,37,56,70,155],"of":[7,49,83,91,100,128,134,160,170,177,205],"stomach":[9],"(pH":[10],"2":[11,36],"or":[12,188,202],"less)":[13],"before":[14],"entering":[15],"intestine":[17],"where":[18],"they":[19],"can":[20],"colonize":[21],"and":[22,63,86,104,118,157,164,179,196],"cause":[23],"disease.":[24],"Escherichia":[25],"coli":[26],"is":[27,79,94,192],"superior":[28],"to":[29],"most":[30,47],"other":[31],"Enterobacteriaceae":[32],"in":[33,123,146,174],"surviving":[34],"pH":[35,124],"stress":[38],"because":[39],"it":[40,191],"has":[41],"four":[42],"known":[43],"acid-resistance":[44,136],"systems,":[45],"studied":[48],"which":[50],"depends":[51],"on":[52],"glutamic":[53],"acid.":[54],"Glutamate-dependent":[55],"resistance":[57],"requires":[58],"glutamate":[59],"decarboxylase":[60],"isozymes":[61],"GadA":[62],"GadB,":[64],"as":[65,67],"well":[66],"a":[68,144],"glutamate/gamma-aminobutyric":[69],"antiporter":[71],"encoded":[72],"by":[73,96],"gadC.":[74],"The":[75,89,140],"regulatory":[76],"protein":[77],"GadE":[78],"essential":[81],"activator":[82],"gadA":[85,163],"gadBC":[87,165],"genes.":[88,166],"transcription":[90],"gadE,":[92,162],"however,":[93],"controlled":[95],"numerous":[97],"proteins.":[98],"Two":[99],"these":[101,129,171],"proteins,":[102],"GadX":[103,178,195],"GadW,":[105],"are":[106,113],"AraC-family":[107],"regulators":[108],"whose":[109],"sensory":[110],"input":[111],"signals":[112],"not":[114,149,185],"known.":[115],"Since":[116,181],"Na(+)":[117,182,200,207],"K(+)":[119],"play":[120],"important":[121],"roles":[122],"homeostasis,":[125],"contribution":[127],"ions":[130],"toward":[131],"regulation":[133,169],"this":[135],"system":[137],"was":[138],"examined.":[139],"results":[141],"indicated":[142],"that":[143,194],"decrease":[145],"Na(+),":[147],"but":[148],"K(+),":[150],"concentration":[151,201],"coincided":[152],"with":[153],"diminished":[154],"resistance,":[156],"decreased":[158],"expression":[159],"However,":[167],"Na(+)-dependent":[168],"genes":[172],"dissipated":[173],"absence":[176],"GadW.":[180],"levels":[183],"did":[184],"regulate":[186],"gadX":[187],"gadW":[189],"transcription,":[190],"proposed":[193],"GadW":[197],"sense":[198],"intracellular":[199],"some":[203],"consequence":[204],"altered":[206],"levels.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}