{"id":"https://openalex.org/W2118971174","doi":"https://doi.org/10.2214/ajr.08.2087","title":"Hepatocellular Carcinoma With Cirrhosis: Are Patients With Neoplastic Main Portal Vein Invasion Eligible for Percutaneous Radiofrequency Ablation of Both the Nodule and the Portal Venous Tumor Thrombus?","display_name":"Hepatocellular Carcinoma With Cirrhosis: Are Patients With Neoplastic Main Portal Vein Invasion Eligible for Percutaneous Radiofrequency Ablation of Both the Nodule and the Portal Venous Tumor Thrombus?","publication_year":2009,"publication_date":"2009-09-21","ids":{"openalex":"https://openalex.org/W2118971174","doi":"https://doi.org/10.2214/ajr.08.2087","mag":"2118971174","pmid":"https://pubmed.ncbi.nlm.nih.gov/19770315"},"language":"en","primary_location":{"id":"doi:10.2214/ajr.08.2087","doi":"https://doi.org/10.2214/ajr.08.2087","is_oa":false,"landing_page_url":"https://doi.org/10.2214/ajr.08.2087","pdf_url":null,"source":{"id":"https://openalex.org/S161085503","display_name":"American Journal of Roentgenology","issn_l":"0002-9580","issn":["0002-9580","0361-803X","1546-3141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315781","host_organization_name":"American Roentgen Ray Society","host_organization_lineage":["https://openalex.org/P4310315781"],"host_organization_lineage_names":["American Roentgen Ray Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Roentgenology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113717698","display_name":"Antonio Giorgio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149343","display_name":"Ospedale D. Cotugno","ror":"https://ror.org/04k078691","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149343"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Giorgio","raw_affiliation_strings":["All authors: Infectious Disease and Interventional Ultrasound Unit, D. Cotugno Hospital, Via Quagliariello 54, 80131 Naples, Italy","Infectious Disease and Interventional Ultrasound Unit, D. Cotugno Hospital, Via Quagliariello 54, 80131 Naples, Italy. assanui1@virgilio.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All authors: Infectious Disease and Interventional Ultrasound Unit, D. Cotugno Hospital, Via Quagliariello 54, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210149343"]},{"raw_affiliation_string":"Infectious Disease and Interventional Ultrasound Unit, D. Cotugno Hospital, Via Quagliariello 54, 80131 Naples, Italy. assanui1@virgilio.it","institution_ids":["https://openalex.org/I4210149343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103440078","display_name":"Antonella Di Sarno","orcid":"https://orcid.org/0000-0003-3620-3275","observed_orcids":["https://orcid.org/0000-0003-3620-3275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonella Di Sarno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520129","display_name":"G. de Stefano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio de Stefano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087922135","display_name":"Nunzia Farella","orcid":"https://orcid.org/0000-0003-4161-612X","observed_orcids":["https://orcid.org/0000-0003-4161-612X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nunzia Farella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058913410","display_name":"Umberto Scognamiglio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umberto Scognamiglio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Manuela de Stefano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuela de Stefano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070090047","display_name":"Valentina Giorgio","orcid":"https://orcid.org/0000-0002-7448-8710","observed_orcids":["https://orcid.org/0000-0002-7448-8710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Giorgio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7765,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76957775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"193","issue":"4","first_page":"948","last_page":"954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"radiofrequency