{"id":"https://openalex.org/W2118977042","doi":"https://doi.org/10.1189/jlb.0313163","title":"Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression","display_name":"Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2118977042","doi":"https://doi.org/10.1189/jlb.0313163","mag":"2118977042","pmid":"https://pubmed.ncbi.nlm.nih.gov/23904439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3800067"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0313163","doi":"https://doi.org/10.1189/jlb.0313163","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0313163","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3800067","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042538221","display_name":"Ana Olivera","orcid":"https://orcid.org/0000-0002-0128-5461","observed_orcids":["https://orcid.org/0000-0002-0128-5461"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Olivera","raw_affiliation_strings":["Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070342040","display_name":"Yoshiaki Kitamura","orcid":"https://orcid.org/0000-0001-8705-9563","observed_orcids":["https://orcid.org/0000-0001-8705-9563"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoshiaki Kitamura","raw_affiliation_strings":["Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089738926","display_name":"Laurel D. Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laurel D Wright","raw_affiliation_strings":["Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004345037","display_name":"Mar\u00eda L. Allende","orcid":"https://orcid.org/0000-0001-9930-8563","observed_orcids":["https://orcid.org/0000-0001-9930-8563"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria L Allende","raw_affiliation_strings":["Genetics of Development and Disease Branch, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics of Development and Disease Branch, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652326","display_name":"Weiping Chen","orcid":"https://orcid.org/0000-0002-0459-0605","observed_orcids":["https://orcid.org/0000-0002-0459-0605"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiping Chen","raw_affiliation_strings":["Genomics Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032871765","display_name":"Tomomi Kaneko-Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Kaneko-Goto","raw_affiliation_strings":["Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute , Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute , Saitama, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009204351","display_name":"Yoshihiro Yoshihara","orcid":"https://orcid.org/0000-0002-0319-7166","observed_orcids":["https://orcid.org/0000-0002-0319-7166"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Yoshihara","raw_affiliation_strings":["Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute , Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute , Saitama, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048492327","display_name":"Richard L. Proia","orcid":"https://orcid.org/0000-0003-0456-1270","observed_orcids":["https://orcid.org/0000-0003-0456-1270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L Proia","raw_affiliation_strings":["Genetics of Development and Disease Branch, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics of Development and Disease Branch, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107252185","display_name":"Juan Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juan Rivera","raw_affiliation_strings":["Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042538221","https://openalex.org/A5070342040","https://openalex.org/A5089738926","https://openalex.org/A5107252185"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.2915,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80168475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"94","issue":"5","first_page":"1013","last_page":"1024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cntn4","display_name":"CNTN4","score":0.8949999809265137},{"id":"https://openalex.org/keywords/s1p-lyase","display_name":"S1P lyase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.6759999990463257},{"id":"https://openalex.org/keywords/ige-mediated-degranulation","display_name":"IgE-mediated degranulation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/th1-th2-skewing","display_name":"Th1/Th2 skewing","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lipid-mediators","display_name":"lipid mediators","score":0.6190000176429749},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.809982419013977},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6437403559684753},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.6220123171806335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5591017603874207},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.44325515627861023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3758854568004608},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.37335288524627686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3313755989074707},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27389442920684814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23507308959960938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0657213032245636}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058966","descriptor_name":"Contactins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058966","descriptor_name":"Contactins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058966","descriptor_name":"Contactins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1189/jlb.0313163","doi":"https://doi.org/10.1189/jlb.0313163","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0313163","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3800067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3800067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},{"id":"pmid:23