{"id":"https://openalex.org/W2119007548","doi":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","title":"Sequence, structure, function, immunity: structural genomics of costimulation","display_name":"Sequence, structure, function, immunity: structural genomics of costimulation","publication_year":2009,"publication_date":"2009-04-21","ids":{"openalex":"https://openalex.org/W2119007548","doi":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","mag":"2119007548","pmid":"https://pubmed.ncbi.nlm.nih.gov/19426233","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001128"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-065x.2009.00778.x","doi":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032761657","display_name":"Kausik Chattopadhyay","orcid":"https://orcid.org/0000-0001-8529-9475","observed_orcids":["https://orcid.org/0000-0001-8529-9475"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kausik Chattopadhyay","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035982074","display_name":"Eszter L\u00e1z\u00e1r\u2010Moln\u00e1r","orcid":"https://orcid.org/0000-0003-0802-9409","observed_orcids":["https://orcid.org/0000-0003-0802-9409"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eszter Lazar\u2010Molnar","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060626136","display_name":"Qingrong Yan","orcid":"https://orcid.org/0000-0001-9434-1540","observed_orcids":["https://orcid.org/0000-0001-9434-1540"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingrong Yan","raw_affiliation_strings":["Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031169990","display_name":"Rotem Rubinstein","orcid":"https://orcid.org/0000-0003-3657-5984","observed_orcids":["https://orcid.org/0000-0003-3657-5984"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rotem Rubinstein","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113179363","display_name":"Chenyang Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyang Zhan","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013636673","display_name":"Vladimir I. Vigdorovich","orcid":"https://orcid.org/0000-0003-4195-4858","observed_orcids":["https://orcid.org/0000-0003-4195-4858"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Vigdorovich","raw_affiliation_strings":["Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088864600","display_name":"Udupi Anantharamachar Ramagopal","orcid":"https://orcid.org/0000-0003-1045-9838","observed_orcids":["https://orcid.org/0000-0003-1045-9838"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Udupi A. Ramagopal","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061741709","display_name":"J.B. Bonanno","orcid":"https://orcid.org/0000-0003-0863-7826","observed_orcids":["https://orcid.org/0000-0003-0863-7826"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Bonanno","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112131090","display_name":"Stanley G. Nathenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley G. Nathenson","raw_affiliation_strings":["Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA","Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven C. Almo","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006013523"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4535,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.43357934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"229","issue":"1","first_page":"356","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/costimulatory-receptors","display_name":"costimulatory receptors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/costimulatory-ligands","display_name":"costimulatory ligands","score":0.9769999980926514},{"id":"https://openalex.org/keywords/immunoglobulin-superfamily","display_name":"immunoglobulin superfamily","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-superfamily","display_name":"tumor necrosis factor superfamily","score":0.9950000047683716},{"id":"https://openalex.org/keywords/receptor-ligand-specificity","display_name":"receptor ligand specificity","score":0.753000020980835},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/oligomeric-state","display_name":"oligomeric state","score":0.9319999814033508},{"id":"https://openalex.org/keywords/valence","display_name":"valence","score":0.6700000166893005},{"id":"https://openalex.org/keywords/immune-signaling-pathways","display_name":"immune signaling pathways","score":0.6340000033378601},{"id":"https://openalex.org/keywords/structural-genomics","display_name":"structural genomics","score":0.7620000243186951},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6804675459861755},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6009478569030762},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4986894130706787},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4895249605178833},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42359471321105957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3055131733417511},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21927005052566528}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-065x.2009.00778.x","doi":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.2009.00778.