{"id":"https://openalex.org/W2118969780","doi":"https://doi.org/10.1093/cercor/bhp022","title":"Medial Prefrontal Cortex 5-HT2A Density Is Correlated with Amygdala Reactivity, Response Habituation, and Functional Coupling","display_name":"Medial Prefrontal Cortex 5-HT2A Density Is Correlated with Amygdala Reactivity, Response Habituation, and Functional Coupling","publication_year":2009,"publication_date":"2009-03-25","ids":{"openalex":"https://openalex.org/W2118969780","doi":"https://doi.org/10.1093/cercor/bhp022","mag":"2118969780","pmid":"https://pubmed.ncbi.nlm.nih.gov/19321655","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2758681"},"language":"en","primary_location":{"id":"doi:10.1093/cercor/bhp022","doi":"https://doi.org/10.1093/cercor/bhp022","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhp022","pdf_url":"https://academic.oup.com/cercor/article-pdf/19/11/2499/1079328/bhp022.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cercor/article-pdf/19/11/2499/1079328/bhp022.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021085020","display_name":"Patrick M. Fisher","orcid":"https://orcid.org/0000-0002-8115-0611","observed_orcids":["https://orcid.org/0000-0002-8115-0611"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. M. Fisher","raw_affiliation_strings":["Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA","Center for Neuroscience","Center for the Neural Basis of Cognition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Neuroscience","institution_ids":[]},{"raw_affiliation_string":"Center for the Neural Basis of Cognition","institution_ids":["https://openalex.org/I4210086114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066006962","display_name":"CAROLYN CIDIS MELTZER","orcid":"https://orcid.org/0000-0003-1127-9783","observed_orcids":["https://orcid.org/0000-0003-1127-9783"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. C. Meltzer","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758454","display_name":"Julie C. Price","orcid":"https://orcid.org/0000-0001-7131-4865","observed_orcids":["https://orcid.org/0000-0001-7131-4865"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Price","raw_affiliation_strings":["Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. L. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. L. Coleman","raw_affiliation_strings":["Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040176146","display_name":"Scott K. Ziolko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Ziolko","raw_affiliation_strings":["Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049522840","display_name":"Carl R Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Becker","raw_affiliation_strings":["Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Radiology , Emory University , Atlanta , GA 30322 , USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006542897","display_name":"Eydie L. Moses\u2010Kolko","orcid":"https://orcid.org/0000-0002-9443-2036","observed_orcids":["https://orcid.org/0000-0002-9443-2036"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. L. Moses-Kolko","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012560465","display_name":"Sarah L. Berga","orcid":"https://orcid.org/0000-0003-1885-0401","observed_orcids":["https://orcid.org/0000-0003-1885-0401"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. L. Berga","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062228109","display_name":"Ahmad R. Hariri","orcid":"https://orcid.org/0000-0003-3052-9880","observed_orcids":["https://orcid.org/0000-0003-3052-9880"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. R. Hariri","raw_affiliation_strings":["Center for Neuroscience","Center for the Neural Basis of Cognition","Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience","institution_ids":[]},{"raw_affiliation_string":"Center for the Neural Basis of Cognition","institution_ids":["https://openalex.org/I4210086114"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5038,"currency":"USD","value_usd":5038},"apc_paid":null,"fwci":3.9831,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.94623345,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"19","issue":"11","first_page":"2499","last_page":"2507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.2053000032901764,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.08129999786615372,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9610000252723694},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.8220000267028809},{"id":"https://openalex.org/keywords/amygdala-reactivity","display_name":"amygdala reactivity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/functional-coupling","display_name":"functional coupling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/corticolimbic-circuitry","display_name":"corticolimbic circuitry","score":0.9700000286102295},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.8604147434234619},{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.8598296046257019},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7779898047447205},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6740898489952087},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6239322423934937},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5814688205718994},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4702654778957367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3307580351829529},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.14965084195137024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14417457580566406},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006185","descriptor_name":"Habituation, Psychophysiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/cercor/bhp022","doi":"https://doi.org/10.1093/cercor/bhp022","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhp022","pdf_url":"https://academic.oup.com/cercor/article-pdf/19/11/2499/1079328/bhp022.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2023377","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2758681","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19321655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19321655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral cortex (New York, N.Y. : 1991)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2758681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2758681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cereb Cortex","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.886.7165","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.886.7165","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cercor.oxfordjournals.org/content/19/11/2499.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.902.843","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.902.843","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cercor.oxfordjournals.org/content/early/2009/03/25/cercor.bhp022.