{"id":"https://openalex.org/W2118965081","doi":"https://doi.org/10.1210/jc.2006-1806","title":"Efficacy and Safety of Intranasal Peptide YY3\u201336 for Weight Reduction in Obese Adults","display_name":"Efficacy and Safety of Intranasal Peptide YY3\u201336 for Weight Reduction in Obese Adults","publication_year":2007,"publication_date":"2007-03-06","ids":{"openalex":"https://openalex.org/W2118965081","doi":"https://doi.org/10.1210/jc.2006-1806","mag":"2118965081","pmid":"https://pubmed.ncbi.nlm.nih.gov/17341568"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2006-1806","doi":"https://doi.org/10.1210/jc.2006-1806","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-1806","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026935251","display_name":"Ira Gantz","orcid":"https://orcid.org/0000-0002-6565-7113","observed_orcids":["https://orcid.org/0000-0002-6565-7113","https://orcid.org/0000-0001-8572-5614"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira Gantz","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065","Clinical Research, Metabolism, Merck Research Laboratories, 126 East Lincoln Avenue, P.O. Box 2000, RY34A-A202, Rahway, NJ 07065-0900, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Clinical Research, Metabolism, Merck Research Laboratories, 126 East Lincoln Avenue, P.O. Box 2000, RY34A-A202, Rahway, NJ 07065-0900, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109448130","display_name":"Ngozi Erondu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ngozi Erondu","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109459935","display_name":"Madhuja Mallick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhuja Mallick","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056285244","display_name":"Bret J. Musser","orcid":"https://orcid.org/0000-0003-2949-211X","observed_orcids":["https://orcid.org/0000-0003-2949-211X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bret Musser","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021441570","display_name":"Rajesh Krishna","orcid":"https://orcid.org/0000-0002-3127-9732","observed_orcids":["https://orcid.org/0000-0002-3127-9732"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Krishna","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114009806","display_name":"Wesley Kiyoshi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley K. Tanaka","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519966","display_name":"Karen Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Snyder","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110225821","display_name":"Cathy Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy Stevens","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062831066","display_name":"Mark Stroh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Stroh","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110216495","display_name":"Haiyuan Zhu","orcid":"https://orcid.org/0009-0007-0903-9349","observed_orcids":["https://orcid.org/0009-0007-0903-9349"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyuan Zhu","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111938300","display_name":"John A. Wagner","orcid":"https://orcid.org/0000-0002-0636-5006","observed_orcids":["https://orcid.org/0000-0002-0636-5006","https://orcid.org/0000-0003-0038-8511"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Wagner","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067821112","display_name":"Douglas J. MacNeil","orcid":"https://orcid.org/0000-0001-7089-0668","observed_orcids":["https://orcid.org/0000-0001-7089-0668"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas J. MacNeil","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065818595","display_name":"Steven B. Heymsfield","orcid":"https://orcid.org/0000-0003-1127-9425","observed_orcids":["https://orcid.org/0000-0003-1127-9425"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven B. Heymsfield","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111981920","display_name":"John M. Amatruda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Amatruda","raw_affiliation_strings":["Merck Research Laboratories, Rahway, New Jersey 07065"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, New Jersey 07065","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026935251"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":9.7075,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.98687031,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"92","issue":"5","first_page":"1754","last_page":"1757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyy3-36","display_name":"PYY3-36","score":0.949999988079071},{"id":"https://openalex.org/keywords/intranasal-administration","display_name":"intranasal administration","score":0.7680000066757202},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6729999780654907},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/satiety-hormones","display_name":"satiety hormones","score":0.8069999814033508},{"id":"https://openalex.org/keywords/low-calorie-diet","display_name":"hypocaloric diet","score":0.8040000200271606},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.8970000147819519},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7879999876022339},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.3499999940395355},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.4059999883174896},{"id":"https://openalex.org/keywords/obesity-pharmacotherapy","display_name":"obesity pharmacotherapy","score":0.4519999921321869},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.3230000138282776},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.784963846206665},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7528337240219116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7067809104919434},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.6064995527267456},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5993241667747498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5905629396438599},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5629695057868958},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5291146636009216},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43757164478302},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4291272759437561},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41391849517822266},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.36721330881118774},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36014634370803833},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.1991007924079895},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.12137579917907715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04885700345039368},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019894","descriptor_name":"Peptide