{"id":"https://openalex.org/W2118955716","doi":"https://doi.org/10.1172/jci117863","title":"Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.","display_name":"Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2118955716","doi":"https://doi.org/10.1172/jci117863","mag":"2118955716","pmid":"https://pubmed.ncbi.nlm.nih.gov/7535800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/295720"},"language":"en","primary_location":{"id":"doi:10.1172/jci117863","doi":"https://doi.org/10.1172/jci117863","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117863","pdf_url":"http://www.jci.org/articles/view/117863/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2118955716"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/117863/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068013715","display_name":"David D.R. Marples","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"D Marples","raw_affiliation_strings":["Department of Cell Biology, University of Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Christensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S Christensen","raw_affiliation_strings":["Department of Cell Biology , Institute of Anatomy , University of Aarhus , DK-8000 Aarhus ;","[Aalborg university]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology , Institute of Anatomy , University of Aarhus , DK-8000 Aarhus ;","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"[Aalborg university]","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056562596","display_name":"Erik Christensen","orcid":"https://orcid.org/0000-0003-1754-0778","observed_orcids":["https://orcid.org/0000-0003-1754-0778"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E I Christensen","raw_affiliation_strings":["Department of Pharmacology , University of Copenhagen , DK-2200 Copenhagen ; and","Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark","Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , University of Copenhagen , DK-2200 Copenhagen ; and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus;","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109149955","display_name":"P D Ottosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210153757","display_name":"Regional Hospital Randers","ror":"https://ror.org/05n00ke18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210153757"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P D Ottosen","raw_affiliation_strings":["Department of Cell Biology , Institute of Anatomy , University of Aarhus , DK-8000 Aarhus ;","Department of Pharmacology, University of Copenhagen, DK-2200 Copenhagen; and tInstitute of Pathology,","Randers Hospital, DK-8900 Randers, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology , Institute of Anatomy , University of Aarhus , DK-8000 Aarhus ;","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Pharmacology, University of Copenhagen, DK-2200 Copenhagen; and tInstitute of Pathology,","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Randers Hospital, DK-8900 Randers, Denmark","institution_ids":["https://openalex.org/I4210153757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088941482","display_name":"S\u00f8ren M\u00f8ller Nielsen","orcid":"https://orcid.org/0000-0002-4414-2508","observed_orcids":["https://orcid.org/0000-0002-4414-2508"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210153757","display_name":"Regional Hospital Randers","ror":"https://ror.org/05n00ke18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210153757"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S Nielsen","raw_affiliation_strings":["Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark","tInstitute of Pathology , Randers Hospital , DK-8900 Randers , Denmark","Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"tInstitute of Pathology , Randers Hospital , DK-8900 Randers , Denmark","institution_ids":["https://openalex.org/I4210153757"]},{"raw_affiliation_string":"Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus;","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":6.3286,"has_fulltext":true,"cited_by_count":432,"citation_normalized_percentile":{"value":0.97727273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"95","issue":"4","first_page":"1838","last_page":"1845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.8799999952316284},{"id":"https://openalex.org/keywords/aquaporin-2","display_name":"aquaporin-2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nephrogenic-diabetes-insipidus","display_name":"nephrogenic diabetes insipidus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/renal-medulla","display_name":"renal medulla","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.7710000276565552},{"id":"https://openalex.org/keywords/polyuria","display_name":"polyuria","score":0.902999997138977},{"id":"https://openalex.org/keywords/thirst","display_name":"thirst","score":0.5490000247955322},{"id":"https://openalex.org/keywords/desmopressin","display_name":"desmopressin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/urinary-concentrating-defect","display_name":"urinary concentrating defect","score":0.8939999938011169},{"id":"https://openalex.org/keywords/bipolar-disorder-treatment","display_name":"bipolar disorder treatment","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C85562759","wikidata":"https://www.wikidata.org/wiki/Q14902527","display_name":"Aquaporin 2","level":4,"score":0.953393816947937},{"id":"https://openalex.org/C2777464133","wikidata":"https://www.wikidata.org/wiki/Q2892779","display_name":"Nephrogenic diabetes insipidus","level":3,"score":0.7728855609893799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6718711853027344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6379097104072571},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6290451884269714},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.550003170967102},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5351020097732544},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.5233054161071777},{"id":"https://openalex.org/C30030713","wikidata":"https://www.wikidata.org/wiki/Q17029513","display_name":"Immunogold labelling","level":3,"score":0.5219904184341431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4692186117172241},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.43200793862342834},{"id":"https://openalex.org/C2780180277","wikidata":"https://www.wikidata.org/wiki/Q1124286","display_name":"Polyuria","level":3,"score":0.41354721784591675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3419071137905121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30096906423568726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1971568763256073},{"id":"https://openalex.org/C2775845273","wikidata":"https://www.wikidata.org/wiki/Q7973466","display_name":"Water