{"id":"https://openalex.org/W2118936358","doi":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","title":"Differential Downregulation of GABAAReceptor Subunits in Widespread Brain Regions in the Freeze-Lesion Model of Focal Cortical Malformations","display_name":"Differential Downregulation of GABAAReceptor Subunits in Widespread Brain Regions in the Freeze-Lesion Model of Focal Cortical Malformations","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2118936358","doi":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","mag":"2118936358","pmid":"https://pubmed.ncbi.nlm.nih.gov/10864962"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.20-13-05045.2000","doi":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","pdf_url":"https://www.jneurosci.org/content/jneuro/20/13/5045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/20/13/5045.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010343687","display_name":"Christoph Redecker","orcid":"https://orcid.org/0000-0001-7452-0525","observed_orcids":["https://orcid.org/0000-0001-7452-0525"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Redecker","raw_affiliation_strings":["Department of Neurology and","Department of Neurology and Institute of Neurophysiology, Heinrich-Heine-University, D-40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology and Institute of Neurophysiology, Heinrich-Heine-University, D-40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065994712","display_name":"Heiko J. Luhmann","orcid":"https://orcid.org/0000-0002-7934-8661","observed_orcids":["https://orcid.org/0000-0002-7934-8661"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko J. Luhmann","raw_affiliation_strings":["Institute of Neurophysiology, Heinrich-Heine-University, D-40225 D\u00fcsseldorf, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurophysiology, Heinrich-Heine-University, D-40225 D\u00fcsseldorf, Germany, and","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013080680","display_name":"Georg Hagemann","orcid":"https://orcid.org/0009-0009-4975-179X","observed_orcids":["https://orcid.org/0009-0009-4975-179X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg Hagemann","raw_affiliation_strings":["Department of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052503226","display_name":"Jean\u2010Marc Fritschy","orcid":"https://orcid.org/0000-0002-8552-3702","observed_orcids":["https://orcid.org/0000-0002-8552-3702"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Marc Fritschy","raw_affiliation_strings":["Institute of Pharmacology, University of Z\u00fcrich, CH-8057 Z\u00fcrich, Switzerland","Institute of Pharmacology, University of Zurich, CH-8057 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Z\u00fcrich, CH-8057 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Institute of Pharmacology, University of Zurich, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016603751","display_name":"Otto Wilhelm Witte","orcid":"https://orcid.org/0000-0003-2101-4105","observed_orcids":["https://orcid.org/0000-0003-2101-4105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otto W. Witte","raw_affiliation_strings":["Department of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.896,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.95269253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"20","issue":"13","first_page":"5045","last_page":"5053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor-subunits","display_name":"GABAA receptor subunits","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neonatal-brain-injury","display_name":"neonatal brain injury","score":0.593999981880188},{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.5410000085830688},{"id":"https://openalex.org/keywords/hyperexcitability","display_name":"hyperexcitability","score":0.7239999771118164},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.4690000116825104},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6830000281333923},{"id":"https://openalex.org/keywords/neocortex","display_name":"neocortex","score":0.6179999709129333},{"id":"https://openalex.org/keywords/subunit-composition","display_name":"subunit composition","score":0.5580000281333923},{"id":"https://openalex.org/keywords/alpha5-subunit","display_name":"alpha5 subunit","score":0.7480000257492065},{"id":"https://openalex.org/keywords/gamma2-subunit","display_name":"gamma2 subunit","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cortical-dysplasia","display_name":"cortical dysplasia","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7589999437332153},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7222315073013306},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6708871126174927},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6435373425483704},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.5933380126953125},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.577579140663147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5447129607200623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4685899615287781},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4525853097438812},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.42956840991973877},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.42690014839172363},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.42634913325309753},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.41497549414634705},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2733415365219116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16701769828796387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11242538690567017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.20-13-05045.2000","doi":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","pdf_url":"https://www.jneurosci.org/content/jneuro/20/13/5045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:10864962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10864962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5749941","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6772268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6772268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6772268","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.324.7739","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.7739","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://physiologie.uni-mainz.de/physio/luhmann/067.