{"id":"https://openalex.org/W2118965502","doi":"https://doi.org/10.1128/jcm.01510-06","title":"Prevalence and Clinical Significance of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Lung Disease","display_name":"Prevalence and Clinical Significance of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Lung Disease","publication_year":2006,"publication_date":"2006-11-16","ids":{"openalex":"https://openalex.org/W2118965502","doi":"https://doi.org/10.1128/jcm.01510-06","mag":"2118965502","pmid":"https://pubmed.ncbi.nlm.nih.gov/17108072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1828983"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.01510-06","doi":"https://doi.org/10.1128/jcm.01510-06","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.01510-06","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1828983","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001160659","display_name":"Silke M. Besier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silke Besier","raw_affiliation_strings":["Institute of Medical Microbiology and Infection Control"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Infection Control","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110795046","display_name":"Christina Smaczny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Smaczny","raw_affiliation_strings":["Department of Pulmonology and Allergology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Allergology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009716657","display_name":"Christian von Mallinckrodt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian von Mallinckrodt","raw_affiliation_strings":["Department of Pulmonology and Allergology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Allergology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027600947","display_name":"Andreas Krahl","orcid":"https://orcid.org/0000-0003-3016-6776","observed_orcids":["https://orcid.org/0000-0003-3016-6776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Krahl","raw_affiliation_strings":["Department of Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088547416","display_name":"Hanns Ackermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanns Ackermann","raw_affiliation_strings":["Department of Biomathematics, University Hospital of Frankfurt am Main, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomathematics, University Hospital of Frankfurt am Main, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084238487","display_name":"Volker Brade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volker Brade","raw_affiliation_strings":["Institute of Medical Microbiology and Infection Control"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Infection Control","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067364341","display_name":"Thomas A. Wichelhaus","orcid":"https://orcid.org/0000-0002-4029-2955","observed_orcids":["https://orcid.org/0000-0002-4029-2955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Wichelhaus","raw_affiliation_strings":["Institute of Medical Microbiology and Infection Control"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Infection Control","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6985,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.92738396,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"45","issue":"1","first_page":"168","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9679999947547913},{"id":"https://openalex.org/keywords/small-colony-variants","display_name":"small colony variants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.6370000243186951},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.6480000019073486},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.4819999933242798},{"id":"https://openalex.org/keywords/forced-expiratory-volume","display_name":"forced expiratory volume","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8966642618179321},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7580296993255615},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6752604246139526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5921965837478638},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5352659225463867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4911439120769501},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4558923542499542},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.44588860869407654},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.42638877034187317},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4256630539894104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31807318329811096},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2786591649055481},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jcm.01510-06","doi":"https://doi.org/10.1128/jcm.01510-06","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.01510-06","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:449987","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1828983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:17108072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17108072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1828983","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1828983/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:449987","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1828983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320333874","display_name":"Bayer