YY","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2006-1806","doi":"https://doi.org/10.1210/jc.2006-1806","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2006-1806","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:17341568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17341568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1964424412","https://openalex.org/W1968704139","https://openalex.org/W1969881895","https://openalex.org/W1986199235","https://openalex.org/W1992804002","https://openalex.org/W1997612728","https://openalex.org/W2000488672","https://openalex.org/W2006098647","https://openalex.org/W2008501546","https://openalex.org/W2013138426","https://openalex.org/W2030664060","https://openalex.org/W2030831607","https://openalex.org/W2031000084","https://openalex.org/W2052519819","https://openalex.org/W2063385321","https://openalex.org/W2068177011","https://openalex.org/W2079539251","https://openalex.org/W2079681415","https://openalex.org/W2084492438","https://openalex.org/W2086190854","https://openalex.org/W2089098385","https://openalex.org/W2091685843","https://openalex.org/W2095386072","https://openalex.org/W2096459471","https://openalex.org/W2099688918","https://openalex.org/W2106158417","https://openalex.org/W2114179943","https://openalex.org/W2114359174","https://openalex.org/W2134221479","https://openalex.org/W2146193981","https://openalex.org/W2148555865","https://openalex.org/W2155419918","https://openalex.org/W2159048625","https://openalex.org/W2170277935","https://openalex.org/W2320224826","https://openalex.org/W3143670616","https://openalex.org/W4240185631","https://openalex.org/W6642084386","https://openalex.org/W6650006514","https://openalex.org/W6653567944","https://openalex.org/W6658277086","https://openalex.org/W6672680027","https://openalex.org/W6673474969","https://openalex.org/W6674418877","https://openalex.org/W6674818618","https://openalex.org/W6677040418","https://openalex.org/W6680065061","https://openalex.org/W6681657631","https://openalex.org/W6683134192","https://openalex.org/W6700382824","https://openalex.org/W6821988314"],"related_works":["https://openalex.org/W2320224826","https://openalex.org/W7112792187","https://openalex.org/W2042011044","https://openalex.org/W2131234408","https://openalex.org/W3157709034","https://openalex.org/W760714358","https://openalex.org/W2114359174","https://openalex.org/W2170277935","https://openalex.org/W2157748967","https://openalex.org/W2127779389"],"abstract_inverted_index":{"CONTEXT:":[0],"The":[1,17,41,61,129,220],"gastrointestinal":[2],"peptide":[3,5],"hormone,":[4],"YY(3-36)":[6],"(PYY(3-36)),":[7],"is":[8,22,277],"implicated":[9],"to":[10,23,33,180],"be":[11,252],"a":[12,46,54,66,113,159,197],"postprandial":[13],"satiety":[14],"factor.":[15],"OBJECTIVE:":[16],"aim":[18],"of":[19,30,74,131,141,145,150,174,243,290],"this":[20],"study":[21,42,62,261],"assess":[24],"the":[25,88,124,137,168,200,255,260],"safety,":[26],"tolerability,":[27],"and":[28,68,108,116,148,162,182,195,210,216,230,274],"efficacy":[29],"intranasal":[31,101],"PYY(3-36)":[32,96,267],"induce":[34],"weight":[35,122,203,282],"loss":[36,283],"in":[37,87,110,280,284],"obese":[38,76,285],"patients.":[39],"DESIGN:":[40],"was":[43,63,97,123,139,207,233,246],"designed":[44],"as":[45,99,268],"randomized,":[47],"2-wk,":[48],"single-blind":[49],"placebo":[50,229],"run-in":[51],"followed":[52],"by":[53],"12-wk":[55],"double-blind,":[56],"placebo-controlled":[57],"treatment":[58],"period.":[59],"SETTING:":[60],"set":[64],"within":[65],"private":[67],"institutional":[69],"practice.":[70],"PATIENTS:":[71],"A":[72,241],"total":[73],"133":[75],"patients":[77,132,177,187,257,286],"(body":[78],"mass":[79],"index,":[80],"30-43":[81],"kg/m(2);":[82],"age,":[83],"18-65":[84],"yr)":[85],"participated":[86],"study.":[89],"INTERVENTION:":[90],"Placebo":[91],"or":[92,94],"200-":[93],"600-microg":[95],"administered":[98,269],"an":[100],"spray":[102],"20":[103],"min":[104],"before":[105],"breakfast,":[106],"lunch,":[107],"dinner":[109],"conjunction":[111],"with":[112],"hypocaloric":[114],"diet":[115],"exercise.":[117],"MAIN":[118],"OUTCOME":[119],"MEASURE:":[120],"Body":[121],"main":[125],"outcome":[126],"measure.":[127],"RESULTS:":[128],"number":[130],"completing":[133],"12":[134,149,288],"wk":[135,289],"on":[136,262],"drug":[138,193],"38":[140],"43":[142],"(88%),":[143],"31":[144],"44":[146],"(70%),":[147],"46":[151,175],"(26%)":[152],"for":[153,213],"placebo,":[154,214],"200":[155,215,231],"microg":[156,164,170,232],"three":[157],"times":[158],"day":[160],"(t.i.d.)":[161],"600":[163,169,217,263],"t.i.d.,":[165],"respectively.":[166,219],"In":[167],"t.i.d.":[171],"group,":[172],"27":[173],"(59%)":[176],"discontinued":[178],"due":[179],"nausea":[181],"vomiting.":[183],"Among":[184],"all":[185],"randomized":[186],"who":[188,258],"took":[189],"at":[190,270],"least":[191,221],"one":[192],"dose":[194],"had":[196],"postbaseline":[198],"measurement,":[199],"mean":[201,223],"body":[202],"change":[204],"from":[205,254],"baseline":[206],"-2.8,":[208],"-3.7,":[209],"-1.4":[211],"kg":[212,237,245],"microg,":[218],"squares":[222],"difference":[224,242],"(95%":[225],"confidence":[226],"interval)":[227],"between":[228],"-0.9":[234],"(-2.6,":[235],"0.7)":[236],"(P":[238],"=":[239],"0.251).":[240],"2.11":[244],"sought.":[247],"No":[248],"meaningful":[249],"inference":[250],"can":[251],"drawn":[253],"few":[256],"completed":[259],"microg.":[264],"CONCLUSIONS:":[265],"Intranasal":[266],"these":[271],"intervention":[272],"doses":[273],"preprandial":[275],"timing":[276],"not":[278],"efficacious":[279],"inducing":[281],"after":[287],"treatment.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}