{"id":"https://openalex.org/W2120002004","doi":"https://doi.org/10.1158/0008-5472.can-08-3920","title":"In situ Expression of Tumor Antigens by Messenger RNA\u2013Electroporated Dendritic Cells in Lymph Nodes of Melanoma Patients","display_name":"In situ Expression of Tumor Antigens by Messenger RNA\u2013Electroporated Dendritic Cells in Lymph Nodes of Melanoma Patients","publication_year":2009,"publication_date":"2009-03-25","ids":{"openalex":"https://openalex.org/W2120002004","doi":"https://doi.org/10.1158/0008-5472.can-08-3920","mag":"2120002004","pmid":"https://pubmed.ncbi.nlm.nih.gov/19318559"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-08-3920","doi":"https://doi.org/10.1158/0008-5472.can-08-3920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/7/2927/2622504/2927.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/69/7/2927/2622504/2927.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072145453","display_name":"Danita H. Schuurhuis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danita H. Schuurhuis","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035396520","display_name":"Pauline Verdijk","orcid":"https://orcid.org/0000-0003-2272-2736","observed_orcids":["https://orcid.org/0000-0003-2272-2736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pauline Verdijk","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021244456","display_name":"Gerty Schreibelt","orcid":"https://orcid.org/0000-0002-0156-8365","observed_orcids":["https://orcid.org/0000-0002-0156-8365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerty Schreibelt","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035000626","display_name":"Erik H.J.G. Aarntzen","orcid":"https://orcid.org/0000-0002-3809-0182","observed_orcids":["https://orcid.org/0000-0002-3809-0182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik H.J.G. Aarntzen","raw_affiliation_strings":["1Tumor Immunology, Departments of","2Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]},{"raw_affiliation_string":"2Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068046073","display_name":"Nicole M. Scharenborg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Scharenborg","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113716183","display_name":"Annemiek J. de Boer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annemiek de Boer","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003310749","display_name":"Mandy W.M.M. van de Rakt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mandy W.M.M. van de Rakt","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086710472","display_name":"Marieke Kerkhoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marieke Kerkhoff","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032995353","display_name":"Marie\u2010Jeanne P. Gerritsen","orcid":"https://orcid.org/0000-0003-3740-3711","observed_orcids":["https://orcid.org/0000-0003-3740-3711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Jeanne P. Gerritsen","raw_affiliation_strings":["3Dermatology,","Dermatology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Dermatology,","institution_ids":[]},{"raw_affiliation_string":"Dermatology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032870509","display_name":"Femke Eijckeler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Femke Eijckeler","raw_affiliation_strings":["4Pathology,","Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pathology,","institution_ids":[]},{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046938432","display_name":"Johannes J. Bonenkamp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes J. Bonenkamp","raw_affiliation_strings":["5Surgery,","Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Surgery,","institution_ids":[]},{"raw_affiliation_string":"Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018011096","display_name":"Willeke A.M. Blokx","orcid":"https://orcid.org/0000-0002-4647-8830","observed_orcids":["https://orcid.org/0000-0002-4647-8830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Willeke Blokx","raw_affiliation_strings":["4Pathology,","Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pathology,","institution_ids":[]},{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031480761","display_name":"J. Han van Krieken","orcid":"https://orcid.org/0000-0002-8105-0450","observed_orcids":["https://orcid.org/0000-0002-8105-0450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Han van Krieken","raw_affiliation_strings":["4Pathology,","Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pathology,","institution_ids":[]},{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012764804","display_name":"Otto C. Boerman","orcid":"https://orcid.org/0000-0001-6832-101X","observed_orcids":["https://orcid.org/0000-0001-6832-101X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otto C. Boerman","raw_affiliation_strings":["6Nuclear Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Nuclear Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000396669","display_name":"Wim J.G. Oyen","orcid":"https://orcid.org/0000-0001-8235-7078","observed_orcids":["https://orcid.org/0000-0001-8235-7078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wim