{"id":"https://openalex.org/W2118977937","doi":"https://doi.org/10.1080/13556210020077055","title":"Polymorphisms at the DRD2 locus in early\u2010onset alcohol dependence in the Indian population","display_name":"Polymorphisms at the DRD2 locus in early\u2010onset alcohol dependence in the Indian population","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2118977937","doi":"https://doi.org/10.1080/13556210020077055","mag":"2118977937","pmid":"https://pubmed.ncbi.nlm.nih.gov/11900611"},"language":"en","primary_location":{"id":"doi:10.1080/13556210020077055","doi":"https://doi.org/10.1080/13556210020077055","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13556210020077055","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048146383","display_name":"Kauser J. Shaikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kauser J. Shaikh","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046749863","display_name":"Daniel Naveen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147481903","display_name":"Jawaharlal Nehru Centre for Advanced Scientific Research","ror":"https://ror.org/0538gdx71","country_code":"IN","type":"facility","lineage":["https://openalex.org/I147481903","https://openalex.org/I2799351866","https://openalex.org/I4210098748","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Daniel Naveen","raw_affiliation_strings":["Jawaharlal Nehru Institute of Advanced Scientific Research, Jakkur, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jawaharlal Nehru Institute of Advanced Scientific Research, Jakkur, Bangalore, India","institution_ids":["https://openalex.org/I147481903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003097877","display_name":"Tessi Sherrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tessi Sherrin","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070968585","display_name":"Ashlesh Krishna Murthy","orcid":"https://orcid.org/0000-0003-4685-6122","observed_orcids":["https://orcid.org/0000-0003-4685-6122"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashlesh Murthy","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054040032","display_name":"Kandavel Thennarasu","orcid":"https://orcid.org/0000-0001-8797-8834","observed_orcids":["https://orcid.org/0000-0001-8797-8834"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Thennarasu","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103071793","display_name":"Anuranjan Anand","orcid":"https://orcid.org/0000-0001-9584-8730","observed_orcids":["https://orcid.org/0000-0001-9584-8730"]},"institutions":[{"id":"https://openalex.org/I147481903","display_name":"Jawaharlal Nehru Centre for Advanced Scientific Research","ror":"https://ror.org/0538gdx71","country_code":"IN","type":"facility","lineage":["https://openalex.org/I147481903","https://openalex.org/I2799351866","https://openalex.org/I4210098748","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anuranjan Anand","raw_affiliation_strings":["Jawaharlal Nehru Institute of Advanced Scientific Research, Jakkur, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jawaharlal Nehru Institute of Advanced Scientific Research, Jakkur, Bangalore, India","institution_ids":["https://openalex.org/I147481903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069096470","display_name":"Vivek Benegal","orcid":"https://orcid.org/0000-0002-8896-9689","observed_orcids":["https://orcid.org/0000-0002-8896-9689"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vivek Benegal","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026751784","display_name":"Sanjeev Jain","orcid":"https://orcid.org/0000-0002-9508-351X","observed_orcids":["https://orcid.org/0000-0002-9508-351X"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjeev Jain","raw_affiliation_strings":["National Institute of Mental Health and Neurosciences, Bangalore, India","National Institute Of Mental health & Neurosciences, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Mental Health and Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"National Institute Of Mental health & Neurosciences, Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069096470"],"corresponding_institution_ids":["https://openalex.org/I699696"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":0.6087,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.60598603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":"4","first_page":"331","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drd2","display_name":"DRD2","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.7680000066757202},{"id":"https://openalex.org/keywords/taqi-polymorphism","display_name":"TaqI polymorphism","score":0.7919999957084656},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.796999990940094},{"id":"https://openalex.org/keywords/early-onset-alcoholism","display_name":"early-onset alcoholism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8429999947547913},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.5960000157356262},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.6790000200271606},{"id":"https://openalex.org/keywords/family-history-of-alcoholism","display_name":"family