{"id":"https://openalex.org/W2119628526","doi":"https://doi.org/10.1101/gad.1978310","title":"Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication","display_name":"Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2119628526","doi":"https://doi.org/10.1101/gad.1978310","mag":"2119628526","pmid":"https://pubmed.ncbi.nlm.nih.gov/21123650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2994037"},"language":"en","primary_location":{"id":"doi:10.1101/gad.1978310","doi":"https://doi.org/10.1101/gad.1978310","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1978310","pdf_url":"http://genesdev.cshlp.org/content/24/23/2627.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/24/23/2627.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064759320","display_name":"Uyanga Chuluunbaatar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uyanga Chuluunbaatar","raw_affiliation_strings":["Department of Microbiology, New York University School of Medicine, New York, 10016, USA","Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA","New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026791436","display_name":"Richard J. Roller","orcid":"https://orcid.org/0000-0001-8340-3224","observed_orcids":["https://orcid.org/0000-0001-8340-3224"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Roller","raw_affiliation_strings":["Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111933725","display_name":"Morris E. Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morris E. Feldman","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 9143,\n                           USA","Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 9143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 9143,\n                           USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 9143, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087430495","display_name":"Stuart M. Brown","orcid":"https://orcid.org/0000-0002-0906-9907","observed_orcids":["https://orcid.org/0000-0002-0906-9907"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Brown","raw_affiliation_strings":["Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, New York, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, New York, 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevan M. Shokat","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 9143,\n                           USA","Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 9143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, California 9143,\n                           USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 9143, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055851463","display_name":"Ian Mohr","orcid":"https://orcid.org/0000-0002-4921-1998","observed_orcids":["https://orcid.org/0000-0002-4921-1998"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Mohr","raw_affiliation_strings":["Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA","New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"23","first_page":"2627","last_page":"2639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mtorc1-activation","display_name":"mTORC1 activation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tsc2-phosphorylation","display_name":"TSC2 phosphorylation","score":0.906000018119812},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/viral-mrna-translation","display_name":"viral mRNA translation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.8740000128746033},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8022815585136414},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6900795698165894},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.6025632619857788},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.599315881729126},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5951405763626099},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47639361023902893},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.46992576122283936},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40879523754119873},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.40574580430984497},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2771158218383789},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2369993031024933}],"mesh":[{"descriptor_ui":"D000077005","descriptor_name":"Tuberous Sclerosis Complex 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039562","descriptor_name":"Eukaryotic Initiation Factor-4F","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/gad.1978310","doi":"https://doi.org/10.1101/gad.1978310","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1978310","pdf_url":"http://genesdev.cshlp.org/content/24/23/2627.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2994037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2994037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"pmid:21123650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21123650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gad.1978310","doi":"https://doi.org/10.1101/gad.1978310","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1978310","pdf_url":"http://genesdev.cshlp.org/content/24/23/2627.