{"id":"https://openalex.org/W2118906288","doi":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","title":"Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial","display_name":"Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial","publication_year":2009,"publication_date":"2009-12-17","ids":{"openalex":"https://openalex.org/W2118906288","doi":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","mag":"2118906288","pmid":"https://pubmed.ncbi.nlm.nih.gov/19730258"},"language":"en","primary_location":{"id":"doi:10.1097/ccm.0b013e3181b02fc1","doi":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073050783","display_name":"E. Christiaan Boerma","orcid":"https://orcid.org/0000-0001-7928-5309","observed_orcids":["https://orcid.org/0000-0001-7928-5309"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E Christiaan Boerma","raw_affiliation_strings":["Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands. e.boerma@chello.nl","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands. e.boerma@chello.nl","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010883150","display_name":"Matty Koopmans","orcid":"https://orcid.org/0000-0003-4148-709X","observed_orcids":["https://orcid.org/0000-0003-4148-709X"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Matty Koopmans","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063488496","display_name":"A. J. M. Konijn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arjan Konijn","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071446946","display_name":"Katerina Kaiferova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Katerina Kaiferova","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113784001","display_name":"Andries J. Bakker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Andries J. Bakker","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010075077","display_name":"Eric Nico van Roon","orcid":"https://orcid.org/0000-0001-8629-7535","observed_orcids":["https://orcid.org/0000-0001-8629-7535"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eric N. van Roon","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056369689","display_name":"Hanneke Buter","orcid":"https://orcid.org/0000-0001-8594-9079","observed_orcids":["https://orcid.org/0000-0001-8594-9079"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hanneke Buter","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029365010","display_name":"Nienke Bruins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nienke Bruins","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111671197","display_name":"Peter H. Egbers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter H. Egbers","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018013582","display_name":"Rik Th. Gerritsen","orcid":"https://orcid.org/0000-0002-2791-0448","observed_orcids":["https://orcid.org/0000-0002-2791-0448"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rik T. Gerritsen","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter M. Koetsier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter M. Koetsier","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112404328","display_name":"W. Peter Kingma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W Peter Kingma","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066083330","display_name":"Michael A. Kuiper","orcid":"https://orcid.org/0000-0001-6201-7332","observed_orcids":["https://orcid.org/0000-0001-6201-7332"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michael A. Kuiper","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057342507","display_name":"Can \u0130nce","orcid":"https://orcid.org/0000-0002-8298-0270","observed_orcids":["https://orcid.org/0000-0002-8298-0270"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Can Ince","raw_affiliation_strings":["Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry (AJB), Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Departments of Intensive Care (ECB, MK, AK, KK, HB, NB, PHE, RTG, PMK, PK, MAK) and Clinical Pharmacy and Clinical Pharmacology (ENvR), Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]},{"raw_affiliation_string":"From the Department of Translational Physiology (ECB, CI), Academic Medical Centre, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900"]},{"raw_affiliation_string":"Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.5376,"has_fulltext":false,"cited_by_count":215,"citation_normalized_percentile":{"value":0.99019078,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"38","issue":"1","first_page":"93","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroglycerin","display_name":"nitroglycerin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sublingual-microcirculation","display_name":"sublingual microcirculation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/microvascular-blood-flow","display_name":"microvascular blood flow","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/microvascular-flow-index","display_name":"microvascular