{"id":"https://openalex.org/W2118968708","doi":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","title":"Survival of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in the Terminal Ileum of Fistulated Go\u0308ttingen Minipigs","display_name":"Survival of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in the Terminal Ileum of Fistulated Go\u0308ttingen Minipigs","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2118968708","doi":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","mag":"2118968708","pmid":"https://pubmed.ncbi.nlm.nih.gov/11526016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/93140"},"language":"en","primary_location":{"id":"doi:10.1128/aem.67.9.4137-4143.2001","doi":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC93140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009758542","display_name":"Sonja Lick","orcid":"https://orcid.org/0000-0002-4081-9542","observed_orcids":["https://orcid.org/0000-0002-4081-9542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonja Lick","raw_affiliation_strings":["<!--label omitted: 1-->Institute for Microbiology1 and","Institute for Microbiology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Institute for Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Institute for Microbiology1 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karsten Drescher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karsten Drescher","raw_affiliation_strings":["<!--label omitted: 2-->Institute for Physiology and Biochemistry of Nutrition,2Federal Dairy Research Center, D-24103 Kiel, Germany","Institute for Physiology and Biochemistry of Nutrition,2Federal Dairy Research Center, D-24103 Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Institute for Physiology and Biochemistry of Nutrition,2Federal Dairy Research Center, D-24103 Kiel, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute for Physiology and Biochemistry of Nutrition,2Federal Dairy Research Center, D-24103 Kiel, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055342974","display_name":"Knut J. Heller","orcid":"https://orcid.org/0000-0003-1757-8805","observed_orcids":["https://orcid.org/0000-0003-1757-8805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Knut J. Heller","raw_affiliation_strings":["<!--label omitted: 1-->Institute for Microbiology1 and","Institute for Microbiology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Institute for Microbiology1 and","institution_ids":[]},{"raw_affiliation_string":"Institute for Microbiology1 and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3314,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.81639076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"67","issue":"9","first_page":"4137","last_page":"4143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactobacillus-delbrueckii-subsp-bulgaricus","display_name":"Lactobacillus bulgaricus","score":1.0},{"id":"https://openalex.org/keywords/streptococcus-thermophilus","display_name":"Streptococcus thermophilus","score":1.0},{"id":"https://openalex.org/keywords/yogurt","display_name":"yogurt","score":0.6520000100135803},{"id":"https://openalex.org/keywords/ileostomy","display_name":"ileostomy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gottingen-minipig","display_name":"G\u00f6ttingen minipig","score":0.8230000138282776},{"id":"https://openalex.org/keywords/probiotic-viability","display_name":"probiotic viability","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2777276588","wikidata":"https://www.wikidata.org/wiki/Q1041276","display_name":"Streptococcus thermophilus","level":4,"score":0.9500752687454224},{"id":"https://openalex.org/C2778682546","wikidata":"https://www.wikidata.org/wiki/Q262677","display_name":"Lactobacillus delbrueckii subsp. bulgaricus","level":5,"score":0.902916669845581},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.8303341865539551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6465696096420288},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5489431619644165},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.5340059995651245},{"id":"https://openalex.org/C2776319035","wikidata":"https://www.wikidata.org/wiki/Q2706090","display_name":"Hymenolepis diminuta","level":4,"score":0.51463782787323},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5126466155052185},{"id":"https://openalex.org/C2780437316","wikidata":"https://www.wikidata.org/wiki/Q578677","display_name":"Lactobacillaceae","level":4,"score":0.4480059742927551},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.4174855351448059},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.39207813143730164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20560944080352783},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.09208926558494568},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.08245670795440674},{"id":"https://openalex.org/C2910083286","wikidata":"https://www.wikidata.org/wiki/Q159715","display_name":"Cestode