{"id":"https://openalex.org/W211873229","doi":null,"title":"IR820-chitosan conjugates for imaging and hyperthermia.","display_name":"IR820-chitosan conjugates for imaging and hyperthermia.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W211873229","mag":"211873229"},"language":"en","primary_location":{"id":"pmh:oai:nsuworks.nova.edu:hpd_pt_facpres-1041","doi":null,"is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/hpd_pt_facpres/42","pdf_url":null,"source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Physical Therapy Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.","raw_type":"poster"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033534450","display_name":"Alicia Fernandez-Fernandez","orcid":"https://orcid.org/0000-0001-6778-3570","observed_orcids":["https://orcid.org/0000-0001-6778-3570"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Fernandez-Fernandez","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":"https://orcid.org/0000-0001-6778-3570","affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079515907","display_name":"Romila Manchanda","orcid":"https://orcid.org/0000-0003-1619-0374","observed_orcids":["https://orcid.org/0000-0003-1619-0374"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romila Manchanda","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":"https://orcid.org/0000-0003-1619-0374","affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075601806","display_name":"Supriya Srinivasan","orcid":"https://orcid.org/0009-0006-9320-6762","observed_orcids":["https://orcid.org/0009-0006-9320-6762"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supriya Srinivasan","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087220018","display_name":"Tingjun Lei","orcid":"https://orcid.org/0000-0002-9043-5600","observed_orcids":["https://orcid.org/0000-0002-9043-5600"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingjun Lei","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":"https://orcid.org/0000-0002-9043-5600","affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065339524","display_name":"Denny A. Carvajal","orcid":"https://orcid.org/0000-0002-1584-5474","observed_orcids":["https://orcid.org/0000-0002-1584-5474"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denny A. Carvajal","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":"https://orcid.org/0000-0002-1584-5474","affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072922405","display_name":"Anthony J. McGoron","orcid":"https://orcid.org/0000-0003-3714-4676","observed_orcids":["https://orcid.org/0000-0003-3714-4676"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. McGoron","raw_affiliation_strings":["1Biomedical Engineering, Florida International University, Miami, FL"],"raw_orcid":"https://orcid.org/0000-0003-3714-4676","affiliations":[{"raw_affiliation_string":"1Biomedical Engineering, Florida International University, Miami, FL","institution_ids":["https://openalex.org/I19700959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19700959"],"apc_list":null,"apc_paid":null,"fwci":0.3643,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59483644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"53","issue":null,"first_page":"1172","last_page":"1172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ir820","display_name":"IR820","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/photothermal-hyperthermia","display_name":"photothermal hyperthermia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/optical-imaging","display_name":"optical imaging","score":0.5360000133514404},{"id":"https://openalex.org/keywords/image-guided-cancer-therapy","display_name":"image-guided cancer therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/in-vivo-biodistribution","display_name":"in vivo biodistribution","score":0.6830000281333923},{"id":"https://openalex.org/keywords/gastrointestinal-contrast-agents","display_name":"gastrointestinal contrast agents","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cancer-cell-imaging","display_name":"cancer cell imaging","score":0.5180000066757202},{"id":"https://openalex.org/keywords/808-nm-laser","display_name":"808 nm laser","score":0.7239999771118164},{"id":"https://openalex.org/keywords/785-nm-excitation","display_name":"785 nm