{"id":"https://openalex.org/W2118909246","doi":"https://doi.org/10.1128/jb.01309-07","title":"Novel Protein Antigen (JHP940) from the Genomic Plasticity Region ofHelicobacter pyloriInduces Tumor Necrosis Factor Alpha and Interleukin-8 Secretion by Human Macrophages","display_name":"Novel Protein Antigen (JHP940) from the Genomic Plasticity Region ofHelicobacter pyloriInduces Tumor Necrosis Factor Alpha and Interleukin-8 Secretion by Human Macrophages","publication_year":2007,"publication_date":"2007-11-10","ids":{"openalex":"https://openalex.org/W2118909246","doi":"https://doi.org/10.1128/jb.01309-07","mag":"2118909246","pmid":"https://pubmed.ncbi.nlm.nih.gov/17993522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2223580"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01309-07","doi":"https://doi.org/10.1128/jb.01309-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01309-07","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2223580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112512253","display_name":"Mohammed Rizwan","orcid":"https://orcid.org/0009-0003-7371-1997","observed_orcids":["https://orcid.org/0009-0003-7371-1997"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammed Rizwan","raw_affiliation_strings":["Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635488","display_name":"Ayesha Alvi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ayesha Alvi","raw_affiliation_strings":["Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045733858","display_name":"Niyaz Ahmed","orcid":"https://orcid.org/0000-0001-6425-7583","observed_orcids":["https://orcid.org/0000-0001-6425-7583"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Niyaz Ahmed","raw_affiliation_strings":["Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78270026"],"apc_list":null,"apc_paid":null,"fwci":2.6561,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.89846869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"190","issue":"3","first_page":"1146","last_page":"1151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chronic-gastritis","display_name":"chronic gastritis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.6909999847412109},{"id":"https://openalex.org/keywords/strain-genotyping","display_name":"strain genotyping","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9089133739471436},{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.8180712461471558},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7604144215583801},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6816543340682983},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6475217938423157},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4812735915184021},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.47277167439460754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.423976868391037},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.418311208486557},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3904667794704437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3381006121635437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2528144121170044},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.08339029550552368},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.01309-07","doi":"https://doi.org/10.1128/jb.01309-07","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01309-07","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2223580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2223580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:17993522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17993522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2223580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2223580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W9610411","https://openalex.org/W211986496","https://openalex.org/W1516144212","https://openalex.org/W1537143297","https://openalex.org/W1633947760","https://openalex.org/W1968442371","https://openalex.org/W1989918204","https://openalex.org/W2002854478","https://openalex.org/W2022948175","https://openalex.org/W2033051264","https://openalex.org/W2047440121","https://openalex.org/W2050548181","https://openalex.org/W2054778956","https://openalex.org/W2069711320","https://openalex.org/W2102521816","https://openalex.org/W2106877484","https://openalex.org/W2107650725","https://openalex.org/W2108018752","https://openalex.org/W2128635872","https://openalex.org/W2133644186","https://openalex.org/W2135443167","https://openalex.org/W2149485503","https://openalex.org/W2160181497","https://openalex.org/W2396556520","https://openalex.org/W4313342441"],"related_works":["https://openalex.org/W4233391179","https://openalex.org/W1965727091","https://openalex.org/W2090794333","https://openalex.org/W2011551027","https://openalex.org/W2093570106","https://openalex.org/W2130001850","https://openalex.org/W2032365563","https://openalex.org/W2901950164","https://openalex.org/W2160181497","https://openalex.org/W2306426763"],"abstract_inverted_index":{"The":[0,106],"plasticity":[1],"region":[2],"of":[3,19,50,60,79,97,108,130],"the":[4,98,109,126],"Helicobacter":[5],"pylori":[6,132],"genome":[7],"comprises":[8],"strain-specific":[9],"gene":[10],"loci.":[11],"We":[12,42],"performed":[13],"genotyping":[14],"and":[15,53,58,76,84],"functional":[16],"biology":[17],"analysis":[18],"one":[20],"such":[21],"locus":[22],"(jhp940)":[23],"that":[24],"was":[25,91],"previously":[26],"found":[27,43],"to":[28,47,93,116],"be":[29,48],"functionally":[30],"unknown":[31],"but":[32],"present":[33],"in":[34,68,86,103,120],"gastric":[35,122,135],"cancer-associated":[36],"strains":[37],"from":[38],"many":[39],"different":[40],"countries.":[41],"its":[44,117],"geographic":[45],"prevalence":[46],"independent":[49],"cagA":[51],"presence":[52],"disease":[54],"status.":[55],"Cloning,":[56],"expression,":[57],"purification":[59],"JHP940":[61,90],"revealed":[62],"a":[63,69],"novel,":[64],"approximately":[65],"36-kDa":[66],"protein":[67],"biologically":[70],"active":[71],"form":[72],"which":[73],"elicited":[74],"strong":[75],"significant":[77],"levels":[78],"tumor":[80],"necrosis":[81],"factor":[82,100],"alpha":[83],"interleukin-8":[85],"human":[87],"macrophages.":[88,105],"Also,":[89],"able":[92],"induce":[94],"enhanced":[95],"translocation":[96],"transcription":[99],"NF-kappaB":[101],"complex":[102],"cultured":[104],"induction":[107],"proinflammatory":[110],"cytokines":[111],"by":[112],"JHP940,":[113],"therefore,":[114],"points":[115],"putative":[118],"role":[119],"chronic":[121],"inflammation":[123],"and,":[124],"possibly,":[125],"various":[127],"other":[128],"outcomes":[129],"H.":[131],"infection,":[133],"including":[134],"cancer.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