904439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23904439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3800067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3800067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W57943505","https://openalex.org/W1519007189","https://openalex.org/W1575766207","https://openalex.org/W1676723559","https://openalex.org/W1824031276","https://openalex.org/W1866106776","https://openalex.org/W1953360647","https://openalex.org/W1967802627","https://openalex.org/W1970180138","https://openalex.org/W1971736820","https://openalex.org/W1974829480","https://openalex.org/W1976352905","https://openalex.org/W1978707192","https://openalex.org/W1979278210","https://openalex.org/W1983241545","https://openalex.org/W1992815669","https://openalex.org/W1996605319","https://openalex.org/W1997492558","https://openalex.org/W1999366816","https://openalex.org/W2002301651","https://openalex.org/W2002361100","https://openalex.org/W2003884388","https://openalex.org/W2004104083","https://openalex.org/W2005244540","https://openalex.org/W2007124301","https://openalex.org/W2008578494","https://openalex.org/W2009251019","https://openalex.org/W2010203793","https://openalex.org/W2022770236","https://openalex.org/W2023691306","https://openalex.org/W2028005403","https://openalex.org/W2034820412","https://openalex.org/W2037155515","https://openalex.org/W2038970416","https://openalex.org/W2039510851","https://openalex.org/W2040300892","https://openalex.org/W2044562348","https://openalex.org/W2047361146","https://openalex.org/W2047607345","https://openalex.org/W2050495774","https://openalex.org/W2050976447","https://openalex.org/W2051861976","https://openalex.org/W2052980020","https://openalex.org/W2056997999","https://openalex.org/W2061519511","https://openalex.org/W2068019570","https://openalex.org/W2071117491","https://openalex.org/W2074119581","https://openalex.org/W2076738925","https://openalex.org/W2099660723","https://openalex.org/W2101093380","https://openalex.org/W2104675641","https://openalex.org/W2105218146","https://openalex.org/W2106099967","https://openalex.org/W2107000889","https://openalex.org/W2114180423","https://openalex.org/W2115065585","https://openalex.org/W2119615960","https://openalex.org/W2120198485","https://openalex.org/W2120959166","https://openalex.org/W2122971055","https://openalex.org/W2124678205","https://openalex.org/W2128323908","https://openalex.org/W2135160600","https://openalex.org/W2135525156","https://openalex.org/W2142887088","https://openalex.org/W2150702063","https://openalex.org/W2156921663","https://openalex.org/W2159245962","https://openalex.org/W2160346848","https://openalex.org/W2162838509","https://openalex.org/W2164258188","https://openalex.org/W2164522180","https://openalex.org/W2165996901","https://openalex.org/W2166842453","https://openalex.org/W2279844920","https://openalex.org/W2317260507","https://openalex.org/W6656191044","https://openalex.org/W6683396827"],"related_works":["https://openalex.org/W161520363","https://openalex.org/W2011119433","https://openalex.org/W2800613191","https://openalex.org/W1985668252","https://openalex.org/W1824031276","https://openalex.org/W1860829309","https://openalex.org/W4313381640","https://openalex.org/W2024952986","https://openalex.org/W2050976447","https://openalex.org/W782110491"],"abstract_inverted_index":{"Both":[0],"genes":[1],"and":[2,12,52,93,99,119,150,172,195,235],"the":[3,8,15,18,26,29,43,46,53,70,91,140,148,157,164,174,208,214,223,236],"environment":[4],"are":[5],"determinants":[6],"in":[7,25,33,90,102,106,117,156,163,191,222,231],"susceptibility":[9],"to":[10,50,75,104,154,179,213],"allergies":[11],"may":[13],"alter":[14],"severity":[16],"of":[17,28,48,55,67,78,83,115,137,161,166,204,225],"disease.":[19,57],"We":[20,58],"explored":[21],"whether":[22],"an":[23],"increase":[24],"levels":[27,63,114,131],"lipid":[30],"mediator":[31],"S1P":[32,62,68,84,116,130,138,167,192,199,226],"vivo,":[34],"a":[35,228],"condition":[36],"found":[37,59],"during":[38],"allergic":[39,56,237],"asthma,":[40],"could":[41],"affect":[42],"sensitivity":[44],"or":[45],"response":[47,103],"MCs":[49,82,162,176,194,196],"IgE/Ag":[51,105],"onset":[54],"that":[60,220],"increasing":[61],"by":[64,134],"genetic":[65],"deletion":[66],"lyase,":[69,139],"enzyme":[71],"catabolizing":[72],"S1P,":[73],"led":[74],"elevated":[76],"activity":[77],"circulating":[79],"tryptase.":[80],"Accordingly,":[81],"lyase-deficient":[85,193],"mice":[86,110,142],"were":[87,132,177],"mostly":[88],"degranulated":[89],"tissues":[92],"showed":[94,143],"enhanced":[95,168,186,215],"calcium":[96],"levels,":[97],"degranulation,":[98],"cytokine":[100],"production":[101],"vitro.":[107],"Th":[108,124],"1-skewed":[109],"(C57BL/6)":[111],"had":[112],"lower":[113],"circulation":[118,149],"histamine":[120,145],"responses":[121,152],"than":[122],"did":[123],"2-skewed":[125],"(129/Sv)":[126],"mice.":[127,159],"However,":[128],"when":[129,173],"increased":[133,144,202],"pharmacologic":[135],"inhibition":[136],"C57BL/6":[141],"release":[146],"into":[147],"anaphylactic":[151],"similar":[153],"those":[155],"129/Sv":[158],"Culturing":[160],"presence":[165],"their":[169],"degranulation":[170],"responses,":[171],"S1P-treated":[175],"used":[178],"reconstitute":[180],"MC-deficient":[181],"(Kit(W-sh))":[182],"mice,":[183],"they":[184],"caused":[185],"anaphylaxis.":[187],"Gene":[188],"expression":[189,203],"arrays":[190],"treated":[197],"with":[198],"continuously":[200],"revealed":[201],"numerous":[205],"genes,":[206],"including":[207],"adhesion":[209],"molecule":[210],"CNTN4,which":[211],"contributed":[212],"responses.":[216],"Our":[217],"findings":[218],"argue":[219],"dysregulation":[221],"metabolism":[224],"is":[227],"contributing":[229],"factor":[230],"modulating":[232],"MC":[233],"responsiveness":[234],"response.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}