{"id":"https://openalex.org/W2119257617","doi":"https://doi.org/10.1007/s13361-015-1128-8","title":"Mass Spectrometry Imaging and GC-MS Profiling of the Mammalian Peripheral Sensory-Motor Circuit","display_name":"Mass Spectrometry Imaging and GC-MS Profiling of the Mammalian Peripheral Sensory-Motor Circuit","publication_year":2015,"publication_date":"2015-03-30","ids":{"openalex":"https://openalex.org/W2119257617","doi":"https://doi.org/10.1007/s13361-015-1128-8","mag":"2119257617","pmid":"https://pubmed.ncbi.nlm.nih.gov/25822927","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4425624"},"language":"en","primary_location":{"id":"doi:10.1007/s13361-015-1128-8","doi":"https://doi.org/10.1007/s13361-015-1128-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-015-1128-8","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4425624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020098405","display_name":"Stanislav S. Rubakhin","orcid":"https://orcid.org/0000-0003-0437-1493","observed_orcids":["https://orcid.org/0000-0003-0437-1493"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav S. Rubakhin","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, 61801, Urbana, IL, USA","Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, Urbana, IL, 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, 61801, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, Urbana, IL, 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077019468","display_name":"ALEXANDER V. ULANOV","orcid":"https://orcid.org/0000-0003-1097-7619","observed_orcids":["https://orcid.org/0000-0003-1097-7619"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Ulanov","raw_affiliation_strings":["Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, 61801, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006238710","display_name":"Jonathan V. Sweedler","orcid":"https://orcid.org/0000-0003-3107-9922","observed_orcids":["https://orcid.org/0000-0003-3107-9922"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan V. Sweedler","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, 61801, Urbana, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, 61801, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7427,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6511011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"6","first_page":"958","last_page":"966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensory-motor-circuits","display_name":"sensory-motor circuits","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peripheral-nerves","display_name":"peripheral nerves","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chemical-imaging","display_name":"chemical imaging","score":0.8069999814033508},{"id":"https://openalex.org/keywords/maldi-mass-spectrometry-imaging","display_name":"MALDI mass spectrometry imaging","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gc-ms-profiling","display_name":"GC-MS profiling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tissue-heterogeneity","display_name":"tissue heterogeneity","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8367842435836792},{"id":"https://openalex.org/C24066741","wikidata":"https://www.wikidata.org/wiki/Q3796564","display_name":"Mass spectrometry imaging","level":3,"score":0.7805863618850708},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7494124174118042},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5229602456092834},{"id":"https://openalex.org/C101092202","wikidata":"https://www.wikidata.org/wiki/Q6714252","display_name":"MALDI imaging","level":5,"score":0.47309282422065735},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.46277937293052673},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.45993685722351074},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37040308117866516},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33617568016052246},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2768356204032898},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.20644110441207886},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s13361-015-1128-8","doi":"https://doi.org/10.1007/s13361-015-1128-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13361-015-1128-8","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:25822927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25822927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3850296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4425624","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4425624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4425624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Soc Mass Spectrom","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3850296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4425624","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3226058708","display_name":null,"funder_award_id":"R21 