{"id":"https://openalex.org/W2118946119","doi":"https://doi.org/10.1093/intimm/dxp023","title":"T cell sensitivity to TGF- is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber","display_name":"T cell sensitivity to TGF- is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber","publication_year":2009,"publication_date":"2009-03-26","ids":{"openalex":"https://openalex.org/W2118946119","doi":"https://doi.org/10.1093/intimm/dxp023","mag":"2118946119","pmid":"https://pubmed.ncbi.nlm.nih.gov/19325036"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/dxp023","doi":"https://doi.org/10.1093/intimm/dxp023","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxp023","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2675031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006276414","display_name":"Robert E. Cone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. E. Cone","raw_affiliation_strings":["Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030-3105, USA. cone@uchc.edu","Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT 06030-3105, USA","Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030-3105, USA. cone@uchc.edu","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT 06030-3105, USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Chattopadhyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Chattopadhyay","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019891745","display_name":"Roshanak Sharafieh","orcid":"https://orcid.org/0000-0003-3396-7544","observed_orcids":["https://orcid.org/0000-0003-3396-7544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Sharafieh","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003067002","display_name":"Yen Lemire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Lemire","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014161485","display_name":"James O\u2019Rourke","orcid":"https://orcid.org/0000-0003-4150-403X","observed_orcids":["https://orcid.org/0000-0003-4150-403X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. O'Rourke","raw_affiliation_strings":["Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT 06030-3105, USA","Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Lions Vascular Vision Center, University of Connecticut Health Center, Farmington, CT 06030-3105, USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064443404","display_name":"Richard Anthony Flavell","orcid":"https://orcid.org/0000-0003-4461-0778","observed_orcids":["https://orcid.org/0000-0003-4461-0778"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. Flavell","raw_affiliation_strings":["Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, TAC S-569 Box 208011, New Haven, CT 06520-1601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, TAC S-569 Box 208011, New Haven, CT 06520-1601, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088661165","display_name":"Robert B. Clark","orcid":"https://orcid.org/0000-0002-7660-5263","observed_orcids":["https://orcid.org/0000-0002-7660-5263"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Clark","raw_affiliation_strings":["Center for Immunotherapy of Cancer and Infectious Diseases and Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030-1601, USA","Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy of Cancer and Infectious Diseases and Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030-1601, USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":0.8905,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74485554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"5","first_page":"567","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-regulatory-t-cells","display_name":"CD8+ regulatory T cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cbl-b","display_name":"Cbl-b","score":0.8140000104904175},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.5490000247955322},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.4440000057220459},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6412844061851501},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6172747611999512},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5945960879325867},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5190237760543823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5093687772750854},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4357840418815613},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4338643550872803},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4130447208881378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.384859561920166},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.310912162065506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3036069869995117},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21175062656402588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.050817012786865234}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000867","descriptor_name":"Anterior