Vital","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1521216397","https://openalex.org/W1536421264","https://openalex.org/W1833207062","https://openalex.org/W1840852119","https://openalex.org/W1892635398","https://openalex.org/W1971952038","https://openalex.org/W1999277244","https://openalex.org/W2013494931","https://openalex.org/W2015895554","https://openalex.org/W2027373007","https://openalex.org/W2038905091","https://openalex.org/W2042085284","https://openalex.org/W2052163067","https://openalex.org/W2052899289","https://openalex.org/W2055857822","https://openalex.org/W2062689424","https://openalex.org/W2066929429","https://openalex.org/W2079774537","https://openalex.org/W2082267277","https://openalex.org/W2088774981","https://openalex.org/W2088960594","https://openalex.org/W2100619015","https://openalex.org/W2101716379","https://openalex.org/W2114660268","https://openalex.org/W2116429140","https://openalex.org/W2138731773","https://openalex.org/W2139076424","https://openalex.org/W2147695950","https://openalex.org/W2151722492","https://openalex.org/W2156302195","https://openalex.org/W2156320834","https://openalex.org/W2158199036","https://openalex.org/W2158467440","https://openalex.org/W2159366663","https://openalex.org/W2159438804","https://openalex.org/W3106798016","https://openalex.org/W4252831606"],"related_works":["https://openalex.org/W2112002895","https://openalex.org/W4410998274","https://openalex.org/W1949766500","https://openalex.org/W2323105080","https://openalex.org/W2114660268","https://openalex.org/W4415695253","https://openalex.org/W2771025570","https://openalex.org/W2986196127","https://openalex.org/W4386385071","https://openalex.org/W2597805557"],"abstract_inverted_index":{"Small-colony":[0],"variants":[1,24],"(SCVs)":[2],"of":[3,14,50,63,89,97,158,202,219,241],"Staphylococcus":[4],"aureus":[5,65,115,118,178,213,243],"can":[6],"be":[7,105,225],"isolated":[8],"from":[9,17],"the":[10,47,61,78,83,95,121,133,231,239],"chronically":[11],"infected":[12],"airways":[13],"patients":[15,91,175,221],"suffering":[16],"cystic":[18],"fibrosis":[19],"(CF).":[20],"These":[21],"slow-growing":[22],"morphological":[23],"have":[25],"been":[26],"associated":[27],"with":[28,82,120,132,149,179],"persistent":[29,248],"and":[30,36,76,155,199,247],"antibiotic-resistant":[31],"infections,":[32,38],"such":[33,162],"as":[34,163,207],"osteomyelitis":[35],"device-related":[37],"but":[39],"no":[40],"information":[41],"is":[42,222],"available":[43],"to":[44,104,111,224,238],"date":[45],"regarding":[46],"clinical":[48,85,217],"significance":[49],"this":[51],"special":[52],"phenotype":[53,123],"in":[54,67,71,168,250],"CF":[55,68,220,252],"lung":[56,69,253],"disease.":[57,254],"We":[58],"therefore":[59],"investigated":[60],"prevalence":[62,100],"S.":[64,114,117,177,212,242],"SCVs":[66,139,244],"disease":[70],"a":[72,180],"12-month":[73],"prospective":[74],"study":[75],"correlated":[77],"microbiological":[79],"culture":[80],"results":[81],"patients'":[84],"data.":[86],"A":[87],"total":[88],"252":[90],"were":[92,140],"screened":[93],"for":[94,138,211],"presence":[96],"SCVs.":[98],"The":[99,184,216],"rate":[101],"was":[102],"determined":[103,188,235],"17%":[106],"(95%":[107],"confidence":[108],"interval,":[109],"10":[110],"25%)":[112],"among":[113],"carriers.":[116],"isolates":[119],"SCV":[122,214],"showed":[124,156],"significantly":[125,141],"higher":[126],"antibiotic":[127],"resistance":[128],"rates":[129],"than":[130,174],"those":[131],"normal":[134,182],"phenotype.":[135,183],"Patients":[136],"positive":[137],"older":[142],"(P":[143,152,171,191,196,204],"=":[144,153,172,192,197,205],"0.0099),":[145],"more":[146,159],"commonly":[147],"cocolonized":[148],"Pseudomonas":[150],"aeruginosa":[151],"0.0454),":[154],"signs":[157],"advanced":[160,194,251],"disease,":[161],"lower":[164,189],"forced":[165],"expiratory":[166],"volume":[167],"1":[169],"s":[170],"0.0148)":[173],"harboring":[176],"solely":[181],"logistic":[185],"regression":[186],"model":[187],"weight":[190],"0.016),":[193],"age":[195],"0.000),":[198],"prior":[200],"use":[201],"trimethoprim-sulfamethoxazole":[203],"0.002)":[206],"independent":[208,232],"risk":[209,233],"factors":[210,234],"positivity.":[215],"status":[218],"known":[223],"affected":[226],"by":[227],"multiple":[228],"parameters.":[229],"Nonetheless,":[230],"here":[236],"point":[237],"impact":[240],"on":[245],"chronic":[246],"infections":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}