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:19426233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19426233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3001128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3001128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3001128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2525293057","display_name":null,"funder_award_id":"T32-CA009173","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2976677977","display_name":"Immunology and Immunooncology Training Program","funder_award_id":"5t32ca009173-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G622805309","display_name":null,"funder_award_id":"5T32CA009173","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7466557775","display_name":"NYSGXRC:A Large Scale Center for the PSI","funder_award_id":"U54GM074945","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8623839475","display_name":"Molecular and Structural Basis for T Cell Costimulation","funder_award_id":"R01AI007289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8821190157","display_name":null,"funder_award_id":"P3OCAO13330","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W650532749","https://openalex.org/W1482523072","https://openalex.org/W1489480103","https://openalex.org/W1492635887","https://openalex.org/W1506782390","https://openalex.org/W1522096076","https://openalex.org/W1535240987","https://openalex.org/W1545402173","https://openalex.org/W1573145410","https://openalex.org/W1639242915","https://openalex.org/W1639942402","https://openalex.org/W1662819364","https://openalex.org/W1913866070","https://openalex.org/W1951252517","https://openalex.org/W1960197119","https://openalex.org/W1971983296","https://openalex.org/W1972073608","https://openalex.org/W1972200894","https://openalex.org/W1973879517","https://openalex.org/W1973991237","https://openalex.org/W1975891070","https://openalex.org/W1977067868","https://openalex.org/W1977146914","https://openalex.org/W1978012062","https://openalex.org/W1978224572","https://openalex.org/W1978436252","https://openalex.org/W1980167867","https://openalex.org/W1980609474","https://openalex.org/W1982875501","https://openalex.org/W1985225964","https://openalex.org/W1987772726","https://openalex.org/W1991701428","https://openalex.org/W1994803330","https://openalex.org/W1995928270","https://openalex.org/W1996655452","https://openalex.org/W1999227421","https://openalex.org/W2007480898","https://openalex.org/W2007610160","https://openalex.org/W2007868209","https://openalex.org/W2013013791","https://openalex.org/W2013177587","https://openalex.org/W2014472703","https://openalex.org/W2015085911","https://openalex.org/W2018572383","https://openalex.org/W2019471689","https://openalex.org/W2026092903","https://openalex.org/W2028376975","https://openalex.org/W2031325281","https://openalex.org/W2032265293","https://openalex.org/W2032466777","https://openalex.org/W2032884741","https://openalex.org/W2037920661","https://openalex.org/W2039038215","https://openalex.org/W2040017420","https://openalex.org/W2043946720","https://openalex.org/W2046382304","https://openalex.org/W2047475159","https://openalex.org/W2047502920","https://openalex.org/W2050457398","https://openalex.org/W2051989434","https://openalex.org/W2053104039","https://openalex.org/W2055248228","https://openalex.org/W2056535502","https://openalex.org/W2057499380","https://openalex.org/W2059232583","https://openalex.org/W2063269147","https://openalex.org/W2065937821","https://openalex.org/W2066015053","https://openalex.org/W2066234762","https://openalex.org/W2066582914","https://openalex.org/W2067305633","https://openalex.org/W2068047393","https://openalex.org/W2070631889","https://openalex.org/W2071724008","https://openalex.org/W2072380594","https://openalex.org/W2073198049","https://openalex.org/W2074545819","https://