J.G. Oyen","raw_affiliation_strings":["6Nuclear Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Nuclear Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043942519","display_name":"Cornelis J.A. Punt","orcid":"https://orcid.org/0000-0003-0846-1445","observed_orcids":["https://orcid.org/0000-0003-0846-1445","https://orcid.org/0000-0003-4196-4896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelis J.A. Punt","raw_affiliation_strings":["2Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052126051","display_name":"Carl Gustav Figdor","orcid":"https://orcid.org/0000-0002-2366-9212","observed_orcids":["https://orcid.org/0000-0002-2366-9212","https://orcid.org/0000-0003-1597-1582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl G. Figdor","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015323424","display_name":"Gosse J. Adema","orcid":"https://orcid.org/0000-0002-6750-1665","observed_orcids":["https://orcid.org/0000-0002-6750-1665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gosse J. Adema","raw_affiliation_strings":["1Tumor Immunology, Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054219763","display_name":"I. Jolanda M. de Vries","orcid":"https://orcid.org/0000-0002-8653-4040","observed_orcids":["https://orcid.org/0000-0002-8653-4040"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"I. Jolanda M. de Vries","raw_affiliation_strings":["1Tumor Immunology, Departments of","7Pediatric Hemato-Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tumor Immunology, Departments of","institution_ids":[]},{"raw_affiliation_string":"7Pediatric Hemato-Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8742,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.90888897,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"7","first_page":"2927","last_page":"2934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/mrna-electroporation","display_name":"mRNA electroporation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8650000095367432},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/gp100","display_name":"gp100","score":0.875},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":1.0},{"id":"https://openalex.org/keywords/dendritic-cell-migration","display_name":"dendritic cell migration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.8149999976158142},{"id":"https://openalex.org/keywords/indium-111-labeling","display_name":"indium-111 labeling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/superparamagnetic-iron-oxide-nanoparticles","display_name":"superparamagnetic iron oxide nanoparticles","score":0.890999972820282},{"id":"https://openalex.org/keywords/intranodal-injection","display_name":"intranodal injection","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.6924712061882019},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6072586178779602},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5930245518684387},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5423300266265869},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.5371497273445129},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5197598338127136},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5162429809570312},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5057542324066162},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.500023365020752},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.47692033648490906},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.4667259752750397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4508192837238312},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.450298011302948},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.43203040957450867},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.42668643593788147},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3708379864692688},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3613891899585724},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3491460084915161},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3458988666534424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34313857555389404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3400159180164337},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2893446385860443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1489672064781189},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1158/0008-5472.can-08-3920","doi":"https://doi.org/10.1158/0008-5472.can-08-3920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/7/2927/2622504/2927.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:19318559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19318559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/efd551bb-1b6f-4532-aa55-aa1177bbeb9e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/in-situ-expression-of-tumor-antigens-by-messenger-rnaelectroporated-dendritic-cells-in-lymph-nodes-of-melanoma-patients(efd551bb-1b6f-4532-aa55-aa1177bbeb9e).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer research, 69(7), 2927 - 2934. