{"id":"https://openalex.org/W2118969396","doi":"https://doi.org/10.3389/fendo.2013.00071","title":"Adipokines Mediate Inflammation and Insulin Resistance","display_name":"Adipokines Mediate Inflammation and Insulin Resistance","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2118969396","doi":"https://doi.org/10.3389/fendo.2013.00071","mag":"2118969396","pmid":"https://pubmed.ncbi.nlm.nih.gov/23781214"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2013.00071","doi":"https://doi.org/10.3389/fendo.2013.00071","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00071","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00071/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00071/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082815889","display_name":"Hyokjoon Kwon","orcid":"https://orcid.org/0000-0002-3436-0608","observed_orcids":["https://orcid.org/0000-0002-3436-0608"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyokjoon Kwon","raw_affiliation_strings":["Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine , Bronx, NY , USA","Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine , Bronx, NY , USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077728712","display_name":"Jeffrey E. Pessin","orcid":"https://orcid.org/0000-0003-2041-2726","observed_orcids":["https://orcid.org/0000-0003-2041-2726"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey E. Pessin","raw_affiliation_strings":["Albert Einstein College of Medicine, Medicine and Molecular Pharmacology, Bronx, 10461, NY, United States","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Medicine and Molecular Pharmacology, Bronx, 10461, NY, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":29.3812,"has_fulltext":true,"cited_by_count":682,"citation_normalized_percentile":{"value":0.99820887,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":null,"first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7639999985694885},{"id":"https://openalex.org/keywords/anti-inflammatory-adipokines","display_name":"anti-inflammatory adipokines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.7770000100135803},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9581629037857056},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8457953929901123},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7638069987297058},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.7424264550209045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6745824813842773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6544268727302551},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6090814471244812},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5592592358589172},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5475413203239441},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.4606393277645111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4570067822933197},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.4235425591468811},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.41567254066467285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3619922697544098},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3014277219772339},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.13508480787277222}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fendo.2013.00071","doi":"https://doi.org/10.3389/fendo.2013.00071","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00071","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00071/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:23781214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23781214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2680712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679475","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3679475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3679475","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3a5bf6063574477991de4ad234087998","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a5bf6063574477991de4ad234087998","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 4 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2013.00071","doi":"https://doi.org/10.3389/fendo.2013.00071","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2013.00071","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2013.00071/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3086232184","display_name":null,"funder_award_id":"P60 DK-020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G788956770","display_name":"Diabetes Research and Training Center","funder_award_id":"5p60dk020541-37","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118969396.pdf","grobid_xml":"https://content.openalex.org/works/W2118969396.