{"id":"https://openalex.org/W2118913158","doi":null,"title":"Mathematical model of granulocytopoiesis and chronic myelogenous leukemia.","display_name":"Mathematical model of granulocytopoiesis and chronic myelogenous leukemia.","publication_year":1991,"publication_date":"1991-04-15","ids":{"openalex":"https://openalex.org/W2118913158","mag":"2118913158","pmid":"https://pubmed.ncbi.nlm.nih.gov/2009527"},"language":"en","primary_location":{"id":"pmid:2009527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2009527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007372240","display_name":"ATHANASSIOS S. FOKAS","orcid":"https://orcid.org/0000-0002-5881-802X","observed_orcids":["https://orcid.org/0000-0002-5881-802X","https://orcid.org/0000-0002-1198-1081"]},"institutions":[{"id":"https://openalex.org/I16944753","display_name":"Clarkson University","ror":"https://ror.org/03rwgpn18","country_code":"US","type":"education","lineage":["https://openalex.org/I16944753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A S Fokas","raw_affiliation_strings":["Department of Mathematics and Computer Science, Clarkson University, Potsdam, New York 13699-5815"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Clarkson University, Potsdam, New York 13699-5815","institution_ids":["https://openalex.org/I16944753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108775680","display_name":"Joseph Bishop Keller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Keller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112065729","display_name":"B Clarkson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Clarkson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0511,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.7512505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"8","first_page":"2084","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.15929999947547913,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-maturation","display_name":"cell maturation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/p210-bcr-abl","display_name":"p210 BCR-ABL","score":0.8529999852180481},{"id":"https://openalex.org/keywords/leukemia-cell-proliferation","display_name":"leukemia cell proliferation","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.7801313400268555},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5795965194702148},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5684988498687744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4895128011703491},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48037251830101013},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44030100107192993},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4402342438697815},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35604357719421387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32478123903274536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15818768739700317}],"mesh":[{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2009527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2009527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2118913158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2009527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7427769988","display_name":"HUMAN HEMATOPOIETIC TUMORS PROGRAM PROJECT","funder_award_id":"P01CA020194","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W111315174","https://openalex.org/W166095048","https://openalex.org/W1562122669","https://openalex.org/W1591430657","https://openalex.org/W1964895030","https://openalex.org/W1973312385","https://openalex.org/W1987759419","https://openalex.org/W1990406235","https://openalex.org/W1998593414","https://openalex.org/W2011917769","https://openalex.org/W2013332168","https://openalex.org/W2020092689","https://openalex.org/W2025449990","https://openalex.org/W2025535815","https://openalex.org/W2027734054","https://openalex.org/W2028193648","https://openalex.org/W2029508196","https://openalex.org/W2036631709","https://openalex.org/W2043761464","https://openalex.org/W2051238176","https://openalex.org/W2057323377","https://openalex.org/W2060856724","https://openalex.org/W2065897990","https://openalex.org/W2067455586","https://openalex.org/W2070076558","https://openalex.org/W2076372887","https://openalex.org/W2085325334","https://openalex.org/W2093723960","https://openalex.org/W2097857054","https://openalex.org/W2111759041","https://openalex.org/W2122455557","https://openalex.org/W2134812776","https://openalex.org/W2148856561","https://openalex.org/W2149025884","https://openalex.org/W2152913296","https://openalex.org/W2170628295","https://openalex.org/W2220386737","https://openalex.org/W2248991688","https://openalex.org/W2275311108","https://openalex.org/W2320932616","https://openalex.org/W2342898717","https://openalex.org/W2397280904","https://openalex.org/W2408132225","https://openalex.org/W2411520984","https://openalex.org/W2412126852","https://openalex.org/W2414390274","https://openalex.org/W2429410018","https://openalex.org/W2438485880"],"related_works":["https://openalex.org/W2030580742","https://openalex.org/W2042958192","https://openalex.org/W3213154242","https://openalex.org/W7096632119","https://openalex.org/W120951549","https://openalex.org/W2328318666","https://openalex.org/W2119584141","https://openalex.org/W4233612401","https://openalex.org/W2469683579","https://openalex.org/W2028764171"],"abstract_inverted_index":{"We":[0],"present":[1],"a":[2,68,92],"mathematical":[3],"model":[4,22,36,66,107],"of":[5,18,95,119,142,148],"granulocytopoiesis":[6],"that":[7,29,91],"depends":[8],"on":[9],"certain":[10],"physiologically":[11],"meaningful":[12],"parameters.":[13],"By":[14],"choosing":[15],"different":[16],"values":[17],"these":[19],"parameters,":[20],"the":[21,25,39,48,54,72,80,117,130,134,140,143],"describes":[23],"both":[24],"normal":[26,55],"process":[27,60],"and":[28,57,76,78,86,121,125],"in":[30,111,123,126,133],"chronic":[31],"myelogenous":[32],"leukemia":[33],"(CML).":[34],"The":[35,65,106],"fits":[37],"all":[38],"available":[40],"experimental":[41],"data":[42],"tested.":[43],"Furthermore,":[44],"it":[45],"shows":[46],"how":[47,58],"CML":[49,96,124],"cells":[50,56,97],"can":[51,61],"ultimately":[52],"outnumber":[53],"this":[59],"be":[62,109],"very":[63],"slow.":[64],"provides":[67],"quantitative":[69],"approach":[70],"to":[71,114,128],"relationship":[73],"between":[74,83],"proliferation":[75,85,120],"maturation":[77,122],"resolves":[79],"apparent":[81],"contradiction":[82],"decreased":[84],"increased":[87],"production,":[88],"by":[89,100,104],"assuming":[90],"greater":[93],"fraction":[94],"is":[98],"produced":[99],"division":[101],"rather":[102],"than":[103],"maturation.":[105],"should":[108],"helpful":[110],"designing":[112],"experiments":[113],"better":[115],"define":[116,129],"abnormalities":[118],"seeking":[127],"specific":[131],"alterations":[132],"cell":[135],"regulatory":[136],"networks":[137],"resulting":[138],"from":[139],"production":[141],"chimeric":[144],"p210bcr-abl":[145],"protein":[146],"characteristic":[147],"CML.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
