{"id":"https://openalex.org/W2119087494","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0297","title":"Galectin-1-Mediated Tumor Invasion and Metastasis, Up-Regulated Matrix Metalloproteinase Expression, and Reorganized Actin Cytoskeletons","display_name":"Galectin-1-Mediated Tumor Invasion and Metastasis, Up-Regulated Matrix Metalloproteinase Expression, and Reorganized Actin Cytoskeletons","publication_year":2009,"publication_date":"2009-03-10","ids":{"openalex":"https://openalex.org/W2119087494","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0297","mag":"2119087494","pmid":"https://pubmed.ncbi.nlm.nih.gov/19276182"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-08-0297","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0297","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0297","pdf_url":"https://aacrjournals.org/mcr/article-pdf/7/3/311/3143975/311.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/mcr/article-pdf/7/3/311/3143975/311.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052242664","display_name":"Ming\u2013Heng Wu","orcid":"https://orcid.org/0000-0002-5740-9144","observed_orcids":["https://orcid.org/0000-0002-5740-9144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming-Heng Wu","raw_affiliation_strings":["1Basic Medical Sciences, Institutes of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Basic Medical Sciences, Institutes of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110267889","display_name":"Tse-Ming Hong","orcid":"https://orcid.org/0000-0002-9333-8451","observed_orcids":["https://orcid.org/0000-0002-9333-8451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tse-Ming Hong","raw_affiliation_strings":["2Clinical Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Clinical Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102161479","display_name":"Hui-Wen Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Wen Cheng","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004560897","display_name":"Szu\u2010Hua Pan","orcid":"https://orcid.org/0000-0002-0138-0434","observed_orcids":["https://orcid.org/0000-0002-0138-0434"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Szu-Hua Pan","raw_affiliation_strings":["6Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111914145","display_name":"Yu-Ray Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Ray Liang","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021200806","display_name":"Hsiao-Chin Hong","orcid":"https://orcid.org/0000-0001-5871-9067","observed_orcids":["https://orcid.org/0000-0001-5871-9067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsiao-Chin Hong","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680754","display_name":"Wei-Fan Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Fan Chiang","raw_affiliation_strings":["5Oral and Maxillofacial Section, Chi-Mei Medical Center, Tainan, Taiwan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Oral and Maxillofacial Section, Chi-Mei Medical Center, Tainan, Taiwan and","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113806112","display_name":"Tung-Yiu Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tung-Yiu Wong","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007401599","display_name":"Dar-Bin Shieh","orcid":"https://orcid.org/0000-0001-9389-4194","observed_orcids":["https://orcid.org/0000-0001-9389-4194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dar-Bin Shieh","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019982228","display_name":"Ai\u2010Li Shiau","orcid":"https://orcid.org/0000-0003-2449-8547","observed_orcids":["https://orcid.org/0000-0003-2449-8547"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ai-Li Shiau","raw_affiliation_strings":["4Department of Microbiology and Immunology, National Cheng Kung University College of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Microbiology and Immunology, National Cheng Kung University College of Medicine;","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114172714","display_name":"Ying\u2010Tai Jin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying-Tai Jin","raw_affiliation_strings":["3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056283282","display_name":"Yuh\u2010Ling Chen","orcid":"https://orcid.org/0000-0001-7760-5954","observed_orcids":["https://orcid.org/0000-0001-7760-5954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuh-Ling Chen","raw_affiliation_strings":["1Basic Medical Sciences, Institutes of","3Oral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Basic Medical Sciences, Institutes of","institution_ids":[]},{"raw_affiliation_string":"3Oral Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8232,"has_fulltext":true,"cited_by_count":158,"citation_normalized_percentile":{"value":0.95649278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":"3","first_page":"311","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":1.0},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9559999704360962},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9449999928474426},{"id":"https://openalex.org/keywords/filopodia","display_name":"filopodia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7119818925857544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6945111155509949},{"id":"https://openalex.org/C90301020","wikidata":"https://www.wikidata.org/wiki/Q14859810","display_name":"Filopodia","level":3,"score":0.5210880041122437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5144451260566711},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4812609851360321},{"id":"https://openalex.org/C2776336362","wikidata":"https://www.wikidata.org/wiki/Q18028529","display_name":"Galectin-3","level":2,"score":0.4308190941810608},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4247286319732666},