{"id":"https://openalex.org/W2118977202","doi":"https://doi.org/10.1186/1471-2164-15-750","title":"Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae","display_name":"Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2118977202","doi":"https://doi.org/10.1186/1471-2164-15-750","mag":"2118977202","pmid":"https://pubmed.ncbi.nlm.nih.gov/25179264"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-15-750","doi":"https://doi.org/10.1186/1471-2164-15-750","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-750","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-750","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-750","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044963170","display_name":"Monnat Pongpanich","orcid":"https://orcid.org/0000-0003-3228-3351","observed_orcids":["https://orcid.org/0000-0003-3228-3351"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Monnat Pongpanich","raw_affiliation_strings":["Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand","Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand","Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025997144","display_name":"Maturada Patchsung","orcid":"https://orcid.org/0000-0002-7831-2034","observed_orcids":["https://orcid.org/0000-0002-7831-2034"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Maturada Patchsung","raw_affiliation_strings":["Inter-Department Program of BioMedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inter-Department Program of BioMedical Sciences, Faculty of Graduate School, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036834118","display_name":"Jirapan Thongsroy","orcid":"https://orcid.org/0000-0002-3312-0135","observed_orcids":["https://orcid.org/0000-0002-3312-0135"]},"institutions":[{"id":"https://openalex.org/I96916377","display_name":"Walailak University","ror":"https://ror.org/04b69g067","country_code":"TH","type":"education","lineage":["https://openalex.org/I96916377"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jirapan Thongsroy","raw_affiliation_strings":["School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand","institution_ids":["https://openalex.org/I96916377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021302353","display_name":"Apiwat Mutirangura","orcid":"https://orcid.org/0000-0003-0238-942X","observed_orcids":["https://orcid.org/0000-0003-0238-942X"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Apiwat Mutirangura","raw_affiliation_strings":["Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand. mapiwat@chula.ac.th","Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand. mapiwat@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Center for Excellence in Molecular Genetics of Cancer and Human Diseases, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021302353"],"corresponding_institution_ids":["https://openalex.org/I158708052"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.365,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.58845652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"750","last_page":"750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.781000018119812},{"id":"https://openalex.org/keywords/sequence-specificity","display_name":"sequence specificity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/chromosome-size","display_name":"chromosome length","score":0.4970000088214874},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sir2","display_name":"Sir2","score":0.6330000162124634},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5839999914169312},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.7689999938011169},{"id":"https://openalex.org/keywords/topoisomerases","display_name":"topoisomerases","score":0.7419999837875366},{"id":"https://openalex.org/keywords/high-mobility-group-box-proteins","display_name":"high mobility group box proteins","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ligation-mediated-pcr","display_name":"ligation-mediated PCR","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.839584231376648},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7625414729118347},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6591853499412537},{"id":"https://openalex.org/C2778512757","wikidata":"https://www.wikidata.org/wiki/Q7314076","display_name":"Replication timing","level":4,"score":0.5929343104362488},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.5192144513130188},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5093623399734497},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47348296642303467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4667656123638153},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.46198636293411255},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4375618100166321},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4255872964859009},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.4119425415992737},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.351912260055542}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2164-15-750","doi":"https://doi.org/10.1186/1471-2164-15-750","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-750","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-750","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4158086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4158086