ablation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/portal-vein-invasion","display_name":"portal vein invasion","score":0.6330000162124634},{"id":"https://openalex.org/keywords/portal-vein-recanalization","display_name":"portal vein recanalization","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/percutaneous-ablation","display_name":"percutaneous ablation","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9700025320053101},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8459774851799011},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7909114360809326},{"id":"https://openalex.org/C2777377203","wikidata":"https://www.wikidata.org/wiki/Q1809554","display_name":"Radiofrequency ablation","level":3,"score":0.6770983934402466},{"id":"https://openalex.org/C2780813298","wikidata":"https://www.wikidata.org/wiki/Q2071287","display_name":"Percutaneous","level":2,"score":0.6691062450408936},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.6687139868736267},{"id":"https://openalex.org/C2779033008","wikidata":"https://www.wikidata.org/wiki/Q464543","display_name":"Portal vein","level":2,"score":0.6291664838790894},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.6182725429534912},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6143458485603333},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.44195783138275146},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.440355509519577},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23396193981170654},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20496249198913574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20462921261787415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2214/ajr.08.2087","doi":"https://doi.org/10.2214/ajr.08.2087","is_oa":false,"landing_page_url":"https://doi.org/10.2214/ajr.08.2087","pdf_url":null,"source":{"id":"https://openalex.org/S161085503","display_name":"American Journal of Roentgenology","issn_l":"0002-9580","issn":["0002-9580","0361-803X","1546-3141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315781","host_organization_name":"American Roentgen Ray Society","host_organization_lineage":["https://openalex.org/P4310315781"],"host_organization_lineage_names":["American Roentgen Ray Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Roentgenology","raw_type":"journal-article"},{"id":"pmid:19770315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19770315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJR. American journal of roentgenology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W126829566","https://openalex.org/W198611670","https://openalex.org/W1919321215","https://openalex.org/W1957587859","https://openalex.org/W1965142411","https://openalex.org/W1968857725","https://openalex.org/W1996749547","https://openalex.org/W1999928502","https://openalex.org/W2020045371","https://openalex.org/W2020215421","https://openalex.org/W2021130499","https://openalex.org/W2021349837","https://openalex.org/W2024802373","https://openalex.org/W2026684234","https://openalex.org/W2028042870","https://openalex.org/W2029055742","https://openalex.org/W2039994523","https://openalex.org/W2040215550","https://openalex.org/W2041261250","https://openalex.org/W2042554205","https://openalex.org/W2079997492","https://openalex.org/W2082096849","https://openalex.org/W2084395636","https://openalex.org/W2086551859","https://openalex.org/W2096947360","https://openalex.org/W2098934885","https://openalex.org/W2103880038","https://openalex.org/W2106268929","https://openalex.org/W2120131212","https://openalex.org/W2132441369","https://openalex.org/W2137553608","https://openalex.org/W2139541532","https://openalex.org/W2145998899","https://openalex.org/W2154239359","https://openalex.org/W2163486683","https://openalex.org/W2163557371","https://openalex.org/W2411539299","https://openalex.org/W2432948416","https://openalex.org/W2437090585"],"related_works":["https://openalex.org/W2003118993","https://openalex.org/W2148920403","https://openalex.org/W2260023297","https://openalex.org/W2323584630","https://openalex.org/W2098934885","https://openalex.org/W4234867990","https