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W61964868","https://openalex.org/W65358577","https://openalex.org/W1523649643","https://openalex.org/W1546304862","https://openalex.org/W1555287564","https://openalex.org/W1555409852","https://openalex.org/W1557744782","https://openalex.org/W1562891630","https://openalex.org/W1590709474","https://openalex.org/W1631449371","https://openalex.org/W1644435722","https://openalex.org/W1675830194","https://openalex.org/W1708748675","https://openalex.org/W1764140709","https://openalex.org/W1967681731","https://openalex.org/W1967724716","https://openalex.org/W1976618972","https://openalex.org/W1979030077","https://openalex.org/W1979598489","https://openalex.org/W1986082361","https://openalex.org/W1988870963","https://openalex.org/W1992259695","https://openalex.org/W1993203791","https://openalex.org/W1993456360","https://openalex.org/W1996713062","https://openalex.org/W1997349446","https://openalex.org/W1998083587","https://openalex.org/W1998493448","https://openalex.org/W2000054651","https://openalex.org/W2003867612","https://openalex.org/W2003990479","https://openalex.org/W2010957046","https://openalex.org/W2011128327","https://openalex.org/W2012846412","https://openalex.org/W2012852339","https://openalex.org/W2015466197","https://openalex.org/W2018192258","https://openalex.org/W2018893673","https://openalex.org/W2022675164","https://openalex.org/W2025447674","https://openalex.org/W2027753197","https://openalex.org/W2033946555","https://openalex.org/W2036400933","https://openalex.org/W2038018821","https://openalex.org/W2038904723","https://openalex.org/W2040245081","https://openalex.org/W2040901874","https://openalex.org/W2041272089","https://openalex.org/W2041510403","https://openalex.org/W2042706232","https://openalex.org/W2043106623","https://openalex.org/W2044948009","https://openalex.org/W2049342816","https://openalex.org/W2049965571","https://openalex.org/W2052620623","https://openalex.org/W2053142936","https://openalex.org/W2053220365","https://openalex.org/W2054472394","https://openalex.org/W2058138221","https://openalex.org/W2059215353","https://openalex.org/W2059261163","https://openalex.org/W2060660919","https://openalex.org/W2060735685","https://openalex.org/W2061565738","https://openalex.org/W2065376152","https://openalex.org/W2067324334","https://openalex.org/W2069038722","https://openalex.org/W2069711307","https://openalex.org/W2070164366","https://openalex.org/W2070335885","https://openalex.org/W2070610372","https://openalex.org/W2070975219","https://openalex.org/W2075792687","https://openalex.org/W2076014158","https://openalex.org/W2077033935","https://openalex.org/W2079332279","https://openalex.org/W2080999576","https://openalex.org/W2081455569","https://openalex.org/W2082848536","https://openalex.org/W2083666530","https://openalex.org/W2086082646","https://openalex.org/W2086102771","https://openalex.org/W2087410169","https://openalex.org/W2088940658","https://openalex.org/W2089413808","https://openalex.org/W2089567564","https://openalex.org/W2092136583","https://openalex.org/W2092412131","https://openalex.org/W2092867947","https://openalex.org/W2093705034","https://openalex.org/W2096979174","https://openalex.org/W2097722989","https://openalex.org/W2101510325","https://openalex.org/W2105506930","https://openalex.org/W2105844711","https://openalex.org/W2107653986","https://openalex.org/W2109813770","https://openalex.org/W2110456510","https://openalex.org/W2110630581","https://openalex.org/W2110871895","https://openalex.org/W2111116814","https://openalex.org/W2113544353","https://openalex.org/W2114083228","https://openalex.org/W2115195372","https://openalex.org/W2116923491","https://openalex.org/W2119519672","https://openalex.org/W2120590109","https://openalex.org/W2120805022","https://openalex.org/W2121477549","https://openalex.org/W2124360636","https://openalex.org/W2124589753","https://openalex.org/W2124861138","https://openalex.org/W2125058279","https://openalex.org/W2125220665","https://openalex.org/W2127934772","https://openalex.org/W2128337755","https://openalex.org/W2128627731","https://openalex.org/W2128721675","https://openalex.org/W2129316761","https://openalex.org/W2131256997","https://openalex.org/W2134133526","https://openalex.org/W2139833921","https://openalex.org/W2145697808","https://openalex.org/W2146433754","https://openalex.org/W2146957741","https://openalex.org/W2148824946","https://openalex.org/W2149613768","https://openalex.org/W2151938344","https://openalex.org/W2152037832