channel","level":3,"score":0.13641738891601562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12853515148162842},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0691281259059906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.0},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003894","descriptor_name":"Deamino Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005629","descriptor_name":"Frozen Sections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011141","descriptor_name":"Polyuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014868","descriptor_name":"Water Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018500","descriptor_name":"Diabetes Insipidus, Nephrogenic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D020346","descriptor_name":"Aquaporins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051403","descriptor_name":"Aquaporin 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci117863","doi":"https://doi.org/10.1172/jci117863","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117863","pdf_url":"http://www.jci.org/articles/view/117863/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:7535800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:295720","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC295720/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/4513ba00-74cd-11db-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/4513ba00-74cd-11db-bee9-02004c4f4f50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marples , D , Christensen , S , Christensen , E I , Ottesen , P D & Nielsen , S 1995 , ' Lithium-induced Downregulation of Aquaporin-2 Water Cannel Expression in Rat Kidney Medulla ' , Journal of Clinical Investigation , no. 95 , pp. 1838-1845 .","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/2b93b770-0abd-11dc-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/2b93b770-0abd-11dc-bee9-02004c4f4f50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marples, D, Christensen, S, Christensen, E I, Ottosen, P D & Nielsen, S 1995, 'Lithium-induced downregulation of Aquaporin-2 water channel expression in rat kidney medulla', J. Clin. Invest., vol. 95, pp. 1838-1845.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci117863","doi":"https://doi.org/10.1172/jci117863","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci117863","pdf_url":"http://www.jci.org/articles/view/117863/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320332676","display_name":"Forskerakademiet","ror":"https://ror.org/00h2bx184"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320335119","display_name":"Fonden til L\u00e6gevidenskabens Fremme","ror":"https://ror.org/02kdrgt12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118955716.pdf","grobid_xml":"https://content.openalex.org/works/W2118955716.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W123775857","https://openalex.org/W218175079","https://openalex.org/W1819269509","https://openalex.org/W1834531680","https://openalex.org/W2018779154","https://openalex.org/W2027475869","https://openalex.org/W2032789959","https://openalex.org/W2036357581","https://openalex.org/W2040010386","https://openalex.org/W2043612532","https://openalex.org/W2052851574","https://openalex.org/W2075084351","https://openalex.org/W2079126167","https://openalex.org/W2080073299","https://openalex.org/W2080699605","https://openalex.org/W2082414348","https://openalex.org/W2093407677","https://openalex.org/W2095366077","https://openalex.org/W2132149363","https://openalex.org/W2148984043","https://openalex.org/W2177935186","https://openalex.org/W2191454809","https://openalex.org/W3035877465","https://openalex.org/W4233003197","https://openalex.org/W4254851986","https://openalex.org/W4297572184","https://openalex.org/W6658455359"],"related_works":["https://openalex.org/W2080101745","https://openalex.org/W2060471952","https://openalex.org/W2048808898","https://openalex.org/W2167138698","https://openalex.org/W3023447619","https://openalex.org/W160047280","https://openalex.org/W7160949536","https://openalex.org/W2072469560","https://openalex.org/W2070502223","https://openalex.org/W2159049721"],"abstract_inverted_index":{"Lithium,":[0],"a":[1],"widely":[2],"used":[3],"treatment":[4,61],"for":[5,53,119],"bipolar":[6],"affective":[7],"disorders,":[8],"often":[9],"causes":[10,186],"nephrogenic":[11],"diabetes":[12],"insipidus.":[13],"The":[14,108],"effect":[15],"of":[16,23,41,84,125,136,141,148,168,174,189,197,207],"chronic":[17],"lithium":[18,60,185],"therapy":[19],"on":[20],"the":[21,24,48,92,145,178],"expression":[22,64,97,152],"vasopressin-regulated":[25],"water":[26],"channel":[27],"Aquaporin-2":[28],"(AQP2)":[29],"in":[30,95,144,177],"rat":[31],"kidney":[32,43],"was":[33,51,110],"examined.":[34],"Membranes":[35],"were":[36],"prepared":[37],"from":[38,44,210],"inner":[39],"medulla":[40],"one":[42,50],"each":[45],"rat,":[46],"while":[47],"contralateral":[49],"fixed":[52],"immunofluorescence":[54],"and":[55,73,88,129,155,181],"immunoelectronmicroscopy.":[56],"Immunoblotting":[57],"revealed":[58,132],"that":[59,133],"reduced":[62],"AQP2":[63,96,151,165,175,190],"dramatically,":[65],"to":[66,74,102,116],"31":[67],"+/-":[68,76,100,104,123],"8%":[69,124],"after":[70,78],"10":[71],"d":[72,135,140],"4":[75],"1%":[77],"25":[79],"d,":[80],"coincident":[81,158],"with":[82,159,204],"development":[83],"severe":[85],"polyuria.":[86],"Immunofluorescence":[87],"immunogold":[89,130],"quantitation":[90,131],"confirmed":[91],"lithium-induced":[93,211],"decrease":[94],"(from":[98],"11.2":[99],"1.0":[101],"1.1":[103],"0.2":[105],"particles/microns":[106],"2).":[107],"downregulation":[109,188],"only":[111,192],"partly":[112],"reversed":[113,194],"by":[114,153,195],"return":[115],"lithium-free":[117],"diet":[118],"1":[120],"wk":[121],"(40":[122],"control).":[126],"Furthermore,":[127],"immunoblotting":[128],"2":[134],"thirsting":[137,199],"or":[138,200],"7":[139],"dDAVP":[142,171,201],"treatment,":[143,202],"continued":[146],"presence":[147],"lithium,":[149],"increased":[150,160,164],"six-":[154],"threefold,":[156],"respectively,":[157],"urinary":[161,212],"osmolality.":[162],"Thirsting":[163],"immunolabeling":[166],"mainly":[167],"vesicles,":[169],"whereas":[170],"caused":[172],"accumulation":[173],"predominantly":[176],"subapical":[179],"region":[180],"plasma":[182],"membrane.":[183],"Thus,":[184],"marked":[187],"expression,":[191],"partially":[193],"cessation":[196],"therapy,":[198],"consistent":[203],"clinical":[205],"observations":[206],"slow":[208],"recovery":[209],"concentrating":[213],"defects.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