://openalex.org/W1997367924","https://openalex.org/W2015664946","https://openalex.org/W2921743982","https://openalex.org/W1999754216"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,298,320],"purpose":[2],"of":[3,11,15,61,144,177,184,189,205,231,238,259,269,370,379,385,414],"this":[4],"study":[5],"was":[6,150,160,179,199,208,218,246,274,324,365],"to":[7,39,265,285,304,313],"examine":[8],"the":[9,22,62,99,131,140,164,173,190,232,239,254,260,270,308,317,334,348,362,368,371,398],"results":[10],"percutaneous":[12,104],"radiofrequency":[13,105,136,178],"ablation":[14,137,159,217,389],"both":[16,392],"medium-sized":[17,395],"hepatocellular":[18],"carcinoma":[19],"(HCC)":[20],"and":[21,56,138,170,186,194,213,243,267,288,292,311,328,337,339,342,361,397,408,410],"accompanying":[23,399],"main":[24,71,100,132,145,165,191,240,271,400],"portal":[25,57,72,101,133,146,166,192,206,241,272,363,401],"venous":[26,58,73,147,167,402],"tumor":[27,74,148,168,403],"thrombus":[28,149,169,404],"in":[29,95,127,155,248,333,347],"patients":[30,46,77,109,250,310,358,377],"with":[31,47,89,121,152,201,210,223,235,405],"cirrhosis.":[32],"SUBJECTS":[33],"AND":[34],"METHODS:":[35],"From":[36],"January":[37,40],"2005":[38],"2008,":[41],"among":[42,307,316],"1,837":[43],"consecutively":[44],"registered":[45],"HCC":[48,55,67,91,123,174,185,197,233,261],"seen":[49],"at":[50,367],"our":[51],"institution,":[52],"412":[53,63],"had":[54,64],"invasion;":[59],"27":[60],"a":[65,224,411],"single":[66,393],"nodule":[68],"accompanied":[69],"by":[70],"thrombus.":[75],"Thirteen":[76],"(10":[78,110],"men,":[79,111],"three":[80,256,282,375],"women;":[81,113],"mean":[82,114],"age,":[83,115],"70":[84],"years;":[85,117],"range,":[86,118],"66-74":[87],"years)":[88,120],"13":[90],"nodules":[92,124],"3.7-5":[93],"cm":[94,126],"diameter":[96,128],"extending":[97,129],"into":[98,130],"trunk":[102,134,193,273],"underwent":[103],"ablation.":[106],"Fourteen":[107],"matched":[108],"four":[112],"69":[116],"67-73":[119],"14":[122],"3.6-4.8":[125],"refused":[135],"composed":[139],"control":[141],"group.":[142],"Diagnosis":[143],"made":[151],"fine-needle":[153],"biopsy":[154],"all":[156],"cases.":[157],"Radiofrequency":[158,216,388],"performed":[161,219],"first":[162],"on":[163,172],"then":[171],"nodule.":[175],"Efficacy":[176],"defined":[180],"as":[181],"complete":[182,187,236],"necrosis":[183,198,230,258],"recanalization":[188,237,268],"its":[195,244],"branches.":[196],"evaluated":[200],"enhanced":[202],"CT.":[203],"Recanalization":[204],"vessels":[207],"analyzed":[209],"color":[211],"Doppler":[212],"contrast-enhanced":[214],"ultrasound.":[215],"under":[220],"ultrasound":[221],"guidance":[222],"perfused":[225],"needle":[226],"electrode.":[227],"RESULTS:":[228],"Complete":[229],"associated":[234],"vein":[242],"branches":[245],"achieved":[247],"10":[249,314,355],"(efficacy,":[251],"77%).":[252],"In":[253,281],"other":[255],"patients,":[257],"ranged":[262,301],"from":[263,302],"70%":[264],"90%,":[266],"not":[275],"complete.":[276],"No":[277],"major":[278],"complications":[279],"occurred.":[280],"cases,":[283],"mild":[284],"moderate":[286],"ascites":[287],"increased":[289],"aspartate":[290],"aminotransferase":[291,294],"alanine":[293],"levels":[295],"were":[296,359],"found.":[297],"follow-up":[299,372],"periods":[300],"3":[303],"36":[305,329],"months":[306,315,330,344,384],"treated":[309,335,357],"2":[312],"untreated":[318,349,376],"patients.":[319],"cumulative":[321],"survival":[322],"rate":[323,413],"77%":[325],"6,":[326],"12,":[327],"after":[331,345],"procedure":[332],"group":[336,350],"43%":[338],"0%":[340],"6":[341],"12":[343],"diagnosis":[346],"(p":[351],"<":[352],"0.0001).":[353],"All":[354,374],"successfully":[356],"alive":[360],"system":[364],"patent":[366],"end":[369],"period.":[373],"died":[378],"progressive":[380],"disease":[381],"within":[382],"5":[383],"diagnosis.":[386],"CONCLUSION:":[387],"can":[390],"destroy":[391],"intraparenchymal":[394],"HCCs":[396],"high":[406],"efficacy":[407],"safety":[409],"low":[412],"complications.":[415]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}