excitation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7549521923065186},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.732391893863678},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7146591544151306},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.6611552238464355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5885413885116577},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4363114833831787},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4106369614601135},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.39690133929252625},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34668493270874023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16072127223014832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0824705958366394},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08202332258224487},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:nsuworks.nova.edu:hpd_pt_facpres-1041","doi":null,"is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/hpd_pt_facpres/42","pdf_url":null,"source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Physical Therapy Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.","raw_type":"poster"},{"id":"pmh:oai:nsuworks.nova.edu:hpd_pt_facpres-1719","doi":null,"is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/hpd_pt_facpres/376","pdf_url":null,"source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Physical Therapy Faculty Proceedings, Presentations, Posters, Speeches, Lectures, etc.","raw_type":"conference"},{"id":"mag:211873229","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/53/supplement_1/1172","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990569959","https://openalex.org/W1570971296","https://openalex.org/W581615497","https://openalex.org/W1010401500","https://openalex.org/W1142759053","https://openalex.org/W1972584598","https://openalex.org/W2793649507","https://openalex.org/W2048276265","https://openalex.org/W3083438273","https://openalex.org/W2887843711"],"abstract_inverted_index":{"1172":[0],"Objectives":[2],"The":[4,120],"design":[5],"of":[6,24,78,107,216,235],"near-infrared":[7],"dye":[8],"conjugates":[9,32,109,137,158,184,227,244,272],"with":[10,63,149,197,256],"hyperthermia":[11,255,279],"and":[12,33,43,71,76,90,101,116,170,252,277,290],"optical":[13],"imaging":[14,46,75,148,181],"capabilities":[15,47],"can":[16,143,228,245],"create":[17],"new":[18],"tools":[19],"for":[20,41,146,269,284],"minimally-invasive":[21],"image-guided":[22,278],"therapy":[23],"cancer.":[25],"In":[26,177,203],"this":[27],"study,":[28],"we":[29],"developed":[30],"IR820-chitosan":[31,136,157,243],"studied":[34],"their":[35],"chemical":[36],"properties,":[37],"in":[38,44,48,59,87,95,98,125,168,179,194,231,263],"vitro":[39],"applications":[40],"imaging/hyperthermia,":[42],"vivo":[45,96,180,264],"a":[49,60,113,117],"rat":[50],"model.":[51],"Methods":[53],"Chitosan":[55],"was":[56,193,214],"covalently":[57],"linked":[58],"two-step":[61],"reaction":[62],"IR820.":[64,176],"Conjugates":[65],"were":[66,85,110,123],"characterized":[67],"by":[68],"FTIR,":[69],"spectrophotometry":[70],"spectrofluorometry.":[72],"Fluorescent":[73],"cell":[74,147,151,165],"determination":[77],"hyperthermia-mediated":[79,164],"cytotoxicity":[80],"using":[81,112,270],"an":[82],"808-nm":[83],"laser":[84,115],"performed":[86,111],"Dx5,":[88],"MES-SA,":[89],"SKOV-3":[91],"cancer":[92,250,258],"cells.":[93],"24-hour":[94],"studies":[97],"intact":[99,205],"rats":[100],"excised":[102],"organs":[103],"after":[104,212,222],"i.v.":[105],"injection":[106,213],"the":[108,160,178,183,195,201,204,207,217,295],"785-nm":[114],"CCD":[118],"camera.":[119],"resulting":[121],"images":[122],"processed":[124],"Matlab":[126],"to":[127,154,162,174,248],"obtain":[128],"background-subtracted":[129],"image":[130,232,249],"intensity":[131],"ratios.":[132],"Results":[134],"(abs.":[138],"669":[139],"nm/emission":[140],"745":[141],"nm)":[142],"be":[144,229,246],"used":[145,230,247],"enhanced":[150,257],"uptake":[152],"compared":[153,173],"free":[155,175],"dye.":[156],"have":[159],"capability":[161],"enhance":[163],"growth":[166,259],"inhibition":[167],"MES-SA":[169],"Dx5":[171],"cells":[172,251],"studies,":[182],"demonstrated":[185],"predominant":[186],"elimination":[187,265],"through":[188,200],"biliary":[189],"excretion.":[190],"Initial":[191],"localization":[192],"liver,":[196],"subsequent":[198],"path":[199],"intestines.":[202],"animal,":[206],"average":[208,218],"signal":[209],"24":[210,238],"hours":[211],"14.6%":[215],"value":[219],"45":[220],"minutes":[221],"injection,":[223],"indicating":[224],"that":[225],"these":[226,271],"collection":[233],"windows":[234],"at":[236],"least":[237],"hours.":[239],"Conclusions":[241],"deliver":[253],"localized":[254],"inhibition.":[260],"Their":[261],"characteristic":[262],"pattern":[266],"opens":[267],"possibilities":[268],"as":[273,281,283],"gastrointestinal":[274],"contrast":[275],"agents":[276],"probes,":[280],"well":[282],"further":[285],"customization":[286],"into":[287],"multifunctional":[288],"gene":[289],"drug":[291],"delivery":[292],"vehicles":[293],"targeting":[294],"digestive":[296],"tract":[297]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2016-06-24T00:00:00"}