{"id":"https://openalex.org/W2118909720","doi":"https://doi.org/10.1002/ddr.430340203","title":"Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen","display_name":"Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2118909720","doi":"https://doi.org/10.1002/ddr.430340203","mag":"2118909720"},"language":"en","primary_location":{"id":"doi:10.1002/ddr.430340203","doi":"https://doi.org/10.1002/ddr.430340203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ddr.430340203","pdf_url":null,"source":{"id":"https://openalex.org/S26306840","display_name":"Drug Development Research","issn_l":"0272-4391","issn":["0272-4391","1098-2299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036206395","display_name":"Michael R. Boyd","orcid":"https://orcid.org/0000-0001-8514-3534","observed_orcids":["https://orcid.org/0000-0001-8514-3534"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Boyd","raw_affiliation_strings":["Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111877396","display_name":"Kenneth D. Paull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Paull","raw_affiliation_strings":["Information Technology Branch, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Technology Branch, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036206395"],"corresponding_institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":30.4948,"has_fulltext":false,"cited_by_count":1561,"citation_normalized_percentile":{"value":0.99886916,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"34","issue":"2","first_page":"91","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.7699999809265137},{"id":"https://openalex.org/keywords/human-cancer-cell-lines","display_name":"human cancer cell lines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.4519999921321869},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6845570802688599},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.5861272811889648},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.500842809677124},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4938402771949768},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.4809533655643463},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.428431898355484},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41481897234916687},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3719469904899597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35176846385002136},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3377440869808197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33269309997558594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27908724546432495},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27692440152168274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08300027251243591}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ddr.430340203","doi":"https://doi.org/10.1002/ddr.430340203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ddr.430340203","pdf_url":null,"source":{"id":"https://openalex.org/S26306840","display_name":"Drug Development Research","issn_l":"0272-4391","issn":["0272-4391","1098-2299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W12646094","https://openalex.org/W19650713","https://openalex.org/W143984920","https://openalex.org/W597762639","https://openalex.org/W1419228847","https://openalex.org/W1503630590","https://openalex.org/W1512405945","https://openalex.org/W1543399622","https://openalex.org/W1827425370","https://openalex.org/W1873164875","https://openalex.org/W1904731887","https://openalex.org/W1966542709","https://openalex.org/W1971585520","https://openalex.org/W1993570389","https://openalex.org/W1997547221","https://openalex.org/W2008702585","https://openalex.org/W2025672266","https://openalex.org/W2026825995","https://openalex.org/W2033384774","https://openalex.org/W2060971151","https://openalex.org/W2063004465","https://openalex.org/W2068040039","https://openalex.org/W2073131935","https://openalex.org/W2080119607","https://openalex.org/W2083888914","https://openalex.org/W2087649053","https://openalex.org/W2091063876","https://openalex.org/W2098426299","https://openalex.org/W2103885797","https://openalex.org/W2109689528","https://openalex.org/W2110831567","https://openalex.org/W2118832394","https://openalex.org/W2137330819","https://openalex.org/W2139324530","https://openalex.org/W2148199272","https://openalex.org/W2155208683","https://openalex.org/W2228808639","https://openalex.org/W2255395527","https://openalex.org/W4238514517","https://openalex.org/W4240870187"],"related_works":["https://openalex.org/W3152305129","https://openalex.org/W2464451760","https://openalex.org/W177472596","https://openalex.org/W2127264463","https://openalex.org/W3164924009","https://openalex.org/W1585256759","https://openalex.org/W4311599928","https://openalex.org/W1992018931","https://openalex.org/W4251759641","https://openalex.org/W1541257716"],"abstract_inverted_index":{"Abstract":[0],"During":[1],"1985\u20131990":[2],"the":[3,22,44,63,69,86,95,100,116,164,174,208,212],"U.S.":[4],"National":[5],"Cancer":[6],"Institute":[7],"(NCI)":[8],"phased":[9],"out":[10],"its":[11],"murine":[12],"leukemia":[13],"P388":[14],"anticancer":[15,138,178],"drug":[16,141,179],"screening":[17,139],"program":[18],"and":[19,50,77,82,140,155],"developed":[20,145],"as":[21,204],"replacement":[23],"a":[24,32,47,199],"new":[25,177],"in":[26,55,117,207,211],"vitro":[27,56,118],"primary":[28],"screen":[29,45,102,119,166],"based":[30],"upon":[31],"diverse":[33,136],"panel":[34],"of":[35,53,79,88,90,92,111,115,163,185,190,215],"human":[36],"tumor":[37],"cell":[38,66],"lines.":[39],"For":[40],"each":[41],"substance":[42],"tested,":[43],"generates":[46],"remarkably":[48],"reproducible":[49],"characteristic":[51],"profile":[52],"differential":[54],"cellular":[57],"sensitivity,":[58],"or":[59,146],"lack":[60],"thereof,":[61],"across":[62],"60":[64],"different":[65],"lines":[67],"comprising":[68],"panel.":[70],"Several":[71],"investigational":[72],"approaches":[73],"to":[74,127,132,135,173],"display,":[75],"analysis,":[76],"interpretation":[78],"such":[80],"profiles":[81,184],"databases,":[83],"derived":[84],"from":[85],"testing":[87],"tens":[89],"thousands":[91],"substances":[93],"during":[94],"past":[96],"4\u20135":[97],"years":[98],"since":[99],"NCI":[101,165],"became":[103],"fully":[104],"operational,":[105],"have":[106,120],"been":[107],"explored.":[108],"A":[109],"variety":[110],"useful,":[112],"practical":[113,153],"applications":[114,125,162],"become":[121],"apparent.":[122],"As":[123],"these":[124],"continue":[126],"evolve,":[128],"they":[129],"are":[130,151],"proving":[131],"be":[133,169],"complementary":[134],"other":[137],"discovery":[142],"strategies":[143],"being":[144],"pursued":[147],"elsewhere.":[148],"Reviewed":[149],"herein":[150],"some":[152],"considerations":[154],"selected":[156],"specific":[157],"examples,":[158],"particularly":[159],"illustrating":[160],"research":[161],"that":[167],"may":[168],"more":[170],"broadly":[171],"applicable":[172],"search":[175],"for":[176],"development":[180],"leads":[181],"with":[182],"novel":[183],"antitumor":[186],"activity":[187],"and/or":[188],"mechanisms":[189],"action.":[191],"\u00a9":[192],"1995":[193],"Wiley\u2010Liss,":[194],"Inc.":[195],"This":[196],"article":[197],"is":[198,206],"US":[200],"Government":[201],"work":[202],"and,":[203],"such,":[205],"public":[209],"domain":[210],"United":[213],"States":[214],"America.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":55},{"year":2024,"cited_by_count":74},{"year":2023,"cited_by_count":58},{"year":2022,"cited_by_count":68},{"year":2021,"cited_by_count":81},{"year":2020,"cited_by_count":74},{"year":2019,"cited_by_count":51},{"year":2018,"cited_by_count":58},{"year":2017,"cited_by_count":39},{"year":2016,"cited_by_count":56},{"year":2015,"cited_by_count":61},{"year":2014,"cited_by_count":78},{"year":2013,"cited_by_count":84},{"year":2012,"cited_by_count":79}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}