{"id":"https://openalex.org/W2118921871","doi":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","title":"Plasma Amino Acids in Phenylketonuric Children Treated Either with Phenylalanine\u2010free Amino Acids or a Protein Hydrolysate","display_name":"Plasma Amino Acids in Phenylketonuric Children Treated Either with Phenylalanine\u2010free Amino Acids or a Protein Hydrolysate","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2118921871","doi":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","mag":"2118921871","pmid":"https://pubmed.ncbi.nlm.nih.gov/2316364"},"language":"en","primary_location":{"id":"doi:10.1111/j.1651-2227.1990.tb11333.x","doi":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076048557","display_name":"Anne\u2010Marie Gerdes","orcid":"https://orcid.org/0000-0002-0328-3320","observed_orcids":["https://orcid.org/0000-0002-0328-3320"]},"institutions":[{"id":"https://openalex.org/I4210094934","display_name":"Kennedy Center","ror":"https://ror.org/00kzzgw26","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210094934"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"A. \u2010M. GERDES","raw_affiliation_strings":["John F. Kennedy Institute, Glostrup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John F. Kennedy Institute, Glostrup, Denmark","institution_ids":["https://openalex.org/I4210094934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102336218","display_name":"Jytte Bieber Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094934","display_name":"Kennedy Center","ror":"https://ror.org/00kzzgw26","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210094934"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J. B. NIELSEN","raw_affiliation_strings":["From The John F. Kennedy Institute, Glostrup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The John F. Kennedy Institute, Glostrup, Denmark","institution_ids":["https://openalex.org/I4210094934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045965373","display_name":"H. C. LOU","orcid":"https://orcid.org/0009-0007-3413-7821","observed_orcids":["https://orcid.org/0009-0007-3413-7821"]},"institutions":[{"id":"https://openalex.org/I4210094934","display_name":"Kennedy Center","ror":"https://ror.org/00kzzgw26","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210094934"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H. LOU","raw_affiliation_strings":["From The John F. Kennedy Institute, Glostrup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The John F. Kennedy Institute, Glostrup, Denmark","institution_ids":["https://openalex.org/I4210094934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112759011","display_name":"Flemming G\u00fcttler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094934","display_name":"Kennedy Center","ror":"https://ror.org/00kzzgw26","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I4210094934"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"F. G\u00dcTTLER","raw_affiliation_strings":["From The John F. Kennedy Institute, Glostrup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The John F. Kennedy Institute, Glostrup, Denmark","institution_ids":["https://openalex.org/I4210094934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076048557"],"corresponding_institution_ids":["https://openalex.org/I4210094934"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.1938,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.4347032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"1","first_page":"69","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":1.0},{"id":"https://openalex.org/keywords/plasma-amino-acids","display_name":"plasma amino acids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-hydrolysates","display_name":"protein hydrolysates","score":0.9240000247955322},{"id":"https://openalex.org/keywords/isoleucine","display_name":"isoleucine","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dietary-therapy","display_name":"dietary therapy","score":0.5350000262260437},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.9044969081878662},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.8677513003349304},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.8526084423065186},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7917083501815796},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.7521566152572632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6165000796318054},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5930655002593994},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.5097464919090271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5088586807250977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4630681574344635},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.36470818519592285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31077325344085693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1865626573562622},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007225","descriptor_name":"Infant Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010661","descriptor_name":"Phenylketonurias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010661","descriptor_name":"Phenylketonurias","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D011492","descriptor_name":"Protein Hydrolysates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1651-2227.1990.tb11333.x","doi":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1651-2227.1990.tb11333.x","pdf_url":null,"source":{"id":"https://openalex.org/S178469169","display_name":"Acta Paediatrica","issn_l":"0365-1436","issn":["0365-1436","0803-5253","1651-2227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Paediatrica","raw_type":"journal-article"},{"id":"pmid:2316364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2316364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta paediatrica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1906723555","https://openalex.org/W1999816987","https://openalex.org/W2015795054","https://openalex.org/W2033091614","https://openalex.org/W2038030566","https://openalex.org/W2093463738"],"related_works":["https://openalex.org/W2015795054","https://openalex.org/W1935007071","https://openalex.org/W1983860328","https://openalex.org/W4242482532","https://openalex.org/W1987868198","https://openalex.org/W3049542835","https://openalex.org/W2168667371","https://openalex.org/W2093109710","https://openalex.org/W1985192314","https://openalex.org/W1990289924"],"abstract_inverted_index":{"The":[0,30,42],"plasma":[1],"amino":[2,16,44,53,98],"acid":[3,17,45,54],"concentrations":[4,55],"were":[5,33,56,77],"measured":[6],"in":[7,111],"10":[8],"children":[9,23,112],"with":[10],"phenylketonuria":[11],"(PKU)":[12],"on":[13,24,72,80,102,113],"the":[14,25,40,47,51,68,73,89],"phenylalanine-free":[15,26],"mixture":[18],"Phenyldon":[19,81],"and":[20,36,50,59,84],"9":[21],"PKU":[22],"protein":[27],"hydrolysate":[28],"Albumaid.":[29],"blood":[31],"samples":[32],"taken":[34],"fasting":[35,83],"two":[37,74],"hours":[38],"after":[39],"meal.":[41],"individual":[43],"concentrations,":[46],"glycine/valine":[48],"ratios,":[49],"total":[52],"mutually":[57],"compared":[58,61],"also":[60],"to":[62],"reference":[63,90],"intervals.":[64,91],"No":[65],"differences":[66],"of":[67,70,96],"concentration":[69],"phenylalanine":[71],"diet":[75,104],"formulas":[76],"observed.":[78],"Children":[79],"showed":[82],"postprandial":[85,94],"isoleucine":[86],"higher":[87],"than":[88],"Furthermore,":[92],"a":[93],"increase":[95],"several":[97],"acids":[99],"was":[100,108],"observed":[101],"both":[103],"formulas.":[105],"This":[106],"response":[107],"statistically":[109],"significant":[110],"Phenyldon.":[114]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}