openalex.org/W2075819066","https://openalex.org/W2076227586","https://openalex.org/W2076338530","https://openalex.org/W2077143212","https://openalex.org/W2080086146","https://openalex.org/W2080831004","https://openalex.org/W2081511824","https://openalex.org/W2082395424","https://openalex.org/W2082686349","https://openalex.org/W2082878575","https://openalex.org/W2083025888","https://openalex.org/W2086635082","https://openalex.org/W2087221993","https://openalex.org/W2088422105","https://openalex.org/W2091969321","https://openalex.org/W2092207202","https://openalex.org/W2094174735","https://openalex.org/W2097855813","https://openalex.org/W2098853737","https://openalex.org/W2101181377","https://openalex.org/W2103532863","https://openalex.org/W2105830118","https://openalex.org/W2106229817","https://openalex.org/W2107346812","https://openalex.org/W2115346550","https://openalex.org/W2115541385","https://openalex.org/W2116364705","https://openalex.org/W2116929481","https://openalex.org/W2117955296","https://openalex.org/W2123982765","https://openalex.org/W2125310843","https://openalex.org/W2126918065","https://openalex.org/W2130513535","https://openalex.org/W2130790725","https://openalex.org/W2131381643","https://openalex.org/W2132146551","https://openalex.org/W2133718112","https://openalex.org/W2135004938","https://openalex.org/W2137780217","https://openalex.org/W2138168141","https://openalex.org/W2138887185","https://openalex.org/W2139021664","https://openalex.org/W2142943268","https://openalex.org/W2144885342","https://openalex.org/W2145476394","https://openalex.org/W2146182770","https://openalex.org/W2149748445","https://openalex.org/W2154450105","https://openalex.org/W2155893315","https://openalex.org/W2159675211","https://openalex.org/W2159751093","https://openalex.org/W2162540156","https://openalex.org/W2169657967","https://openalex.org/W2172851764","https://openalex.org/W3120153401","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2050917968","https://openalex.org/W1506782390","https://openalex.org/W2066234762","https://openalex.org/W2066364057","https://openalex.org/W2804307434","https://openalex.org/W2103532863","https://openalex.org/W4237703962","https://openalex.org/W1997488342","https://openalex.org/W4234369525","https://openalex.org/W1510051975"],"abstract_inverted_index":{"SUMMARY:":[0],"Costimulatory":[1],"receptors":[2],"and":[3,17,34,44,62,88,112,117,124,143,181],"ligands":[4],"trigger":[5],"the":[6,14,32,57,85,110,135,145,151,158],"signaling":[7,65],"pathways":[8,66],"that":[9,53,90,100],"are":[10,54],"responsible":[11],"for":[12,56,80,121,134,140,157,178],"modulating":[13],"strength,":[15],"course,":[16],"duration":[18],"of":[19,59,84,106,127,137,148,153,160],"an":[20],"immune":[21],"response.":[22],"High-resolution":[23],"structures":[24,48,105],"have":[25,101],"provided":[26],"invaluable":[27],"mechanistic":[28,125],"insights":[29,99],"by":[30,104],"defining":[31,179],"chemical":[33],"physical":[35],"features":[36,52,87],"underlying":[37],"costimulatory":[38,107,155],"receptor:ligand":[39],"specificity,":[40],"affinity,":[41],"oligomeric":[42],"state,":[43],"valency.":[45],"Furthermore,":[46],"these":[47,60],"revealed":[49,103],"general":[50],"architectural":[51],"important":[55],"integration":[58],"interactions":[61],"their":[63],"associated":[64],"into":[67],"overall":[68],"cellular":[69],"physiology.":[70],"Recent":[71],"technological":[72],"advances":[73],"in":[74,150,161,165],"structural":[75,86,123],"biology":[76],"promise":[77],"unprecedented":[78],"opportunities":[79],"furthering":[81],"our":[82],"understanding":[83],"mechanisms":[89],"govern":[91],"costimulation.":[92,128],"In":[93],"this":[94],"review,":[95],"we":[96],"highlight":[97],"unique":[98],"been":[102],"molecules":[108,139,156],"from":[109],"immunoglobulin":[111],"tumor":[113],"necrosis":[114],"factor":[115],"superfamilies":[116],"describe":[118],"a":[119,166,175],"vision":[120,130],"future":[122],"analysis":[126],"This":[129,170],"includes":[131],"simple":[132],"strategies":[133],"selection":[136],"candidate":[138],"structure":[141,149],"determination":[142],"highlights":[144],"critical":[146],"role":[147],"design":[152],"mutant":[154],"generation":[159],"vivo":[162],"structure-function":[163],"correlations":[164],"mammalian":[167],"model":[168],"system.":[169],"integrated":[171],"'atoms-to-animals'":[172],"paradigm":[173],"provides":[174],"comprehensive":[176],"approach":[177],"atomic":[180],"molecular":[182],"mechanisms.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}