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/cercor/bhp022","doi":"https://doi.org/10.1093/cercor/bhp022","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhp022","pdf_url":"https://academic.oup.com/cercor/article-pdf/19/11/2499/1079328/bhp022.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1073347873","display_name":"Serotonin-1A receptors in postpartum depression","funder_award_id":"R01MH079164","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2985821791","display_name":"Imaging the Depression/Dementia Interace","funder_award_id":"K24MH064625","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7900650922","display_name":"Multi-modal Neuroimaging Training Program","funder_award_id":"R90DA023420","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7918067990","display_name":"Development of Amygdala-Prefrontal Interactions","funder_award_id":"K01MH072837","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8479585387","display_name":"Age/Sex Effects on the Central Serotonin System","funder_award_id":"R01MH067602","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118969780.pdf","grobid_xml":"https://content.openalex.org/works/W2118969780.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W195739245","https://openalex.org/W1847168837","https://openalex.org/W1957103591","https://openalex.org/W1963759133","https://openalex.org/W1963945289","https://openalex.org/W1967996189","https://openalex.org/W1970629443","https://openalex.org/W1971737428","https://openalex.org/W1975335756","https://openalex.org/W1978168325","https://openalex.org/W1978489779","https://openalex.org/W1981364522","https://openalex.org/W1984754451","https://openalex.org/W1990644324","https://openalex.org/W1995452282","https://openalex.org/W1998069074","https://openalex.org/W2004172377","https://openalex.org/W2005159512","https://openalex.org/W2005950756","https://openalex.org/W2009375902","https://openalex.org/W2013336473","https://openalex.org/W2015780545","https://openalex.org/W2016660677","https://openalex.org/W2022951276","https://openalex.org/W2026720425","https://openalex.org/W2026841873","https://openalex.org/W2030292675","https://openalex.org/W2032671919","https://openalex.org/W2032734169","https://openalex.org/W2033615409","https://openalex.org/W2036970657","https://openalex.org/W2040453412","https://openalex.org/W2041907941","https://openalex.org/W2044071327","https://openalex.org/W2044952535","https://openalex.org/W2046638602","https://openalex.org/W2047558255","https://openalex.org/W2052869567","https://openalex.org/W2061231754","https://openalex.org/W2063017390","https://openalex.org/W2066525901","https://openalex.org/W2068697920","https://openalex.org/W2071614008","https://openalex.org/W2071970255","https://openalex.org/W2072268612","https://openalex.org/W2073061978","https://openalex.org/W2075273444","https://openalex.org/W2078204079","https://openalex.org/W2080279425","https://openalex.org/W2081564348","https://openalex.org/W2085459598","https://openalex.org/W2087209021","https://openalex.org/W2088525127","https://openalex.org/W2092261616","https://openalex.org/W2103748523","https://openalex.org/W2104516271","https://openalex.org/W2107056293","https://openalex.org/W2108459864","https://openalex.org/W2110601854","https://openalex.org/W2111464173","https://openalex.org/W2117155939","https://openalex.org/W2126299527","https://openalex.org/W2126449881","https://openalex.org/W2127485482","https://openalex.org/W2132089117","https://openalex.org/W2140279481","https://openalex.org/W2140425130","https://openalex.org/W2146747402","https://openalex.org/W2147351252","https://openalex.org/W2147969224","https://openalex.org/W2149823098","https://openalex.org/W2151487996","https://openalex.org/W2156743186","https://openalex.org/W2158553737","https://openalex.org/W2162426787","https://openalex.org/W2167814096","https://openalex.org/W2169764325","https://openalex.org/W2170045804","https://openalex.org/W2171372543","https://openalex.org/W2275444639","https://openalex.org/W2327678034","https://openalex.org/W2415735795","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7099615383","https://openalex.org/W2189383466","https://openalex.org/W2133194768","https://openalex.org/W2016647678","https://openalex.org/W2087107397","https://openalex.org/W2118492070","https://openalex.org/W2911018813","https://openalex.org/W1988466178","https://openalex.org/W2019817589","https://openalex.org/W2594821078"],"abstract_inverted_index":{"Feedback":[0],"inhibition":[1],"of":[2,17,24,114,139,161],"the":[3,15,40,63,115,137,147],"amygdala":[4,67,110,118,141,148,191],"via":[5],"medial":[6],"prefrontal":[7,203],"cortex":[8],"(mPFC)":[9],"is":[10,186],"an":[11],"important":[12],"component":[13],"in":[14,29,88,117,174],"regulation":[16],"complex":[18],"emotional":[19],"behaviors.":[20],"The":[21],"functional":[22,74,144,200],"dynamics":[23],"this":[25,52,166],"corticolimbic":[26,53,167],"circuitry":[27,168],"are,":[28],"part,":[30,175],"modulated":[31],"by":[32,122,176],"serotonin":[33],"(5-HT).":[34],"Serotonin":[35],"2A":[36],"(5-HT(2A))":[37],"receptors":[38],"within":[39,165],"mPFC":[41,79,101,123,133,150,177,184],"represent":[42],"a":[43,57,95,129],"potential":[44],"molecular":[45],"mechanism":[46],"through":[47],"which":[48],"5-HT":[49],"can":[50],"modulate":[51],"circuitry.":[54],"We":[55,93,126],"employed":[56],"multimodal":[58],"neuroimaging":[59],"strategy":[60],"to":[61],"explore":[62],"relationship":[64,98],"between":[65,132,146],"threat-related":[66,108,190],"reactivity,":[68],"assessed":[69,82],"using":[70,83],"blood":[71],"oxygen":[72],"level-dependent":[73],"magnetic":[75],"resonance":[76],"imaging,":[77],"and":[78,136,149,199],"5-HT(2A)":[80,102,124,134,155,185],"density,":[81],"[(18)F]altanserin":[84],"positron":[85],"emission":[86],"tomography":[87],"35":[89],"healthy":[90],"adult":[91],"volunteers.":[92],"observed":[94,128],"significant":[96],"inverse":[97],"wherein":[99],"greater":[100],"density":[103,135,156],"was":[104,120,151],"associated":[105,188],"with":[106,154,189,202],"reduced":[107],"right":[109,140],"reactivity.":[111],"Remarkably,":[112],"25-37%":[113],"variability":[116],"reactivity":[119,192],"explained":[121],"density.":[125],"also":[127],"positive":[130],"correlation":[131],"magnitude":[138],"habituation.":[142],"Furthermore,":[143],"coupling":[145,201],"positively":[152],"correlated":[153],"suggesting":[157],"that":[158,183],"effective":[159],"integration":[160],"emotionally":[162],"salient":[163],"information":[164],"may":[169],"be":[170],"modulated,":[171],"at":[172],"least":[173],"5-HT(2A).":[178],"Collectively,":[179],"our":[180],"results":[181],"indicate":[182],"strongly":[187],"as":[193,195],"well":[194],"its":[196],"temporal":[197],"habituation":[198],"regulatory":[204],"regions.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