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.20-13-05045.2000","doi":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.20-13-05045.2000","pdf_url":"https://www.jneurosci.org/content/jneuro/20/13/5045.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118936358.pdf","grobid_xml":"https://content.openalex.org/works/W2118936358.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W111104","https://openalex.org/W1551663317","https://openalex.org/W1554692577","https://openalex.org/W1964287283","https://openalex.org/W1983532871","https://openalex.org/W1985220401","https://openalex.org/W1986903653","https://openalex.org/W1998236920","https://openalex.org/W2002287054","https://openalex.org/W2004371395","https://openalex.org/W2005492539","https://openalex.org/W2006771521","https://openalex.org/W2008492335","https://openalex.org/W2011353598","https://openalex.org/W2019119601","https://openalex.org/W2025256394","https://openalex.org/W2027970152","https://openalex.org/W2038567507","https://openalex.org/W2039738625","https://openalex.org/W2046722406","https://openalex.org/W2050382554","https://openalex.org/W2050385725","https://openalex.org/W2055590786","https://openalex.org/W2062541970","https://openalex.org/W2074417504","https://openalex.org/W2075723143","https://openalex.org/W2077506421","https://openalex.org/W2079083206","https://openalex.org/W2079425072","https://openalex.org/W2082956732","https://openalex.org/W2083954196","https://openalex.org/W2091393718","https://openalex.org/W2100535980","https://openalex.org/W2106512757","https://openalex.org/W2124079851","https://openalex.org/W2130215954","https://openalex.org/W2131234693","https://openalex.org/W2136807926","https://openalex.org/W2157450933","https://openalex.org/W2162666247","https://openalex.org/W2167636494","https://openalex.org/W2207725518","https://openalex.org/W2231078989","https://openalex.org/W2303631713","https://openalex.org/W2334662310","https://openalex.org/W2401699257","https://openalex.org/W2403424936","https://openalex.org/W2407377771","https://openalex.org/W2439046886","https://openalex.org/W2443205685","https://openalex.org/W4238823049","https://openalex.org/W4300787910","https://openalex.org/W4406059090"],"related_works":["https://openalex.org/W2057524090","https://openalex.org/W2273563535","https://openalex.org/W2140588832","https://openalex.org/W2135835495","https://openalex.org/W2087599741","https://openalex.org/W2062055081","https://openalex.org/W2044057114","https://openalex.org/W1964177466","https://openalex.org/W2067940293","https://openalex.org/W2432783729"],"abstract_inverted_index":{"Focal":[0],"cortical":[1,26,63,101],"malformations":[2,27,64],"comprise":[3],"a":[4,75,118,201],"heterogeneous":[5],"group":[6],"of":[7,9,25,42,51,87,124,160,189,191,204,219],"disturbances":[8,179],"brain":[10],"development,":[11],"commonly":[12],"associated":[13],"with":[14,61,80],"drug-resistant":[15],"epilepsy":[16],"and/or":[17],"neuropsychological":[18],"deficits.":[19],"Electrophysiological":[20],"studies":[21],"on":[22],"rodent":[23],"models":[24],"demonstrated":[28],"intrinsic":[29],"hyperexcitability":[30,229],"in":[31,48,58,180,209,236],"the":[32,35,100,116,131,134,158,166,181,196,214,227],"lesion":[33],"and":[34,44,95,111,120,142,148,183,216,230],"structurally":[36],"intact":[37],"surround,":[38],"indicating":[39,177],"widespread":[40,178,228],"imbalances":[41],"excitation":[43],"inhibition.":[45],"Here,":[46],"alterations":[47,208,223],"regional":[49],"expression":[50],"GABA(A)":[52,88,161,192,220],"receptor":[53,89,162,193],"subunits":[54,90,109,126,145,163,194],"were":[55],"investigated":[56],"immunohistochemically":[57],"adult":[59],"rats":[60],"focal":[62],"attributable":[65],"to":[66,77,115,130,226,232],"neonatal":[67],"freeze-lesions.":[68],"These":[69],"lesions":[70],"are":[71],"morphologically":[72],"characterized":[73],"by":[74],"three-":[76],"four-layered":[78],"cortex":[79],"microsulcus":[81],"formation.":[82],"Widespread":[83],"regionally":[84],"differential":[85],"reduction":[86],"alpha1,":[91,146],"alpha2,":[92,147],"alpha3,":[93],"alpha5,":[94,149],"gamma2":[96,141],"was":[97,105,127,136,153],"observed.":[98],"Within":[99],"malformation,":[102],"this":[103],"downregulation":[104,159,190],"most":[106,137],"prominent":[107,138],"for":[108,139,144],"alpha5":[110],"gamma2,":[112],"whereas":[113,150],"medial":[114],"lesion,":[117],"significant":[119],"even":[121],"stronger":[122],"decrease":[123,135],"all":[125],"detected.":[128],"Lateral":[129],"dysplastic":[132],"cortex,":[133],"subunit":[140,151,205,210],"moderate":[143],"alpha3":[152],"not":[154],"consistently":[155],"altered.":[156],"Interestingly,":[157],"also":[164],"involved":[165],"ipsilateral":[167],"hippocampal":[168,184],"formation,":[169],"as":[170,172],"well":[171],"restricted":[173],"contralateral":[174],"neocortical":[175,182],"areas,":[176],"network.":[185],"The":[186],"described":[187],"pattern":[188],"allows":[195],"conclusion":[197],"that":[198],"there":[199],"is":[200],"considerable":[202],"modulation":[203],"composition.":[206],"Because":[207],"composition":[211],"critically":[212],"influence":[213],"electrophysiological":[215],"pharmacological":[217],"properties":[218],"receptors,":[221],"these":[222],"might":[224],"contribute":[225],"help":[231],"explain":[233],"pharmacotherapeutic":[234],"characteristics":[235],"epileptic":[237],"patients.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}