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.42367878556251526},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41739532351493835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32144296169281006},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2752712368965149},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.2511008679866791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24816906452178955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1877439022064209},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.17757189273834229},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16549274325370789},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.mcr-08-0297","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0297","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0297","pdf_url":"https://aacrjournals.org/mcr/article-pdf/7/3/311/3143975/311.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:19276182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19276182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.mcr-08-0297","doi":"https://doi.org/10.1158/1541-7786.mcr-08-0297","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-08-0297","pdf_url":"https://aacrjournals.org/mcr/article-pdf/7/3/311/3143975/311.pdf","source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2119087494.pdf","grobid_xml":"https://content.openalex.org/works/W2119087494.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W2731502","https://openalex.org/W232368323","https://openalex.org/W1520425169","https://openalex.org/W1577717236","https://openalex.org/W1604955250","https://openalex.org/W1839381104","https://openalex.org/W1945339140","https://openalex.org/W1946767955","https://openalex.org/W1966573085","https://openalex.org/W1975238439","https://openalex.org/W1977298105","https://openalex.org/W1978854347","https://openalex.org/W1980156271","https://openalex.org/W1981444242","https://openalex.org/W1982095943","https://openalex.org/W1983609115","https://openalex.org/W1991622808","https://openalex.org/W1992885568","https://openalex.org/W1994183296","https://openalex.org/W1995480433","https://openalex.org/W1997693725","https://openalex.org/W1999264835","https://openalex.org/W1999761349","https://openalex.org/W2006519535","https://openalex.org/W2007671824","https://openalex.org/W2008135090","https://openalex.org/W2010026333","https://openalex.org/W2015805460","https://openalex.org/W2016394200","https://openalex.org/W2016479978","https://openalex.org/W2022233074","https://openalex.org/W2041586000","https://openalex.org/W2044431281","https://openalex.org/W2046148841","https://openalex.org/W2048291886","https://openalex.org/W2048611893","https://openalex.org/W2052315444","https://openalex.org/W2059748853","https://openalex.org/W2061385217","https://openalex.org/W2077468106","https://openalex.org/W2081545593","https://openalex.org/W2085643068","https://openalex.org/W2087963453","https://openalex.org/W2089260591","https://openalex.org/W2091977407","https://openalex.org/W2092634237","https://openalex.org/W2094674011","https://openalex.org/W2098576665","https://openalex.org/W2106161218","https://openalex.org/W2121643017","https://openalex.org/W2123642928","https://openalex.org/W2126578659","https://openalex.org/W2154154147"],"related_works":["https://openalex.org/W2253794239","https://openalex.org/W3135782121","https://openalex.org/W2076084423","https://openalex.org/W3182184901","https://openalex.org/W1972897394","https://openalex.org/W2901738162","https://openalex.org/W2605235754","https://openalex.org/W1525058971","https://openalex.org/W2103665067","https://openalex.org/W2084169296"],"abstract_inverted_index":{"Galectin-1":[0],"(Gal-1)":[1],"is":[2,18,56,66,183],"a":[3,145],"beta-galactose-binding":[4],"lectin;":[5],"its":[6,70],"expression":[7,65,193],"level":[8],"has":[9],"been":[10],"reported":[11],"to":[12],"correlate":[13],"with":[14,42,69,88],"tumor":[15,54,124,163,186],"progression.":[16],"Gal-1":[17,52,64,87,114,122,139,182],"highly":[19,93],"expressed":[20],"in":[21,29,36,53,75,92,172,177,185,197],"the":[22,30,37,48,102,141,151,156],"invasive":[23,94,107],"front":[24],"of":[25,33,40,51,73,105,116,143,150,160],"primary":[26],"tumors":[27],"and":[28,78,132,134,148,158,188,194,200],"cancer":[31,95,108],"cells":[32,96,109,167],"metastatic":[34,170],"lesions":[35],"lymph":[38],"nodes":[39],"patients":[41],"oral":[43,79,198],"squamous":[44,80],"cell":[45,81,83],"carcinoma.":[46],"However,":[47],"molecular":[49],"mechanism":[50],"metastasis":[55,175,189],"not":[57],"completely":[58],"clear.":[59],"We":[60,179],"found":[61],"that":[62,121,181],"increased":[63,112],"closely":[67],"associated":[68],"high":[71],"levels":[72],"invasion":[74,99,103,125,187],"lung":[76,201],"adenocarcinoma":[77],"carcinoma":[82],"lines.":[84],"Knocking":[85],"down":[86],"small":[89,146],"interfering":[90],"RNA":[91],"reduced":[97],"their":[98],"levels.":[100],"Moreover,":[101],"ability":[104],"poorly":[106],"was":[110],"significantly":[111],"after":[113],"overexpression":[115],"Gal-1.":[117],"Mechanism":[118],"studies":[119],"revealed":[120],"promoted":[123],"mainly":[126],"by":[127,135,190],"up-regulating":[128],"matrix":[129],"metalloproteinase":[130],"(MMP)-9":[131],"MMP-2":[133],"reorganizing":[136,195],"actin":[137],"cytoskeleton.":[138],"enhanced":[140],"activation":[142],"Cdc42,":[144],"GTPase":[147],"member":[149],"Rho":[152],"family,":[153],"thus":[154],"increasing":[155,191],"number":[157],"length":[159],"filopodia":[161],"on":[162],"cells.":[164],"Furthermore,":[165],"Gal-1-overexpressing":[166],"had":[168],"higher":[169],"abilities":[171],"tail":[173],"vein":[174],"assays":[176],"vivo.":[178],"conclude":[180],"involved":[184],"MMP":[192],"cytoskeletons":[196],"cancers":[199],"adenocarcinoma.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}