flow index","score":0.6079999804496765},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vasodilator-therapy","display_name":"vasodilator therapy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.6259999871253967},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.7059999704360962},{"id":"https://openalex.org/keywords/vasopressors","display_name":"vasopressors","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9492897987365723},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.8224897384643555},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.6763583421707153},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.641555905342102},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5794554948806763},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5515176057815552},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5384549498558044},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5216039419174194},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5004122257232666},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.4720003604888916},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.45707282423973083},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42997249960899353},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.4200460910797119},{"id":"https://openalex.org/C2779350572","wikidata":"https://www.wikidata.org/wiki/Q784720","display_name":"Sublingual administration","level":2,"score":0.4139374792575836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31115370988845825},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.228877454996109},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.18228119611740112},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08159393072128296},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006784","descriptor_name":"Hospitals, Teaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006784","descriptor_name":"Hospitals, Teaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006784","descriptor_name":"Hospitals, Teaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009060","descriptor_name":"Mouth Floor","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009060","descriptor_name":"Mouth Floor","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009060","descriptor_name":"Mouth Floor","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/ccm.0b013e3181b02fc1","doi":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0b013e3181b02fc1","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:19730258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19730258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/250cfe07-b671-43b7-a350-0acdd032576e","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/250cfe07-b671-43b7-a350-0acdd032576e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Boerma, E C, Koopmans, M, Konijn, A, Kaiferova, K, Bakker, A J, van Roon, E N, Buter, H, Bruins, N, Egbers, P H, Gerritsen, R T, Koetsier, P M, Kingma, W P, Kuiper, M A & Ince, C 2010, 'Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol : a double-blind randomized placebo controlled trial', Critical Care Medicine, vol. 38, no. 1, pp. 93-100. https://doi.org/10.1097/CCM.0b013e3181b02fc1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/69b3e5d1-0767-4c45-8fbb-8d1b245284da","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/effects-of-nitroglycerin-on-sublingual-microcirculatory-blood-flow-in-patients-with-severe-sepsisseptic-shock-after-a-strict-resuscitation-protocol-a-doubleblind-randomized-placebo-controlled-trial(69b3e5d1-0767-4c45-8fbb-8d1b245284da).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical care medicine, 38(1), 93 - 100. Lippincott Williams and Wilkins","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/3e1e7c20-ee72-4ed4-a207-647d130fc3d9","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/3e1e7c20-ee72-4ed4-a207-647d130fc3d9","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boerma, E C, Koopmans, M, Konijn, A, Kaiferova, K, Bakker, A J, van Roon, E N, Buter, H, Bruins, N, Egbers, P H, Gerritsen, R T, Koetsier, P M, Kingma, W P, Kuiper, M A & Ince, C 2010, 'Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial', Critical care medicine, vol. 38, no. 1, pp. 93-100. https://doi.org/10.1097/CCM.0b013e3181b02fc1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/250cfe07-b671-43b7-a350-0acdd032576e","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/250cfe07-b671-43b7-a350-0acdd032576e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care Medicine, 38(1), 93 - 100. LIPPINCOTT WILLIAMS & WILKINS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1630781445","https://openalex.org/W1882734793","https://openalex.org/W1959535156","https://openalex.org/W1980471018","https://openalex.org/W1984248420","https://openalex.org/W1985274709","https://openalex.org/W1991864206","https://openalex.org/W2000566182","https://openalex.org/W2004087191","https://openalex.org/W2006216692","https://openalex.org/W2014423374","https://openalex.org/W2029493246","https://openalex.org/W2036140137","https://openalex.org/W2039733992","https://openalex.org/W2039949381","https://openalex.org/W2054499486","https://openalex.org/W2057364247","https://openalex.org/W2067068240","https://openalex.org/W2078206871","https://openalex.org/W2078546046","https://openalex.org/W2097980836","https://openalex.org/W2104418170","https://openalex.org/W2109637252","https://openalex.org/W2113689749","https://openalex.org/W2116403540","https://openalex.org/W2120878408","https://openalex.org/W2121391159","https://openalex.org/W2131700854","https://openalex.org/W2131868847","https://openalex.org/W2139937737","https://openalex.org/W2148911959","https://openalex.org/W2151426785","https://openalex.org/W2157532432","https://openalex.org/W2160691650","https://openalex.org/W3143362397","https://openalex.org/W4238566795"],"related_works":["https://openalex.org/W2992165696","https://openalex.org/W2357188473","https://openalex.org/W3135753594","https://openalex.org/W2426108400","https://openalex.org/W2348691413","https://openalex.org/W75619350","https://openalex.org/W2349687057","https://openalex.org/W2013529578","https://openalex.org/W1964182148","https://openalex.org/W2095110868"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Microcirculatory":[1],"alterations":[2,14],"have":[3],"been":[4],"associated":[5],"with":[6,30,82,137,298],"morbidity":[7],"and":[8,88,221,246,270],"mortality":[9],"in":[10,33,49,71,171,180,188,195,210,217,227,247,266,272,296],"human":[11],"sepsis.":[12,54],"Such":[13],"occur":[15],"despite":[16],"pressure-guided":[17],"resuscitation.":[18],"Earlier":[19],"data":[20],"suggested":[21],"that":[22,307],"impaired":[23],"microcirculatory":[24,149,182,314],"blood":[25,150,315],"flow":[26,151,183,199,208],"could":[27],"be":[28],"corrected":[29],"intravenous":[31,308],"nitroglycerin":[32,117,219,268,309],"these":[34],"patients.":[35],"We":[36],"tested":[37],"this":[38],"concept":[39],"after":[40,126,185],"fulfillment":[41,127,290],"of":[42,53,94,128,152,168,283,291],"preset":[43],"systemic":[44,292],"hemodynamic":[45,293],"resuscitation":[46,130,286],"end":[47,131,294],"points":[48,295],"the":[50,98,181,196,218,228,234,267,273,281],"early":[51,92],"phase":[52],"DESIGN:":[55],"Prospective,":[56],"single":[57],"center,":[58],"randomized,":[59],"placebo-controlled,":[60],"double-blind":[61],"clinical":[62],"trial.":[63],"SETTING:":[64],"Closed-format":[65],"22-bed":[66],"mixed":[67],"intensive":[68,102],"care":[69,103],"unit":[70,104],"a":[72,177,261,284],"tertiary":[73],"teaching":[74],"hospital.":[75],"PATIENTS:":[76],"Patients":[77,111],">":[78],"or":[79,121,302],"=18":[80],"yrs":[81],"sepsis,":[83],"according":[84],"to":[85,115,190],"international":[86],"criteria,":[87],"at":[89],"least":[90],"one":[91],"sign":[93],"organ":[95],"dysfunction,":[96],"as":[97,139,155,174,260],"principal":[99],"reason":[100],"for":[101,108],"admission,":[105],"were":[106,112,237],"eligible":[107],"enrollment.":[109],"INTERVENTIONS:":[110],"randomly":[113],"assigned":[114],"receive":[116],"(n":[118,123],"=":[119,124,225,244,256,277],"35)":[120,125],"placebo":[122,229,274],"protocol-driven":[129],"points.":[132],"This":[133],"trial":[134],"is":[135],"registered":[136],"ClinicalTrials.gov":[138],"NCT00493415.":[140],"MEASUREMENTS":[141],"AND":[142],"MAIN":[143],"RESULTS:":[144],"Primary":[145],"outcome":[146],"was":[147,201,214,264],"sublingual":[148,169,197,211,313],"small":[153],"vessels,":[154,233,249],"assessed":[156],"by":[157,176],"side-stream":[158],"dark":[159],"field":[160],"imaging.":[161],"After":[162],"protocolized":[163],"resuscitation,":[164],"we":[165,305],"observed":[166,202],"recruitment":[167],"microcirculation":[170],"both":[172],"groups,":[173],"indicated":[175],"significant":[178],"improvement":[179],"index":[184,200,209],"24":[186],"hrs,":[187],"comparison":[189],"baseline.":[191],"However,":[192],"no":[193],"difference":[194],"microvascular":[198,207],"between":[203],"groups.":[204],"The":[205],"median":[206],"small-sized":[212],"vessels":[213],"2.71":[215,222],"(1.85-3)":[216],"group":[220,269],"(1.27-3),":[223],"p":[224,243,255,276],".80,":[226],"group.":[230],"In":[231,280],"medium-sized":[232],"respective":[235],"values":[236],"3":[238,250,253],"(2.75-3)":[239],"vs.":[240,252],"2.86":[241],"(2.19-3),":[242],".21,":[245],"large-sized":[248],"(3-3)":[251],"(2.89-3),":[254],".06.":[257],"In-hospital":[258],"mortality,":[259],"secondary":[262],"outcome,":[263],"34.3%":[265],"14.2%":[271],"group,":[275],".09.":[278],"CONCLUSIONS:":[279],"context":[282],"strict":[285],"protocol,":[287],"based":[288],"upon":[289],"patients":[297],"early-phase":[299],"severe":[300],"sepsis":[301],"septic":[303],"shock,":[304],"conclude":[306],"does":[310],"not":[311],"promote":[312],"flow.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}