{"id":"https://openalex.org/W2118735797","doi":"https://doi.org/10.1161/hq0102.101818","title":"Adrenoceptor Hyporeactivity Is Responsible for Escherichia coli Endotoxin\u2013Induced Acute Vascular Dysfunction in Humans","display_name":"Adrenoceptor Hyporeactivity Is Responsible for Escherichia coli Endotoxin\u2013Induced Acute Vascular Dysfunction in Humans","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2118735797","doi":"https://doi.org/10.1161/hq0102.101818","mag":"2118735797","pmid":"https://pubmed.ncbi.nlm.nih.gov/11788467"},"language":"en","primary_location":{"id":"doi:10.1161/hq0102.101818","doi":"https://doi.org/10.1161/hq0102.101818","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hq0102.101818","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014859179","display_name":"Johannes Pleiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johannes Pleiner","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Johannes Pleiner From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Johannes Pleiner From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002174658","display_name":"Elisabeth Heere\u2010Ress","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Elisabeth Heere-Ress","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Elisabeth Heere-Ress From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Elisabeth Heere-Ress From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019765272","display_name":"Herbert Langenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Herbert Langenberger","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Herbert Langenberger From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Herbert Langenberger From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113669560","display_name":"Anna E. Sieder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna E. Sieder","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Anna E. Sieder From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Anna E. Sieder From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035598634","display_name":"Michaela Bayerle\u2010Eder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michaela Bayerle-Eder","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Michaela Bayerle-Eder From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Michaela Bayerle-Eder From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111913571","display_name":"Fritz Mittermayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Fritz Mittermayer","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Fritz Mittermayer From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Fritz Mittermayer From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052901535","display_name":"Gabriele Fuchsj\u00e4ger\u2010Mayrl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gabriele Fuchsja\u0308ger-Mayrl","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686281","display_name":"J B\u00f6hm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johannes Bo\u0308hm","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056905219","display_name":"Burkhard Jansen","orcid":"https://orcid.org/0000-0003-3425-444X","observed_orcids":["https://orcid.org/0000-0003-3425-444X"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Burkhard Jansen","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Burkhard Jansen From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Burkhard Jansen From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054404247","display_name":"Michael Wolzt","orcid":"https://orcid.org/0000-0001-6049-1890","observed_orcids":["https://orcid.org/0000-0001-6049-1890"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Wolzt","raw_affiliation_strings":["From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","Michael Wolzt From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Michael Wolzt From the Department of Clinical Pharmacology (J.P., E.H.-R., H.L., A.E.S., M.B.-E., F.M., G.F.-M., J.B., B.J., M.W.) and the Department of Dermatology (E.H.-R., B.J.), University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":null,"apc_paid":null,"fwci":6.4891,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.96965728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"1","first_page":"95","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.875},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9190000295639038},{"id":"https://openalex.org/keywords/escherichia-coli-endotoxin","display_name":"Escherichia coli endotoxin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.6940000057220459},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/phenylephrine-pressor-response","display_name":"phenylephrine pressor response","score":0.824999988079071},{"id":"https://openalex.org/keywords/forearm-blood-flow","display_name":"forearm blood flow","score":0.8220000267028809},{"id":"https://openalex.org/keywords/l-nmma","display_name":"L-NMMA","score":0.7289999723434448},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/catecholamine-response","display_name":"catecholamine response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/systemic-vasodilation","display_name":"systemic