Chamber","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/intimm/dxp023","doi":"https://doi.org/10.1093/intimm/dxp023","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxp023","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2675031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2675031","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Immunol","raw_type":"Text"},{"id":"pmid:19325036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19325036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2675031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2675031","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2093196249","display_name":null,"funder_award_id":"1R56 AI 072533","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2176826904","display_name":null,"funder_award_id":"EY017537","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5848984276","display_name":"Ocular Regulation of Autoimmunity","funder_award_id":"R01EY017537","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6434252992","display_name":null,"funder_award_id":"EY017289","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G759353905","display_name":"The Role of PPARGamma in the Generation and Function of Tregs","funder_award_id":"1r56ai072533-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7805156572","display_name":"Thymic Influence on Ocular Immunoregulation","funder_award_id":"5r01ey017289-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W130833706","https://openalex.org/W179891234","https://openalex.org/W1486444559","https://openalex.org/W1503852969","https://openalex.org/W1513014113","https://openalex.org/W1546009562","https://openalex.org/W1554580921","https://openalex.org/W1568334393","https://openalex.org/W1596079370","https://openalex.org/W1920195031","https://openalex.org/W1963912509","https://openalex.org/W1975605578","https://openalex.org/W2019497869","https://openalex.org/W2024060364","https://openalex.org/W2026454599","https://openalex.org/W2027913339","https://openalex.org/W2030758522","https://openalex.org/W2039347592","https://openalex.org/W2047430467","https://openalex.org/W2056207471","https://openalex.org/W2069701927","https://openalex.org/W2071360012","https://openalex.org/W2096303665","https://openalex.org/W2098661740","https://openalex.org/W2108860192","https://openalex.org/W2113883987","https://openalex.org/W2114747261","https://openalex.org/W2114954367","https://openalex.org/W2122096954","https://openalex.org/W2122560063","https://openalex.org/W2131484200","https://openalex.org/W2159751491","https://openalex.org/W2160613479","https://openalex.org/W2169410509","https://openalex.org/W2341226735","https://openalex.org/W4237573620","https://openalex.org/W4404443409"],"related_works":["https://openalex.org/W2022425754","https://openalex.org/W1995532972","https://openalex.org/W2020684972","https://openalex.org/W2340237593","https://openalex.org/W2041921061","https://openalex.org/W3030597314","https://openalex.org/W1490833013","https://openalex.org/W1572148375","https://openalex.org/W2187150553","https://openalex.org/W4238746596"],"abstract_inverted_index":{"The":[0,147],"introduction":[1],"of":[2,9,15,37,116,123,143,149,166,199,231,239],"antigen":[3,53,61,144],"into":[4,178],"the":[5,10,13,35,114,121,140,163,179,184,197,205,227,237],"anterior":[6],"chamber":[7],"(AC)":[8],"eye":[11],"induces":[12],"production":[14],"antigen-specific":[16],"splenic":[17,135,172],"CD8(+)":[18,104,126,136,154,173,201,232,246],"regulatory":[19,39,137],"T":[20,40,89,216,234],"cells":[21,41,56,69,90,106,138,156,175,203,235,248],"(AC-SPL":[22],"cells)":[23],"that":[24,215],"suppress":[25],"a":[26,150],"delayed-type":[27],"hypersensitivity":[28],"(DTH)":[29],"reaction":[30,152,181,186,244],"in":[31,62,72,107,157,187,228,241],"immunized":[32,130,188],"mice.":[33],"Because":[34],"generation":[36],"these":[38,68,212],"is":[42,98,221,249],"also":[43],"induced":[44],"by":[45,100,125,153,162,196,245],"exposure":[46],"to":[47,58,93,118,168,204,219],"transforming":[48,77],"growth":[49,78],"factor":[50,79],"(TGF)-beta":[51],"and":[52,60,109,112,131,145,190],"or":[54,85],"F4/80(+)":[55],"exposed":[57],"TGF-beta":[59,119,169,220],"vitro,":[63],"we":[64],"investigated":[65],"(i)":[66],"whether":[67,96],"are":[70,91],"produced":[71,134],"dominant":[73],"negative":[74],"receptor":[75,81],"for":[76,226],"beta":[80],"type":[82,102],"II":[83],"(dnTGFbetaRII)":[84],"Cbl-b(-/-)":[86,108,132,191],"mice":[87,111,133,159,192],"whose":[88],"resistant":[92],"TGF-beta,":[94],"(ii)":[95],"DTH":[97,124,151,180,185,243],"suppressed":[99,195],"wild":[101],"(WT)":[103],"AC-SPL":[105,127,155,174,202,233,247],"dnTGFbetaRII":[110,189],"(iii)":[113],"effect":[115],"antibodies":[117,167],"on":[120,251],"suppression":[122,148,238],"cells.":[128],"DnTGFbetaRII":[129],"after":[139],"intracameral":[141],"injection":[142],"immunization.":[146],"WT":[158,171,200],"was":[160,193],"blocked":[161],"local":[164],"inclusion":[165],"when":[170],"were":[176],"injected":[177],"site.":[182],"Moreover,":[183],"not":[194,222],"transfer":[198],"site":[206],"challenged":[207],"with":[208],"antigen.":[209],"In":[210],"aggregate,":[211],"observations":[213],"suggest":[214],"cell":[217],"sensitivity":[218],"an":[223,240],"obligate":[224],"requirement":[225],"vivo":[229,242],"induction":[230],"but":[236],"dependent":[250],"TGF-beta.":[252]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}