MH100704A","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5492073889","display_name":"Glia classification via single cell metabolomics","funder_award_id":"R21MH100704","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000863082","display_name":"Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling","funder_award_id":"P30DA018310","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W58543270","https://openalex.org/W160435972","https://openalex.org/W168130375","https://openalex.org/W605885233","https://openalex.org/W1483086770","https://openalex.org/W1496422635","https://openalex.org/W1599833391","https://openalex.org/W1863470918","https://openalex.org/W1964814761","https://openalex.org/W1965011257","https://openalex.org/W1966286178","https://openalex.org/W1966960464","https://openalex.org/W1972219555","https://openalex.org/W1975462395","https://openalex.org/W1978286026","https://openalex.org/W1978781045","https://openalex.org/W1979504805","https://openalex.org/W1984832858","https://openalex.org/W1987772965","https://openalex.org/W1987918216","https://openalex.org/W1992483596","https://openalex.org/W2004222972","https://openalex.org/W2009337748","https://openalex.org/W2010141982","https://openalex.org/W2013818002","https://openalex.org/W2015320412","https://openalex.org/W2016360252","https://openalex.org/W2017932539","https://openalex.org/W2021459181","https://openalex.org/W2025733760","https://openalex.org/W2033278243","https://openalex.org/W2036770961","https://openalex.org/W2039428368","https://openalex.org/W2047127389","https://openalex.org/W2047130157","https://openalex.org/W2048269418","https://openalex.org/W2048401319","https://openalex.org/W2054014227","https://openalex.org/W2055881608","https://openalex.org/W2057235898","https://openalex.org/W2060952451","https://openalex.org/W2061672127","https://openalex.org/W2066347053","https://openalex.org/W2070012684","https://openalex.org/W2074363469","https://openalex.org/W2085946009","https://openalex.org/W2094309702","https://openalex.org/W2094619602","https://openalex.org/W2101379454","https://openalex.org/W2105381419","https://openalex.org/W2107410539","https://openalex.org/W2107878083","https://openalex.org/W2111387415","https://openalex.org/W2114683502","https://openalex.org/W2119699023","https://openalex.org/W2121807337","https://openalex.org/W2123722582","https://openalex.org/W2124911115","https://openalex.org/W2132514608","https://openalex.org/W2145022634","https://openalex.org/W2146215399","https://openalex.org/W2158943130","https://openalex.org/W2159901810","https://openalex.org/W2164215561","https://openalex.org/W2165553407","https://openalex.org/W2407660274","https://openalex.org/W2417435365","https://openalex.org/W2914655414"],"related_works":["https://openalex.org/W2563843641","https://openalex.org/W2164215561","https://openalex.org/W1733250784","https://openalex.org/W2315687228","https://openalex.org/W2581784457","https://openalex.org/W1183660748","https://openalex.org/W2521798457","https://openalex.org/W7097498569","https://openalex.org/W2048269418","https://openalex.org/W2123722582"],"abstract_inverted_index":{"Matrix-assisted":[0],"laser":[1],"desorption/ionization":[2],"(MALDI)":[3],"mass":[4],"spectrometry":[5,91],"imaging":[6,23],"(MSI)":[7],"has":[8],"evolved":[9],"to":[10,27,101],"become":[11],"an":[12],"effective":[13],"discovery":[14],"tool":[15],"in":[16],"science":[17],"and":[18,42,54,76,95,111,119],"clinical":[19],"diagnostics.":[20],"Here,":[21],"chemical":[22,118,124],"approaches":[24],"are":[25,59],"applied":[26],"well-defined":[28],"regions":[29,68,79,87,114],"of":[30,85,107,122],"the":[31,37,70,74,81,102,108,116],"mammalian":[32],"peripheral":[33],"sensory-motor":[34,71],"system,":[35,72],"including":[36],"dorsal":[38],"root":[39],"ganglia":[40],"(DRG)":[41],"adjacent":[43,77],"nerves.":[44],"By":[45],"combining":[46],"several":[47],"MSI":[48],"approaches,":[49],"analyte":[50],"coverage":[51],"is":[52],"increased":[53],"195":[55],"distinct":[56],"molecular":[57],"features":[58],"observed.":[60],"Principal":[61],"component":[62],"analysis":[63],"suggests":[64],"three":[65],"chemically":[66],"different":[67],"within":[69],"with":[73],"DRG":[75],"nerve":[78],"being":[80],"most":[82],"distinct.":[83],"Investigation":[84],"these":[86,93],"using":[88],"gas":[89],"chromatography-mass":[90],"corroborate":[92],"findings":[94],"reveal":[96],"important":[97],"metabolic":[98],"markers":[99],"related":[100],"observed":[103],"differences.":[104],"The":[105],"heterogeneity":[106],"structurally,":[109],"physiologically,":[110],"functionally":[112],"connected":[113],"demonstrates":[115],"intricate":[117],"spatial":[120],"regulation":[121],"their":[123],"composition.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}