vasodilation","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.8612332940101624},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7281568646430969},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6302934288978577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.601162850856781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5967370271682739},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5851492881774902},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5751921534538269},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.536867082118988},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.520846426486969},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5043622255325317},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.4528038799762726},{"id":"https://openalex.org/C2908937200","wikidata":"https://www.wikidata.org/wiki/Q6823955","display_name":"Omega-N-Methylarginine","level":4,"score":0.41954392194747925},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.398625910282135},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.2553953528404236}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/hq0102.101818","doi":"https://doi.org/10.1161/hq0102.101818","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hq0102.101818","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:11788467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11788467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W79838143","https://openalex.org/W1980752706","https://openalex.org/W1982072215","https://openalex.org/W1992644897","https://openalex.org/W2009977522","https://openalex.org/W2010489806","https://openalex.org/W2013069817","https://openalex.org/W2014112698","https://openalex.org/W2023170094","https://openalex.org/W2023368717","https://openalex.org/W2042027599","https://openalex.org/W2051484288","https://openalex.org/W2053684366","https://openalex.org/W2057747874","https://openalex.org/W2061689063","https://openalex.org/W2072142711","https://openalex.org/W2072376419","https://openalex.org/W2089877069","https://openalex.org/W2093523673","https://openalex.org/W2096279873","https://openalex.org/W2104733318","https://openalex.org/W2113265360","https://openalex.org/W2115929723","https://openalex.org/W2116931632","https://openalex.org/W2128035214","https://openalex.org/W2141018820","https://openalex.org/W2154927731","https://openalex.org/W2187706372","https://openalex.org/W2236311348","https://openalex.org/W2244491391","https://openalex.org/W2405166251","https://openalex.org/W2415904954","https://openalex.org/W2416511103","https://openalex.org/W2470058005","https://openalex.org/W2768146862"],"related_works":["https://openalex.org/W2019161209","https://openalex.org/W2236311348","https://openalex.org/W2219050306","https://openalex.org/W1978092182","https://openalex.org/W1991099035","https://openalex.org/W2093976157","https://openalex.org/W2187826465","https://openalex.org/W2015960226","https://openalex.org/W2001887083","https://openalex.org/W2126215854"],"abstract_inverted_index":{"Impaired":[0],"response":[1,116],"to":[2,5,15,54,83,126,186],"catecholamines":[3],"contributes":[4],"the":[6,22,60,71,115,132,162,182],"altered":[7],"hemodynamics":[8],"in":[9,38,161,171,181],"sepsis,":[10],"which":[11],"has":[12],"been":[13],"attributed":[14],"excessive":[16],"NO":[17,31,166],"formation.":[18],"We":[19],"have":[20],"studied":[21,93],"systemic":[23,61,184],"hemodynamic":[24],"and":[25,29,69,89,96,104,109,122],"local":[26],"forearm":[27,79],"responses":[28,82],"inducible":[30],"synthase":[32],"(iNOS)":[33],"expression":[34,170],"during":[35],"experimental":[36],"endotoxemia":[37],"humans.":[39],"Escherichia":[40],"coli":[41],"endotoxin":[42],"(lipopolysaccharide":[43],"[LPS])":[44],"was":[45,66,102,128,136,146,152],"administered":[46],"at":[47,94],"doses":[48],"of":[49,64,73,117,164,177],"1":[50],"or":[51,150,168],"2":[52],"ng/kg":[53],"healthy":[55],"volunteers.":[56],"In":[57,75,131],"10":[58],"subjects,":[59,78],"pressor":[62],"effect":[63],"phenylephrine":[65,127],"assessed":[67],"before":[68],"after":[70,97,113],"administration":[72],"LPS.":[74,187],"9":[76],"further":[77],"blood":[80,101,119],"flow":[81],"intra-arterial":[84],"noradrenaline,":[85],"acetylcholine,":[86],"glyceryl":[87],"trinitrate,":[88],"N(G)-monomethyl-L-arginine":[90],"(L-NMMA)":[91],"were":[92],"baseline":[95],"LPS":[98],"administration.":[99],"Peripheral":[100],"collected":[103],"analyzed":[105],"for":[106],"iNOS":[107,148,169,179],"mRNA":[108,149],"protein.":[110],"Four":[111],"hours":[112],"LPS,":[114],"systolic":[118],"pressure":[120],"(P<0.0005)":[121],"heart":[123],"rate":[124],"(P<0.05)":[125],"significantly":[129],"reduced.":[130],"forearm,":[133],"noradrenaline-induced":[134],"vasoconstriction":[135],"also":[137],"reduced":[138],"by":[139],"approximately":[140],"50%":[141],"(P<0.01),":[142],"but":[143],"L-NMMA":[144],"responsiveness":[145],"unchanged.":[147],"protein":[151],"not":[153],"increased.":[154],"Marked":[155],"vascular":[156,178],"adrenoceptor":[157],"hyporeactivity":[158],"is":[159],"detectable":[160],"absence":[163],"increased":[165],"activity":[167,180],"endotoxemia,":[172],"arguing":[173],"against":[174],"major":[175],"involvement":[176],"acute":[183],"vasodilation":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
