{"id":"https://openalex.org/W2118970553","doi":null,"title":"Effects of clozapine and typical antipsychotic drugs on plasma 5-HT turnover and impulsivity in patients with schizophrenia: a cross-sectional study.","display_name":"Effects of clozapine and typical antipsychotic drugs on plasma 5-HT turnover and impulsivity in patients with schizophrenia: a cross-sectional study.","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2118970553","mag":"2118970553","pmid":"https://pubmed.ncbi.nlm.nih.gov/11022399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1407731"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1407731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1407731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1407731","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089267199","display_name":"Serdar Murat Dursun","orcid":"https://orcid.org/0000-0001-9943-851X","observed_orcids":["https://orcid.org/0000-0001-9943-851X"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S M Dursun","raw_affiliation_strings":["Department of Psychiatry, Faculty of Medicine, University of Leicester, England. sdursun@is.dal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine, University of Leicester, England. sdursun@is.dal.ca","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039496673","display_name":"A Szemis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Szemis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016974093","display_name":"H Andrews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Andrews","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Whitaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Whitaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911222","display_name":"M.A. Reveley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Reveley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8404,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.75006037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"25","issue":"4","first_page":"347","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/typical-antipsychotics","display_name":"typical antipsychotics","score":0.9639999866485596},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/impulsivity","display_name":"impulsivity","score":0.996999979019165},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9620000123977661},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antipsychotic-efficacy","display_name":"antipsychotic efficacy","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.9534181952476501},{"id":"https://openalex.org/C2780319597","wikidata":"https://www.wikidata.org/wiki/Q1549918","display_name":"Impulsivity","level":2,"score":0.7925382852554321},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7820141911506653},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.7588874101638794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5318911671638489},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.49700549244880676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45817798376083374},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43859827518463135},{"id":"https://openalex.org/C2910202354","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic Agent","level":4,"score":0.4316104054450989},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.42649024724960327},{"id":"https://openalex.org/C2775870346","wikidata":"https://www.wikidata.org/wiki/Q2554162","display_name":"Typical antipsychotic","level":5,"score":0.4156438112258911},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3320055603981018}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007174","descriptor_name":"Disruptive, Impulse Control, and Conduct Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007174","descriptor_name":"Disruptive, Impulse Control, and Conduct Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007174","descriptor_name":"Disruptive, Impulse Control, and Conduct Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1407731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1407731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},{"id":"pmid:11022399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11022399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychiatry & neuroscience : JPN","raw_type":"Clinical Trial"},{"id":"mag:2118970553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11022399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1407731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1407731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Psychiatry Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W80598485","https://openalex.org/W92999253","https://openalex.org/W154761492","https://openalex.org/W1690841230","https://openalex.org/W1980723288","https://openalex.org/W1990530036","https://openalex.org/W2000030766","https://openalex.org/W2008128806","https://openalex.org/W2014646681","https://openalex.org/W2030998472","https://openalex.org/W2033230112","https://openalex.org/W2033854876","https://openalex.org/W2071304674","https://openalex.org/W2083069545","https://openalex.org/W2083640920","https://openalex.org/W2092947897","https://openalex.org/W2093388578","https://openalex.org/W2118527319","https://openalex.org/W2121961960","https://openalex.org/W2139791914","https://openalex.org/W2204325885","https://openalex.org/W2407780889"],"related_works":["https://openalex.org/W2038070649","https://openalex.org/W2029931677","https://openalex.org/W2082213093","https://openalex.org/W154761492","https://openalex.org/W1986898531","https://openalex.org/W2017439001","https://openalex.org/W1968998559","https://openalex.org/W2160623370","https://openalex.org/W2078344249","https://openalex.org/W2043429480"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,17,61,136,140,145,165,175,193,197,207,213],"efficacy":[4],"of":[5,20,144,154,162,164,174,187],"clozapine":[6,71,85,123,194,223],"with":[7,22,70,122,127,157,181,222,229],"typical":[8,76,87,128,146,166],"antipsychotic":[9,77,88,147,167],"drugs":[10,82,89],"in":[11],"controlling":[12],"impulsivity":[13,21,133,142],"and":[14,32,43,55,58,72,97,116,124,139,178,234],"to":[15,41,45],"explore":[16],"possible":[18],"correlation":[19],"plasma":[23,27,33,111,185],"5-hydroxytryptamine":[24],"(5-HT)":[25],"levels,":[26,113],"5-hydroxyindoleacetic":[28],"acid":[29],"(5-HIAA)":[30],"levels":[31,115,186],"5-HT":[34,112,117,163,201],"turnover.":[35,118],"DESIGN:":[36],"Prospective,":[37],"cross-sectional":[38],"study":[39],"open":[40],"medication":[42],"blinded":[44],"biochemical":[46],"analyses.":[47],"PARTICIPANTS:":[48],"Healthy":[49],"control":[50,137,176,214],"subjects":[51,98],"(n":[52],"=":[53],"24)":[54],"46":[56],"inpatients":[57],"outpatients":[59],"meeting":[60],"DSM-IV":[62],"criteria":[63],"for":[64,92,192,206,212,227],"schizophrenia;":[65],"20":[66],"were":[67,74,90,103,189],"being":[68],"treated":[69,121,126,156,180],"26":[73],"taking":[75],"drugs.":[78],"INTERVENTIONS:":[79],"All":[80],"psychotropic":[81],"other":[83,198],"than":[84,135,152,172,196,211],"or":[86],"discontinued":[91],"at":[93],"least":[94],"5":[95],"days":[96],"fasted":[99],"overnight":[100],"before":[101],"they":[102],"assessed.":[104],"OUTCOME":[105],"MEASURES:":[106],"Coccaro":[107],"Impulsivity":[108],"Scale":[109],"scores,":[110],"5-HIAA":[114,188],"RESULTS:":[119],"Patients":[120],"those":[125],"antipsychotics":[129],"had":[130],"significantly":[131,150,170,190,204],"higher":[132,151,191,205],"scores":[134],"group,":[138],"mean":[141,160,184],"score":[143],"group":[148,168,177,195],"was":[149,169,203],"that":[153,173,220],"patients":[155,179,228],"clozapine.":[158],"The":[159],"concentration":[161],"lower":[171],"clozapine;":[182],"however,":[183],"2":[199,208],"groups.":[200],"turnover":[202],"drug-treatment":[209],"groups":[210],"group.":[215],"CONCLUSIONS:":[216],"These":[217],"results":[218],"suggest":[219],"treatment":[221],"should":[224],"be":[225],"considered":[226],"schizophrenia":[230],"who":[231],"are":[232],"impulsive":[233],"aggressive.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
