{"id":"https://openalex.org/W2118909779","doi":"https://doi.org/10.1152/ajpendo.90462.2008","title":"Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1","display_name":"Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1","publication_year":2008,"publication_date":"2008-08-20","ids":{"openalex":"https://openalex.org/W2118909779","doi":"https://doi.org/10.1152/ajpendo.90462.2008","mag":"2118909779","pmid":"https://pubmed.ncbi.nlm.nih.gov/18713960"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.90462.2008","doi":"https://doi.org/10.1152/ajpendo.90462.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.90462.2008","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101531378","display_name":"Hui Sheng","orcid":"https://orcid.org/0009-0005-4765-7338","observed_orcids":["https://orcid.org/0009-0005-4765-7338"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Sheng","raw_affiliation_strings":["Departments of Physiology, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001986694","display_name":"Tingting Sun","orcid":"https://orcid.org/0000-0002-2531-9072","observed_orcids":["https://orcid.org/0000-0002-2531-9072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tingting Sun","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066924048","display_name":"Binhai Cong","orcid":"https://orcid.org/0000-0001-6913-1779","observed_orcids":["https://orcid.org/0000-0001-6913-1779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binhai Cong","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459646","display_name":"Ping He","orcid":"https://orcid.org/0000-0002-8005-8119","observed_orcids":["https://orcid.org/0000-0002-8005-8119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping He","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanmin Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanmin Zhang","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888973","display_name":"Yan Jin","orcid":"https://orcid.org/0000-0002-9250-2766","observed_orcids":["https://orcid.org/0000-0002-9250-2766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Yan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103397955","display_name":"Chang\u2010Lin Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changlin Lu","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062415019","display_name":"Xin Ni","orcid":"https://orcid.org/0000-0002-1565-327X","observed_orcids":["https://orcid.org/0000-0002-1565-327X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Ni","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0328,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.739345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"295","issue":"4","first_page":"E938","last_page":"E946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.04879999905824661,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":1.0},{"id":"https://openalex.org/keywords/sgk1","display_name":"SGK1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/crh-receptor-1","display_name":"CRH receptor 1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antalarmin","display_name":"antalarmin","score":0.7480000257492065},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8149999976158142},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.824999988079071},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.846158504486084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7348242402076721},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7263081073760986},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6421846747398376},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6062697172164917},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5590831637382507},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4858095645904541},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45186737179756165},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4199703633785248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41460371017456055},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.41452455520629883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.374031662940979},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37202316522598267},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32243263721466064},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1940205693244934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07205915451049805}],"mesh":[{"descriptor_ui":"D000099052","descriptor_name":"CRF Receptor, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099184","descriptor_name":"Serum-Glucocorticoid Regulated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.90462.2008","doi":"https://doi.org/10.1152/ajpendo.90462.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.90462.2008","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:18713960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18713960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W303421800","https://openalex.org/W1633118497","https://openalex.org/W1681520334","https://openalex.org/W1906168141","https://openalex.org/W1938551146","https://openalex.org/W1944491216","https://openalex.org/W1964504843","https://openalex.org/W1977180767","https://openalex.org/W1984780819","https://openalex.org/W1986510344","https://openalex.org/W1990829953","https://openalex.org/W1990861420","https://openalex.org/W1992523889","https://openalex.org/W1993517945","https://openalex.org/W1995892920","https://openalex.org/W1997986332","https://openalex.org/W2002260497","https://openalex.org/W2004710215","https://openalex.org/W2006676086","https://openalex.org/W2010637356","https://openalex.org/W2012016665","https://openalex.org/W2016867400","https://openalex.org/W2028862108","https://openalex.org/W2031762224","https://openalex.org/W2034225169","https://openalex.org/W2038078341","https://openalex.org/W2041736210","https://openalex.org/W2042629507","https://openalex.org/W2047877548","https://openalex.org/W2052600593","https://openalex.org/W2055335169","https://openalex.org/W2058995181","https://openalex.org/W2061622320","https://openalex.org/W2061983836","https://openalex.org/W2063160879","https://openalex.org/W2067058885","https://openalex.org/W2070159018","https://openalex.org/W2073697680","https://openalex.org/W2079413441","https://openalex.org/W2081264545","https://openalex.org/W2089370109","https://openalex.org/W2091334965","https://openalex.org/W2094853228","https://openalex.org/W2095036452","https://openalex.org/W2107277218","https://openalex.org/W2110305256","https://openalex.org/W2111123535","https://openalex.org/W2127552596","https://openalex.org/W2154363920","https://openalex.org/W2158368575","https://openalex.org/W2162193671","https://openalex.org/W2169494292","https://openalex.org/W2206511590","https://openalex.org/W2322856271"],"related_works":["https://openalex.org/W2033507772","https://openalex.org/W2371927909","https://openalex.org/W2028862108","https://openalex.org/W7030008757","https://openalex.org/W2042633875","https://openalex.org/W2612965268","https://openalex.org/W2734574363","https://openalex.org/W2393499516","https://openalex.org/W2133024133","https://openalex.org/W2023678585"],"abstract_inverted_index":{"Corticotropin-releasing":[0],"hormone":[1],"(CRH)":[2],"has":[3],"been":[4],"shown":[5],"to":[6,59,63,124],"exhibit":[7],"various":[8],"functions":[9],"in":[10,34,42,131,141],"hippocampus.":[11],"In":[12],"the":[13,18,23,72,80],"present":[14],"study,":[15],"we":[16],"examined":[17],"effect":[19],"of":[20,25,47,53,103,106],"CRH":[21,60,120],"on":[22,122],"expression":[24,102,130],"serum/glucocorticoid-inducible":[26],"protein":[27,32,45,101,129],"kinase-1":[28],"(SGK-1),":[29],"a":[30,136],"novel":[31],"kinase,":[33],"primary":[35],"cultured":[36,132],"hippocampal":[37,133],"neurons.":[38],"A":[39],"dose-dependent":[40],"increase":[41],"mRNA":[43,99,127],"and":[44,92,100,128],"levels":[46],"SGK-1":[48,114,126],"as":[49,51],"well":[50],"frequency":[52],"SGK-1-positive":[54],"neurons":[55,134],"occurred":[56],"upon":[57],"exposure":[58],"(1":[61],"pmol/l":[62],"10":[64],"nmol/l).":[65],"These":[66],"effects":[67],"can":[68],"be":[69],"reversed":[70],"by":[71,79],"specific":[73],"CRH-R1":[74,123],"antagonist":[75,82],"antalarmin":[76],"but":[77],"not":[78,111],"CRH-R2":[81],"astressin":[83],"2B.":[84],"Blocking":[85],"adenylate":[86],"cyclase":[87],"(AC)":[88],"activity":[89],"with":[90,94],"SQ22536":[91],"PKA":[93],"H89":[95],"completely":[96],"prevented":[97],"CRH-induced":[98,113],"SGK-1.":[104],"Blockage":[105],"PLC":[107],"or":[108],"PKC":[109],"did":[110],"block":[112],"expression.":[115],"Our":[116],"results":[117],"suggest":[118],"that":[119,138],"act":[121],"stimulate":[125],"via":[135],"mechanism":[137],"is":[139],"involved":[140],"AC/PKA":[142],"signaling":[143],"pathways.":[144]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}