","https://openalex.org/W2152377123","https://openalex.org/W2154993634","https://openalex.org/W2155216472","https://openalex.org/W2156280702","https://openalex.org/W2159081962","https://openalex.org/W2159346623","https://openalex.org/W2161012482","https://openalex.org/W2161257972","https://openalex.org/W2162940414","https://openalex.org/W2164012871","https://openalex.org/W2164928543","https://openalex.org/W2165202791","https://openalex.org/W2165275387","https://openalex.org/W2165334726","https://openalex.org/W2167825438","https://openalex.org/W2167972746","https://openalex.org/W2168015220","https://openalex.org/W2169246660","https://openalex.org/W2169514045","https://openalex.org/W2169612876","https://openalex.org/W2411826498","https://openalex.org/W4234401381","https://openalex.org/W4243711342"],"related_works":["https://openalex.org/W2059411416","https://openalex.org/W2406660090","https://openalex.org/W2415557033","https://openalex.org/W2018227331","https://openalex.org/W2763780577","https://openalex.org/W3029291832","https://openalex.org/W2604785448","https://openalex.org/W3047633609","https://openalex.org/W1947875006","https://openalex.org/W3146532088"],"abstract_inverted_index":{"For":[0],"many":[1],"years,":[2],"adipose":[3,37,61,83,93,128,150],"tissue":[4,38,62,84,94,129,151,162,187],"was":[5],"considered":[6],"as":[7,43,88,111,155],"an":[8,64,101,233],"inert":[9],"energy":[10,19,29,53,72,173],"storage":[11],"organ":[12],"that":[13,51,74,222],"accumulates":[14],"and":[15,21,47,55,70,127,143,167,172,191,197,203,240,253,262],"stores":[16],"triacylglycerols":[17],"during":[18],"excess":[20],"releases":[22],"fatty":[23],"acids":[24],"in":[25,67,71,138,149,180,230,235,258],"times":[26],"of":[27,100,103,133,183,208,238,256],"systemic":[28],"need.":[30],"However,":[31],"over":[32],"the":[33,98,124,181,206,236,247,251,259],"last":[34],"two":[35],"decades":[36],"depots":[39],"have":[40,152,220],"been":[41,136,153],"established":[42],"highly":[44],"active":[45],"endocrine":[46],"metabolically":[48],"important":[49],"organs":[50,119],"modulate":[52,195],"expenditure":[54],"glucose":[56],"homeostasis.":[57],"In":[58,200],"rodents,":[59],"brown":[60],"plays":[63],"essential":[65],"role":[66],"non-shivering":[68],"thermogenesis":[69],"dissipation":[73],"can":[75],"serve":[76],"to":[77,115,159,194,213],"protect":[78],"against":[79],"diet-induced":[80],"obesity.":[81],"White":[82],"collectively":[85],"referred":[86],"too":[87],"either":[89],"subcutaneous":[90],"or":[91],"visceral":[92],"is":[95,211],"responsible":[96],"for":[97],"secretion":[99],"array":[102],"signaling":[104],"molecules,":[105],"termed":[106],"adipokines.":[107,242],"These":[108],"adipokines":[109,134,176,193,210,257],"function":[110],"classic":[112],"circulating":[113],"hormones":[114],"communicate":[116],"with":[117,265],"other":[118],"including":[120],"brain,":[121],"liver,":[122],"muscle,":[123],"immune":[125],"system,":[126],"itself.":[130],"The":[131],"dysregulation":[132],"has":[135],"implicated":[137],"obesity,":[139],"type":[140],"2":[141],"diabetes,":[142],"cardiovascular":[144],"disease.":[145],"Recently,":[146],"inflammatory":[147,184],"responses":[148],"shown":[154],"a":[156],"major":[157],"mechanism":[158],"induce":[160,214],"peripheral":[161],"insulin":[163,198,215,224,263],"resistance.":[164,199,216],"Although":[165],"leptin":[166],"adiponectin":[168],"regulate":[169],"feeding":[170],"behavior":[171],"expenditure,":[174],"these":[175,218],"are":[177],"also":[178],"involved":[179],"regulation":[182],"responses.":[185],"Adipose":[186],"secretes":[188],"various":[189],"pro-":[190,239],"anti-inflammatory":[192,241],"inflammation":[196,261],"obese":[201],"humans":[202],"rodent":[204],"models,":[205],"expression":[207,237],"pro-inflammatory":[209],"enhanced":[212],"Collectively,":[217],"findings":[219],"suggested":[221],"obesity-induced":[223,260],"resistance":[225,264],"may":[226],"result,":[227],"at":[228],"least":[229],"part,":[231],"from":[232],"imbalance":[234],"Thus":[243],"we":[244],"will":[245],"review":[246],"recent":[248],"progress":[249],"regarding":[250],"physiological":[252],"molecular":[254],"functions":[255],"perspectives":[266],"on":[267],"future":[268],"directions.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":59},{"year":2023,"cited_by_count":59},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":57},{"year":2020,"cited_by_count":63},{"year":2019,"cited_by_count":58},{"year":2018,"cited_by_count":64},{"year":2017,"cited_by_count":46},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":15}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2025-10-10T00:00:00"}