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/d2fe25c4-95d4-48d0-9ec2-ab563f113798","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/d2fe25c4-95d4-48d0-9ec2-ab563f113798","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/80296","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/80296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/80296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/80296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 69, 2927 - 34","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-08-3920","doi":"https://doi.org/10.1158/0008-5472.can-08-3920","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-3920","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/7/2927/2622504/2927.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G269535760","display_name":null,"funder_award_id":"R01-NS045062","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6984360092","display_name":"MR and BL Tracking of Stem/Progenitor Cells in the CNS","funder_award_id":"5r01ns045062-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000217999","display_name":null,"funder_award_id":"NS 045062","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000265697","display_name":null,"funder_award_id":"RO1 NS045062","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120002004.pdf","grobid_xml":"https://content.openalex.org/works/W2120002004.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1521418395","https://openalex.org/W1591392487","https://openalex.org/W1650579874","https://openalex.org/W1661544713","https://openalex.org/W1899330274","https://openalex.org/W1908804993","https://openalex.org/W1976750839","https://openalex.org/W1983076937","https://openalex.org/W1992331311","https://openalex.org/W2002918113","https://openalex.org/W2009671073","https://openalex.org/W2011007492","https://openalex.org/W2026364942","https://openalex.org/W2031454462","https://openalex.org/W2045545228","https://openalex.org/W2052065441","https://openalex.org/W2052714233","https://openalex.org/W2056316684","https://openalex.org/W2058205936","https://openalex.org/W2058271074","https://openalex.org/W2065530371","https://openalex.org/W2066964346","https://openalex.org/W2082730287","https://openalex.org/W2090464403","https://openalex.org/W2095825164","https://openalex.org/W2112724852","https://openalex.org/W2116324456","https://openalex.org/W2117216774","https://openalex.org/W2121324391","https://openalex.org/W2124034595","https://openalex.org/W2124430059","https://openalex.org/W2131177116","https://openalex.org/W2131365547","https://openalex.org/W2135288013","https://openalex.org/W2148510816","https://openalex.org/W2154041075","https://openalex.org/W2162666572","https://openalex.org/W3021508179"],"related_works":["https://openalex.org/W2046718813","https://openalex.org/W2104401785","https://openalex.org/W2135087025","https://openalex.org/W2286416783","https://openalex.org/W178663247","https://openalex.org/W1976750839","https://openalex.org/W2418503820","https://openalex.org/W2116324456","https://openalex.org/W2197816349","https://openalex.org/W2019962265"],"abstract_inverted_index":{"Electroporation":[0],"of":[1,25,38,55,97,103,121,148],"dendritic":[2],"cells":[3],"(DC)":[4],"with":[5,70,77,152,162],"mRNA":[6,71,163],"encoding":[7,72,164],"tumor-associated":[8],"antigens":[9,169],"(TAA)":[10],"for":[11,41],"cancer":[12],"immunotherapy":[13],"has":[14],"been":[15],"proved":[16],"efficient":[17],"and":[18,27,33,51,79,84,124,167,174],"clinically":[19],"safe.":[20],"It":[21],"obviates":[22],"prior":[23],"knowledge":[24],"CTL":[26],"Th":[28],"epitopes":[29,40],"in":[30,59,64,87,146,170],"the":[31,36,48,52,104,114,118,122,131,135,171],"antigen":[32,53,132],"leads":[34],"to":[35,91],"presentation":[37],"multiple":[39],"several":[42],"HLA":[43],"alleles.":[44],"Here":[45],"we":[46],"studied":[47],"migration":[49],"capacity":[50],"expression":[54],"mRNA-electroporated":[56],"DC":[57,67,160],"(mRNA-DC)":[58],"lymph":[60,99,105,126,172],"nodes":[61,106,173],"after":[62,107],"vaccination":[63],"melanoma":[65,88],"patients.":[66],"were":[68],"electroporated":[69,136,161],"gp100":[73],"or":[74],"tyrosinase,":[75],"labeled":[76],"indium-111":[78],"superparamagnetic":[80],"iron":[81],"oxide":[82],"particles,":[83],"injected":[85],"intranodally":[86],"patients":[89,150],"24":[90],"48":[92],"hours":[93],"before":[94],"scheduled":[95],"dissection":[96],"regional":[98],"nodes.":[100],"Immunohistochemical":[101],"analysis":[102],"surgery":[108],"revealed":[109],"that":[110,158],"mRNA-DC":[111],"migrated":[112],"from":[113],"injection":[115],"site":[116],"into":[117],"T-cell":[119,141],"areas":[120],"same":[123],"subsequent":[125],"nodes,":[127],"where":[128],"they":[129],"expressed":[130],"encoded":[133],"by":[134],"mRNA.":[137],"Furthermore,":[138],"vaccine-related":[139],"CD8(+)":[140],"responses":[142],"could":[143],"be":[144],"detected":[145],"7":[147],"11":[149],"vaccinated":[151],"mRNA-DC.":[153],"Together":[154],"these":[155],"data":[156],"show":[157],"mature":[159],"TAA":[165],"migrate":[166],"express":[168],"induce":[175],"specific":[176],"immune":[177],"responses.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}