history of alcoholism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/indian-population","display_name":"Indian population","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.7190313339233398},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.6845060586929321},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.5516147613525391},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5113851428031921},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.48349979519844055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44257792830467224},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.43209075927734375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37853673100471497},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3460233807563782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2189602255821228},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.20430129766464233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20426034927368164},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1313314437866211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11787879467010498},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/13556210020077055","doi":"https://doi.org/10.1080/13556210020077055","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13556210020077055","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},{"id":"pmid:11900611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11900611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1964631257","https://openalex.org/W1966821675","https://openalex.org/W1971192317","https://openalex.org/W1974313171","https://openalex.org/W1978797635","https://openalex.org/W1986259516","https://openalex.org/W1990490435","https://openalex.org/W1992502198","https://openalex.org/W2004210251","https://openalex.org/W2004835825","https://openalex.org/W2005821863","https://openalex.org/W2009784590","https://openalex.org/W2041120655","https://openalex.org/W2041776485","https://openalex.org/W2042736429","https://openalex.org/W2043107024","https://openalex.org/W2056332127","https://openalex.org/W2057465373","https://openalex.org/W2074938292","https://openalex.org/W2081089225","https://openalex.org/W2088236736","https://openalex.org/W2088829922","https://openalex.org/W2090368091","https://openalex.org/W2100882412","https://openalex.org/W2105562312","https://openalex.org/W2105710977","https://openalex.org/W2111513360","https://openalex.org/W2111666128","https://openalex.org/W2114159014","https://openalex.org/W2144634347","https://openalex.org/W2160598573","https://openalex.org/W2163199765","https://openalex.org/W2166954596","https://openalex.org/W2171171573","https://openalex.org/W2314225431","https://openalex.org/W3147333439"],"related_works":["https://openalex.org/W2139490113","https://openalex.org/W3017368165","https://openalex.org/W4362472976","https://openalex.org/W2347870866","https://openalex.org/W4242295065","https://openalex.org/W4232985089","https://openalex.org/W2068294300","https://openalex.org/W2096017454","https://openalex.org/W2167545256","https://openalex.org/W2043107024"],"abstract_inverted_index":{"The":[0,135,145],"susceptibility":[1],"to":[2,14,22,25,58,102,127,151],"alcohol":[3,81,111],"dependence":[4,82],"is":[5],"probably":[6],"of":[7,30,41,71,73,80,87,159,164],"polygenic":[8],"origin.":[9],"Association":[10],"studies":[11],"have":[12,34,56],"attempted":[13],"identify":[15,103],"possible":[16],"candidate":[17],"genes":[18],"that":[19],"may":[20,55],"contribute":[21],"the":[23,31,42,47,59,69,94,117,122,142,168],"risk":[24],"developing":[26],"dependence.":[27,112],"Severe":[28],"forms":[29],"alcoholism":[32,155],"phenotype":[33,54],"been":[35],"associated":[36,153],"with":[37,110,154],"an":[38],"increased":[39],"frequency":[40],"Taq":[43],"A1":[44],"allele":[45,136],"at":[46],"DRD2":[48],"locus.":[49],"Ethnic":[50],"stratification":[51],"and":[52],"non-comparable":[53],"contributed":[57],"contradictory":[60],"results":[61],"in":[62,156,167],"previous":[63],"studies.":[64],"We":[65],"identified":[66],"probands,":[67],"using":[68,93],"Schedules":[70],"Assessment":[72],"Neuropsychiatry":[74],"(SCAN)":[75],"schedule,":[76],"who":[77,105,115],"had":[78,106],"onset":[79,165],"(ICD-10)":[83],"before":[84],"25":[85],"years":[86],"age.":[88],"Family":[89,95],"members":[90],"were":[91,119,125],"interviewed":[92],"Interview":[96],"for":[97,121],"Genetic":[98],"Studies":[99],"(FIGS)":[100],"schedule":[101],"patients":[104],"two":[107,143],"first-degree":[108],"relatives":[109],"Fifty":[113],"subjects":[114],"fulfilled":[116],"criteria":[118],"selected":[120],"study.":[123],"These":[124],"compared":[126],"a":[128,132],"normal":[129],"population":[130],"from":[131],"similar":[133],"background.":[134],"frequencies":[137],"did":[138],"not":[139,149],"differ":[140],"between":[141],"groups.":[144],"Taq1a":[146],"polymorphism":[147],"does":[148],"seem":[150],"be":[152],"this":[157],"group":[158],"severely":[160],"affected,":[161],"young":[162],"age":[163],"probands":[166],"southern":[169],"Indian":[170],"population.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