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:25179264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25179264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"doi:10.60692/77vw5-29607","doi":"https://doi.org/10.60692/77vw5-29607","is_oa":true,"landing_page_url":"https://doi.org/10.60692/77vw5-29607","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/dybb9-b0e64","doi":"https://doi.org/10.60692/dybb9-b0e64","is_oa":true,"landing_page_url":"https://doi.org/10.60692/dybb9-b0e64","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-15-750","doi":"https://doi.org/10.1186/1471-2164-15-750","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-750","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-750","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G817179877","display_name":null,"funder_award_id":"PHD/0131/2554","funder_id":"https://openalex.org/F4320322614","funder_display_name":"Thailand Research Fund"}],"funders":[{"id":"https://openalex.org/F4320322437","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"},{"id":"https://openalex.org/F4320327548","display_name":"Royal Golden Jubilee (RGJ) Ph.D. Programme","ror":"https://ror.org/05fp08r12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118977202.pdf","grobid_xml":"https://content.openalex.org/works/W2118977202.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1515564094","https://openalex.org/W1990381590","https://openalex.org/W1994562270","https://openalex.org/W1998681909","https://openalex.org/W2051193631","https://openalex.org/W2055043387","https://openalex.org/W2062093164","https://openalex.org/W2065498897","https://openalex.org/W2077861623","https://openalex.org/W2077892030","https://openalex.org/W2078028724","https://openalex.org/W2082521202","https://openalex.org/W2096136751","https://openalex.org/W2114595412","https://openalex.org/W2131612302","https://openalex.org/W2145373200","https://openalex.org/W2152203766","https://openalex.org/W2152745581","https://openalex.org/W2153357138","https://openalex.org/W2161619169","https://openalex.org/W2163126627","https://openalex.org/W2171834876","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W2982595724","https://openalex.org/W2114765935","https://openalex.org/W2001243940","https://openalex.org/W2108556453","https://openalex.org/W2806544696","https://openalex.org/W3013628633","https://openalex.org/W2114169525","https://openalex.org/W2111999017","https://openalex.org/W2761741611","https://openalex.org/W2166856833"],"abstract_inverted_index":{"BACKGROUND:":[0],"Replication-independent":[1],"endogenous":[2],"double-strand":[3],"breaks":[4,165,187],"(RIND-EDSBs)":[5],"occur":[6,203,222],"in":[7,12,29,53,68,88,205],"both":[8],"humans":[9],"and":[10,18,32,93,105,229,241],"yeast":[11,40,207],"the":[13,30,42,47,73,100,107,152,168,171,175,183,186,191,198,206,212],"absence":[14],"of":[15,49,57,72,90,109,137,160,164,170,185,211],"inductive":[16],"agents":[17],"DNA":[19,63],"replication.":[20],"In":[21,36,80,95,119,129],"human":[22],"cells,":[23],"RIND-EDSBs":[24,50,82,104,124,221,247],"are":[25,45,83,155,227],"hypermethylated,":[26],"preferentially":[27],"retained":[28,230],"heterochromatin":[31],"unbound":[33],"by":[34,231],"\u03b3-H2AX.":[35],"single":[37],"gene":[38],"deletion":[39],"strains,":[41],"RIND-EDSB":[43,134,147],"levels":[44],"altered;":[46],"number":[48,159,163],"is":[51],"higher":[52],"strains":[54,69],"with":[55,70,167],"deletions":[56,71],"histone":[58],"deacetylase,":[59],"endonucleases,":[60],"topoisomerase,":[61],"or":[62,78],"repair":[64],"regulators,":[65],"but":[66],"lower":[67],"high-mobility":[74],"group":[75],"box":[76],"proteins":[77],"Sir2.":[79],"summary,":[81],"different":[84],"from":[85],"pathologic":[86],"DSBs":[87],"terms":[89],"their":[91,115,239],"causes":[92],"consequences.":[94],"this":[96,130,209],"study,":[97,131],"we":[98,122,132],"identified":[99],"nucleotide":[101],"sequences":[102,111],"surrounding":[103],"investigated":[106],"features":[108],"these":[110,235],"as":[112,114],"well":[113],"break":[116,153,176],"locations.":[117],"RESULTS:":[118],"recent":[120],"work,":[121],"detected":[123],"using":[125,142],"ligation":[126],"mediated":[127],"PCR.":[128],"sequenced":[133],"PCR":[135],"products":[136],"resting":[138],"state":[139],"Saccharomyces":[140],"cerevisiae":[141],"next-generation":[143],"sequencing":[144],"to":[145,218],"analyze":[146],"sequences.":[148],"We":[149],"found":[150],"that":[151,224],"locations":[154],"scattered":[156],"across":[157],"a":[158],"chromosomes.":[161,172],"The":[162],"correlated":[166],"size":[169],"Most":[173],"importantly,":[174],"occurrences":[177],"had":[178],"sequence":[179,192,200,214],"pattern":[180],"specificity.":[181],"Specifically,":[182],"majority":[184],"occurred":[188],"immediately":[189],"after":[190],"\"ACGT\"":[193,199,213],"(P":[194],"=":[195],"2.2E-156).":[196],"Because":[197,234],"does":[201],"not":[202],"primarily":[204],"genome,":[208],"specificity":[210],"cannot":[215],"be":[216,249],"attributed":[217],"chance.":[219],"CONCLUSIONS:":[220],"non-randomly;":[223],"is,":[225],"they":[226,242],"produced":[228],"specific":[232,245],"mechanisms.":[233],"particular":[236],"mechanisms":[237],"regulate":[238],"generation":[240],"possess":[243],"potentially":[244],"functions,":[246],"could":[248],"epigenetic":[250],"marks.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}