{"id":"https://openalex.org/W2118960506","doi":"https://doi.org/10.1080/15376520600620232","title":"Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-\u03b2-Boswellic Acid (AKBA)-EnrichedBoswellia serrataExtract (5-Loxin\u00ae)","display_name":"Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-\u03b2-Boswellic Acid (AKBA)-EnrichedBoswellia serrataExtract (5-Loxin\u00ae)","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2118960506","doi":"https://doi.org/10.1080/15376520600620232","mag":"2118960506","pmid":"https://pubmed.ncbi.nlm.nih.gov/20021046"},"language":"en","primary_location":{"id":"doi:10.1080/15376520600620232","doi":"https://doi.org/10.1080/15376520600620232","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15376520600620232","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026870927","display_name":"K. Lalithakumari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Lalithakumari","raw_affiliation_strings":["Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037550042","display_name":"Krishnaraju Venkata Alluri","orcid":"https://orcid.org/0000-0002-0550-7164","observed_orcids":["https://orcid.org/0000-0002-0550-7164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. V. Krishnaraju","raw_affiliation_strings":["Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001249760","display_name":"K. Sengupta","orcid":"https://orcid.org/0000-0001-6600-2621","observed_orcids":["https://orcid.org/0000-0001-6600-2621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Sengupta","raw_affiliation_strings":["Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110618271","display_name":"Gottumukkala Venkata Subbaraju","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. V. Subbaraju","raw_affiliation_strings":["Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laila Research Center, Unit I, Phase III, Jawahar Autonagar, Vijaywada, 520 007, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113865601","display_name":"Archana Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Chatterjee","raw_affiliation_strings":["Creighton University Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I2800482329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5708,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.70441092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"199","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14297","display_name":"Plant-Derived Bioactive Compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-o-acetyl-11-keto-beta-boswellic-acid","display_name":"3-O-acetyl-11-keto-\u03b2-boswellic acid","score":0.8989999890327454},{"id":"https://openalex.org/keywords/boswellia-serrata","display_name":"Boswellia serrata","score":0.8830000162124634},{"id":"https://openalex.org/keywords/boswellic-acids","display_name":"boswellic acids","score":0.8849999904632568},{"id":"https://openalex.org/keywords/5-lipoxygenase-inhibition","display_name":"5-lipoxygenase inhibition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8759999871253967},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/acute-oral-toxicity","display_name":"acute oral toxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/skin-toxicity","display_name":"skin toxicity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/subchronic-toxicity","display_name":"subchronic toxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780574456","wikidata":"https://www.wikidata.org/wiki/Q2367334","display_name":"Boswellia serrata","level":3,"score":0.9852793216705322},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6062983870506287},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.5261092782020569},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.5047808885574341},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5030857920646667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46292731165885925},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4131205677986145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35466572642326355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1516367495059967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10903239250183105},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10282409191131592},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/15376520600620232","doi":"https://doi.org/10.1080/15376520600620232","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15376520600620232","pdf_url":null,"source":{"id":"https://openalex.org/S93207707","display_name":"Toxicology Mechanisms and