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1621308200","display_name":null,"funder_award_id":"AI073898","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G239743816","display_name":null,"funder_award_id":"GM056927","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3084026282","display_name":null,"funder_award_id":"R01-GM056927","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3761063458","display_name":null,"funder_award_id":"R01-AI073898","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5002256833","display_name":"Control of Translation in Herpesvirus Infected Cells - Resubmission - 1","funder_award_id":"5r01gm056927-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5565679999","display_name":"Virus Host Interactions that Regulate Translation in Cells Infected with HSV-1","funder_award_id":"5r01ai073898-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6386076924","display_name":"Infectious Disease and Basic Microbiological Mechanisms.","funder_award_id":"T32AI007180","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8581608661","display_name":"UL34 and herpes simplex virus envelopment","funder_award_id":"R01AI041478","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000107337","display_name":null,"funder_award_id":"AI073898","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000170123","display_name":null,"funder_award_id":"GM056927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2119628526.pdf","grobid_xml":"https://content.openalex.org/works/W2119628526.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W645171471","https://openalex.org/W1487781539","https://openalex.org/W1969883219","https://openalex.org/W1970905916","https://openalex.org/W1971663674","https://openalex.org/W1993881377","https://openalex.org/W2002226709","https://openalex.org/W2008460142","https://openalex.org/W2008720923","https://openalex.org/W2020094759","https://openalex.org/W2022850278","https://openalex.org/W2030966943","https://openalex.org/W2033036465","https://openalex.org/W2033679149","https://openalex.org/W2035109828","https://openalex.org/W2035521247","https://openalex.org/W2037313242","https://openalex.org/W2042144075","https://openalex.org/W2049277771","https://openalex.org/W2056739383","https://openalex.org/W2056889415","https://openalex.org/W2060261905","https://openalex.org/W2075059034","https://openalex.org/W2082779452","https://openalex.org/W2091472124","https://openalex.org/W2094941511","https://openalex.org/W2095169342","https://openalex.org/W2097706568","https://openalex.org/W2098912234","https://openalex.org/W2102102802","https://openalex.org/W2103062754","https://openalex.org/W2103417324","https://openalex.org/W2107777605","https://openalex.org/W2108357729","https://openalex.org/W2109863815","https://openalex.org/W2110845720","https://openalex.org/W2113363982","https://openalex.org/W2116877629","https://openalex.org/W2120259492","https://openalex.org/W2120898863","https://openalex.org/W2125121305","https://openalex.org/W2135433503","https://openalex.org/W2135539857","https://openalex.org/W2137015675","https://openalex.org/W2139591514","https://openalex.org/W2147881941","https://openalex.org/W2150595264","https://openalex.org/W2157582689","https://openalex.org/W2160079255","https://openalex.org/W2161697105","https://openalex.org/W2610208464"],"related_works":["https://openalex.org/W2103605356","https://openalex.org/W2049483592","https://openalex.org/W2611494511","https://openalex.org/W2103062754","https://openalex.org/W2895510381","https://openalex.org/W2802663305","https://openalex.org/W7206453707","https://openalex.org/W2074901911","https://openalex.org/W7096358089","https://openalex.org/W2019324195"],"abstract_inverted_index":{"All":[0],"viruses":[1],"require":[2],"cellular":[3,57],"ribosomes":[4],"to":[5,26,46,88,120],"translate":[6],"their":[7],"mRNAs.":[8],"Viruses":[9],"producing":[10],"methyl-7":[11],"(m\u2077)":[12],"GTP-capped":[13],"mRNAs,":[14],"like":[15],"Herpes":[16],"Simplex":[17],"Virus-1":[18],"(HSV-1),":[19],"stimulate":[20],"cap-dependent":[21],"translation":[22,124],"by":[23,85],"activating":[24],"mTORC1":[25],"inhibit":[27],"the":[28,39,56,69],"translational":[29],"repressor":[30],"4E-binding":[31],"protein":[32],"1":[33],"(4E-BP1).":[34],"Here,":[35],"we":[36],"establish":[37],"that":[38,81],"HSV-1":[40,111],"kinase":[41,58,135],"Us3":[42,50,82,98,130],"masquerades":[43],"as":[44,72,131],"Akt":[45,100,114],"activate":[47,90,121],"mTORC1.":[48],"Remarkably,":[49],"displays":[51],"no":[52],"sequence":[53],"homology":[54],"with":[55,116,136],"Akt,":[59],"yet":[60],"directly":[61],"phosphorylates":[62],"tuberous":[63],"sclerosis":[64],"complex":[65],"2":[66],"(TSC2)":[67],"on":[68],"same":[70],"sites":[71],"Akt.":[73],"TSC2":[74,87],"depletion":[75],"rescued":[76],"Us3-deficient":[77],"virus":[78,126],"replication,":[79],"establishing":[80],"enhances":[83],"replication":[84],"phosphorylating":[86],"constitutively":[89],"mTORC1,":[91,122],"effectively":[92],"bypassing":[93],"S6K-mediated":[94],"feedback":[95],"inhibition.":[96],"Moreover,":[97],"stimulated":[99],"substrate":[101,118],"phosphorylation":[102],"in":[103],"infected":[104],"cells,":[105],"including":[106],"FOXO1":[107],"and":[108,125],"GSK3.":[109],"Thus,":[110],"encodes":[112],"an":[113],"surrogate":[115],"overlapping":[117],"specificity":[119],"stimulating":[123],"replication.":[127],"This":[128],"establishes":[129],"a":[132],"unique":[133],"viral":[134],"promising":[137],"drug":[138],"development":[139],"potential.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
