{"id":"https://openalex.org/W2118933235","doi":"https://doi.org/10.1136/jcp.45.8.742-b","title":"Modifying the request behaviour of clinicians.","display_name":"Modifying the request behaviour of clinicians.","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2118933235","doi":"https://doi.org/10.1136/jcp.45.8.742-b","mag":"2118933235","pmid":"https://pubmed.ncbi.nlm.nih.gov/1401196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/495165"},"language":"en","primary_location":{"id":"doi:10.1136/jcp.45.8.742-b","doi":"https://doi.org/10.1136/jcp.45.8.742-b","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.45.8.742-b","pdf_url":"https://jcp.bmj.com/content/jclinpath/45/8/742.2.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jcp.bmj.com/content/jclinpath/45/8/742.2.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113769072","display_name":"T. E. Blecher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T E Blecher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113769072"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"8","first_page":"742.2","last_page":"743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vitamin-k-deficiency","display_name":"vitamin K deficiency","score":0.8259999752044678},{"id":"https://openalex.org/keywords/vitamin-k-supplementation","display_name":"vitamin K supplementation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/factor-viia","display_name":"factor VIIa","score":0.4339999854564667},{"id":"https://openalex.org/keywords/antibiotic-use","display_name":"antibiotic use","score":0.6460000276565552},{"id":"https://openalex.org/keywords/assay-reliability","display_name":"assay reliability","score":0.3880000114440918},{"id":"https://openalex.org/keywords/monoclonal-antibody-immunoassay","display_name":"monoclonal antibody assay","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45026543736457825},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.43125855922698975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4124950170516968},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4014444351196289},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3982675075531006},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3750218152999878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1797739863395691},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007755","descriptor_name":"Laboratories, Hospital","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D011787","descriptor_name":"Quality of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016526","descriptor_name":"Workload","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/jcp.45.8.742-b","doi":"https://doi.org/10.1136/jcp.45.8.742-b","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.45.8.742-b","pdf_url":"https://jcp.bmj.com/content/jclinpath/45/8/742.2.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:1401196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1401196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pathology","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:495165","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC495165/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Pathol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/jcp.45.8.742-b","doi":"https://doi.org/10.1136/jcp.45.8.742-b","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.45.8.742-b","pdf_url":"https://jcp.bmj.com/content/jclinpath/45/8/742.2.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118933235.pdf","grobid_xml":"https://content.openalex.org/works/W2118933235.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W59486429","https://openalex.org/W1968943493","https://openalex.org/W1975640639","https://openalex.org/W1980303527","https://openalex.org/W1986891908","https://openalex.org/W1993341494","https://openalex.org/W2018239509","https://openalex.org/W2030712191","https://openalex.org/W2035291374","https://openalex.org/W2044742839","https://openalex.org/W2045382514","https://openalex.org/W2074929045","https://openalex.org/W2075401970","https://openalex.org/W2078104442","https://openalex.org/W2086393273","https://openalex.org/W2088712225","https://openalex.org/W2093581114","https://openalex.org/W2166728168","https://openalex.org/W2325016013","https://openalex.org/W2325029863"],"related_works":["https://openalex.org/W1974902113","https://openalex.org/W3032903716","https://openalex.org/W2946931133","https://openalex.org/W3033085412","https://openalex.org/W2947208326","https://openalex.org/W3033613369","https://openalex.org/W4281735063","https://openalex.org/W7163217842","https://openalex.org/W2947059686","https://openalex.org/W4281962378"],"abstract_inverted_index":{"PIVKA-II":[0,11,41,74,89,117,134,162],"concentrations":[1],"in":[2,14,44,102,135],"patients":[3,17,139,157],"with":[4,18,55,60,140,146,158],"cystic":[5,19,141,159],"fibrosisMontalembert":[6],"et":[7,81],"al":[8,82],"report":[9],"that":[10,31,49,92],"was":[12,42,121,161],"detected":[13],"33%":[15],"of":[16,35,63,96,116,137,154,175,181],"fibrosis,":[20],"while":[21],"vitamin":[22,56,147,172,187,190,192],"K,":[23,148,173,193],"plasma":[24],"concentra-":[25],"tions":[26],"were":[27,144],"normal.'It":[28],"is":[29,52,65,79],"astonishing":[30],"despite":[32],"daily":[33],"supplements":[34],"5-10":[36],"mg":[37],"vita-":[38],"min":[39],"K,,":[40,191],"detectable":[43],"these":[45],"patients.The":[46],"authors":[47,78,183],"conclude":[48],"PIVKA-":[50],"II":[51,99],"not":[53,111,132,185],"associated":[54],"K":[57],"deficiency,":[58],"but":[59],"the":[61,71,77,107,125],"use":[62],"antibiotics.There":[64],"some":[66],"doubt":[67],"as":[68],"to":[69,123],"whether":[70],"assay":[72],"for":[73,87,189],"used":[75],"by":[76,118],"reliable.Widdershoven":[80],"compared":[83],"differ-":[84],"ent":[85],"methods":[86],"measuring":[88],"and":[90,128,178],"reported":[91],"techniques":[93],"involving":[94],"adsorption":[95],"normal":[97],"factor":[98],"may":[100,110],"result":[101],"false":[103],"positive":[104],"values,":[105],"because":[106],"carboxylated":[108],"prothrombin":[109],"be":[112,124,195],"removed":[113],"com-":[114],"pletely.2Determination":[115],"monoclonal":[119],"antibody":[120],"found":[122,163],"most":[126],"specific":[127],"sensitive":[129],"method.2We":[130],"did":[131],"detect":[133],"any":[136],"eight":[138],"fibrosis":[142,160],"who":[143],"supplemented":[145],"(4-30":[149],"mg/day).3In":[150],"only":[151],"one":[152],"out":[153],"16":[155],"unsupplemented":[156],"(0-16":[164],"AU/ml).This":[165],"patient":[166],"took":[167],"antibiotics,":[168],"had":[169],"a":[170,179],"low":[171],"concentration":[174],"0-06":[176],",ug/l":[177],"Thrombotest":[180],"56%.3The":[182],"do":[184],"mention":[186],"K,.Except":[188],"must":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}