Methods","issn_l":"1537-6516","issn":["1537-6516","1537-6524"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Mechanisms and Methods","raw_type":"journal-article"},{"id":"pmid:20021046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20021046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology mechanisms and methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W5450535","https://openalex.org/W1936122156","https://openalex.org/W1985363587","https://openalex.org/W1986258565","https://openalex.org/W2054699515","https://openalex.org/W2067434392","https://openalex.org/W2091235061","https://openalex.org/W2092619081","https://openalex.org/W2092792517","https://openalex.org/W2171837775","https://openalex.org/W2311902495","https://openalex.org/W2341050657","https://openalex.org/W3128233165"],"related_works":["https://openalex.org/W2185727170","https://openalex.org/W4200539226","https://openalex.org/W2043085333","https://openalex.org/W2086504730","https://openalex.org/W1974787536","https://openalex.org/W2091235061","https://openalex.org/W4414569901","https://openalex.org/W1993516845","https://openalex.org/W2471067061","https://openalex.org/W1967132787"],"abstract_inverted_index":{"The":[0,29,71],"novel":[1,59],"anti-inflammatory":[2,76],"properties":[3],"of":[4,32,52,74,78,85,100,112,115,128,153,185,250,271,298],"the":[5,33,41,75,97,113,125,230,294],"gum":[6,34],"resin":[7,35],"derived":[8],"from":[9],"Boswellia":[10,60],"serrata,":[11],"also":[12],"known":[13],"as":[14,210,226,248],"Salai":[15],"guggal":[16],"in":[17,82,89,163,172,242,261,285],"Ayurvedic":[18],"medicine,":[19],"are":[20,36],"well":[21],"recognized":[22],"and":[23,103,107,109,136,139,166,206,222,247,252,276],"highly":[24],"recommended":[25],"for":[26],"human":[27,90],"consumption.":[28],"active":[30],"constituents":[31],"boswellic":[37],"acids":[38],"(BAs).":[39],"Among":[40],"BAs,":[42],"AKBA":[43,67],"potently":[44],"inhibits":[45],"5-lipoxygenase":[46],"product":[47],"formation":[48],"with":[49,65,199,218],"an":[50],"IC(50)":[51],"1.5":[53],"m":[54],"muM.":[55],"We":[56],"developed":[57],"a":[58,83],"serrata":[61],"extract":[62],"(5-Loxin(R))":[63],"enriched":[64],"30%":[66],"(US":[68],"Patent":[69],"2004/0073060A1).":[70],"genetic":[72],"basis":[73],"effects":[77,177,284],"5-Loxin(R)":[79,94,154,186,200,207,223,255],"was":[80,155,187,197,208,216,224],"explored":[81],"system":[84],"TNFalpha-induced":[86,98],"gene":[87],"expression":[88,99,111],"microvascular":[91],"endothelial":[92],"cells.":[93],"significantly":[95],"prevented":[96],"matrix":[101],"metalloproteinases":[102],"adhesion":[104],"molecules":[105],"(ICAM-1":[106],"VCAM-1),":[108],"inducible":[110],"mediators":[114],"apoptosis.":[116],"With":[117],"such":[118],"interesting":[119],"findings,":[120],"we":[121],"planned":[122],"to":[123,157,189,229],"determine":[124],"broad-spectrum":[126],"safety":[127,148,297],"5-Loxin(R).":[129,299],"Acute":[130,182],"oral,":[131],"acute":[132,150],"dermal,":[133],"primary":[134],"skin":[135,194],"eye":[137,213],"irritation,":[138],"dose-dependent":[140,233],"90-day":[141,234],"subchronic":[142,235],"toxicity":[143,236],"studies":[144],"were":[145,178],"conducted.":[146],"In":[147],"studies,":[149],"oral":[151],"LD(50)":[152,184],"found":[156,188],"be":[158,190],"greater":[159],"than":[160],"5,000":[161],"mg/kg":[162],"both":[164],"male":[165],"female":[167],"Sprague-Dawley":[168],"rats.":[169],"No":[170],"changes":[171,241,260],"body":[173,251],"weight":[174],"or":[175,268],"adverse":[176,283],"observed":[179],"following":[180],"necropsy.":[181],"dermal":[183],">2,000":[191],"mg/kg.":[192],"Primary":[193,212],"irritation":[195,214],"test":[196,215],"conducted":[198,217],"on":[201,220,265],"New":[202],"Zealand":[203],"Albino":[204],"rabbits":[205,221],"classified":[209,225],"nonirritating.":[211],"5-Loxin":[219],"mildly":[227],"irritating":[228],"eye.":[231],"A":[232],"study":[237],"demonstrated":[238],"no":[239],"significant":[240],"selected":[243],"organ":[244],"weights":[245],"individually":[246],"percentages":[249],"brain":[253],"weights.":[254],"supplementation":[256],"did":[257,279],"not":[258,280],"cause":[259],"hepatic":[262],"DNA":[263],"fragmentation":[264],"30,":[266],"60,":[267],"90":[269],"days":[270],"treatment.":[272],"Hematology,":[273],"clinical":[274],"chemistry,":[275],"histopathological":[277],"evaluations":[278],"show":[281],"any":[282],"all":[286],"organs":[287],"tested.":[288],"Taken":[289],"together,":[290],"these":[291],"results":[292],"demonstrate":[293],"broad":[295],"spectrum":[296]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}