infections","level":3,"score":0.058076411485672},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05191776156425476}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005766","descriptor_name":"Gastrointestinal Contents","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007081","descriptor_name":"Ileostomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015014","descriptor_name":"Yogurt","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/aem.67.9.4137-4143.2001","doi":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.67.9.4137-4143.2001","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:67980","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC93140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:93140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/93140","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},{"id":"pmid:11526016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11526016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:www.openagrar.de:import_mods_00000162","doi":null,"is_oa":false,"landing_page_url":"https://www.openagrar.de/receive/import_mods_00000162","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:67980","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC93140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310065","display_name":"Danone","ror":"https://ror.org/00aj77a24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W276614505","https://openalex.org/W1516970256","https://openalex.org/W1535425217","https://openalex.org/W1541075638","https://openalex.org/W1553078406","https://openalex.org/W1592389388","https://openalex.org/W1968315276","https://openalex.org/W1969271557","https://openalex.org/W1995381856","https://openalex.org/W2002499900","https://openalex.org/W2007638112","https://openalex.org/W2018707711","https://openalex.org/W2047281877","https://openalex.org/W2048201539","https://openalex.org/W2050523712","https://openalex.org/W2061799513","https://openalex.org/W2080359390","https://openalex.org/W2081347102","https://openalex.org/W2097678114","https://openalex.org/W2112560954","https://openalex.org/W2117700686","https://openalex.org/W2125687014","https://openalex.org/W2138740429","https://openalex.org/W2145957687","https://openalex.org/W2151916489","https://openalex.org/W2167113011","https://openalex.org/W2473317406","https://openalex.org/W2511680923","https://openalex.org/W2521896090","https://openalex.org/W4249244804","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2076240605","https://openalex.org/W2167350133","https://openalex.org/W1998045922","https://openalex.org/W2164533412","https://openalex.org/W2106047791","https://openalex.org/W2126128914","https://openalex.org/W379328385","https://openalex.org/W2747601001","https://openalex.org/W2754339163","https://openalex.org/W2804097489"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,35,66,72,84,88,141],"Lactobacillus":[3],"delbrueckii":[4,55,113,122,153,161,171,192],"subsp.":[5,56,123,172],"bulgaricus":[6,57,173],"and":[7,58,114,117,181,188],"Streptococcus":[8],"thermophilus":[9,60,116,168],"administered":[10,94],"in":[11,63,77,164],"yogurt":[12,36,135,157],"to":[13,68,105],"survive":[14],"the":[15,18,64,85],"passage":[16],"through":[17],"upper":[19],"gastrointestinal":[20],"tract":[21],"was":[22,103,108,158,162,174],"investigated":[23],"with":[24,30],"G\u00f6ttingen":[25],"minipigs":[26],"that":[27,91,178],"were":[28,42,61],"fitted":[29],"ileum":[31],"T-cannulas.":[32],"After":[33],"ingestion":[34],"containing":[37],"viable":[38],"microorganisms,":[39],"ileostomy":[40,101],"samples":[41,102],"collected":[43],"nearly":[44],"every":[45],"hour":[46],"beginning":[47],"3":[48],"h":[49],"after":[50,134,139],"food":[51],"uptake.":[52],"Living":[53],"L.":[54,112,121,152,160,170,191],"S.":[59,115,167],"detected":[62,131,163],"magnitude":[65],"10(6)":[67],"10(7)":[69],"per":[70],"gram":[71],"intestinal":[73],"contents":[74],"(wet":[75],"weight)":[76],"all":[78,165],"animals":[79],"under":[80],"investigation.":[81],"A":[82],"calculation":[83],"minimum":[86],"amount":[87],"surviving":[89],"bacteria":[90],"had":[92,148,184,194],"been":[93,186,195],"is":[95],"presented.":[96],"Total":[97],"DNA":[98],"extracted":[99],"from":[100],"subjected":[104],"PCR,":[106],"which":[107],"species":[109],"specific":[110,119],"for":[111,120,197],"subspecies":[118],"bulgaricus.":[124],"All":[125],"three":[126],"bacterial":[127],"groups":[128],"could":[129],"be":[130],"by":[132],"PCR":[133],"uptake":[136,140],"but":[137],"not":[138,175],"a":[142],"semisynthetic":[143],"diet.":[144],"One":[145],"pig":[146],"apparently":[147],"developed":[149],"an":[150],"endogenous":[151],"flora.":[154],"When":[155],"heat-treated":[156],"administered,":[159],"animals.":[166],"or":[169],"detected,":[176],"indicating":[177],"heat-inactivated":[179],"cells":[180],"their":[182,189],"DNAs":[183],"already":[185],"digested":[187],"own":[190],"flora":[193],"stimulated":[196],"growth.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}