{"id":"https://openalex.org/W2119204875","doi":"https://doi.org/10.1681/asn.v351113","title":"Effect of epidermal growth factor in the rat 5/6 renal ablation model.","display_name":"Effect of epidermal growth factor in the rat 5/6 renal ablation model.","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2119204875","doi":"https://doi.org/10.1681/asn.v351113","mag":"2119204875","pmid":"https://pubmed.ncbi.nlm.nih.gov/1482751"},"language":"en","primary_location":{"id":"doi:10.1681/asn.v351113","doi":"https://doi.org/10.1681/asn.v351113","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v351113","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035239198","display_name":"David W. Moskowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W Moskowitz","raw_affiliation_strings":["Department of Internal Medicine, St. Louis University Medical Center, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Louis University Medical Center, MO","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A N Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A N Schneider","raw_affiliation_strings":["Department of Internal Medicine, St. Louis University Medical Center, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Louis University Medical Center, MO","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111948247","display_name":"Pascale Hammond Lane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P H Lane","raw_affiliation_strings":["Department of Internal Medicine, St. Louis University Medical Center, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Louis University Medical Center, MO","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024714006","display_name":"Paul G. Schmitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P G Schmitz","raw_affiliation_strings":["Department of Internal Medicine, St. Louis University Medical Center, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Louis University Medical Center, MO","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074126434","display_name":"Kathleen N. Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K N Gillespie","raw_affiliation_strings":["Department of Internal Medicine, St. Louis University Medical Center, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Louis University Medical Center, MO","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":2.1668,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.86869706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"5","first_page":"1113","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.21799999475479126,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/5-6-nephrectomy","display_name":"5/6 nephrectomy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chronic-renal-insufficiency","display_name":"chronic renal insufficiency","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.9100000262260437},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8230000138282776},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5270000100135803},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6489999890327454},{"id":"https://openalex.org/keywords/urine-flow-rate","display_name":"urinary flow rate","score":0.6209999918937683},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.734000027179718},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.843999981880188},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7075497508049011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6926393508911133},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6905704736709595},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.6672253608703613},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6660395860671997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6422773599624634},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.5962790846824646},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5123296976089478},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5059053301811218},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.4940391182899475},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.45854973793029785},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3492058515548706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09247025847434998}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.v351113","doi":"https://doi.org/10.1681/asn.v351113","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v351113","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:1482751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1482751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2157363739","https://openalex.org/W4302855356","https://openalex.org/W2140909153","https://openalex.org/W2925333346","https://openalex.org/W2109143521","https://openalex.org/W1975993184","https://openalex.org/W2209019250","https://openalex.org/W7216761121","https://openalex.org/W2061717127","https://openalex.org/W64289664"],"abstract_inverted_index":{"Acute":[0],"administration":[1,28],"of":[2,24,29,42,124,140],"epidermal":[3],"growth":[4],"factor":[5],"(EGF)":[6],"has":[7],"been":[8],"shown":[9],"to":[10,49,99],"promote":[11],"recovery":[12],"from":[13,92],"ischemic":[14],"and":[15,71,82,138,144],"nephrotoxic":[16],"acute":[17,93],"renal":[18,44,62,75,78,89],"failure":[19,45],"in":[20,46,61,96,108],"vivo.":[21],"The":[22,121],"question":[23],"whether":[25],"chronic":[26,43,88],"subcutaneous":[27],"EGF":[30,103,125,152],"(19.1":[31],"micrograms/day":[32],"for":[33,169],"3":[34],"or":[35,77,158,167],"6":[36],"wk)":[37],"could":[38],"alter":[39],"the":[40,106,115],"course":[41],"rats":[47],"subjected":[48],"5/6":[50,119],"nephrectomy":[51],"was":[52,58,126],"studied.":[53],"By":[54],"week":[55,117,130],"6,":[56,159],"there":[57],"no":[59],"difference":[60],"function,":[63],"as":[64],"assessed":[65],"by":[66,114,151],"animal":[67],"survival,":[68],"BUN,":[69],"urea":[70],"inulin":[72],"clearances,":[73],"proteinuria,":[74],"morphometry,":[76],"size,":[79],"between":[80],"EGF-":[81],"vehicle-treated":[83],"rats.":[84],"This":[85],"suggests":[86],"that":[87,112],"insufficiency":[90],"differs":[91],"tubular":[94],"injury":[95],"its":[97],"sensitivity":[98],"exogenous":[100],"EGF.":[101],"Unexpectedly,":[102],"significantly":[104,149],"attenuated":[105],"rise":[107],"systolic":[109],"blood":[110],"pressure":[111],"occurred":[113],"fourth":[116],"after":[118],"nephrectomy.":[120],"antihypertensive":[122,171],"effect":[123],"still":[127],"evident":[128],"at":[129,153],"5.":[131],"Urinary":[132],"flow":[133],"rate,":[134],"free":[135],"water":[136],"clearance,":[137],"excretion":[139],"total":[141],"solutes,":[142],"Na+,":[143],"K+,":[145],"however,":[146],"were":[147],"not":[148],"altered":[150],"weeks":[154],"2,":[155],"4,":[156],"5,":[157],"suggesting":[160],"a":[161],"mechanism":[162],"other":[163],"than":[164],"increased":[165],"natriuresis":[166],"diuresis":[168],"this":[170],"effect.":[172]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}